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Surgical Pathology and CurrentMolec
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Barrett’s EsophagusDefinition•
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Barrett’s EsophagusEpithelial Typ
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Multilayered Epithelium
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Short (Ultrashort) BE vs.Chronic Ca
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Esophageal versus Cardia___________
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Barrett’s Dysplasia/CarcinomaRisk
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Barrett’s Dysplasia/CarcinomaRisk
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DysplasiaPathologic Features1. Gros
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Non-Recommended Terms“Atypia”
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Barrett’s-related DysplasiaIntero
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Adjunctive TechniquesProliferation
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Esophagectomy forHigh-Grade Dysplas
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ACG guidelines for Surveillance in
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Management ConsiderationsSurveillan
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Molecular Basis ofBarrett’s Esoph
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Non-DysplasticBarrett’s Esophagus
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Aneuploidy Predicts Progressionin B
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p53 Gene Detection•17p loss of he
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17p LOH & Progressionin Barrett’s
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p53 “Positive” Immunostaining
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p53 Positive Barrett’s Indefinite
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Detection of p16 Inactivationin Bar
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Cyclin D1 Gene•Cyclin/CDK complex
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Molecular Summary ofBarrett’s Eso
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Molecular Summary ofBarrett’s Eso
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Dysplasia in Crohn’s Disease• R
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Dysplasia in Crohn’s Disease(Sige
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Risk of Neoplasia in UC1. Dysplasia
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Primary Sclerosing CholangitisRisk
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UC-Associated DysplasiaInterobserve
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Flat DysplasiaNatural History(Berns
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Colectomy for Low Grade Dysplasia__
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DALMAdenoma LikeSessile/Pedunculate
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Adenoma vs Polypoid Dysplasia1. Mor
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Adenoma vs Polypoid DysplasiaValue
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Genetic Alterations inChronic ulcer
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Is it possible to reliablydifferent
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______Feature CUC patients Non-CUCA
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Rubin et al________________________
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DALMAdenoma-likeNon-Adenoma-like(br
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Genetic Progression inColitis-Assoc
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Colitis-AssociatedVersus Sporadic N
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Aneuploidy Associations inColitis-A
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neuploidy Predicts Progressionin No
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p53 inNegative/IndefiniteMucosa
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Other Markers inColitis-Associated
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Chromosomal Instability (CIN)in Col
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Telomere Erosion inColitis-Associat
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Fecal DNA Mutation Testing•High s
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Squamous Dysplasia
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Squamous dysplasiaclinical features
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Pathologic features• Gross: eryth
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- Page 209 and 210: Squamous dysplasia- treatmentDYSPLA
- Page 211 and 212: Genetic Progression inEsophageal Sq
- Page 213 and 214: p53 Immunostaining inEsophageal Squ
- Page 215 and 216: Small Intestinal Metaplasia andDysp
- Page 217: Mucous cell metaplasia• Feature o
- Page 225 and 226: Small intestinal dysplasia• Crohn
- Page 234 and 235: Gastric Metaplasia and Dysplasia
- Page 236 and 237: Gastric carcinoma- risk factors•
- Page 242: Intestinal metaplasiaclassification
- Page 246 and 247: Gastric dysplasiaPadova classificat
- Page 272 and 273: Gastric dysplasia- natural historyS
- Page 274 and 275: Gastric polypsNon-neoplasticDysplas
- Page 278: Dysplasia in hyperplastic polyps•
- Page 285: Dysplasia in fundic gland polyps•
- Page 289 and 290: Genetic Progressionin Gastric Neopl
- Page 291 and 292: Microsatellite Instability inGastri
- Page 293 and 294: Analysis of DNA MismatchRepair From
- Page 295 and 296: Microsatellite Instability inGastri
- Page 297 and 298: CpG Island Methylation inGastric Me
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APC inWNTSignalingAXINAPCWNTFrizzle
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Molecular Summary ofGastric Dysplas
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