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146 ABSTRACTS PNEUMOLOGY / NEUMONOLOGÍA P-10-25 | ASTHMA CONTROL TEST TM (ACT) SCORES CORRELATIONS IN COMORBIDITIES Gemicioglu B, Dogan I, Musellim B, Guven K. Istanbul University, Cerrahpasa Faculty of Medicine, Dept of Pulmonary Diseases. Turkey Asthma Control TestTM (ACT) is a validated practical questionnaire to understand asthma control in asthmatics. Comorbidities in asthma patients become important problem in asthma control. The correlation of ACT with different comorbidities was evaluated in this study to demostrate the usefulness of ACT in follow-up of asthma patients also with comorbidities. ACT, pulmonary functions was measured in 294 (70.7%) female, 122 (29.3%) male persistent asthma patients on combined therapy, with a mean age of 41.8±13.9. All patients responded prepared comorbities questionnaire. 74.6% were nonsmokers, 42.6% were skin prick test positive. During past year only 16.8% of them had emergency room visit and 5.8% was hospitalized. Mean FEV1 was 2.4±0.9 lt (%83.4±19.3). Mean ACT was 19±5.2. In only 55% ACT was above 20; that means controlled. ACT scores were positively correlated with FEV1 (r=-0.22; p=0.001). But FeNO levels were not correlated with FEV1. Hospitalization and emergency room visit last year decrease significantly ACT scores (p
P-10-29 | COMPARISON OF SELF ASSESSMENT SCOR- ING METHOD WITH QUALITY OF LIFE QUESTIONABLE FOR ADULT KOREAN ASTHMATICS Ji Ye Jung, Yong Won Lee, Yoo Seob Shin, Jung-Won Park, Chein-Soo Hong Department of Internal Medicine, Yonsei Univeristy College of Medicine, Seoul, Republic of Korea Introduction: Quality of life questionnaire for adult Korean asthmatics (QLQAKA) is a valid and reproducible tool for evaluating and monitoring Korean adult asthmatics. However, questionnaire is still burden to some patients, so we developed a simple self assessment scoring method. – OBJECTIVE: The goal of this study is to compare self assessment score with QLQAKA scores and evaluate how well it reflects quality of life of asthmatics. Materials and Methods: 199 adult asthmatics were enrolled and asked to answer QLQAKA composed of 17 items in 4 domains (activity, symptoms, emotion, and exposure to environmental stimuli) and one more self assessment question of a 5-point scale was added. According to Global Initiative for Asthma (GINA) 2006 guideline, patients were divided into three groups : controlled, partly controlled, and uncontrolled. – Results: The mean QLQAKA scores and self assessment score showed statistically significant differences within the three different asthma control status groups. Pulmonary function tests also showed statistically significant differences not only within the 5 different QLQAKA total score groups but also within the 5 different self assessment score groups. Moreover, self assessment score was well correlated with QLQAKA scores. Conclusion: Therefore, in busy outpatient clinic, we may estimate QOL of asthma patients using simple self assessment scoring method. P-10-31 | CT VIRTUAL TRACHEOBRONCHOSCOPY: SPECTRUM OF FINDINGS Capuñay, Carlos; Carrascosa, Patricia; Vallejos, Javier.; Martin López, Elba.; Carrascosa, Jorge. Diagnóstico Maipú- Argentina Introduction: CT virtual tracheobronchoscopy is a new technique developed in order to assess airway’s pathology diagnosis. We will illustrate its usefulness on the base of the imaging findings from our daily CT cases. The objective of this paper is to be familiar with the CT virtual tracheobronchoscopy technique and with its main advantages and major goals. Material and Methods: Chest CT scans performed between January 2006 and March 2008 were retrospectively reviewed. CT´s were performed on a 16-row and 64-row CT scanners (Brilliance 16 and 64; Philips Medical Systems) using 16x1.5 configuration; 2mm collimation and 64x0.625 configuration and 1mm collimation respectively. Scans were carried out with or without the injection of iodine contrast, based on the clinical indication. Images were evaluated on a dedicated workstation. A systematic analysis using multiplanar reconstructions, maximum intensity projections, three-dimensional and endoscopic views for evidence of airways pathology and its localization was performed. Results: the sprectrum of CT findings were illustrated and the major key features were pointed out. In the CT findings we encountered: 2 tracheal bronchi; 3 tracheal diverticula; 1 patient with tracheo-papillomatosis; 23 tracheal stenosis; 5 endotracheal polyps; 4 endobronchial tumors; 10 compressions. Conclusions: virtual tracheobronchoscopy can improve airways pathology diagnosis showing different endoluminal projections with characteristic CT features for each pathological condition. ABSTRACTS P-10-30 | AUTOMATED VOLUME LUNG NODULE AS- SESSMENT BY MULTIDETECTOR CT Capuñay, Carlos; Carrascosa, Patricia; Vallejos, Javier.; Martin López, Elba.; Carrascosa, Jorge. Diagnóstico Maipú- Argentina PNEUMOLOGY / NEUMONOLOGÍA Introduction: This automatic technique demonstrates the potential for a clinically useful automated nodule assessment system that quantifies nodule size and characterize growth in solid pulmonary nodules. The purpose of the presentation is to determine the performance of an automated three-dimensional software for quantifying pulmonary nodule volume compared with the manual measurement. Method and materials: Thirty-one patients with the suspected diagnosis of pulmonary nodule were evaluated. All CT examinations were performed on a 16-row CT scanner (Brilliance 16; Philips Medical Systems, Cleveland, OH). Scanning parameters were: collimation 16 x 0.75 mm; slice thickness 1mm; slice increment 0.5mm; 140 kV; 180 mAs/slice. The images were evaluated in the axial plane to identify the lung nodule and these selected images were transferred to a workstation on which the nodule assessment computer system was implemented. The nodule selection was based on solid nodules, calcified or not. Those sub-solid or larger than 50mm in the greatest diameter nodules were excluded. Data were analyzed by two different operators. The operators performed twice the measurements with an automatic nodule assessment software and with a manual method. The volume of the nodule and its diameters (x, y, z axis) were determined. The repeatability of the measurements were assessed using the ! Bland and Altman method. Results: The automated nodule assessment system was applied to the database of 31 CT scans and 39 nodules were evaluated. Among these nodules, 26 (67%) were non-calcified nodules, 2 (5%) were partially calcified nodules, and 11 (28%) were totally calcified nodules. The mean of nodule volume was 1847.42 mL (SD: 91.48). The variability between first and second automated measurements was lower to 1%, and the variability between manual and automated measurements was lower to 10%. Conclusion: There was good agreement and repeatability in automatic lung nodule measurements, and when was compared with manual measurements. P-10-32 | SISTEMIC DISEASE MARKERS IN COPD Scarímbolo, Juan José; Martínez Cortizas, María Alicia; Pereiro, Miriam Patricia.; Artana, Cristina Noemí.; Leone, Fabio; Pistillo, N ; Majewski; G; Figueroa; JM. Hospital Interzonal General de Agudos Pedro Fiorito: Servicio de Terapia Intensiva, Servicio de Neumonología, Laboratorio de Inmunología.Instituto Médico Adrogué. Hospital Evita Pueblo Berazategui. Centro de Estudios Respiratorios y del Sueño. Buenos Aires.; Argentina Objectives: To assess the usefulness of C-reactive protein (CRP), leukotriene E4 (LTE4) and bombesin like peptides (BLP) in both functional and clinical COPD follow-up. Materials and Methods: 77 COPD patients who had neither smoked, nor required hospitalization in the last year and without corticoid treatment during the last four weeks, were enrolled in the study. Patients were classified by GOLD. Serum high sensibility CRP, urinary LTE4 and BLP were measured initially. Afterwards, salmeterol/fluticasone treatment (25/125 or 25/250 mcg) was started according to severity. After a year follow-up (±3 months), serum CRP was measured and the patients were separated in bad and good follow-up. Bad follow-up was considered when there was functional class impairment, increase in the number of visits to doctors, hospitalizations or deaths. Data were expressed as mean ± DS. Significant p
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