MADIT Randomized Trial to Reduce Inappropriate Therapy ... - 1

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MADIT‐RIT: HypothesisHypothesisDual-chamber ICD or CRT-D devices with:- high-rate cutoff (>200bpm), or- duration-delay (initial 60sec monitoring delay@>170bpm) plus rhythm ID detectiontiwill be associated with fewer 1 st inappropriatetherapies than standard/conventionalprogramming (2.5sec delay @ >170bpm)without increase in mortalityRandomized, 3-arm study using Boston ScientificRandomized, 3 arm study using Boston Scientificdevices
MADIT-RIT: Three Treatment Arms*Randomization Arm Bi ArmsC(Conventional)Arm A(High-rate)Zone 1: Zone 1: Zone 1:(Duration-delay)>170 bpm, 2.5s delay 170 bpm >170 bpm, 60s delayOnset/Stability DetectionEnhancements ONATP + ShockMonitor onlyRhythm ID DetectionEnhancements ONATP + ShockZone 2: Zone 2: Zone 2:>200 bpm, 1s delay >200 bpm, 2.5s delay >200 bpm, 12s delayQuick Convert ATPShockQuick Convert ATPShock* All programming is within approved labelingRhythm ID DetectionEnhancements ONATP + ShockZone 3 :>250 bpm, 25 2.5s delayQuick Convert ATP + Shock
Page 1 and 2: MADIT Randomized Trial to ReduceIna
Page 3: MADIT-RIT: BACKGROUND• ICD is hig
Page 7 and 8: MADIT-RIT: MADIT-RIT Prespecified P
Page 9 and 10: Baseline Demographic and ClinicalCh
Page 11 and 12: Figure 2.Cumulative Probability of
Page 13 and 14: Arrhythmias Triggering FirstInappro
Page 15 and 16: MADIT-RIT: CONCLUSIONSImproved ICD

MADIT Randomized Trial to Reduce Inappropriate Therapy ... - 1

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