MADIT Randomized Trial to Reduce Inappropriate Therapy ... - 1

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MADIT-RIT: ELIGIBILITYInclusion Criteria- I 0 prevention patients t with no Hx of VT/VF- Sinus rhythm at enrollment; Hx PAF ok- Pt. on stable, optimal pharmacologic therapy-Age >21 yrs; informed consentExclusion Criteria- Pt. with pacemaker, ICD or CRT-D device- CABG or PTCA in past 3 months- MI (enzyme +) or AF in past 3 months- 2 nd or 3 rd degree heart block-NYHA IV- Chronic AF- Renal disease:BUN>50mg/dlor Creatinine>2.5mg/dL
MADIT-RIT: MADIT-RIT Prespecified PrimaryEnd PointsEndpointPRIMARY (90% power for hazard ratio 0.5 at p
Page 1 and 2: MADIT Randomized Trial to ReduceIna
Page 3 and 4: MADIT-RIT: BACKGROUND• ICD is hig
Page 5: MADIT-RIT: Three Treatment Arms*Ran
Page 9 and 10: Baseline Demographic and ClinicalCh
Page 11 and 12: Figure 2.Cumulative Probability of
Page 13 and 14: Arrhythmias Triggering FirstInappro
Page 15 and 16: MADIT-RIT: CONCLUSIONSImproved ICD

MADIT Randomized Trial to Reduce Inappropriate Therapy ... - 1

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