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issue 10 volume 12 novemBeR • 2010 www.greencrosspublishing.ie<br />

neWs<br />

CPD model to be<br />

“supportive, enabling<br />

and transformative” p4<br />

Disciplinary implications<br />

of failure to collect<br />

50 cent charge p4<br />

Pharmacy education<br />

reforms “very<br />

challenging” p4<br />

Statutory responsibilities<br />

of superintendent<br />

pharmacists p4<br />

Inaugural conference of<br />

Irish Medication Safety<br />

Network p6<br />

New award to recognise<br />

outstanding healthcare<br />

professionals p12<br />

EU ditches direct to<br />

consumer advertising<br />

plan p14<br />

MEPs plan ‘black label’<br />

for high risk products p14<br />

The THE independenT INDEPENDENT monThly MONTHLY foR FOR iRish IRISH phaRmacisTs<br />

PHARMACISTS<br />

<strong>inTervieW</strong><br />

Masters of Pharmacy<br />

series – ingrid Hook<br />

Terry Maguire<br />

The joy of<br />

respectful<br />

listening<br />

Des Corrigan<br />

The medicinal<br />

merits of<br />

allspice<br />

DaviD JorDan<br />

Producing<br />

pharmacists for<br />

the 'mail boat"<br />

FinanCe<br />

How safe<br />

are your<br />

investments?<br />

FinTan Moore<br />

O’Sean’s Eleven<br />

LeTTers Page<br />

Prof Weedle’s<br />

comments on codeine<br />

Made to leap from<br />

your shelves<br />

Benylin Mucus Relief. PA Number: 823/35/1. PA Holder: McNeil Healthcare(Ireland) Ltd., Airton Road, Tallaght, Dublin 24, Ireland.<br />

Full prescribing information available upon request. Product not subject to medical prescription. BEN/039/00


INDICATED FOR MILD TO MODERATE PAIN RELIEF<br />

Effective Pain Relief including:<br />

Headache Migraine Headache Dental Pain Period Pain Fever<br />

ABBREVIATED PRESCRIBING INFORMATION. Please refer to the Summary of Product Characteristics before dispensing: Buplex 200 mg Film-coated Tablets.<br />

Indications: Mild to moderate pain, such as headache including migraine headache, dental pain. Primary dysmenorrhoea. Fever. Dosage: Short-term use only, not<br />

longer than 7 days. Dose depends on the patient’s age and body weight. Tablet should be swallowed with a glass of water during or after a meal. Mild to moderate pain<br />

and fever: Adults and adolescents older than 12 years (≥40 kg): 200-400 mg as a single dose or 3-4 times a day every 4 to 6 hours. In migraine, 400 mg as a single dose, if<br />

necessary 400 mg every 4-6 hours. Maximum daily dose: 1200 mg. Children 6-9 years (20-29 kg): 200 mg 1-3 times a day every 4 to 6 hours as required. Maximum daily<br />

dose: 600 mg. Children 10-12 years (30-40 kg): 200 mg 1-4 times a day every 4 to 6 hours as required. Maximum daily dose: 800 mg. Primary dysmenorrhoea: Adults and<br />

adolescents over 12 years of age: 200-400 mg 1-3 times a day, every 4-6 hours, as required. Maximum daily dose: 1200 mg. Contraindications: Hypersensitivity, Last<br />

trimester of pregnancy, History of gastrointestinal bleeding or perforation related to previous NSAID therapy, Active or recurrent peptic ulcer/haemorrhage, Severe<br />

hepatic or renal insu� ciency, Severe heart failure or coronary heart disease, Signi� cant dehydration, Cerebrovascular or other active bleeding, Dishaematopoiesis of<br />

unknown origin, Children younger than 6 years of age. Warnings and Precautions: Use the lowest e� ective dose for the shortest duration necessary. Symptoms of<br />

an infection may be masked. Avoid concomitant use with other NSAIDs, including COX-2 inhibitors. GI bleeding, ulceration and perforation may occur with or without<br />

warning symptoms or previous history of GI events. Consider combination therapy with protective agents (e.g. misoprostol or proton pump inhibitors) for at risk<br />

patients. NSAIDS should be used with caution in patients with a history of peptic ulcer, GI bleeding, intestinal in� ammation, hepatic, renal or cardiac insu� ciency,<br />

hypertension, congestive heart failure, disturbed haematopoiesis, blood coagulation defects, respiratory disorders and immediately after surgical intervention. All<br />

patients, particularly the elderly and patients with impaired hepatic and renal function, on long term NSAID treatment should be kept under regular surveillance with<br />

monitoring of renal, cardiac and hepatic function and of haematological parameters. High dose and long term use may be associated with a small increased risk of<br />

arterial thrombotic events. Careful consideration before long term use in patients with cardiovascular disease or risk factors. Discontinue at � rst sign of skin rash,<br />

mucosal lesion or other sign of hypersensitivity. May impair female fertility. Strict consideration should be given to the bene� t-risk ratio in the following conditions: SLE<br />

or other autoimmune diseases, Congenital disturbance of porphyrin metabolism, First and second trimesters of pregnancy and Lactation. Interactions: Other NSAIDs;<br />

Anticoagulants; Ticlopidine; Methotrexate; Moclobemide; Phenytoin; Lithium; Cardiac glycosides; Diuretics and antihypertensives; Captopril; Aminoglycosides; SSRIs;<br />

Ciclosporin; Cholestyramine; Tacrolimus; Zidovudine; Ritonavir; Mifepristone; Probenecid; Sul� npyrazone; Quinolone antibiotics; Sulphonylureas; Corticosteroids;<br />

Anti-platelet aggregation agents; Alcohol; Bisphosphonates; Oxpentifylline; Baclofen. Side E� ects: Headache, somnolence, vertigo, fatigue, agitation, dizziness,<br />

insomnia, irritability, heartburn, nausea, vomiting, diarrhoea, � atulence, constipation, dyspepsia, abdominal pain, gastrointestinal ulcers, sometimes with bleeding<br />

and perforation, occult blood loss which may lead to anaemia, melaena, heamatemesis, ulcerative stomatitis, colitis, exacerbation of in� ammatory bowel disease and<br />

Crohn’s disease, complications of colonic diverticula. Shelf Life: 2 years. Pack Sizes: Blister: 12, 24 & 50 � lm-coated tablets. Marketing Authorisation Holder: Actavis<br />

Group PTC ehf, Reykjavikurvegi 76-78, 220 Hafnar� ordur, Iceland. Marketing Authorisation Number: PA 1380/87/1. Legal Category: Product not subject to medical<br />

prescription. Retail sale through pharmacies only. Further information including the SPC is available on request from Actavis Ireland Limited, Euro House, Little Island, Co.<br />

Cork or email: contact@actavis.ie. Information about adverse event reporting can be found on the IMB website (www.imb.ie) or by contacting Actavis Ireland Limited.<br />

Date of Generation of API: January 2010.<br />

Date of Preparation: August 2010. FADHCP-02710.<br />

NEW


The independenT monThly foR iRish phaRmacisTs<br />

issue 10 volume 12 • novemBeR 2010<br />

4 neWs<br />

10 LeTTers<br />

Reaction to Prof Weedle’s comments on<br />

codeine<br />

14 eu neWs<br />

16 HerbaL MeDiCine<br />

The merits of Christmas cooking<br />

Des Corrigan<br />

18 <strong>inTervieW</strong><br />

Masters of Pharmacy<br />

ingrid Hook – teaching legend<br />

20 THe CoaLFaCe<br />

Are we producing pharmacists for export?<br />

David Jordan<br />

Irish Pharmacist is published by<br />

<strong>Green</strong><strong>Cross</strong> <strong>Publishing</strong>,<br />

7 Adelaide Court, Adelaide Road, Dublin 2.<br />

Tel: 01 418 9799. Fax: 01 478 9449.<br />

maura@greencrosspublishing.ie<br />

www.greencrosspublishing.ie<br />

Irish Pharmacist endeavours to ensure<br />

accuracy of information given and of<br />

claims made in articles and advertisements.<br />

Nevertheless, no responsibility is accepted<br />

in respect of such information or claims.<br />

Any opinions expressed by contributors are<br />

entirely their own and do not purport to be<br />

the views of Irish Pharmacist.<br />

© Copyright <strong>Green</strong><strong>Cross</strong><br />

<strong>Publishing</strong> 2010<br />

No part of this publication<br />

may be reproduced,<br />

stored in a retrieval system, or transmitted in any<br />

form by any means – electronic, mechanical or<br />

photocopy recording or otherwise – whole or in<br />

part, in any form whatsoever for advertising or<br />

promotional purposes without the prior written<br />

permission of the publishers.<br />

<strong>Green</strong><strong>Cross</strong> <strong>Publishing</strong> is a recently established<br />

publishing house which is jointly owned by Graham<br />

Cooke and Maura Henderson. Between them Graham<br />

and Maura have over 30 years experience working in<br />

healthcare publishing. Their stated aim is to publish<br />

titles which are incisive, vibrant and pertinent to their<br />

readership.<br />

EDITOR: Maura Henderson<br />

DESIGn: Barbara Vasic<br />

REPORTER: June Shannon<br />

SUB-EDITOR: Tim Ilsley<br />

PUBlISHER: Graham Cooke<br />

PUBlISHER: Maura Henderson<br />

COnTRIBUTORS: Iain Cahill, Dr Des Corrigan,<br />

Garry Finnegan, David Jordan, Julian Judge,<br />

Fintan Moore, Terry McGuire, Cormac O’neill<br />

PHOTOGRAPHy: Audrey Hanley<br />

PRInTERS: newman Thomson ltd<br />

lETTERS TO THE EDITOR:<br />

maura@greencrosspublishing.ie<br />

Advertising:<br />

graham@greencrosspublishing.ie<br />

or 0872222221<br />

22 vieW FroM above<br />

listening to your ‘difficult’ clients can be<br />

most rewarding<br />

Terry Maguire<br />

24 LaW<br />

Treating children – the legal implications<br />

for pharmacists<br />

Cormac o'neill<br />

26 FinanCe<br />

How safe are your investments?<br />

iain Cahill<br />

28 CreaTive WriTing<br />

lefty<br />

Julian Judge<br />

Exputex 145x210 16/10/2008 10:51 Page 1<br />

conTenTs<br />

Good News<br />

for chesty coughs<br />

Exputex<br />

Carbocisteine mucolytic syrup<br />

COMPLETE WITH<br />

CHILD RESISTANT<br />

TAMPER EVIDENT<br />

CAP<br />

SUGAR FREE<br />

✓ Non drowsy<br />

✓ Mentholated<br />

✓ 300ml - the lowest cost<br />

sugar free carbocisteine<br />

mucolytic syrup (on a ml<br />

per ml basis 250mg/5ml) 1<br />

Prescribing Information<br />

(Please refer to full Summary of Product Characteristics [SmPC])<br />

Exputex 250mg/5ml Oral Solution<br />

Presentation: Carbocisteine provided as 250mg/5ml oral solution. Uses: As<br />

a mucolytic adjunct for respiratory tract disorders characterised by excessive<br />

or viscous mucous. Dosage and administration: Oral. Adults/Elderly:<br />

Three 5ml spoonfuls three times daily initially. Reduce to two 5ml spoonfuls<br />

three times daily when a satisfactory response has been obtained. Children:<br />

6-12 years: 5ml spoonful (250mg) two to three times daily. 2-5 years: Half a<br />

5ml spoonful (125mg) two to three times daily. Under 2 years: Not recommended.<br />

Contraindications: Hypersensitivity, patients with known active<br />

peptic ulceration. Special Warnings and Precautions: Patients with a history<br />

of peptic ulceration, avoid in patients with active ulceration, patients on a<br />

controlled sodium diet. Contains parahydroxybenzoates (E215, E217 and<br />

E219), sunset yellow FCF (E110) and ethanol. Interactions: None listed.<br />

Pregnancy and Lactation: Not recommended. Undesirable Effects:<br />

Nausea, headache, gastrointestinal upset and skin rash. Overdose: No<br />

experience. Serious effects not expected. Legal category: S1B(E) Product<br />

Authorisation number: PA 488/14/1. Product Authorisation holder:<br />

30 e-PHarMaCy<br />

Depression – new campaign – something<br />

to sing about<br />

June shannon<br />

32 Case sTuDy<br />

Cluster headache in a 24 year old woman<br />

Dr edward M o'sullivan<br />

34 ProDuCTs<br />

38 <strong>Cross</strong>WorD<br />

38 CLassiFieDs anD<br />

reCruTiMenT<br />

40 ouTsiDe eDge<br />

O’Sean’s Eleven<br />

Fintan Moore<br />

Monmouth Pharmaceuticals Limited, Hampshire International Business Park,<br />

Chineham, Basingstoke, Hampshire, RG24 8EP, UK. Distributed by: Cahill<br />

May Roberts, Pharmapark, Chapelizod, Dublin 20. Further information is<br />

available from: Shire Pharmaceuticals Limited, Hampshire International<br />

Business Park, Chineham, Basingstoke, Hampshire, RG24 8EP, UK. Tel: +44<br />

1256 894000. Date of revision: June 2008. Exputex is a registered trademark<br />

of Shire US Inc. in Ireland.<br />

Adverse events should be reported to the Pharmacovigilance Unit<br />

at the Irish Medicines Board (IMB) (imbpharmacovigilance@imb.ie).<br />

Information about adverse event reporting can be found on the IMB<br />

website (www.imb.ie). Adverse events may also be reported to<br />

Shire Pharmaceuticals Ltd on +44 1256 894000.<br />

MONMOUTH<br />

P H A R M A C E U T I C A L S<br />

Monmouth Pharmaceuticals Ltd,<br />

Hampshire International Business<br />

Park, Chineham, Basingstoke, Hants<br />

RG24 8EP<br />

1 MIMS May 2008 Date of preparation: October 2008 IRE/EXP/08/0001


4<br />

news<br />

The PSI and the Irish Centre<br />

for Continuing Pharmacuetical<br />

Education (ICCPE) are to<br />

hold a number of information<br />

meetings for superintendent<br />

pharmacists to advise them on<br />

their statutory responsibilities<br />

under the 2007 Pharmacy Act.<br />

The meetings, which will<br />

take place at a number of<br />

locations around the country<br />

later this month and in early<br />

December, are also intended<br />

to facilitate a dialogue with<br />

superintendent pharmacists<br />

and to clarify any issues or<br />

concerns they may have.<br />

Attendants will also hear<br />

about the development of<br />

new resource material for the<br />

training and development of<br />

superintendent pharmacists,<br />

who have a key professional,<br />

clinical and strategic role in<br />

the management and operation<br />

of pharmacies.<br />

The ICCPE has also recently<br />

launched its autumn 2010<br />

educational programme that<br />

includes a number of important<br />

lectures specifically<br />

designed for pharmacists.<br />

Theses include: Men’s health,<br />

Schizophrenia, Challenging<br />

Behaviour, Making Medicines<br />

Management Safer, High<br />

Tech Medicines, and needle<br />

Exchange.<br />

For more information please<br />

see: www.iccpe.ie<br />

issue 10 volume 12 • novemBeR 2010<br />

irish CPD model: "supportive, enabling, and transformative"<br />

THE PSI is planning to host a<br />

number of Continuing Professional<br />

Development (CPD) information<br />

meetings for pharmacists<br />

around the country in the new<br />

year Irish Pharmacist reports.<br />

The meetings, which are<br />

planned for late January/early<br />

February 2011, aim to inform and<br />

advise pharmacists about the<br />

PSI’s new CPD model for Irish<br />

pharmacists which was launched<br />

by the Minister for Health last<br />

month.<br />

Under the 2007 Pharmacy<br />

Act all pharmacists on the PSI<br />

register must be compliant with<br />

the new CPD system of lifelong<br />

learning by 2014.<br />

The Review of International CPD<br />

Models was one of two reports<br />

commissioned by the PSI and<br />

launched by the Minister on the<br />

15th October last, which form<br />

part of a new framework of<br />

education and training for Irish<br />

pharmacists.<br />

The report’s vision of a CPD<br />

system for pharmacists in Ireland<br />

is one, which is focused on patient<br />

safety, assures competency<br />

across the profession to meet<br />

patient needs and demonstrates<br />

this competency to others.<br />

According to the report the<br />

new CPD model will provide for<br />

a mechanism to allow for innovation<br />

and development in the role<br />

of the pharmacist. The system<br />

will also be supportive, enabling<br />

and transformative and one that<br />

meets personal and professional<br />

needs. It will also be flexible,<br />

user-friendly, contemporaneous<br />

and recognised by pharmacists<br />

Ms Deanna Williams, registrar of the ontario College of<br />

Pharmacists, spoke about the merits of the ontario CPD<br />

model.<br />

as helping to support the way<br />

in which they practise. The new<br />

report envisions a system that<br />

rewards learning by professionals<br />

and provides internationally<br />

recognised accreditation as well<br />

as encouraging and supporting<br />

engagement with other healthcare<br />

professionals.<br />

Speaking at the launch Professor<br />

Paul Gallagher, Chair of the<br />

Professional Development and<br />

learning Committee of the PSI,<br />

said that the new CPD framework<br />

should become an integral<br />

part of a healthcare professional’s<br />

practice experience.<br />

“The new system has been<br />

determined by the Council of<br />

the PSI, on the basis of best<br />

international practice and experience<br />

and following a thorough<br />

consultation with pharmacists<br />

and other key stakeholders.<br />

There is no doubt that there is<br />

solid support for this new CPD<br />

system. Pharmacists are anxious<br />

to expand on the services they<br />

provide and to provide the best<br />

possible care to their patients<br />

and to the public.”<br />

Ms Deanna Williams, Registrar<br />

of the Ontario College of Pharmacists,<br />

was also present at the<br />

announcement and outlined the<br />

merits of the new CPD model,<br />

which is based on a template<br />

that has existed in Ontario since<br />

1997. Ms Williams said that the<br />

effectiveness of the Ontario<br />

CPD model for pharmacists was<br />

reflected in its roll out across<br />

other healthcare professions in<br />

the region.<br />

At the launch the PSI also<br />

unveiled its new Tutor Training<br />

and Accreditation Programme<br />

(TTAP), an innovative programme<br />

that has been developed<br />

by the RCSI on behalf of<br />

the PSI to train and accredit tutor<br />

pharmacists who oversee the<br />

workplace training of pharmacy<br />

interns.<br />

Pharmacy education reforms will be “very challenging” to implement<br />

The recently announced pharmacy<br />

education reforms which<br />

will see the current 4+1 model<br />

of pharmacy education replaced<br />

by an integrated five-year programme<br />

will be “very challenging<br />

to implement” in the current<br />

economic climate the Head of<br />

the School of Pharmacy at TCD<br />

has said.<br />

Commenting on the reforms,<br />

which were announced by the<br />

Minister for Heath last month<br />

Professor Marek Radomski said<br />

that while the proposals were<br />

“groundbreaking” they would<br />

be “very challenging to implement.”<br />

According to Prof Radomski<br />

the current economic climate<br />

across Ireland has not escaped<br />

higher education and Irish<br />

pharmacy programmes have<br />

become “chronically underfunded.”<br />

“The budget for the School<br />

of Pharmacy and Pharmaceutical<br />

Sciences has been reduced<br />

over the past two years. We’ve<br />

managed to weather the storm<br />

by the hard work and dedication<br />

of our staff but resources<br />

are now stretched to breaking<br />

point. While we are enthusiastic<br />

about the delivery of a new programme<br />

we are acutely aware<br />

of the necessity for adequate resourcing<br />

of undergraduate cur-<br />

Psi/iCCPe meetings on role of<br />

superintendent pharmacists<br />

ricula. As a result, I believe that<br />

these new reforms in pharmacy<br />

education will be difficult to<br />

implement without concomitant<br />

changes in the funding of Irish<br />

higher education. The School<br />

of Pharmacy and Pharmaceutical<br />

Science looks forward to<br />

working together with government,<br />

PSI and other educational<br />

institutions to ensure the future<br />

success of our students and<br />

schools”.<br />

According to the TCD School<br />

of Pharmacy the new curriculum<br />

“will better integrate academic<br />

studies with pharmaceutical<br />

practice and experience from<br />

the beginning, allowing stu-<br />

dents to get the hands-on experience<br />

they’re currently lacking.”<br />

The national Pharmacy Forum<br />

will oversee the implementation<br />

of this new programme across<br />

the three schools of pharmacy in<br />

TCD, UCC and RCSI.<br />

The TCD School said that<br />

it “embraces these proposed<br />

changes” championed by the<br />

PSI. “Trinity recognises that these<br />

plans are founded on the most<br />

progressive trends in undergraduate<br />

pharmacy education worldwide.<br />

This new programme will<br />

enable students to be on top<br />

of the latest pharmaceutical<br />

studies and research while at the<br />

same time getting the hands on<br />

patient care experience that is<br />

crucial for practising pharmacists.”<br />

Pharmacists legally obliged to collect 50 cent prescription charge<br />

Pharmacists who fail to collect<br />

the controversial 50 cent<br />

prescription charge as mandated<br />

by the Minister for Health may be<br />

subject to disciplinary proceedings<br />

the PSI has warned.<br />

According to a letter sent by<br />

the PSI to all pharmacists, the<br />

Society notes that it has “received<br />

a large number of queries in<br />

relation to the requirement on<br />

the part of community pharmacy<br />

contractors to collect the<br />

prescription levy introduced by<br />

the Health (Amendment) (no. 2)<br />

Act 2010.”<br />

In the letter the PSI explains<br />

that as of 1st October 2010 “it is a<br />

legal requirement for a community<br />

pharmacy contractor to<br />

collect the levy of €0.50 per item<br />

dispensed under the Medical<br />

Card Scheme.”<br />

Prof Marek radomski<br />

“A failure to collect the prescription<br />

levy is a breach of this<br />

legislation and it should be noted<br />

that all pharmacists are obliged<br />

to “comply with all relevant laws,<br />

regulations, rules, professional<br />

standards” (Principle 3 of the<br />

Code of Conduct for Pharmacists)<br />

and also to “practise within relevant<br />

legislative and professional<br />

regulatory guidance” (Principle<br />

4 of the Code of Conduct for<br />

Pharmacists). Any pharmacist<br />

who fails to collect this levy in accordance<br />

with this legislation may<br />

be subject to disciplinary process<br />

under Part 6 of the Pharmacy Act<br />

2007,” the PSI stated.<br />

The disciplinary process under<br />

part 6 of the Pharmacy Act forms<br />

part of the complaints, inquiries<br />

and discipline process. Where a<br />

formal complaint is made about a<br />

pharmacist this would be initially<br />

considered by the PSI’s Preliminary<br />

Proceedings Committee<br />

and then progressed through the<br />

process in accordance with the<br />

legislation.<br />

Meanwhile the President of<br />

the IPU Mr Darragh O’loughlin<br />

last month criticized the HSE for<br />

its failure to communicate to the<br />

public about the introduction of<br />

the new levy<br />

In terms of the implementation<br />

of the levy he said: “Pharmacists<br />

are opposed to the levy;<br />

however, we are legally obliged<br />

to collect it on behalf of the HSE.<br />

We would encourage patients to<br />

continue taking their medicines<br />

as prescribed. If people have any<br />

questions on their medication,<br />

they should drop in to their local<br />

pharmacist for advice.”


NEW<br />

Won’t irritate your stomach like ibuprofen might<br />

Soluble is the fastest growing segment in adult analgesics**<br />

*When compared to standard Paracetamol, Panadol Extra Soluble can give 30% more pain relieving power.<br />

CONTAINS PARACETAMOL. ALWAYS READ THE LABEL/LEAFLET. **Source IMS OTCIRL MAT AUG 2010.<br />

Abbreviated prescribing information: Please consult the summary of product characteristics for full prescribing information. Product<br />

information for Panadol Extra 500mg/65mg Soluble Effervescent Tablets. Composition Each tablet contains Paracetamol 500mg and<br />

Caffeine 65mg. Therapeutic Indications The tablets are recommended for use as an analgesic in the relief of mild to moderate pain such as<br />

is associated with rheumatism, neuralgia, musculoskeletal disorders, and headache and of discomfort associated with influenza, feverishness<br />

and feverish colds, toothache and dysmenorrhoea. Posology and Method of Administration For oral administration Panadol Extra Soluble<br />

should be dissolved in at least half a tumbler full of water. Children Not recommended for children under 12 years of age. Minimum dosing<br />

interval: 4 hours. Should not be used with other paracetamol-containing products. Contraindications Known hypersensitivity to paracetamol,<br />

caffeine or any of the other ingredients. Special Warnings or Precautions for Use Paracetamol should only be used with caution in patients<br />

with liver or kidney impairment. Prolonged use except under medical supervision may be harmful. Do not exceed the stated dose. Take<br />

only when necessary. If symptoms persist, consult your doctor. Each tablet contains sodium (427mg). Persons on a low sodium diet should<br />

not take this product unless advised by a doctor. Keep out of reach and sight of children. Interactions with other Medicaments and<br />

other forms of Interactions Paracetamol may increase the elimination half-life of chloramphenicol. The absorption of paracetamol may be<br />

increased by metaclopramide and decreased by cholestyramine. Oral contraceptives may increase the rate of clearance of paracetamol.<br />

The anticoagulant effect of Warfarin and other Coumarins may be enhanced by prolonged regular daily use of paracetamol with increased<br />

risk of bleeding; occasional doses have no significant effect. Pregnancy and Lactation Epidemiological studies in human pregnancy have<br />

*<br />

shown no ill effects due to caffeine or paracetamol used in the recommended dosage, but patients should follow the advice of their doctor<br />

regarding its use. Paracetamol is excreted in breast milk but not in a clinically significant amount. Undesirable Effects Adverse effects<br />

of paracetamol are rare but hypersensitivity including skin rashes may occur. The most common adverse effects associated with caffeine<br />

are nausea due to gastrointestinal irritation, insomnia and restlessness as a result of stimulation of the central nervous system. Overdose<br />

Immediate medical attention (in-hospital, if possible) is required in the event of overdose, even if there are no significant early symptoms.<br />

Marketing Authorisation Holder GlaxoSmithKline Consumer Healthcare (Ireland) Limited, Stonemasons Way, Rathfarnham, Dublin 16<br />

Marketing Authorisation Number PA 678/39/10. Date of (Partial) Revision of the Text October 2008 Legal Category: Pharmacy Only.<br />

Further information available on request from GlaxoSmithKline, Stonemasons Way, Rathfarnham, Dublin 16, Ireland.<br />

GSKCH 2010/0344


6<br />

news<br />

The key role of the hospital<br />

pharmacist in medication safety<br />

was highlighted at the inaugural<br />

conference of the Irish Medication<br />

Safety network (IMSn) which took<br />

place in Farmleigh House in Dublin<br />

last month.<br />

Entitled ‘networking for Safety’,<br />

the conference, which sought to<br />

improve standards in medication<br />

safety, was officially opened by<br />

the Minister for Health Ms Mary<br />

Harney and was attended by a<br />

number of pharmacists and other<br />

healthcare professionals. Speakers<br />

included Dr Deirdre Madden, author<br />

of the Patient Safety Commission’s<br />

2008 publication ‘Building a<br />

Culture of Patient Safety’; Ms Marita<br />

Kinsella, Chief Pharmacist at the<br />

Department of Health; and senior<br />

Hospital pharmacist and<br />

winner of the 2009 Helix<br />

Health Pharmacist of the year<br />

Award, Mr Tim Delaney has<br />

been seconded to the HSE<br />

from Tallaght Hospital as<br />

national Programme lead of<br />

the Executive’s new national<br />

Medication Safety Programme.<br />

The HSE’s new medication<br />

safety programme was<br />

established by the Executive<br />

within its Quality, Safety and<br />

Risk Framework and forms<br />

part of the HSE’s Quality and<br />

Clinical Care Directorate under<br />

Dr Barry White.<br />

Initial projects currently<br />

being developed by the<br />

new programme include: a<br />

standard drug prescription<br />

and administration record<br />

The Irish Medicines Board<br />

(IMB) has recently signed<br />

three separate co-operation<br />

arrangements with its<br />

counterpart regulatory bodies<br />

in Canada, new Zealand and<br />

Singapore. The arrangements,<br />

which will facilitate enhanced<br />

regulatory performance<br />

and public safety, are<br />

designed to broaden existing<br />

contacts and to establish<br />

a co-operative framework<br />

of mutual support and<br />

information exchange.<br />

The three new<br />

arrangements were signed<br />

by Mr Pat O’Mahony, Chief<br />

Executive of the IMB, at the<br />

hospital pharmacists with a special<br />

interest in medication safety.<br />

The IMSn’s principal aim is to<br />

improve patient safety with regard<br />

to the use of medicines through<br />

improved sharing of information<br />

throughout the acute healthcare<br />

sector and the adoption of national<br />

and global initiatives to help<br />

minimise risks to patients. A key<br />

aim of the IMSn is to have medication<br />

safety included in HIQA’s new<br />

hospital licensing regime which<br />

is currently going through the<br />

consultation process.<br />

Speaking at the conference,<br />

Minister for Health Ms Mary<br />

Harney said : “I am pleased to<br />

see the Irish Medication Safety<br />

network working hard to raise the<br />

standards of medication safety in<br />

for acute hospitals; a national<br />

medication management<br />

standard for acute hospitals<br />

and self – assessment system;<br />

and the implementation<br />

of the Irish Medication<br />

Safety network’s guidance<br />

5th international Summit<br />

of Heads of Medicines<br />

Regulatory Agencies, which<br />

took place last month in<br />

the UK. According to Mr<br />

O’Mahony, “Increased<br />

communication and cooperation<br />

between the<br />

IMB and our counterparts<br />

in Canada, new Zealand<br />

and Singapore will assist<br />

each organisation to better<br />

achieve our common goal of<br />

protecting and enhancing<br />

the health and safety of our<br />

respective populations.”<br />

Co-operation arrangements<br />

were signed by the IMB with:<br />

Health Canada represented<br />

our hospitals, and I thank them for<br />

their commitment and dedication<br />

in this area. I’d like to acknowledge<br />

their work in highlighting<br />

the importance of implementing<br />

best practice in medication safety<br />

standards throughout our acute<br />

healthcare system.”<br />

Established in 2007, the IMSn is<br />

a voluntary network of independent<br />

pharmacists and other<br />

specialists working in the acute<br />

healthcare sector with a special<br />

interest in medication safety. The<br />

network has representation from<br />

all major hospitals in the country,<br />

both public and private, reaching<br />

over 50 acute healthcare facilities<br />

in Ireland.<br />

For more information please see<br />

www.imsn.ie<br />

documents on specific highrisk<br />

medications and the<br />

monitoring of compliance by<br />

individual hospitals.<br />

As national lead with the<br />

medication safety programme<br />

Mr Delaney will also be the<br />

HSE representative on the<br />

Medication Safety Forum,<br />

which was set up by the<br />

Department of Health in<br />

response to the report of<br />

the Commission on Patient<br />

Safety and Quality Assurance.<br />

Chaired by the Chief<br />

Pharmacist at the Department<br />

of Health Ms Marita Kinsella,<br />

the Forum is monitoring<br />

29 separate improvement<br />

projects designed to achieve<br />

safer, more effective use of<br />

medicines.<br />

by Ms Meena Ballantyne,<br />

Assistant Deputy Minister,<br />

Health Products and Food<br />

Branch; new Zealand<br />

Medicines and Medical Device<br />

Safety Authority (Medsafe)<br />

represented by Dr Stewart<br />

Jessamine, Group Manager;<br />

and the Health Sciences<br />

Authority of Singapore<br />

represented by Dr John lim,<br />

Chief Executive Officer.<br />

Similar arrangements are<br />

already in place between<br />

the IMB and its American<br />

counterpart, the US FDA, the<br />

UK regulator, the MHRA, and<br />

Australia’s Therapeutic Goods<br />

Administration (TGA).<br />

The majority of medication errors<br />

in Irish residential care facilities<br />

are “entirely preventable” a<br />

new study has revealed.<br />

According to the research which<br />

involved a three year prospective<br />

study of medication errors in<br />

residential settings as reported<br />

to the national Poisons Information<br />

Centre (nPIC) of Ireland, almost<br />

half of all errors or 43.1 per<br />

cent involved the administration<br />

of the wrong medication while<br />

45.1 per cent related to patients<br />

being given the wrong dose.<br />

The study, which was carried<br />

out by researchers from the nPIC<br />

and the Department of Geriatric<br />

Medicine at Beaumont Hospital<br />

in Dublin, reviewed a total of<br />

102 cases where residential care<br />

patients experienced a medication<br />

error between January 2007<br />

and December 2009. Medication<br />

errors were categorised as: administration<br />

errors, prescribing/<br />

physician errors or dispensing/<br />

pharmacy errors.<br />

While the study found that errors<br />

involving the administration<br />

of the wrong medication and<br />

the wrong dose predominated,<br />

there were two pharmacy errors<br />

involving the dispensing of the<br />

wrong medication.<br />

According to the research the<br />

principle medicines implicated<br />

in medication errors in patients<br />

over the age of 65 were cardiac<br />

drugs at 15.2 per cent and gastrointestinal<br />

preparations at 13.6<br />

per cent, while anti-epileptics<br />

accounted for 11.9 per cent of<br />

errors.<br />

Anti-epileptic medication was<br />

implicated in the vast majority of<br />

medication errors in the under<br />

issue 10 volume 12 • novemBeR 2010<br />

Hospital pharmacists have key role in medication safety<br />

Tim Delaney seconded to the Hse’s<br />

medication safety programme<br />

Mr Tim Delany<br />

IMB signs co-operation arrangements with<br />

counterparts in Canada, new Zealand and Singapore<br />

Minister for Health, Mary Harney and geraldine Creaton,<br />

irish Medication safety network (iMsn) at the inaugural<br />

iMsn conference in Dublin.<br />

Majority of medication errors<br />

in irish residential care facilities<br />

“entirely preventable”<br />

65s at 36.1 per cent, followed by<br />

anti-psychotics at 13.3 per cent<br />

and antidepressants at 12. 4 per<br />

cent.<br />

According to the study 12<br />

patients were symptomatic at<br />

the time of the nPIC enquiry.<br />

A total of 11 patients were<br />

referred to a hospital emergency<br />

department, 18 were referred to<br />

a GP, while supportive management<br />

was recommended for 38<br />

patients.<br />

“Cardiac and anti-epileptic<br />

medications predominated in<br />

patients aged over 65 and under<br />

65 respectively. The majority of<br />

errors involved the administration<br />

of the wrong medication<br />

and the wrong dose. These<br />

errors are entirely preventable,”<br />

the study concluded.<br />

Meanwhile another new study<br />

by the same research team entitled<br />

‘Medication errors in older<br />

adults: The Experience of the<br />

nPIC Ireland’ has revealed that<br />

the vast majority of medication<br />

errors among the elderly were<br />

the result of individuals inadvertently<br />

taking an additional dose<br />

of their medication(s). While the<br />

study found that most incidents<br />

took place at home and did not<br />

result in any harm, the researchers<br />

concluded “healthcare professionals<br />

should always discuss<br />

correct dosing procedures with<br />

older adults.”<br />

These research studies were<br />

presented by researchers from<br />

the nPIC, Ireland at the 6th<br />

Congress of the European Union<br />

Geriatric Medicine Society,<br />

which took place in Dublin from<br />

the 29th of September to the 1 st<br />

of October last.


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square, coated, cream coloured chewing gum. Therapeutic Indications: For the treatment of tobacco dependence by relieving nicotine craving and withdrawal symptoms: thereby facilitating smoking cessation in smokers motivated to quit. - helping smokers temporarily abstain from smoking. Posology and Method of Administration: Nicorette Icy White Gum should be<br />

chewed slowly. Smoking cessation Adults The strength of gum to be used will depend on the smoking habit of the individual. In general, if the patient smokes fewer than 20 cigarettes a day, Nicorette Icy White 2mg Gum is indicated. If more than 20 cigarettes per day are smoked Nicorette Icy White 4mg Gum will be needed to meet the withdrawal of the high serum nicotine<br />

levels from heavy smoking. The patient should be urged to stop smoking completely when initiating therapy with Nicorette Icy White Gum. The chewing gum should be used whenever there is an urge to smoke according to the “chew and rest” technique described on the pack. After about 30 minutes of such use, the gum will be exhausted. Not more that 15 pieces of the<br />

chewing gum may be used each day. Absorption of nicotine is through the buccal mucosa, any nicotine which is swallowed being destroyed by the liver. Nicorette Icy White Gum may be used for up to 3 months during which time the habits associated with smoking will be lost. For those using the 4mg Gum, the 2mg will be helpful during withdrawal. If not successful after 12<br />

weeks the patient should be encouraged to make a fresh attempt to stop smoking. This may necessitate full or partial re-treatment with an NRT programme. Temporary Abstinence During periods of temporary abstinence, the patient should use Nicorette Icy White Gum when required to relieve nicotine cravings and withdrawal symptoms. The strength of gum to be used will<br />

depend on the smoking habits of the individual. In general, if the patient smokes fewer than 20 cigarettes a day, Nicorette Icy White 2mg Gum is indicated. If more that 20 per day are smoked Nicorette Icy White 4mg Gum is indicated. Not more than 15 pieces of the gum should be used per day. A minor reduction in total clearance of nicotine has been demonstrated in healthy<br />

elderly patients, however, not justifying adjustment of dosage. Contraindications: Use in non-smokers and use in persons hypersensitive to nicotine or any ingredient in Nicorette Icy White Gum. Special Warnings and Precautions for use: Nicotine in any dose form is capable of inducing a dependence syndrome after chronic use and is highly toxic after acute use. However,<br />

dependence with Nicorette Icy White Gum is a rare side-effect and is both less harmful and easier to break than smoking dependence. Nicorette should be used with caution in patients with cardiovascular disease, severe/moderate hepatic impairment, severe renal impairment, active and duodenal ulcers. Nicotine, both from NRT and smoking, causes the release of catecholamines<br />

from the adrenal medulla. Therefore, Nicorette should be used with caution in patients with hyperthyroidism or pheochromocytoma. Patients with diabetes mellitus may require lower doses of insulin as a result of smoking cessation. Smokers who wear dentures may experience difficulties in chewing Nicorette Icy White Gum. Interactions with other medicinal products<br />

and other forms of interaction: Smoking (but not nicotine) is associated with an increase in CYP1A2 activity. After cessation of smoking, reduced clearance of substrates for this enzyme may occur. This may lead to an increase in plasma levels for some medicinal products of potential clinical importance and for products with a narrow therapeutic window, e.g. theophylline,<br />

tacrine and clozapine. The plasma concentration of other drugs metabolised in part by CYP1A2 e.g. imipramine, olanzapin, clonipramine and fluvoxamine may also increase on cessation of smoking, although data to support this are lacking and the possible clinical significance of this effect is unknown. Limited data indicate the metabolism of flecainide and pentazocine<br />

may also be induced by smoking. Undesirable Effects: Nicorette Icy White Gum may cause adverse reactions similar to those associated with nicotine administered by other means and are dose dependent. Common (>1/100) CNS: Headache Gastrointestinal: Nausea, GI discomfort, vomiting, hiccups. Local:Irritation of the mouth or throat, jaw muscle ache. Less common<br />

(1/100-1/1000) Circulation: Palpitations. Skin: Erythema, urticaria. Rare (


8<br />

news<br />

issue 10 volume 12 • novemBeR 2010<br />

sanctions against pharmacists who fail to pass<br />

on benefit of lower prices discussed in the Dáil<br />

In a recent Dáil debate<br />

lucinda Creighton questioned<br />

Mary Harney about any<br />

action the Minister intends<br />

to take to ensure pharmacies<br />

are passing on the benefits<br />

of savings of the price of<br />

commonly used drugs to non<br />

medical card holders.<br />

The minister gave the<br />

following reply: "I have<br />

introduced a number of<br />

measures in the past year<br />

to reduce the costs of drugs<br />

and medicines for both the<br />

State and consumers. These<br />

measures have included a<br />

reduction in the wholesale<br />

and retail mark-ups under<br />

the Financial Emergency<br />

Measures in the Public Interest<br />

Act 2009 and new price<br />

agreements with IPHA (Irish<br />

Pharmaceutical Healthcare<br />

Association) and APMI<br />

(Association of Pharmaceutical<br />

Manufacturers in Ireland)<br />

which have reduced the<br />

price of hundreds of the<br />

most commonly prescribed<br />

off-patent medicines by 40%.<br />

Cumulatively these measures<br />

are expected to deliver<br />

savings to the State of over<br />

€200m in 2010.<br />

"I was most concerned to<br />

learn that some pharmacists<br />

were not passing on the<br />

benefits of these price and<br />

margin reductions to those<br />

patients whose expenditure<br />

on drug purchases are not<br />

met by the Health Service<br />

Executive e.g. persons whose<br />

monthly expenditure is below<br />

the €120 per month threshold<br />

under the Drugs Payment<br />

Scheme.<br />

"I have raised this matter<br />

with the Irish Pharmacy Union.<br />

It is disappointing that some<br />

pharmacists are withholding<br />

the benefit of the lower prices<br />

from some of their customers.<br />

The public deserve better<br />

in these difficult economic<br />

times.<br />

"The Code of Conduct for<br />

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lactose. Uses Treatment of erectile dysfunction in adult males. Dosage and Administration<br />

Adult men: The recommended dose is 10mg orally, taken at least 30 minutes prior to sexual<br />

activity. In those patients in whom tadalafil 10mg does not produce an adequate effect, 20mg<br />

might be tried. Maximum dosing frequency, once per day. 10mg or 20mg tadalafil is not<br />

recommended for continuous daily use. In responder patients to an on-demand regimen, who<br />

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Once a day dosing of Cialis is not recommended in patients with severe renal impairment. In men<br />

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10<br />

Dear Madam,<br />

news<br />

reaction to Professor Weedle’s comments<br />

on the new codeine regulations<br />

The interview with Prof. Peter<br />

Weedle in the last edition<br />

of the Irish Pharmacist was<br />

an interesting insight into a<br />

man who has garnered great<br />

respect within his profession.<br />

It is for that reason that I<br />

write to you. While Peter may<br />

be right in stating that the<br />

codeine regulations have<br />

made a positive impression on<br />

people of influence, it is a sad<br />

reflection on those self same<br />

individuals, if something as<br />

half baked and ill conceived<br />

actually impresses them. It<br />

may go some way to explain<br />

why there is a lack of appreciation<br />

in the same quarters for<br />

the substance and potential<br />

of community pharmacy. Signicant<br />

progress for pharmacy<br />

took place in the mid 90s with<br />

the advent of clause 9 in our<br />

contract. However, a new government<br />

- with an unfettered<br />

free market approach - viewed<br />

pharmacy simply as another<br />

retail opportunity. Changing<br />

the view of these people is<br />

akin to trying the impossible,<br />

however given the economic<br />

destruction thy have overseen,<br />

their days are hopefully numbered.<br />

My comments do not<br />

detract from the achievement<br />

of bringing in new pharmacy<br />

legislation. Politicians however<br />

will always be open to<br />

legislation that gives cover in<br />

crisis, it is a different process to<br />

make them more amenable to<br />

responsible innovation. This is<br />

true particularily where there<br />

are strong contrary lobbies.<br />

These regulations have<br />

copper-fastened in the minds<br />

of many, the view that pharmacists<br />

are mere conduits for<br />

the dispersal of medicines.<br />

People, respectable citizens,<br />

have been given the third<br />

degree by some of our more<br />

zealous colleagues, their only<br />

Pharmacists – to provide Drug<br />

Treatment Pharmacist Services<br />

The Irish Prison Service (IPS) invites tenders for the provision of Drug<br />

Treatment Pharmacist Services.<br />

Pharmacists are now being sought to provide Drug Treatment<br />

Services (i.e. to include methadone dispensing and administration and<br />

all associated professional services), as part of a multidisciplinary team,<br />

in Wheatfield Prison. This presents an opportunity for pharmacists<br />

to become involved in the area of drug treatment services in prisons.<br />

The contract will be managed by the Chief Pharmacist, Healthcare<br />

Directorate, IPS.<br />

Lot 1: Wheatfield Prison<br />

Cloverhill road, Clondalkin, Dublin 22<br />

For full tender information please visit the public sector procurement<br />

opportunities website at www.etenders.gov.ie<br />

Tender documents are available on www.etenders.gov.ie; or by<br />

email from cputenders@irishprisons.ie.<br />

Completed tender documents must be returned, in hard copy,<br />

by 4:00pm on 1st December 2010 to Irish Prison Service, Central<br />

Procurement Unit, IDA Business Park, Ballinalee Road, longford. Ph 043<br />

333 5187.<br />

For further information, please contact the Healthcare Directorate,<br />

IPS on 043 333 5119.<br />

sin, requesting a packet of<br />

soluble solpadeine to alleviate<br />

the effects of excess. For<br />

this grave sin, they have been<br />

condemned to wander for an<br />

eternity from one pharmacy<br />

to another seeking remedy for<br />

their discomfort.<br />

More seriously, for pharmacy<br />

it has created a mindset<br />

in the public at large that<br />

pharmacists cannot be trusted<br />

in their professional judgement,<br />

and lack the ability to<br />

judge circumstances as they<br />

present themselves. Given the<br />

fact that within three weeks of<br />

Aug 1, there was an epidemic<br />

of period pain, chronic back<br />

pain, hard to shift headaches,<br />

none of which responded to<br />

paracetamol or ibuprofen and<br />

even a segment on a radio programme<br />

telling people what<br />

to say to ensure a purchase, all<br />

this has left the pharmacist in<br />

an invidious position.<br />

The reality is that that these<br />

Letters to the editor:<br />

email: maura@<br />

greencrosspublishing.ie<br />

Post:<br />

The Editor<br />

Irish Pharmacist<br />

7 Adelaide Court<br />

Adelaide Road<br />

Dublin 2<br />

Fax:<br />

01 4789449<br />

regulations were conceived<br />

to impress others. This is to<br />

misread the direction the<br />

supply of medicines is taking<br />

and merely reflects our age old<br />

ability to underrate ourselves.<br />

More open supply channels for<br />

medicines are the future if only<br />

for economic reasons. Boots<br />

are being proactive in this area<br />

already. Pharmacy services<br />

are available, accessable<br />

with qualified and motivated<br />

people ideally positioned to<br />

drive this more open access<br />

with a solid professional<br />

approach. Unfortunately the<br />

codeine regs have undermined<br />

issue 10 volume 12 • novemBeR 2010<br />

us in the eyes of the public.<br />

They have reflected a very<br />

shallow approach to the<br />

problem of addiction, creating<br />

an impression that does not<br />

enhance our case for a wider<br />

professional role. The PSI<br />

would be better advised in<br />

future to involve themselves<br />

in real dialogue as distinct<br />

from the HSE patented variety;<br />

there is no substitute for open<br />

and frank exchange of views,<br />

everyone learns.<br />

yours sincerely<br />

richard Collis<br />

PHARMACY SUPPLY & SERVICES<br />

The Irish Prison Service (IPS) invites tenders for the provision of<br />

pharmacy supplies and services to the prison below.<br />

This service will, in addition to the provision of dispensing services,<br />

include the planning and delivery of pharmaceutical care to all<br />

prisoners. This contract will be managed by the Chief Pharmacist,<br />

Healthcare Directorate, IPS.<br />

Lot 1: Castlerea Prison<br />

Harristown, Castlerea, Co. roscommon<br />

Tender documents are available on www.etenders.gov.ie or by<br />

email from cputenders@irishprisons.ie. Completed tender documents<br />

must be returned in hard copy, by 4:00pm on 20th December 2010<br />

to the Irish Prison Service, Central Procurement Unit, IDA Industrial<br />

Estate, Ballinalee Road, longford, Ph. 043 333 5187.<br />

For further information, please contact Healthcare Directorate, IPS,<br />

on 043 333 5119.


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12<br />

news<br />

n500,000 worth counterfeit<br />

drugs seized in ireland<br />

The Irish Medicines Board<br />

(IMB), Revenue Commissioners,<br />

Customs Service and An Garda<br />

were among authorities from<br />

more than 45 countries who<br />

participated in an InTERPOl-coordinated<br />

international internet<br />

week of action recently targeting<br />

the online sale of counterfeit<br />

and illegal medicines, to raise<br />

awareness of the associated<br />

health risk. The action resulted<br />

in arrests across the globe and<br />

the seizure of thousands of<br />

potentially harmful medicines.<br />

In Ireland, a joint operation by<br />

the IMB, Customs and Garda led<br />

to the seizure of 262,000 tablets<br />

and capsules worth an estimated<br />

€500,000. The substances seized<br />

included products for weight<br />

loss and erectile dysfunction as<br />

well as mood stabilisers.<br />

Focusing on websites supplying<br />

illegal and dangerous<br />

If the menopause was discussed<br />

more openly, fewer Irish women<br />

would feel isolated, uncertain and<br />

frustrated by menopausal symptoms.<br />

That’s according to the Dublin<br />

Well Woman Centres, which<br />

recently launched a new online<br />

forum where women can discuss<br />

the menopause with medical<br />

experts as well as their peers.<br />

The online forum, called On the<br />

Vine, is being launched to mark<br />

World Menopause Day today. Also<br />

to mark the Day, Well Woman has<br />

initiated a series of fact-sheets on<br />

the menopause, which will see<br />

factsheets on various topics being<br />

published approximately every<br />

two months. The first factsheet<br />

deals with the topic of ‘hot flushes.<br />

Both the online forum and the<br />

factsheets are being hosted on<br />

www.wellwomancentre.ie.<br />

medicines, Operation PAnGEA<br />

III involved national medicines<br />

agencies, police and customs<br />

with support from Internet<br />

Service Providers (ISPs), payment<br />

systems providers and<br />

delivery services. Together<br />

they targeted the three main<br />

components abused by people<br />

seeking to make a profit in this<br />

illegal website trade, the Internet<br />

Service Provider (ISP), electronic<br />

payment system and the delivery<br />

service.<br />

On an international scale<br />

267,855 packages were inspected<br />

globally by regulators<br />

and customs throughout the<br />

week-long operation resulting in<br />

the seizure of 10,916 packages.<br />

1,014,043 tablets were seized in<br />

total largely relating to erectile<br />

dysfunction pills, weight loss<br />

tablets, antibiotics, hormones<br />

and steroid products, anti-<br />

Speaking on World Menopause<br />

Day, Well Woman’s Chief<br />

Executive, Alison Begas, said: “In<br />

spite of our more open society,<br />

menopause is still one of those<br />

topics that gets very little public<br />

airing. In fact, more often than<br />

not when it is mentioned, it is the<br />

butt of jokes, which does nothing<br />

to encourage open discussion of<br />

the issue.<br />

“Our new online forum, On the<br />

Vine, is an attempt to get women<br />

talking about menopause. We<br />

want them to share experiences<br />

and discuss their approaches to<br />

dealing with symptoms,” said Ms<br />

Begas. “We know from research<br />

– and indeed from feedback<br />

from women at our clinics – that<br />

most women are not informed<br />

about the menopause. According<br />

to research conducted by the<br />

depressants, pain killers, cardiac<br />

medication, anti-cholesterol,<br />

stimulants/amphetamines,<br />

cancer medication and insulin.<br />

328 portal hubs were inspected<br />

for illegal activity resulting in the<br />

removal of 290 websites.<br />

Operation PAnGEA has grown<br />

extensively since it first took<br />

place in 2008 involving eight<br />

countries including Ireland. It is<br />

the largest internet-based action<br />

of its kind co-ordinated by the<br />

Permanent Forum of International<br />

Pharmaceutical Crime (PFIPC),<br />

the Heads of Medicines Agencies<br />

Working Group on Enforcement<br />

Officers (HMA WGEO), InTERPOl<br />

and World Customs Organisation<br />

(WCO) with the assistance of the<br />

pharmaceutical industry and the<br />

electronics payment industry<br />

in support of the International<br />

Medical Products Anti-Counterfeiting<br />

Taskforce (IMPACT).<br />

Menopause still not discussed openly<br />

Women’s Health Council in 2008,<br />

almost 60 per cent of women<br />

aged 35 to 50 wanted more information<br />

about the menopause.<br />

By getting women talking about<br />

menopause, we hope to achieve<br />

a better understanding about this<br />

change in life.”<br />

In addition to the on-line forum<br />

and fact-sheets, Well Woman also<br />

publishes a leaflet on the menopause,<br />

which is available online<br />

or in hard copy from its clinics at<br />

Pembroke Road, liffey Street and<br />

Coolock in Dublin. For further<br />

information, see: www.wellwomancentre.ie<br />

To access the factsheet, see:<br />

www.wellwomancentre.ie/content/downloads/menopausefactsheet1.pdf<br />

The web-forum : www.wellwomancentre.ie/forum/forum<br />

A new booklet has been<br />

launched by the Irish<br />

Osteoporosis Society to mark<br />

World Osteoporosis Day 2010<br />

which took place on October<br />

20th. Osteoporosis Guidelines<br />

is aimed at healthcare<br />

professionals to aid diagnosis<br />

and recognise symptoms of an<br />

otherwise silent disease.<br />

Currently, 300,000 people<br />

in Ireland over the age of<br />

50 are estimated to have<br />

osteoporosis and one in two<br />

Irish women and 1 in five<br />

men over the age of 50 will<br />

have an osteoporosis-related<br />

fracture in their lifetime.<br />

This is predicted to become<br />

a major healthcare burden<br />

over the next 25 years as the<br />

population ages.<br />

President of the Irish<br />

Osteoporosis Society,<br />

Professor Moira O’Brien<br />

warned that osteoporosis is set<br />

to become a ‘new epidemic’.<br />

“Osteoporosis suffers from<br />

severe under recognition<br />

and often goes unnoticed<br />

until a fracture occurs.<br />

Unfortunately, only 15% of<br />

people who have osteoporosis<br />

are actually diagnosed. Even<br />

after a fracture, the majority<br />

of these women will not<br />

issue 10 volume 12 • novemBeR 2010<br />

new award to recognise<br />

outstanding healthcare<br />

professionals<br />

Healthcare professionals who strive to deliver outstanding service to<br />

their patients are to be recognised. Astellas recently announced the<br />

launch of a new initiative, the Astellas Changing tomorrow Awards<br />

2010, which aims to recognise the outstanding achievements of<br />

healthcare professionals who are striving to change the course of<br />

tomorrow for patients in Ireland. Astellas has launched this new<br />

initiative in Ireland to identify those in healthcare who endeavour to<br />

deliver an outstanding service for their patients, as often these vital<br />

efforts can go unnoticed. To enter your nomination and for more information<br />

visit www.changingtomorrowawards.ie The closing date<br />

for entries is 5pm, Thursday, 18th of november, 2010. Professionals<br />

working in health who are interested in entering can also request<br />

more details from their local Astellas representative.<br />

The closing date for entries is 5pm, Thursday, 18th of november,<br />

2010, soon after which a shortlist of entries will be chosen and announced<br />

in early January. The winner of each category will then be<br />

chosen and announced at the Astellas Changing tomorrow Awards<br />

2010 ceremony on Monday, 31st of January, 2011.<br />

osteoporosis guidelines for healthcare professionals<br />

receive treatment for their<br />

osteoporosis.<br />

“We have drafted these<br />

guidelines to help healthcare<br />

professionals look out for<br />

signs of osteoporosis. While<br />

there have been many<br />

advances in the management<br />

of the disease, there are still<br />

important care gaps and we<br />

must do all we can to promote<br />

the detection of osteoporosis<br />

before the first fracture<br />

occurs.”<br />

To order copies of the<br />

Osteoporosis Guidelines contact<br />

the Irish Osteoporosis Society on<br />

1890 252 751.


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14<br />

eu news<br />

Gary Finnegan,<br />

European Correspondent and Irish<br />

winner of 2009 and 2010 EU Health<br />

Prize for Journalists<br />

issue 10 volume 12 • novemBeR 2010<br />

eu ditches drug ‘advertising’ plan<br />

A<br />

key European Parliament<br />

committee<br />

has scrapped proposals<br />

that would<br />

have allowed infor-<br />

and critics claimed any change<br />

to the legislation would put<br />

the EU on a slippery slope to<br />

the kind of all-pervasive drug<br />

commercials seen on US televi-<br />

steering the directive through<br />

the parliament, has changed<br />

the emphasis of the Commission’s<br />

proposal to focus on<br />

patients’ rights to information.<br />

tal impact of their products,<br />

provided regulators give<br />

permission.<br />

Fjellner said MEPs on the<br />

public health committee want<br />

mation on medicines to be<br />

sion.<br />

The onus will now be on companies to engage more<br />

published in print and online<br />

The original directive had national authorities and the with patients but will have to<br />

consumer media.<br />

been put forward by the industry to provide citizens operate under strict supervi-<br />

The move was greeted with<br />

European Commission’s with objective and unbiased sion, adding that the rewritten<br />

relief by patient and con-<br />

industry department which information on medicines, directive focuses on transparsumer<br />

organisations who have<br />

insisted that a clear distinc- while maintaining protections ency and consumer rights.<br />

mounted fierce resistance to<br />

tion would be drawn between for the public against “unso- The directive will now be<br />

the Information to Patients Di-<br />

promotional material – which licited communication” from debated by health ministers,<br />

rective, fearing it would open<br />

would still be prohibited – and manufacturers.<br />

in consultation with MEPs and<br />

the door to drug advertising.<br />

factual information designed Companies will be allowed the European Commission,<br />

Advertising prescription<br />

medicines to the general<br />

public is banned in Europe<br />

swedish MeP Christofer<br />

Fjellner<br />

to empower the consumer.<br />

Swedish MEP Christofer Fjellner,<br />

who was responsible for<br />

to provide the public with<br />

non-promotional material on,<br />

for example, the environmen-<br />

before finally coming before<br />

a full sitting of the European<br />

Parliament next year.<br />

MePs strengthen drug monitoring system<br />

The EU has overhauled its<br />

medicines surveillance rules<br />

and looks set to force high-risk<br />

product to carry a black symbol<br />

on their packaging.<br />

Two years after the changes<br />

were first proposed, the European<br />

Parliament has finally<br />

voted in favour of sweeping<br />

reforms which will require national<br />

governments to set up<br />

designated pharmacovigilance<br />

websites.<br />

The new rules mean phar-<br />

Ineffective counterfeit<br />

medicines, forged pharmacy<br />

receipts and dodgy sick<br />

certs are costing Europe an<br />

estimated €56 billion a year,<br />

according to a new report<br />

on corruption in the health<br />

sector.<br />

The European Healthcare<br />

Fraud and Corruption<br />

network (EHFCn) said<br />

funding that should be used<br />

for patient care is being<br />

maceutical companies will<br />

have to do more to inform patients<br />

on how to use medicines<br />

and report adverse reactions.<br />

Authorities across Europe<br />

will also be expected to pool<br />

information on dangerous<br />

side effects of medicines in an<br />

effort to pick up rare problems<br />

which can be missed in clinical<br />

trials.<br />

The ‘Eudravigilance’ database<br />

will become the single<br />

point of contact for informa-<br />

billions squandered on healthcare fraud<br />

swallowed up by fraudsters –<br />

something governments have<br />

begun to take seriously in a<br />

time of dwindling budgets.<br />

Poor quality treatment,<br />

sometimes from unqualified<br />

practitioners, continues to be<br />

a problem, according to the<br />

EHFCn, along with perverse<br />

incentives that encourage<br />

overuse of medicines.<br />

In a study of fraud in seven<br />

European countries, it was<br />

tion on adverse events associated<br />

with medicines. MEPs<br />

backed the new rules after<br />

intense negotiations with EU<br />

member states, some of whom<br />

have been reluctant to cede<br />

control to Brussels and share<br />

data with European counterparts.<br />

The European Commission,<br />

European Medicines Agency<br />

(EMA) and national regulators<br />

will have full access to the<br />

database, while companies,<br />

concluded that the “pay<br />

for service” system in The<br />

netherlands and Belgium<br />

incentivises doctors to<br />

provide as much treatment<br />

as possible and ultimately<br />

squeezes more money from<br />

the public coffers than<br />

necessary.<br />

EHFCn President Paul<br />

Vincke said cross-border<br />

“healthcare shopping”<br />

is also a major source of<br />

healthcare professionals and<br />

the public will be given “appropriate”<br />

access, according to<br />

a compromise text hammered<br />

out in late September.<br />

The deal, which was broadly<br />

welcomed by health professionals,<br />

industry and consumer<br />

groups, became the first element<br />

of the three-part pharmaceutical<br />

package to clear all<br />

stages of European Parliament<br />

approval. The legislation<br />

comes into force in mid-2012.<br />

fraud, with patients in the<br />

Republic of Ireland accessing<br />

free healthcare services in<br />

northern Ireland by using<br />

false addresses.<br />

Closer cooperation<br />

between authorities and<br />

the use of sophisticated<br />

computer systems to track<br />

patients and medicines<br />

will help curb corruption in<br />

the health sector, experts<br />

concluded.<br />

EMA beefs<br />

up conflict of<br />

interest rules<br />

The European Medicines Agency<br />

(EMA) has unveiled a more robust<br />

process for ensuring members of<br />

its scientific committees have no<br />

commercial interests that would<br />

affect their impartiality.<br />

The move came after transparency<br />

groups criticised the<br />

authorities for taking advice from<br />

experts who had worked with the<br />

pharmaceutical industry during<br />

the H1n1 flu pandemic. The World<br />

Health Organisation (WHO) has<br />

also pledged to review its approach<br />

to avoiding conflicts of interest<br />

in the wake of the furore over the<br />

pandemic.<br />

Meanwhile, the regulator has<br />

also promised to take a more open<br />

approach to requests for access to<br />

documents related to medicines.<br />

The EMA came under fire from the<br />

European Ombudsman on two<br />

separate occasions this year for its<br />

reluctance to hand over documents<br />

requested by citizens.<br />

The Agency says it wants to become<br />

more transparent but will still<br />

have to edit some documents prior<br />

to disclosure in order to protect<br />

commercially sensitive information<br />

and to safeguard personal data.


16<br />

heRBal medicine<br />

Adding spice to the<br />

Christmas baking<br />

What we eat at Christmas is not necessarily all bad<br />

– Des Corrigan takes a closer look at the benefits of<br />

yuletide spices<br />

as soon as I opened the front door<br />

I realised that it was THAT time of<br />

the year. Given the foul weather<br />

outside it was comforting to come<br />

home to the fabulous smell of<br />

the Christmas baking wafting out<br />

from the kitchen. The welcoming aroma of the<br />

mixed spices which the Higher Management was<br />

using as part of her tried and trusted cake and<br />

pudding recipes reminded me that the festive<br />

season was just around the corner.<br />

At first glance it is difficult to see anything<br />

healthy in the way we celebrate Christmas in<br />

Ireland with over-eating and drinking the norm.<br />

However, the familiar scents of cinnamon, cloves,<br />

nutmeg, ginger and allspice which make up what<br />

is called mixed spice, got me thinking about<br />

these and the other herbs and spices which form<br />

part of our Christmas traditions. Given that these<br />

herbs and spices all contain pharmacologically<br />

active chemicals I wonder if in fact we might<br />

be doing our bodies some good by ingesting<br />

them alongside all the calories, saturated fat and<br />

alcohol we consume over the Christmas holidays.<br />

“<br />

Sometimes a little<br />

common-sense<br />

is needed...no one has<br />

suggested that pregnant<br />

women avoid ginger<br />

biscuits or Thai food.<br />

CLove oiL – Pain kiLLer<br />

Allspice is a peppercorn-like spice from a<br />

Caribbean plant called Pimenta. While it is central<br />

to Caribbean cooking its main medical effect<br />

is on flatulence and given the impact of rich<br />

Christmas food on the human digestive system,<br />

maybe that is no bad thing to have in the diet.<br />

The main chemical in allspice is eugenol which<br />

is also the major component of the essential oil<br />

of cloves. As is well known, that oil is used as a<br />

dental pain reliever which may be as effective<br />

as a benzocaine gel. There is good scientific<br />

evidence for this and for the effectiveness of a<br />

combination of clove oil with zinc oxide paste<br />

in cases of dry socket inflammation after tooth<br />

extraction. It is active against many bacteria<br />

especially those associated with dental caries and<br />

periodontal disease.<br />

nuTMeg – naTuraL HigH?<br />

nutmeg is a traditional component of eggnog<br />

but does anyone actually drink eggnog at<br />

Christmas nowadays? It is also a component<br />

of mixed spice. The main chemical in Myristica<br />

fragrans as it is known botanically is called<br />

(with great originality) myristicin. This molecule<br />

has a similar structure to MDMA (Ecstasy), the<br />

main difference being that it has no nitrogen<br />

atom. nutmeg has long had a reputation as a<br />

hallucinogenic drug in US prisons where inmates<br />

reportedly consumed several dessert spoons<br />

of the powdered seed in order to get high.<br />

Intoxication is likely to occur after ingestion of 5g<br />

or more of nutmeg which is equivalent to about<br />

1 to 2 mg of myristicin per kilo of body weight.<br />

It has been suggested by way of explanation of<br />

the psychotropic effects that myristicin might<br />

be metabolised in the body to an amphetamine<br />

derivative but extensive studies in humans have<br />

shown no evidence of such metabolites.<br />

ginger – anTi-eMeTiC<br />

The remaining two ingredients in the mix are<br />

the real ‘biggies’ in terms of their health impact.<br />

Ginger has been used for centuries in cooking<br />

and as a medicine because of its characteristic<br />

smell and pungent (heat inducing) taste. In<br />

recent times attention has focussed on its<br />

anti-emetic effects and on its role in alleviating<br />

arthritic complaints.<br />

While the evidence for the latter shows<br />

considerable promise it is not yet comparable<br />

to that for the effect on nausea and vomiting.<br />

Studies in animals show evidence of the ability<br />

of ginger products to counteract vomiting. A<br />

large number of RCTs confirm this in cases of<br />

travel sickness with the added advantage that<br />

ginger does not cause the drowsiness associated<br />

with other travel sickness products which is<br />

important if one has to drive on continental roads<br />

after leaving the ferry. There is also high level<br />

clinical evidence supporting the use of ginger in<br />

morning sickness and in post-operative nausea<br />

and vomiting.<br />

Use in morning sickness raises the question<br />

of the safety of the spice during pregnancy,<br />

issue 10 volume 12 • novemBeR 2010<br />

Dr Des Corrigan is the former Director<br />

of the School of Pharmacy at TCD, and<br />

won the lifetime Achievement Award<br />

at the 2009 Pharmacist Awards.<br />

He is the Irish representative on the<br />

Scientific Committee of the European<br />

Monitoring Centre for Drugs and Drug<br />

Addiction. He also currently chairs<br />

the national Advisory Committee<br />

on Drugs as well as the chair of the<br />

Traditional Herbal Medicinal Products<br />

Subcommittee of the Advisory<br />

Committee on Human Medicines at<br />

the Irish Medicines Board.<br />

dr des CorrIGAN<br />

with a number of commentators pointing out<br />

that no formal safety studies during pregnancy<br />

have been carried out and that effects on the<br />

foetus cannot therefore be ruled out. There have<br />

been follow-up evaluations during the morning<br />

sickness trials which did not show any evidence<br />

of abnormalities or increased risk of stillbirth or<br />

miscarriages. Sometimes a little common-sense is<br />

needed in these situations because most of the 1<br />

million tons of ginger produced worldwide ends<br />

up in confectionery, soft drinks and ethnic dishes.<br />

And no one has suggested that pregnant women<br />

avoid ginger biscuits or Thai food.<br />

CinnaMon – For DiabeTes<br />

It is the aroma of cinnamon bark and its more<br />

widely available Chinese variety which evokes<br />

Christmas for me. Medically the focus in recent<br />

years has been on the anti-diabetic effects of<br />

the oligomeric procyanidins in cinnamon rather<br />

than the fragrant oil. Animal studies show that<br />

these effects could lead to a reduction in diabetic<br />

complications.<br />

Human studies have given mixed results with<br />

some RCTs showing reductions in fasting blood<br />

glucose in type 2 diabetics of between 8 and<br />

29 per cent. Other RCTs have not shown such<br />

effects. It is likely that dosage is an issue as the<br />

range has been from 1 to 10g of bark daily. This<br />

is an awful lot of spice and certainly your average<br />

cake would not get anywhere near that amount.<br />

A 2007 review in the journal Pharmacotherapy<br />

concluded that there was a modest effect on<br />

glucose levels but that cinnamon should not<br />

be recommended as a replacement for proven<br />

lifestyle modifications, oral antidiabetics and<br />

insulin but it did not say that supplementation<br />

with a high quality product might not be a<br />

worthwhile idea.<br />

sPiCe Wars<br />

Christmas is traditionally a time of peace and<br />

goodwill so it is easy to forget that all of the<br />

aforementioned spices are sourced from exotic<br />

locations such as Grenada, Sri lanka, and<br />

Zanzibar and that over the centuries the spice<br />

trade was the cause of many wars costing many<br />

lives with empires, colonies and huge fortunes<br />

won and lost. Such concerns are however far<br />

from most peoples minds as they tuck in to their<br />

Christmas pudding and cake.


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Prescribing Information for Grepid 75 mg film-coated tablets. Qualitative and Quantitative Composition: Each film-coated tablet contains 75 mg of clopidogrel (as besilate). Pharmaceutical Form: Pink, round, biconvex, film-coated tablets. Therapeutic Indications: For the prevention of atherothrombotic events in<br />

patients suffering from myocardial infarction (from a few days until less than 35 days), ischaemic stroke (from 7 days until less than 6 months) or established peripheral arterial disease. Dosage and Method of Administration: Oral use. Adults and elderly: Administered as a single daily dose of 75 mg with or without food. Paediatric<br />

Patients: Not recommended. Contraindications: Pregnancy & Breast-feeding: It is preferable not to use clopidogrel during pregnancy as a precautionary measure. Breast-feeding should not be continued during treatment with Grepid. Not to be administered in patients with severe liver impairment and those experiencing active<br />

pathological bleeding. Hypersensitivity to clopidogrel or to any of the excipients. Special warnings and precautions for use: Therapeutic experience is limited in patients with renal and moderate hepatic impairment. Grepid should be used with caution in patients at increased risk of bleeding. Discontinue use with this medication<br />

7 days prior to surgery. Alert physician upon any unusual bleeding. Clopidogrel may lead to a rare event of Thrombotic Thrombocytopenia Purpura (TTP). Delay treatment with Grepid in patients that have experienced an acute ischaemic stroke in the past 7 days. Contains Lactose. For further information, please refer to the SPC. Drug<br />

Interactions: Concomitant use of clopidogrel and oral anticoagulants is not recommended due to increased intensity of bleeding. To be used with caution with the concomitant use of glycoprotein IIb/IIa inhibitors, aspirin, heparin, thrombolytics, NSAID’s & CYP2C19 inhibitors. Undesirable effects: Common: Bleeding, haematoma,<br />

epistaxis, gastrointestinal haemorrhage, diarrhoea, abdominal pain, dyspepsia, bruising, bleeding at puncture site. For further information, please refer to the SPC. Shelf Life: 2 years. Marketing Authorisation Holder: Pharmathen S.A., 6 Dervenakion, 15351-Pallini, Attiki, Greece. Licence number: EMEA/H/C/001059//0000. Grepid<br />

75 mg film-coated tablets is a prescription only product. Further prescribing information is available upon request from Pinewood Laboratories Ltd. Date of revision of text: August 2010.<br />

Ireland’s No. 1 Generic Healthcare Specialists


18<br />

inTeRview<br />

In part two of our series on the<br />

Masters of Irish Pharmacy June<br />

Shannon talked to the teaching<br />

legend – Ingrid Hook<br />

if you are an Irish pharmacist working in<br />

Ireland today chances are that you have<br />

been taught by Ms Ingrid Hook, who for<br />

the past 40 years has dedicated her career<br />

to the teaching of Pharmacognosy and the<br />

development of the School of Pharmacy<br />

at TCD.<br />

Ms Hook was born in what was then<br />

Czechoslovakia and grew up in Innsbruck,<br />

Austria. An only child, she followed her widowed<br />

mother to England at the age of eight. Despite<br />

a hugely difficult start to her new life in the UK<br />

– which included travelling alone to a strange<br />

country at the tender age of eight without a<br />

word of English – Ingrid went on to become a<br />

gifted and successful scholar. A love of science,<br />

especially botany, proved to be the stimulus for<br />

a hugely successful career in the subject area<br />

of pharmacognosy, the historic ‘roots’ of the<br />

pharmacy profession.<br />

Medicine’s loss…<br />

According to Ms Hook she originally wanted to<br />

study medicine but was put off by the length<br />

of time it took to qualify. Thankfully for the<br />

hundreds of Irish pharmacy students she went on<br />

to teach, Ms Hook instead opted for pharmacy,<br />

a choice that she said she never once lived to<br />

regret.<br />

Ms Hook qualified with a BSc (Pharm) at the<br />

UK Manchester University in 1965, where she<br />

specialised in Pharmacognosy. She did her preregistration<br />

year in the hospital pharmacy at<br />

Withington Hospital in Manchester. That had a<br />

“wonderful pharmacy. It was…a manufacturing<br />

pharmacy as well so I got exposure to the<br />

whole aseptic scene. We made ampoules…<br />

large volume parenterals, we also made a lot of<br />

ointments because there was a big skin clinic<br />

there…at that stage we had already started<br />

ward rounds so it was a big pharmacy and it<br />

really proved to me that hospital pharmacy was<br />

issue 10 volume 12 • novemBeR 2010<br />

Ms INGrId Hook<br />

First woman Head of School of<br />

Pharmacy and teaching supremo<br />

my number one choice of direction,” Ms Hook<br />

explained.<br />

The 60s<br />

In 1966 she moved to Blackpool to try her hand<br />

at community pharmacy, or, in her own words:<br />

“I decided to check that I didn’t like community<br />

pharmacy”. After two years and satisfied that<br />

community pharmacy was not for her, Ingrid was<br />

appointed as a hospital pharmacist at Fulwood<br />

Hospital in Preston, lancashire.<br />

In 1969 Ingrid married the now well-known<br />

rugby pundit and broadcaster George Hook<br />

whom she had met in the UK. They both decided<br />

to return to live in Ireland but unfortunately at<br />

that time in Ireland there was no reciprocity<br />

for Ingrid’s UK Pharmacy degree and when she<br />

went to make enquires about practising here she<br />

learned that she would have had to repeat the<br />

entire three years.<br />

Almost by default therefore Ms Hook sought


issue 10 volume 12 • novemBeR 2010<br />

out an alternative career path and in 1970 was<br />

lucky enough to be appointed lecturer in<br />

Pharmacognosy at what was then known as<br />

the College of the Pharmaceutical Society of<br />

Ireland based in the headquarters of the PSI in<br />

Shrewsbury Road and administered by UCD.<br />

In 1977 administration of the Pharmacy<br />

College was transferred to TCD, although it was<br />

to be another 20 years before the School was<br />

transferred physically to a purpose built building<br />

on the main TCD campus at College <strong>Green</strong> in<br />

October 1997. In 1993 Ingrid was appointed<br />

Senior lecturer in Pharmacognosy at TCD and six<br />

years later became Head of the Department.<br />

FirsT woMan<br />

In 2003 Ms Hook became the first female head<br />

of the School of Pharmacy at TCD, a position to<br />

which she was elected by her peers, and she<br />

went on to successfully steer the School through<br />

what she described as a particularly difficult and<br />

challenging time.<br />

Ms Hook faced a myriad of difficulties on<br />

her appointment in 2003, chief of which was a<br />

significant staff shortage, especially in the areas<br />

of Pharmacy Practice and Pharmacology due to<br />

the very sudden and untimely death of Professor<br />

Graham Shaw, TCD’S highly respected Professor<br />

of Pharmacology and the early retirement of Mr<br />

Gordon Davis, Senior lecturer in Pharmacology.<br />

This took place against a backdrop of<br />

organisational, financial and administrative<br />

changes at TCD in July 2003, which resulted in the<br />

once separate departments of Pharmacognosy,<br />

Pharmaceutical Chemistry, Pharmaceutics,<br />

Pharmacology and the Centre for the Practice of<br />

Pharmacy, being amalgamated into one School<br />

of Pharmacy, within the Faculty of Science.<br />

Bologna declaraTion<br />

Staff retirements, accreditation issues and the<br />

imminent impact of the European Bologna<br />

Declaration – which called for the modularisation<br />

of higher education – made for a very busy and<br />

challenging time for the new Head of Pharmacy.<br />

The 1999 Bologna Declaration called for<br />

massive reforms to be introduced across all<br />

European higher education institutions so that<br />

all courses were compatible and comparable.<br />

This pan European ideal aimed to facilitate the<br />

integration of universities within Europe so that<br />

theoretically students would be able to move<br />

seamlessly between universities or different<br />

subject areas. Ms Hook was instrumental in the<br />

modularisation of the BSc Pharm degree in TCD,<br />

which was introduced in October 2007.<br />

“<br />

“What saddens<br />

me is that<br />

the people who are<br />

actually losing out<br />

are what you now are<br />

calling the ‘end users’<br />

i.e. the students.”<br />

During her five years as Head of School from<br />

2003-2008, Ms Hook, together with all the<br />

School’s staff worked hard to successfully guide<br />

the pharmacy course through four accreditation<br />

visits by the PSI. Staff numbers were brought<br />

back to full complement and in July 2005 she<br />

was involved in the transfer of the School of<br />

Pharmacy from the Faculty of Science to what<br />

was seen as its more natural home in the Faculty<br />

of Health Sciences.<br />

TrouBle coMes in Threes!<br />

During Ms Hook’s tenure the School was also<br />

visited by three major disasters, which included,<br />

two major fires one in May 2004 and another in<br />

July 2006 and a major flood in January 2006.<br />

Reflecting on her time as Head of School Ms<br />

Hook stated that the biggest challenge was the<br />

staffing issues “because everything else worked<br />

from that point on.”<br />

If you had the staff you could have the course<br />

running but if you didn’t have the staff then<br />

obviously the staff in-house wouldn’t have<br />

been able to cope. Once we had the staff in<br />

place it meant then that we could continue<br />

with accreditation and allow the graduation of<br />

pharmacy students, she explained.<br />

In September 2009 Ms Hook retired following<br />

more than four decades in academic pharmacy in<br />

Ireland. However, like most highly committed and<br />

dedicated professionals she is still an amazingly<br />

busy woman for someone who is supposed to be<br />

retired.<br />

She continues to come to College three days<br />

a week as a visiting academic, still gives some<br />

lectures in Pharmacognosy to undergraduate and<br />

postgraduate students. She is also still involved<br />

in research and is a member of a number of high<br />

profile boards and institutions including the<br />

Irish Medicines Board (IMB), the Science Subcommittee<br />

of the Royal Dublin Society (RDS),<br />

and the Scientific Committee of the European<br />

Scientific Co operative on Phytotherapy.<br />

Ms Hook also serves as an expert member on<br />

the Herbal Medicines Sub-Committee of the<br />

IMB and a Pan European Working Party in Good<br />

Practice in Traditional Chinese Medicine Research<br />

in the Post-genomic era (GP-TCM) – a European<br />

Coordination Action project to inform best<br />

practice and harmonise research of the safety<br />

and efficacy of traditional Chinese medicine in EU<br />

member states.<br />

work/liFe Balance<br />

As a mother of three and grandmother of four Ms<br />

Hook told Irish Pharmacist that although she may<br />

have come to a career in academic pharmacy<br />

by default she never saw herself as a “true blue<br />

academic” and as a busy working mother she was<br />

“grateful” to academia for allowing her to strike a<br />

happy work/ life balance.<br />

According to Ms Hook, striking a good work/<br />

life balance today is not so easy to achieve due to<br />

what she sees as a shift in emphasis in academia<br />

over the past decade from one which was very<br />

much teaching-oriented to today where the<br />

focus seems to be more on research, publications<br />

and research funding.<br />

“About ten years ago the whole emphasis in<br />

academia changed and it became very researchoriented<br />

where your whole career was based<br />

on the number of publications that you had, the<br />

type of publications, the amount of money that<br />

you brought in. Whereas when I was in academia<br />

inTeRview<br />

“<br />

“About ten<br />

years ago the<br />

whole emphasis in<br />

academia changed …<br />

your whole career was<br />

[now] based on the<br />

number of publications<br />

that you had, the type<br />

of publications, the<br />

amount of money you<br />

brought in.”<br />

at the beginning…the emphasis was more on<br />

teaching, the students and student welfare and<br />

student ability…and your subject…we loved our<br />

subjects, we carried on with our research…the<br />

research that we were allowed to do was what we<br />

felt was relevant research. now I don’t think you<br />

have the same kind of choice.”<br />

sTudenTs losing ouT<br />

“What saddens me is that the people who are<br />

actually losing out are what you now are calling<br />

the ‘end users’ i.e. the students.”<br />

Ms Hook said that it was possible to learn to be<br />

a good teacher and that it was important to gain<br />

students’ respect and to be respectful of them.<br />

“you need to be available to them, you need<br />

to be able to answer their questions whenever<br />

they arise, you need to be able to give them the<br />

information in a format that they can understand<br />

at a level that they can understand with the<br />

background information that you can hand out<br />

to them. “<br />

The Trinity academic added that teaching itself<br />

has changed very much over the past decade<br />

with technological advances and the advent of<br />

e-learning.<br />

“I don’t know whether it is going to make<br />

better pharmacists or better graduates,” she<br />

added.<br />

Asked what one piece of advice she would give<br />

to someone thinking of studying pharmacy she<br />

said that what she has always said to prospective<br />

students over the years was that pharmacy was a<br />

good comprehensive science-based education,<br />

that allows graduates to work in a wide range of<br />

areas from community to hospital to industry and<br />

journalism to name but a few.<br />

“I would always recommend it to somebody<br />

good at science because it gives you a very large<br />

number of opportunities.”<br />

Reflecting on a career spanning four decades<br />

during which hugely committed teachers like<br />

herself and Dr Des Corrigan dedicated their time<br />

to teaching and mentoring future generations<br />

of Irish pharmacists Ms Hook said “I hope we<br />

taught them well, that they had a good Trinity<br />

experience…and that we showed them that<br />

natural products still have a place in modern<br />

pharmacy.”<br />

19


20<br />

opinion<br />

tHe CoAlfACe<br />

brain drain or over-<br />

supply – you decide<br />

David Jordan has dug up some interesting figures<br />

relating to the future supply of pharmacists.<br />

so we have reached October and for<br />

the interns and tutors it is a case<br />

of another year over. And from all<br />

our points of view the last year has<br />

certainly been a memorable one.<br />

The old Chinese curse ‘May you live<br />

in interesting times’ springs to mind. I had a chat<br />

with my departing intern about her job prospects<br />

and the outlook is indeed gloomy. Once again<br />

the talk is of emigration. Mostly Australia and<br />

Canada, the UK does not get much of a look in<br />

with today’s graduates. Even though emigration<br />

is not the big deal that it was when I qualified<br />

this still saddens me. After five years of hard slog<br />

at the expense of the taxpayer they, through no<br />

fault of their own, will now be lost to Ireland.<br />

now those of you accustomed to my<br />

scribblings will know that this is the kind of thing<br />

which gets me thinking. Just how many positions<br />

are available to the 170 graduates who will be<br />

sitting their final exams this november? not<br />

enough it seems. The current freeze on hospital<br />

appointments is not helping. Maybe in a few<br />

years this might change but for now it just adds<br />

to the woe. But just how many new pharmacists<br />

does Ireland need every year?<br />

“<br />

I would readily<br />

have more<br />

pharmacists practising<br />

in my pharmacy if I<br />

could get away with<br />

paying them the<br />

minimum wage.<br />

Foraging For Figures<br />

So I set off to find out. My first port of call, as with<br />

any pharmaceutical matter, was the PSI. no don’t<br />

worry, this is not going to be another PSI rant. I’ll<br />

have plenty more of them in articles to come. I<br />

emailed them asking if they were aware of any<br />

manpower studies in relation to pharmacists.<br />

I also emailed the Department of Education as<br />

they pay for all the pharmacy courses. By return<br />

the Department replied that they did not have<br />

any studies but referred me to the HEA. They in<br />

turn referred me to Fórfas on whose website I<br />

found surveys for 2005, 2006 and 2007. At the<br />

time of writing the PSI hasn’t even replied to my<br />

original email. OK so I’m allowed a little rant! I<br />

also culled some figures from the PSI’s Corporate<br />

Strategy. So they weren’t totally useless.<br />

WoManPoWer<br />

I started by calling these ‘Manpower’ surveys.<br />

However Womanpower may be more accurate. In<br />

2005 the fairer sex accounted for 50 per cent of<br />

the pharmacist workforce, by 2007 this figure had<br />

risen to 70 per cent.<br />

Aside from this, the number of pharmacists<br />

on the PSI register increased from 2,500 in 2005<br />

to 4,500 in 2010. (lets not forget the 500 or so<br />

Qualified Assistants who are still on the register<br />

as well.) Assuming that approximately 10 per cent<br />

of the register is not in active practice this gives<br />

a workforce of 4,000 to 4,100. This is a massive<br />

increase in any workforce in such a short period.<br />

When you look at the age profile the numbers<br />

over 55 years of age in 2005 was 10 per cent.<br />

This rises to 18 per cent in 2007. So in the next 7<br />

years (i.e. up to 2017) we can expect about 500<br />

pharmacists to retire from active practice. So how<br />

are they being replaced? The surveys reported<br />

a growth rate on 10-12 per cent p.a. in pharmacy<br />

with a replacement rate of 2.8 per cent required.<br />

The PSI’s Corporate Strategy estimates that they<br />

will register 150 from Irish universities, 90 EU<br />

nationals and 10 from outside the EU every year.<br />

I suspect that many of the EU nationals will be<br />

Irish students currently studying pharmacy in<br />

the UK. That is 250 new pharmacists every year.<br />

A replacement rate of 5.5 per cent. Twice the rate<br />

that Fórfas recommends. So the 500 retirements<br />

from 2007 to 2017 have already been replaced<br />

by 2009. By 2017 500 retirements will have been<br />

replaced by 2,500 new pharmacists. Even with<br />

my B in leaving Cert maths these numbers<br />

don’t add up. So why all the pharmacy places<br />

in universities?<br />

over-suPPLy<br />

All of the studies mentioned above noted the<br />

pharmacist shortages which certainly existed<br />

at stages in the past. But it seems that when<br />

planning for university places – if any such<br />

planning occurred – no account was taken of<br />

EU pharmacists who now have free movement<br />

and mutual recognition of qualifications. Also no<br />

allowance was made for all the Irish students who<br />

might travel to the UK to study there. So now it<br />

would seem that we are heading for massive over<br />

supply.<br />

The PSI has stated in their strategy that<br />

they would like to see more pharmacists per<br />

pharmacy. They have also said that they would<br />

like to see a return to a version of geographic<br />

distribution via some form of licensing. While<br />

these are laudable desires there is no mention<br />

dAvId jordAN<br />

issue 10 volume 12 • novemBeR 2010<br />

David Jordan has worked<br />

in community pharmacy<br />

since 1979, qualifying as<br />

a pharmacist in 1983. He<br />

was chairperson of the<br />

Community Employee<br />

Committee of the IPU from<br />

1990 to 1998 and treasurer<br />

from 1994 to 1996. His<br />

main stress relief is riding<br />

his motorbike with his<br />

friends from<br />

www.irishbikerforum.com<br />

of how this is to be paid for. I would readily have<br />

more pharmacists practising in my pharmacy if I<br />

could get away with paying them the minimum<br />

wage. If the current over-supply continues this<br />

may yet be a practicable proposition.<br />

The same market forces may deal with this<br />

matter at least on a short term basis. numbers<br />

aren’t available yet but I suspect that the<br />

numbers of Irish students travelling to the UK<br />

to study pharmacy is on the wane. Those who<br />

started in the last few years will most likely finish<br />

their course but I doubt if many have started<br />

in 2010. Also the current recession/depression/<br />

double dip/'we’re all screwed anyway', will<br />

discourage pharmacists from the eastern states<br />

of the EU from travelling here.<br />

But for now unless the PSI, Department of<br />

Education and the HEA sit down together and<br />

discuss this it looks like we will be pumping our<br />

taxes into training our best and brightest for<br />

export.<br />

Just to finish on a side note. When UCC<br />

announced the start of their pharmacy course I<br />

asked a southern colleague why did Cork need a<br />

School of Pharmacy. His reply was “Sure Dublin has<br />

two, boy.” Hate mail<br />

can be sent<br />

to me via the<br />

editor!


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22<br />

PINIoN<br />

opinion vIew froM Above<br />

Pharmacy<br />

listening service<br />

There was a time when Terry Maguire pitied those<br />

who studied the social sciences but all that has<br />

changed now that he has become a de facto social<br />

worker.<br />

as a career I never considered<br />

social work, as a student I pitied<br />

as misguided those studying the<br />

social sciences and as a graduate<br />

I worried for those condemned to<br />

a life in the social services since<br />

in later life they were most likely to contemplate<br />

suicide on a weekly if not daily basis. So it has<br />

come as somewhat of a surprise that I now find<br />

I have by default ended up performing a job<br />

that is more social work than anything else. I<br />

am a case worker for the manic, the confused<br />

and downright bewildered and the surprising<br />

thing is I rather like being the listening ear, the<br />

unpaid community counsellor. It’s all part of a<br />

pharmacist’s job it seems and there are rewards;<br />

my customers can prove the most colourful<br />

threads in the rich weave that forms the beautiful<br />

fabric of life. let’s meet a few of them; those<br />

whom I see more regularly than most since their<br />

GP considers them possessing more than one<br />

day’s supply of medicines a major clinical risk.<br />

“<br />

leticia...<br />

removed the<br />

toilet-roll from its<br />

holder and shoved<br />

it over the smoke<br />

detector, something<br />

she tells me she had<br />

seen in a movie.<br />

angela’s aspiraTions<br />

Angela is convinced her daughter will become<br />

a famous paediatrician and I am supporting her<br />

in this belief since belief is the best she can have<br />

now that the child has been removed from her<br />

by the real social services. In mid-August she let<br />

me know, to my delight I must say, that her little<br />

darling had obtained 9 A* in her GCSEs. She has<br />

recently revised this story to an aspiration for<br />

these heady grades when the exams are taken<br />

in two years time. This may prove difficult since<br />

Angela’s daughter is only taking six subjects<br />

at GCSE and is seldom found in her academic<br />

establishment. The little angel is difficult, wilful<br />

and as vicious as a burning wasps’ nest and I feel<br />

genuine remorse for the foster family who have<br />

got her; nothing could pay this family.<br />

And then there’s leticia. leticia’s moods swing<br />

more than a pendulum clock. Her mental health<br />

is indeed poor but when she’s manic – and if you<br />

don’t have to live with her – she can be great fun.<br />

She changes GP more than I change the tyres<br />

on my car. Her current GP is keeping a sensible<br />

distance but she claims to be deeply in love with<br />

him and she believes he secretly reciprocates her<br />

feelings.<br />

leticia has just been in court charged with<br />

smoking on a flight. She could not last without a<br />

cigarette during the three hour flight time from<br />

Benidorm, indeed she had great trouble getting<br />

through the first hour so she got into the aircraft<br />

toilet and before she lit up she removed the<br />

toilet-roll from its holder and shoved it over the<br />

smoke detector, something she tells me she had<br />

seen in a movie. This cunning plan failed and the<br />

stewards were quickly battling against the door.<br />

She refused to come out claiming to be unwell.<br />

On arriving at Belfast International Airport, the<br />

captain, using some of the extensive library of<br />

emergency anti-terrorist legislation available to<br />

him, had her arrested and charged.<br />

The judge was particularly unhappy with her<br />

behaviour and handed down a £300 fine but she<br />

rages against this perceived injustice to anyone<br />

who will listen and most mornings lately that is<br />

me.<br />

respecTFul lisTening<br />

Sean has been smoking for 20 years and has been<br />

trying to stop for 19 years. He finds stopping<br />

smoking easy he has, like Mark Twain, found<br />

it so easy to stop he has done it 50 times. It’s<br />

staying stopped that seems to be his problem.<br />

He has obtained so much nRT from his GP in the<br />

last 6 months that he is now trying to talk me<br />

into buying his unused<br />

nRT stock back at a<br />

discount.<br />

And then<br />

there’s Steven<br />

who, to<br />

his credit,<br />

overcame a<br />

significant<br />

alcohol<br />

problem about<br />

10 years ago.<br />

When his elderly<br />

terry M AGuIre<br />

issue 10 volume 12 • novemBeR 2010<br />

Terry Maguire owns two<br />

pharmacies in Belfast.<br />

He is an honorary<br />

senior lecturer at the<br />

School of Pharmacy,<br />

the Queen’s University<br />

of Belfast. His research<br />

interests include<br />

the contribution of<br />

community pharmacy<br />

to improving public<br />

health.<br />

aunt, with whom he lived and cared for, was in<br />

the final stages of Alzheimer’s, he was refused<br />

respite care. So he simply walked out leaving<br />

the front door open and from a phone box in the<br />

centre of Belfast rang the police telling them he<br />

was a concerned neighbour and was reporting<br />

himself (Steven) missing and telling the police<br />

that something needed to be done for the old<br />

dear who would soon be wandering the streets.<br />

He turned up two weeks later with a tan and<br />

reclaimed his aunt from the geriatric ward of<br />

the local hospital. Since her death he has tried<br />

several times to get, as he keeps telling me, “his<br />

career going”. Firstly, he decided to become<br />

a sculptor and bought a second hand furnace<br />

that he set up in his small living room. He made<br />

twisted iron designs until the furnace burned a<br />

hole through the floor into which it collapsed<br />

and where it remains in situ to this day. He also<br />

had a go at sculpturing tree stumps but now-adays<br />

he is trying to become a writer and insists<br />

I read the copious rubbish he produces. These<br />

are ostensibly short-stories about old Belfast and<br />

its great characters but, from what I have read, it<br />

seems he merely plagiarises story-lines from the<br />

nightly TV soaps.<br />

But to them all, and may more, I will continue<br />

to respectfully listen, as all pharmacists do. I have<br />

become convinced that listening is the glue that<br />

retains a semblance of civilisation within our<br />

fragile communities. As the credit crunch bites<br />

deeper north and South there will<br />

be an even greater need<br />

for more respectful<br />

listening.


Communication is important 1-3<br />

If only I could<br />

fi nd the<br />

words<br />

Abbreviated Prescribing Information:<br />

For full prescribing information refer to the Summary of Product Characteristics. Name: Ebixa Active Substance: Memantine Hydrochloride.<br />

Indication: Treatment of patients with moderate to severe Alzheimer’s disease. Dosage & Administration: Treatment<br />

should be initiated and supervised by a physician experienced in the diagnosis and treatment of Alzheimer’s dementia. Therapy<br />

should only be started if a caregiver is available who will regularly monitor the intake of the medicinal product by the patient. Treatment<br />

is orally either as tablets (10 mg) or solution (10 mg/g) taken with or without food at the same time every day. The solution<br />

should only be dosed onto a spoon or into a glass of water using the pump. Maintenance dose is 20mg/day, (two tablets or 2ml<br />

solution [4 downward strokes] once daily). Treatment starts with 5mg/day (half a tablet or 0.5 ml solution [1 downward stroke]<br />

once daily) for the fi rst week; the 2nd week 10mg/day (one tablet or 1 ml solution [2 downward strokes] once daily); the 3rd week<br />

15mg/day (one and a half tablets or 1.5ml solution [3 downward strokes] once daily) and the 4th week 20mg/day (two tablets or<br />

2ml solution [4 downward strokes] once daily). Moderate renal impairment 10mg/day (one tablet or 1 ml solution [2 downward<br />

strokes] once daily), if well tolerated after 7 days the dose can be titrated up to 20mg/day (two tablets or 2 ml solution [4 downward<br />

strokes] once daily). Severe renal impairment- dose is 10 mg/day (one tablet or 1 ml solution [2 downward strokes] once daily).<br />

Mild-moderate hepatic impairment- no dose adjustment. Severe hepatic impairment- no data available. Children & Adolescents:<br />

Not recommended. Contraindications: Hypersensitivity to the active substance or any of the excipients. Pregnancy and Lactation:<br />

Pregnancy: Memantine should not be used in pregnant women unless clearly necessary. Lactation: Memantine should not<br />

be used in women who are breastfeeding. Special Warnings and Precautions for use: Caution is recommended in patients with<br />

epilepsy. Caution is advised in patients with raised urine pH as this may elevate plasma levels. Clinical trial data are limited on patients<br />

with recent myocardial infarction, uncompensated congestive heart failure and uncontrolled hypertension and patients with<br />

these conditions should be closely supervised. Avoid concomitant use of NMDA antagonists (see also interactions). Patients with<br />

sugar intolerance should not take Ebixa. Patients should be warned to take special care if driving and using machines as Ebixa has<br />

minor to moderate infl uence on these tasks. Interactions: Effects of L-Dopa, dopaminergic agonists and anticholinergics may be<br />

enhanced. Effects of barbiturates and neuroleptics may be reduced. Concomitant administration of Ebixa with antispasmodic agents<br />

Ebixa<br />

Approved from the moderate stage<br />

of Alzheimer’s Disease onwards 5<br />

e.g. dantrolene and baclofen can modify their effects, dose adjustments may be necessary. Plasma levels of cimetidine, ranitidine,<br />

procainamide, quinidine, quinine and nicotine may be increased. Co-administration with hydrochlorothiazide (HCT) may lead to a<br />

reduced serum level of HCT. Concomitant use of NMDA antagonist- amantadine, ketamine, dextromethorphan or phenytoin should<br />

be avoided. Close monitoring of prothrombin time or INR is advisable for patients treated concomitantly with oral anticoagulants.<br />

Adverse reactions: Common (≥1/100 to


24<br />

law<br />

lAw<br />

Treating children<br />

– the legal implications<br />

The law Reform Commission’s consultation paper<br />

on Children and the law: Medical Treatment has<br />

implications for the practice of pharmacy.<br />

The law considers children to be persons<br />

under the age of 18. The law Reform<br />

Commission makes over 20 provisional<br />

recommendations for reform. This is a<br />

first step in the long journey to becoming<br />

law. The paper notes the fact that there<br />

is no explicit statutory definition of what constitutes<br />

‘medical treatment’ or ‘healthcare’ and recommends<br />

that, in the context of determining the scope of consent<br />

to medical care and treatment, a broad definition of<br />

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system from colds and fl u<br />

these terms should be used to encompass diagnosis<br />

and treatment (of course this includes pharmacological<br />

treatments) and invites submissions on the form of<br />

these definitions.<br />

Pharmacists are welcome to forward their opinions<br />

on the matters arising in this area of the Commissions<br />

work to the law Reform Commission and they will be<br />

received graciously and with great interest.<br />

The law Reform Commission provisionally recommends<br />

that:<br />

...with<br />

Rubex is used for the prophylaxis and<br />

treatment of ascorbic acid defi ciency.<br />

CorM AC o’NeIll<br />

issue 10 volume 12 • novemBeR 2010<br />

Cormac O’neill is a barrister<br />

practising on the Dublin<br />

and South Western circuits.<br />

He is also a chartered<br />

management accountant<br />

with considerable<br />

experience in industry<br />

and banking. In addition,<br />

Cormac lectures on<br />

Business and law in the<br />

Institute of Technology<br />

in Tralee and can be<br />

contacted on 087 657 1124.<br />

1. 16 and 17 year olds should be presumed to have<br />

full capacity (based on a functional test of understanding)<br />

to consent to, and refuse, medical treatment. This<br />

should apply to surgery and access to contraception.<br />

The latter being of direct interest to Irish pharmacists as<br />

they are charged with dispensing contraception.<br />

2. It should be provided in legislation that a person<br />

who is 16 years of age is presumed to have capacity to<br />

consent to and refuse healthcare and medical treatment.<br />

In the context of refusal of life sustaining treatment,<br />

it provisionally recommends that a 16 year old<br />

may make a High Court application to have his or her<br />

purported refusal appraised. It also provisionally recommends<br />

that children aged over 12 years of age but less<br />

than 14 years of age may not be regarded as being<br />

capable of refusing medical treatment and therefore<br />

any person of this age who refuses necessary treatment<br />

will be treated none the less.<br />

3. A 14 or 15 year old person could be regarded as<br />

capable of giving consent to healthcare and medical<br />

treatment, provided he or she has the capacity<br />

to understand the nature and consequences of the<br />

treatment being provided, and subject to the following<br />

conditions:<br />

a. In the opinion of the medical practitioner, the<br />

patient understands the nature and consequences of<br />

the proposed treatment;<br />

b. The medical practitioner must encourage the<br />

patient to inform his parents or guardians;<br />

c. The medical practitioner must consider the best<br />

interests of the patient; and<br />

d. The medical practitioner must have due regard to<br />

any public health concerns.<br />

There is obviously plenty of scope for conflict to arise<br />

with regard to the above guidelines. not only is the<br />

decision a pharmacist faces in this area an ethical one it<br />

may also be a legal one.<br />

4. It would be lawful for a healthcare professional<br />

such as a pharmacist to provide healthcare and medical<br />

treatment to 12 and 13 year olds provided that:<br />

a. The medical practitioner must notify the parents or<br />

guardians of the child and take account of their views;<br />

b. The medical practitioner must take account of the<br />

views of the child in question;<br />

c. The medical practitioner must consider the best<br />

interests of the patient, the pharmacist should bear in<br />

mind that some patients need to be protected from<br />

themselves; and<br />

d. The medical practitioner shall have due regard to<br />

any public health concerns. Therefore, if the disease will<br />

infect others if it is untreated the public health concerns<br />

must be addressed and accounted for in the pharmacist’s<br />

decision.<br />

5. It should be provided in legislation that a person<br />

who is 16 years of age is presumed to have capacity to<br />

make an Advance Care Directive.<br />

6. The Mental Health Act 2001 be amended to make<br />

separate provision for people under 18; that all persons<br />

under 18 who are admitted and treated under the Mental<br />

Health Act 2001 should have access to an independent<br />

advocate; and that a Mental Heath Tribunal (with<br />

an age appropriate focus) should hear from such an<br />

advocate at the earliest possible opportunity.


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26<br />

finance<br />

How safe are your<br />

investments?<br />

Across Europe insurers have been busy preparing for<br />

Solvency II legislation and how does this affect little<br />

old me you ask...<br />

With all the noise about<br />

pensions and tax<br />

season, I wanted this<br />

month to call attention<br />

to two things. Both of<br />

which are very much in<br />

the space I find myself in<br />

at the moment.<br />

Firstly its about looking at how I can work<br />

with clients to protect what they have. As many<br />

of you may recall, last year we launched our<br />

book Surviving to Win, which was our attempt<br />

to bring solutions in a world where everyone is<br />

quick to define the problems but slow to bring<br />

forward solutions. The release of the book has<br />

lead us to renegotiating over €150m of debt<br />

on behalf of investors who have been seeking<br />

how to deal with banks around their own issues.<br />

Unfortunately while we thought that this would<br />

be a process that would be both logical and<br />

sensible, neither has prevailed, as the banks<br />

have been slow to be able to deal with their own<br />

problems let alone that of the debt holder.<br />

“<br />

It is becoming<br />

clearer to people<br />

that: 'how safe are the<br />

holders of my assets' is<br />

as important a question<br />

as 'how safe are my<br />

investments'?<br />

how To deal wiTh The Banks<br />

Frankly, from an investor perspective it has been<br />

both frustrating and difficult to handle even<br />

when all of the potential solutions are presented<br />

to them. While we have been getting the results<br />

that work for all parties, it has been slower than<br />

it needed to be. As a bye the bye, we are running<br />

information evenings and a two day course on<br />

dealing with the banks which has come about as<br />

a result of people requesting us to do so. If you<br />

want details, go to survivingtowin.com or drop<br />

me an email.<br />

Having got the infomercial out of the way,<br />

I want to address the issues around dealing<br />

with people with debt. That is ensuring that<br />

we cover all of the ways that a client protects<br />

themselves and their family. With this in mind<br />

and considering the time of year, the question<br />

of pensions comes to the fore. For many the<br />

notion is that all pensions are equal subject<br />

to management fees and fund manager. But<br />

as the recent Brendan Murtagh case outlined,<br />

the ability to put a trust structure in place is<br />

an important measure in protecting assets for<br />

potential creditors into the future. While I am not<br />

suggesting that this is the case for many people,<br />

it is becoming clearer to people that how safe<br />

are the holders of my assets is as important a<br />

question as how safe are my investments. When<br />

you couple this thinking with the advent of a<br />

new directive called Solvency II being introduced<br />

within the EU on the 1st January 2013, it really is<br />

time to take stock of your own position.<br />

solvency ii?<br />

Solvency II will govern capital adequacy<br />

standards in the European insurance and life<br />

insurance industry. It represents a complete<br />

overhaul of the existing rules (Solvency I), which<br />

date back to the 1970s. One of the pillars of the<br />

new directive is the introduction of a risk-based<br />

approach to reserving. In future, European<br />

insurers will have to be able to pass a 1-in-200<br />

years’ event stress test, which has been designed<br />

to give the industry enough cushion to withstand<br />

even the most severe of bear markets without<br />

being forced to sell out in the darkest hour. Risky<br />

asset classes such as equities, commodities and<br />

other alternative investments will be assigned<br />

much higher reserve requirements than less risky<br />

asset classes such as bonds.<br />

While that is the more academic version of<br />

the story, in layman’s terms (or in my simple<br />

thinking), it means that insurance companies<br />

(and pension funds) need to hold a far greater<br />

portion of their assets in bonds than they needed<br />

to do so before. While it can be argued that<br />

the regulation is not specific to pension funds,<br />

the fact that it impacts insurance companies<br />

does affect those people who do not operate<br />

their own self administered pensions and rely<br />

on insured arrangements. It has been a while<br />

since I had a bit of a rant about the need for<br />

taking charge of all that we do. Whether it is<br />

understanding how to handle our new world of<br />

high net debt and low net assets or deciphering<br />

how we can mind our own investments, it has<br />

IAIN CAHIll<br />

issue 10 volume 12 • novemBeR 2010<br />

iain Cahill aCCa Mba QFa<br />

Director<br />

art of Wealth Ltd.<br />

Dunlair House<br />

old athlumney<br />

navan<br />

Co. Meath<br />

Mob: 087 2411371<br />

Tel: 046 9072824<br />

never been a more important time to look at<br />

the small print in how we manage our wealth.<br />

If you use insurance companies as a means<br />

of managing your pension funds, below is an<br />

interesting break down of where pension funds<br />

are currently invested after the recent melt down.<br />

Across Europe insurers have been busy<br />

preparing for when the new rules to come into<br />

effect. As you can see from chart 1 below, the<br />

average exposure to equities is already very low<br />

– around 7 per cent according to Deutsche Bank.<br />

As Solvency II (unlike Solvency I) penalises the<br />

insurer if there is a duration mis-match between<br />

assets and liabilities, forced buying of bonds<br />

from the insurance sector may have been a major<br />

feature in the bond market rally of the past six<br />

months.<br />

Is it any wonder that the insurance companies<br />

are moving away from the with profits<br />

guarantees and in particular have you noticed<br />

that any projections that you may be receiving<br />

on your pension statements now talk about a<br />

projected growth of 4.8 per cent as opposed to<br />

the heady days of 8 per cent. I don’t know about<br />

you, but even at my age it would take too long<br />

to make any headway on my retirement needs if<br />

that is the best Gross return on offer.<br />

Please please please heed the need to be<br />

thinking protection of assets and the need<br />

for more informed control of the investment<br />

strategy. Secondly, if your own debt is a challenge<br />

and you need to understand more about what<br />

to do about it, come online or drop me an email<br />

and learn to be in charge. Finally, is now a good<br />

time to invest in Irish property? I am beginning to<br />

think so if you get the location right. Remember<br />

you heard it here first…Happy and safe investing.<br />

Chart 1: european insurance industry asset allocations<br />

Source: Deutsche Bank


28<br />

cReaTive wRiTing<br />

Lefty<br />

Donnie looked up at the lunar-like<br />

ceiling of spacelights that added<br />

to that morning’s world of white.<br />

The trolley hit a bump and he<br />

increased his grip on lefty. It was<br />

like the bump was a reminder of<br />

the fate that lay in store for lefty in about half<br />

an hour’s time. After 43 years of living together,<br />

sharing each milestone in his life, Donnie<br />

and lefty were parting company forever that<br />

morning. Donnie was scared.<br />

It had all began just over a fortnight ago<br />

with that most invasive of four letter words, ‘a<br />

lump’. The English language is full of four letter<br />

words but that word ‘lump’ has transcended<br />

literal meaning. There’d been no symptoms, no<br />

warnings, nothing, none of that, just a lump on<br />

lefty that couldn’t be wished away or justified by<br />

any sort of activity. It was there in the morning,<br />

and like the princess that no matter which way<br />

she turned or lay could always feel the pea in her<br />

bed, Donnie could always feel the lump.<br />

Donnie thought of that as the trolley waited for<br />

the lift to open. The nurse wanted to check his<br />

wristband, make sure she had the right patient,<br />

that sort of thing. Donnie had his right hand<br />

cradling lefty which entailed the nurse having<br />

to go and get it but she’d seen it many a time<br />

before.<br />

It’s alright … you’re not the first.’ And checked<br />

the band.<br />

‘When’d you discover it?’<br />

‘late last week.’<br />

‘That’s good … time’s everything with these.<br />

you’d be surprised at how many just ignore it…<br />

leave ‘til it’s too late…hope that it will go away…<br />

that sort of thing…especially men.’<br />

“<br />

How lefty was<br />

the one that<br />

‘hung low’ and how as<br />

many years ago he’d<br />

considered lefty as his<br />

barometer for a girl.<br />

Satisfied with what she’d checked she returned<br />

his hand to lefty. They’d laughed at that. His<br />

other hand was free, lying loose over his chest.<br />

She’d moved that to lefty also and they’d<br />

laughed more. Then she’d gone back to checking<br />

charts and he returned to his thoughts of lefty.<br />

Initially, he’d assumed that they’d just cut<br />

it, the lump, out and then when he learnt that<br />

everything on the left had to go, he’d accepted it<br />

pretty quickly because he’d just wanted that out,<br />

out, out of him, out of that inside of him forever.<br />

And everyone reassured him that because he’d<br />

got attention that he’d be fine, so much that he<br />

had himself convinced also and that’s when he<br />

became sorry for lefty. like he was abandoning<br />

a friend of old, someone who’d been there<br />

always, that half of a team that gave the complete<br />

backup.<br />

Donnie thought back to when he’d last held<br />

lefty with this sort of protection. It was a soccer<br />

match and the opposition had a free kick. He and<br />

lefty were the wall. The kicker didn’t like him.<br />

They’d had history throughout the match and<br />

he’d come across to say.<br />

‘Hey Donnie, I don’t care about the goal but his<br />

ball’s taking your head off.’<br />

Initially he’d held his arms over his face but at<br />

the penultimate moment just as the boot was<br />

coming into the leather he’d thought ‘What<br />

about Righty and lefty!! Forget the head…<br />

protect them nOW!’ and he had and they’d been<br />

very grateful.<br />

And then there was the time, Donnie’d been<br />

about 13 or so when lefty had disappeared after<br />

a cold swim and he’d told his Mother and his<br />

sisters had laughed and how he’d thought he was<br />

gone forever but like the faithful friend he was<br />

lefty had come back and now here was Donnie<br />

having him cut out.<br />

The lift opened and a team of white crowded<br />

over, questions, questions…name, date of birth,<br />

mother’s maiden name and all the faces were<br />

unfamiliar and he knew they were just checking<br />

to make sure they’d the right patient but Donnie<br />

just gripped lefty even more.<br />

And then the surgeon, Donnie knew<br />

him, ‘thank God’ … someone he knew…his<br />

jack-hammered heart relaxed, and then the<br />

anaesthetist. She was attractive, foreign looking,<br />

her hand on his chest, soothing:<br />

julIAN judGe<br />

issue 10 volume 12 • novemBeR 2010<br />

Julian Judge qualified as a pharmacist in 1990.<br />

He has recently completed a Masters in Creative<br />

Writing at the Department of english at uCD.<br />

Contact Julian at email: julianjudge@hotmail.com<br />

‘Breathe slowly and deeply.’ Said with a deep<br />

eastern-like accent as a mask descended over his<br />

mouth.<br />

‘Think of something pleasant, far away and<br />

count to ten…you won’t beyond five.’ Said the<br />

exotic eastern throat and Donnie relaxed into a<br />

far away pleasant place and thought of lefty and<br />

43 years of being together.<br />

How lefty was the one that ‘hung low’ and<br />

how as many years ago he’d considered lefty as<br />

his barometer for a girl. If lefty didn’t respond<br />

she could forget about it and he’d go find<br />

another for him, how crossing his legs, although<br />

easier would never be the same again, nothing<br />

to adjust.<br />

Donnie got to three and had an immediate<br />

thought of ‘this was it, time to say goodbye to<br />

lefty.’ Initially he was panicked: just how was he<br />

to say goodbye to a testicle? He heard:<br />

‘Slow and deeply…that’s it.’ Again and the<br />

answer came to him.<br />

So, somewhere between four and five in his<br />

count Donnie relaxed his grip and gave lefty one<br />

last scratch.<br />

Author’s note.<br />

A friend of mine, 43 years old, otherwise completely<br />

healthy, recently discovered a lump on his left<br />

testicle. He had it removed last week and is now<br />

waiting on biopsy results.<br />

The main symptom of testicular cancer is a<br />

swelling or lump on one of your testicles. The lump<br />

is usually completely painless, no matter how<br />

small. Other symptoms are a swelling in either ball,<br />

discomfort or heaviness or a dull ache in the groin.<br />

For further information visit www.cancer.ie or<br />

phone National Cancer Helpline at 1800-200-700.


When it comes to<br />

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because we’re<br />

re-writing it..<br />

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www.intervene.ie


30<br />

e-phaRmacy<br />

issue 10 volume 12 • novemBeR 2010<br />

juNe sHANNoN<br />

Depression – new campaign<br />

– something to sing about<br />

Mr Johnny Logan and Ms niamh kavanagh; pictured at the launch of a new campaign called Lean on Me.<br />

Despite the high<br />

prevalence of<br />

depression worldwide<br />

and the fact that an<br />

estimated 400,000<br />

people in Ireland<br />

today experience depression at any<br />

one time, the issue is still surrounded<br />

by a wall of silence and stigma.<br />

According to the WHO globally,<br />

mental health conditions account<br />

for 13 per cent of the total burden<br />

of disease, and 31 per cent of all<br />

years lived with disability. “By 2030,<br />

depression alone is likely to be the<br />

single highest contributor to burden<br />

of disease in the world – more so<br />

than heart disease, stroke, road<br />

traffic accidents, and HIV/AIDS.”<br />

“<br />

“There<br />

is strong<br />

evidence that<br />

depression can be<br />

a hidden disorder<br />

and can manifest<br />

itself in many<br />

different ways.”<br />

epidemic<br />

A major new international survey<br />

on the prevalence of depression<br />

in Europe has revealed that almost<br />

half or 48 per cent of people have<br />

experienced depression at some<br />

stage in their lives and a massive 80<br />

per cent know someone affected by<br />

the condition.<br />

However despite the huge<br />

prevalence of depression the new<br />

online survey by market research<br />

agency Ipsos MORI, carried out<br />

among 7,122 people in seven<br />

European counties including Ireland,<br />

also found that over half or 55 per<br />

cent of those who had experienced<br />

depression, did not tell their family<br />

and friends. In fact the survey found<br />

that two thirds of those surveyed<br />

or 75 per cent reported that they<br />

actually withdrew from family and<br />

friends when they were depressed.<br />

The reasons those surveyed gave<br />

for withdrawing from social and<br />

family supports when depressed<br />

included: 28 per cent saying they<br />

were “too scared, ashamed or<br />

overwhelmed”; 18 per cent thought<br />

that family and friends would not<br />

understand and would turn away<br />

from them; 57 per cent stated that<br />

they “didn’t want to burden them”<br />

with their problems and 29 per cent<br />

said that they didn’t know how to tell<br />

them.<br />

There is an estimated 400,000<br />

people in Ireland experiencing<br />

depression at any one time yet<br />

despite the huge prevalence of the<br />

disease it is clear from this Ipsos<br />

MORI survey that a significant<br />

amount of stigma still surrounds the<br />

issue.<br />

lean on Me<br />

In an effort to break down the walls<br />

of stigma and silence that continue<br />

to surround mental health issues<br />

such as depression lundbeck,<br />

in association with AWARE, has<br />

launched a new mental health<br />

awareness campaign and website<br />

entitled ‘lean on Me’ which aims<br />

to encourage friends and family<br />

to support those affected by<br />

depression.<br />

The results of the IPOS Mori survey<br />

were published last month to mark<br />

the launch of the ‘lean on Me’<br />

campaign.<br />

The ‘lean on Me’ campaign has<br />

been developed to dispel the myths<br />

surrounding depression. Its aim is<br />

to encourage better understanding<br />

of the condition, and, above all,<br />

empower people by providing<br />

support to those affected and<br />

encouraging them to seek treatment<br />

if necessary.<br />

The campaign includes an<br />

interactive website – www.<br />

June Shannon<br />

reports on a new<br />

mental health<br />

awareness<br />

campaign and<br />

website www.<br />

leanonme.net which<br />

hopes to break<br />

down barriers by<br />

encouraging friends<br />

and family members<br />

to support those<br />

suffering with the<br />

condition.<br />

leanonme.net – which provides<br />

detailed information on the causes,<br />

symptoms and impact of depression.<br />

eurovision legends<br />

Johnny logan and niamh Kavanagh<br />

were on hand to launch the<br />

campaign last month. The singers<br />

teamed up with Bray Gospel Choir to<br />

deliver a surprise performance of Bill<br />

Withers’ classic song ‘lean on Me’ to<br />

passers by and lunchtime shoppers<br />

in the centre of Dublin.<br />

Speaking at the launch two-time<br />

Eurovision winner Johnny logan<br />

explained why he got involved with<br />

lean on Me: “lean on Me has an<br />

important message – be a friend<br />

to lean on. I know that I wouldn’t<br />

be where I am today without the<br />

support and love of my friends and<br />

family.“<br />

niamh Kavanagh commented<br />

“Just by being a friend to someone<br />

affected by depression you could<br />

help them on the road to recovery.<br />

The campaign challenged my<br />

perception of depression. It uses a<br />

different approach to encourage<br />

better understanding, empower you


issue 10 volume 12 • novemBeR 2010<br />

to provide support to those affected<br />

and, encourage them to seek<br />

treatment.”<br />

The campaign was formally<br />

launched at an event at the RCPI on<br />

Kildare Street in Dublin at which Mr<br />

David Carton, Chairman of Aware,<br />

spoke about depression in Ireland.<br />

“Aware greatly welcomes the launch<br />

of lean on Me, focusing as it does<br />

on the importance of support for<br />

anyone experiencing depression.<br />

We urge anyone who is concerned<br />

about a friend or family member to<br />

encourage them to see their GP or<br />

mental health professional to ensure<br />

that they receive the appropriate<br />

care.”<br />

Kerry based GP Dr Eamonn<br />

Shanahan emphasised the crucial<br />

role played by family and friends<br />

in supporting a loved one with<br />

depression. “Studies have shown<br />

that the support of friends and<br />

family can help improve the recovery<br />

outcomes for those with depression,”<br />

he said. “Indeed, the World Health<br />

Organisation says that ‘psychological<br />

support from family, friends or health<br />

providers is powerfully protective<br />

hidden disorder<br />

Dr Conor Farren, Consultant<br />

Psychiatrist at St Patrick’s Hospital,<br />

Dublin, said, “There is strong<br />

evidence that depression can be a<br />

hidden disorder and can manifest<br />

itself in many different ways. It is vital<br />

to appreciate that even the most<br />

complicated cases of depression<br />

can be effectively treated, and<br />

the start of that treatment for the<br />

sufferer is through recognition of Mr David Carton, aware; Ms eithne boyan, Lundbeck; Dr Conor<br />

Metatone Irish their problem, Pharmacist and then Ad sharing 11/09/2009 the 03:23 Farren, pm st Patrick’s Page 1university<br />

Hospital; and Dr eamon shanahan,<br />

burden, with family, friends, support pictured at the launch of a new campaign.<br />

groups or professionals.”<br />

e-phaRmacy<br />

in depression. I encourage anyone<br />

who is concerned about a friend or<br />

family member to visit the lean on<br />

Me website to learn more about the<br />

ways in which they can provide this<br />

valuable support.”<br />

website<br />

Ms Eithne Boyan, Managing<br />

Director, lundbeck (Ireland) ltd,<br />

said, “lundbeck is committed to<br />

promoting awareness of depression<br />

Further information available on request.<br />

Chefaro Ireland Limited, Farnham Drive, Finglas, Dublin 11, Ireland.<br />

Tel: 01 879 0647 E-mail: info@omega-pharma.ie<br />

and in recent years has worked<br />

on a number of public awareness<br />

campaigns aimed at reducing the<br />

stigma associated with depression.<br />

We are delighted to support this<br />

innovative and uplifting new<br />

initiative.”<br />

As well as information on<br />

depression, www.leanonme.<br />

net features a downloadable<br />

leaflet, “How to Say lean on Me”,<br />

which provides information on<br />

how to begin a conversation<br />

about depression, and advice on<br />

supporting a friend who is affected<br />

by depression. The site also features<br />

a Friend Clip feature, which gives<br />

visitors the opportunity to star in<br />

their own ‘lean on Me’ video and<br />

share it with a friend.<br />

lean on Me is being supported<br />

with a comprehensive nationwide<br />

advertising campaign, including<br />

radio, outdoor, postcard and GP<br />

posters.<br />

Further information can be found on<br />

www.leanonme.net.<br />

Aware, the depression support<br />

organisation, is supporting the<br />

campaign and is urging anyone who<br />

needs help to call their helpline – 1890<br />

302 302.<br />

when recovering from the flu you<br />

may not be getting all the vitamins and<br />

minerals you need to aid a speedy recovery<br />

metatone for use after illness, colds or flu, when<br />

feeling tired or run down and after loss of appetite<br />

metatone - just the tonic<br />

Licensed Medicine. Always read the leaflet.<br />

31


32<br />

case sTudy<br />

Cluster headache in a 24<br />

year old woman<br />

a<br />

24-year-old female patient<br />

presented with a four year history<br />

of daily headaches. She reported<br />

8-10 attacks per day and the<br />

duration of attacks lasted from 30-<br />

90 minutes. Most of these attacks<br />

would occur spontaneously but she always got<br />

an attack awakening her from sleep at around<br />

2am. When she awoke with this attack it would<br />

make her restless and agitated, forcing her to<br />

pace the bedroom floor until it subsided after<br />

approximately 30 minutes. The typical clinical<br />

characteristics of her headaches and associated<br />

symptoms were:<br />

• Abrupt in onset and occurred without warning<br />

• Always unilateral in location in the left<br />

periorbital/frontal region and extending to<br />

the temple<br />

• Duration 30-90 minutes<br />

• Sharp, piercing and burning in character<br />

• Very severe<br />

• Forehead sweating<br />

• Associated with restlessness, agitation and a<br />

feeling like ‘banging’ her head off a wall<br />

• Ipsilateral conjunctival tearing<br />

• Ipsilateral conjunctival reddening<br />

• Ipsilateral nasal congestion.<br />

• Ipsilateral nasal rhinorrhoea.<br />

• Ipsilateral ptosis of left upper eye lid.<br />

• Ipsilateral miosis of left pupil.<br />

Other symptoms associated with some<br />

attacks included intermittant photophobia,<br />

Prevalence Common: 10-12 per cent<br />

population<br />

phonophobia, nausea and occasional vomiting.<br />

The rest of the physical and neurological<br />

examination was normal.<br />

These headaches were having a major impact<br />

on her life. She was unable to get any relief from<br />

the attacks and as an acute therapy she was<br />

consuming up to 10 paracetamol daily without<br />

benefit. She was also on amitriptylline 25mg<br />

nocte as a preventive therapy, with no resultant<br />

change in the frequency of attacks. Over the<br />

years she had tried many other analgesics and<br />

preventive therapies without benefit. In addition<br />

she had been prescribed courses of antibiotics<br />

for a presumptive diagnosis of chronic sinusitis.<br />

Her life was being controlled by the headaches<br />

and she was unable to pursue a career or get a<br />

job. She previously had been working as a clerical<br />

officer but was forced to give up her job. Her<br />

social life had become non-existent. During this<br />

four-year period she had attended emergency<br />

departments and GP out-of-hours services on<br />

many occasions, all of whom either diagnosed<br />

‘severe migraine’ or ‘sinusitis’ and for immediate<br />

pain relief she was treated acutely with either<br />

parenteral courses of nSAIDs or narcotic agents,<br />

all of which were ineffective.<br />

Investigations carried out over the four-year<br />

period included a CTScan brain, CTScan sinuses,<br />

MRI scan brain and many blood tests, all of which<br />

were entirely normal.<br />

This patient has a diagnosis of chronic cluster<br />

headaches, a benign primary headache disorder.<br />

Migraine Cluster headache<br />

Femalea:Male 3:1 1:5<br />

Rare:0.5 per cent Population<br />

Frequency of attacks 2 attacks per month 2-8 attack per day<br />

Duration 4-72 hours 15 minutes –180 minutes<br />

Headache Unilateral (70 per cent) or bilateral<br />

(30 per cent)<br />

Always unilateral<br />

Character of headache Throbbing and Pounding Sharp/piercing or ‘boring’<br />

Location Vary from frontal to temporal,<br />

parietal and occipital locations.<br />

Periobital, orbital and<br />

temporal in location<br />

severity Severe Excruciatingly painful<br />

autonomic symptoms Seldom Frequent<br />

nausea / vomiting Common Rare<br />

Photophobia and<br />

Phonophobia<br />

Common Rare<br />

impact Patient needs to lie down in a<br />

quiet dark room<br />

Patient becomes restless,<br />

agitated and paces the floor<br />

issue 10 volume 12 • novemBeR 2010<br />

dr edwArd M. o’sullIvAN<br />

ClINICAl dIreCtor HeAdACHe/MIGr AINe<br />

dePArtMeNt of NeuroloGy<br />

Cork uNIversIt y HosPItAl<br />

ANd GP Cork CIt y.<br />

At her initial consultation, the following<br />

management plan was put in place:<br />

• Keep a headache diary<br />

• Discontinue paracetamol and amitriptylline<br />

• As an acute therapy, the patient was<br />

commenced on 100 per cent oxygen through<br />

a non re-breathing mask at a high flow rate of<br />

7-10 litres per minute for 15 minutes for each<br />

attack.<br />

• As a preventive therapy, she was prescribed<br />

verapramil 240mg daily.<br />

• Patient was advised to stop smoking.<br />

Ten days after presentation the patient was<br />

followed-up with a telephone consultation. She<br />

was much improved. Her cluster attack rate was<br />

now two per day and the attacks were relieved<br />

by the oxygen therapy within 10 minutes. The<br />

attacks were also less severe.<br />

At a subsequent telephone consultation<br />

another week later the patient was experiencing<br />

her first headache-free days in four years. The<br />

frequency of attacks was 1-2 per day and with<br />

the oxygen therapy, the attack was aborted in 10<br />

minutes.<br />

discussion<br />

Cluster headache is a rare primary benign<br />

headache disorder which exists in acute and<br />

chronic forms. It is characterised by a headache<br />

described as being excruciatingly painful and<br />

known as one of the ‘worst pains known to man’.<br />

Women have described it as being more painful<br />

then childbirth. Many patients have been driven<br />

to suicide because of their severity.<br />

The headache is always a unilateral headache<br />

typically located in the periorbital/orbital and<br />

temporal regions with ipsilateral autonomic<br />

symptoms: conjunctival tearing, reddening, nasal<br />

congestion, rhinnorhoea, ptosis and miosis. The<br />

case study outlined is a text book description<br />

of the disorder, nevertheless the patient went<br />

for many years without a correct diagnosis<br />

and as a consequence the most appropriate<br />

treatment choices to optimise her care were<br />

never prescribed. The delay in diagnosis I would<br />

attribute to the rarity at which cluster headache<br />

is encountered in clinical practice. Many doctors<br />

will only see a few cases during the course of<br />

their career. It is most often wrongly diagnosed<br />

as migraine which, by comparison, is the most<br />

frequent headache disorder for which a patient<br />

attends their doctor. The clinical symptoms<br />

which differentiate between migraine and cluster<br />

headache are tabulated below.<br />

neurophysiology<br />

The understanding of the neuro/<br />

pathophysiology mechanisms of cluster<br />

headaches is hypothesised on the activation<br />

and integration of the trigeminovascular<br />

and cranial parasympathetic systems. The<br />

ophthalmic division of the trigeminal nerve is<br />

the pain sensitive pathway of the intracranial<br />

structures: cerebral arteries, meninges. The<br />

driving mechanism for trigeminovascular<br />

activation is hypothalamic dysfunction. On<br />

activation, neurotransmitters (CGRP, neurokinin<br />

and substance P) are released via a retrograde<br />

transmission from the peripheral end of the<br />

trigeminal nerve which innervate the proximal


Date of preparation: April 2010<br />

Tevirl PO4/04/10<br />

•Effective at reducing headache recurrence 1<br />

PHARMACEUTICALS<br />

IRELAND<br />

Naramerg<br />

Naratriptan 2.5mg<br />

•Well tolerated with a lower incidence of adverse events<br />

than sumatriptan 2 and zolmitriptan 3<br />

For further information, please contact: Teva Pharmaceuticals Ireland, Unit 1, The Business Centre, Blackthorn Business Park, Coe’s Road, Dundalk, Co Louth Tel 042 939 5892 Fax 042 939 5898 www.teva.ie Freephone 1800 201700<br />

Abbreviated Prescribing Information<br />

Naramerg 2.5 mg Film-Coated Tablets<br />

Refer to Summary of Product Characteristics before prescribing.<br />

Presentation: Each tablet contains 2.5 mg naratriptan (as naratriptan hydrochloride). Indications: Acute treatment of<br />

the headache phase of migraine attacks with or without aura.<br />

Dosage and Administration: Naramerg should be taken as early as possible after the onset of a migraine headache,<br />

but is effective if taken at a later stage. Do not use prophylactically. Swallow whole with water. Adults (18-65 years of<br />

age): Single dose of 2.5 mg. A second dose as required, with minimum interval of 4 hours between doses. Do not<br />

exceed two 2.5 mg tablets in any 24 hour period. Children and adolescents 65 years: Not recommended. Renal impairment: Mild or moderate renal impairment - maximum total daily dose of<br />

2.5 mg. Severe renal impairment - Do not use. Hepatic impairment: Mild or moderate impairment - maximum total<br />

daily dose of single 2.5 mg tablet. Severe impairment - Do not use. Contraindications: Hypersensitivity to any of<br />

the ingredients, heart disease, myocardial infarction, vascular disease, cerebrovascular accident, transient ischaemic<br />

attack, hypertension, severely impaired renal/hepatic function, concomitant administration of ergotamine, derivatives of<br />

ergotamine (including methysergide) and any triptan/5-hydroxytryptamine 1 (5-HT 1 ) receptor agonist with naratriptan.<br />

Special Warnings and Precautions for Use: Only use where there is a clear diagnosis of migraine. Not indicated<br />

for use in the management of hemiplegic, basilar or ophthalmoplegic migraine. Not be used in patients with risk factors<br />

for ischaemic heart disease. Following administration, naratriptan can be associated with transient symptoms including<br />

chest pain and tightness. There is a theoretical risk of a hypersensitivity reaction in patients with known hypersensitivity<br />

to sulphonamides. Should not be used with products containing St John’s Wort. There is a risk of medication-overuse<br />

headache with prolonged use. Contains Lactose. Drug Interactions: Theoretical possibility of increased risk of<br />

coronary vasospasm with co-administrations of ergotamine, ergotamine-containing preparations, dihydroergotamine,<br />

sumatriptan and 5-HT 1 receptor agonists, risk of serotonin syndrome following the use of selective serotonin reuptake<br />

inhibitors or serotonin noradrenaline reuptake inhibitors and triptans. Pregnancy and Lactation: Safety in pregnancy<br />

has not been established. Balance risks against benefits. Avoid breast-feeding for 24 hours after treatment. Effects on<br />

Ability to Drive and Operate Machines: Drowsiness and other symptoms of migraine may reduce ability to perform<br />

skilled tasks. Adverse Reactions: Some of the symptoms reported as adverse events may be part of the migraine<br />

attack. Common (≥1/100,


34<br />

portions of the cerebral arteries and dura. This<br />

mediates a local inflammatory reaction (plasma<br />

extravasation) which in turn stimulates painful<br />

sensory receptors located on the cerebral<br />

arteries. The sensory afferent painful information<br />

is relayed along the ophthalmic division of the<br />

trigeminal nerve and synapses in the trigeminal<br />

nucleus caudalis in the brainstem (pons). Second<br />

order neurones further relay this information<br />

to the thalamus and third neurones relay the<br />

information to the higher cortical functions in the<br />

brain where pain is perceived.<br />

In addition, at the trigeminal nucleus caudalis<br />

(TnC) in the pons, there is an inter-neuronal<br />

connection between the TnC and superior<br />

salivatory nucleus and this results in activation of<br />

the cranial parasympathetic system which travels<br />

via the greater petrosal, a branch of the 7th<br />

cranial nerve, thus explaining the secreto-motor<br />

symptoms seen in cluster headache (trigeminalautonomic<br />

reflex). The partial Horner’s syndrome<br />

which completes the symptoms and signs is<br />

postulated to be due to sympathetic dysfunction<br />

caused by internal carotid dilatation as it<br />

traverses the cavernous sinus.1<br />

It is prudent that all patients who present with<br />

cluster headaches should be investigated and<br />

have MRI neuroimaging for potential secondary<br />

causes such as an internal carotid artery<br />

aneurysm or lateral protrusion of a pituitary<br />

macroadenoma into the cavernous sinus, both of<br />

which can mimic this disorder.<br />

case sTudy<br />

pRoducT news<br />

new Toleriane Teint Mineral Compact<br />

– for intolerant normal/combination<br />

sensitive skin<br />

nearly 60 per cent of women encounter skin discomfort and claim to<br />

have sensitive skin and of those, 30 per cent of women have skin which is<br />

sensitive to make-up. Skincare expert la Roche-Posay recenty launched new<br />

Toleriane Teint Mineral Compact for sensitive skin available in pharmacies<br />

nationwide from October. la Roche-Posay has created a new generation of<br />

foundation for women with sensitive, normal/combination or oily skin who<br />

find covering skin’s irregularities difficult.<br />

Sensitive skin with imperfections requires a foundation which provides<br />

good coverage whilst looking natural and respecting the skin’s fragility.<br />

la Roche-Posay’s expertise in foundations coupled with their skincare<br />

knowledge guarantee maximum tolerance along<br />

with unique make-up know-how.<br />

Women with these skin types (norm/comb<br />

or oily) often find that foundation is shiny and<br />

does not stay on throughout the day. They also<br />

notice that foundations can suffocate skin<br />

or aggravate imperfections. nEW Toleriane<br />

Teint Mineral offers the high coverage of<br />

a corrective foundation with the purifying<br />

properties of a mineral powder in a compact.<br />

It covers imperfections and mattifies the skin<br />

without blocking the pores whilst improving<br />

skin health. It has a buildable coverage for a<br />

perfectly corrected complexion with a natural<br />

long-lasting finish. Following one month of use, results<br />

showed a reduction in imperfections and improved complexion.<br />

TreaTMenT<br />

For over a generation, neurologists have been<br />

using oxygen therapy in the management of the<br />

acute attack. Oxygen therapy has established<br />

itself as a first-line agent and treatment of choice.<br />

The mode of delivery and action is unique to<br />

cluster headache and should be administered as<br />

100 per cent oxygen through a non re-breathing<br />

mask at a high flow rate of 7-10 litres per minute<br />

for 15 minutes.<br />

The efficacy of this treatment has, up to<br />

recently, been anecdotal with up to 70 per cent<br />

of cluster patients getting relief of their headache<br />

and associated symptoms within 10-15 minutes.<br />

A pivotal study by Goadsby et al was published<br />

in JAMA in December 2009 confirming and<br />

validating the use of oxygen therapy.2<br />

The mode of action of oxygen therapy is now<br />

better understood and it is postulated that it<br />

inhibits trigeminovascular and parasympathetic<br />

activation. This inhibition is concentrated at<br />

the superior salivatory nucleus where there is<br />

suppression of parasympathetic nerve fibre<br />

transmission in those fibres travelling via the<br />

greater petrosal nerve.<br />

The only pharmaceutical agent which<br />

has proven efficacy for the acute attack is<br />

subcutaneous sumatriptan 6mg, the triptan<br />

therapy (5-HT-1B/1D receptor agonist). This<br />

parenteral medication is not licensed in Ireland<br />

and is only available on a named patient basis. Its<br />

efficacy is similar to oxygen. nasal sumatriptan<br />

issue 10 volume 12 • novemBeR 2010<br />

has also demonstrated a benefit but has a slower<br />

onset of action. 3<br />

All narcotic agents and other analgesics have<br />

no role in the management of the acute attack.<br />

They have no proven efficacy and this case study<br />

bears testament to this. In addition their habitual<br />

use predisposes the patient to developing<br />

chronic daily headache and medication overuse<br />

headache.<br />

The calcium antagonist, verapramil, is the<br />

treatment of choice as a preventive therapy.<br />

There are many randomised and nonrandomised<br />

clinical trials proving its efficacy. It<br />

can be commenced at a dose of 80mg tds and<br />

titrated upwards if required. Some patients need<br />

to go up to a dose of 480mg. Patients should<br />

be monitored at the higher doses as verapramil<br />

can prolong the PR interval and patients should<br />

have an ECG prior to commencement. Verapramil<br />

blocks the entry of calcium into smooth muscle,<br />

reducing blood vessel dilatation which is<br />

responsible for the severe pain. Patients achieve<br />

a reduction in cluster headache days and the<br />

number of attacks per day.4<br />

references<br />

1. Journal of Headache and Facial Pain. Sept 2009<br />

1131-43.<br />

2. Journal of the American Medical Association.<br />

December 2009.<br />

3. Journal of neurology 2003. 630-33.<br />

4. Headache 2009. 117-25.<br />

Panadol Extra Soluble 24s – 30 per cent<br />

more powerful*<br />

Ireland’s no.1 brand of pain reliever** has introduced Panadol Extra Soluble<br />

Tablets this month. Pharmacy only Panadol Extra Soluble provides your<br />

customers with a non-codeine solution for pain relief. Panadol Extra Soluble<br />

Tablets 24s contains 500mg paracetamol plus 65mg caffeine in a soluble<br />

format – the fastest growing format***. The product is available as from<br />

October 14 th and will be supported by a heavy weight TV campaign and<br />

in-store POS.<br />

*when compared to standard paracetamol, Panadol Extra Soluble can give<br />

30 per cent more pain relieving power<br />

**Source: IMS & nielsen June 2010<br />

***IMS OTCIRl MAT Aug 2010<br />

www.yourmedicines.ie


36<br />

pRoducT news<br />

‘Change one thing’ information pack<br />

launched for patients with high blood<br />

pressure<br />

Sanofi-aventis has launched a new patient advice tool for doctors and nurses<br />

treating patients with high blood pressure under the Triapin brand. The<br />

Change One Thing pack provides physicians with ready-made patient advice<br />

literature for those patients who may need to adapt their lifestyle to help<br />

lower their blood pressure.<br />

Change One Thing provides advice across five lifestyle areas in the<br />

management of blood pressure – salt intake; smoking; stress reduction,<br />

being more active, and; complying with medications. Patients are often<br />

presented with a range of lifestyles habits to adapt in one go. It can be hard<br />

to maintain these changes. Change One Thing pack helps to achieve this.<br />

The doctor or nurse enters an agreement with the patient on changing one<br />

lifestyle habit over an agreed period of time by giving only one item from<br />

the pack. When this becomes a new habit a new item can be added and so<br />

on.<br />

Dr Garrett Hayes lent his support to the launch of the news tool and<br />

he said: “The EUROASPIRE study has demonstrated a high prevalence of<br />

modifiable risk factors in coronary heart disease patients. We have seen the<br />

positive impact made on the treatment of coronary heart disease through<br />

statins and other medications, but there has not been a corresponding<br />

improvement in patient lifestyle management.”<br />

Dr Velichka Valcheva, Medical Director of sanofi-aventis said: “Our goal<br />

is to assist doctors in delivering meaningful, lasting lifestyle advice to their<br />

patients”<br />

If you would like a Change One Thing pack sent to you, please contact<br />

Celine Reilly at 01 403 5600 or email celine.reilly@sanofi-aventis.com.<br />

Caption<br />

Dr Garrett Hayes, with Elaine Ryan, sanofi-aventis and Dr Elen Shiryayeva<br />

also of sanofi-aventis.<br />

Centrum – supplies restored<br />

Pfizer Consumer Healthcare has announced that supplies of Centrum are<br />

being restored.<br />

Initially, Centrum Advance and Centrum Select 50+ will be available from<br />

the beginning of november from your usual wholesaler. Supplies of Centrum<br />

Junior and Centrum Cardio will follow shortly thereafter.<br />

Following resumption of shipping, batch numbering will be as follows:<br />

• for Centrum Advance, the last three digits will read 103 and above.<br />

• for Centrum Select 50+, the last three digits will read 090 and above.<br />

Only product with lot numbers corresponding to the above numbering<br />

system should be sold to consumers.<br />

The full Centrum range will now comprise the following four products<br />

(pictured); Centrum Advance (30s and 60s packs); Centrum Select 50+<br />

(30s and 60s packs); Centrum Junior (30s pack) and Centrum Cardio (60s<br />

pack). Full product details are available from Pfizer Consumer Healthcare<br />

representatives and from the IPU data base.<br />

Customers can be assured that Pfizer is committed to driving Centrum<br />

sales growth and will be supporting the brand with a high level of marketing<br />

support over the coming months.<br />

issue 10 volume 12 • novemBeR 2010<br />

Roger & Gallet – Christmas Coffret<br />

Roger & Gallet Christmas Coffrets are available in three different Roger<br />

& Gallet fragrances – their signature scent, Jean Marie Farina which is<br />

refreshing, their fragrance for invigoration – Bois D’Orange and Rose with<br />

relaxing properties. Each Coffret contains 30ml Eau de Cologne, 100ml<br />

perfumed soap and 75ml perfumed luxurious bath & shower gel.<br />

Rose Christmas Coffret<br />

Jean Marie Farina Christmas Coffret<br />

Bois D’Orange Christmas Coffret<br />

Roger & Gallet, whose perfumes promote well-being through the powers<br />

of Aromachology, recently launched in pharmacies in Ireland. Concentrated<br />

in rare natural essences and essential oils, these fragrant ranges offer a<br />

complete sensory experience: perfumed waters, as well as round and liquid<br />

soaps, shower gels and body milks.<br />

Each Coffret contains 30ml Eau de Cologne, 100ml perfumed soap, and a<br />

75ml perfumed luxurious shower & bath gel.<br />

– Eau de Cologne 30ml – Roger & Gallet’s fragranced waters with<br />

recognized properties of Aromachology channel the<br />

art of well-being through fragrance.<br />

– Perfumed soaps – delicately wrapped in pleated silk paper and<br />

manufactured using the traditional “cauldron method”<br />

and fragranced using a process that seals natural essential oils into the<br />

heart of the soap, so as to keep the fragrance<br />

intact and maintain its authenticity throughout its use. The soap’s highly<br />

extended life-span results from a<br />

manufacturing technique kept secret by the brand for over a century. The<br />

100 per cent vegetal-based formula enriched<br />

with essential oils does not dry out the epidermis, it leaves skin feeling<br />

sublimely soft.<br />

– Perfumed bath and shower gels – Roger & Gallet bath and shower gels<br />

gently cleanse the skin. For optimum comfort,<br />

a calcium ion complexing agent is incorporated into the formula to help<br />

prevent skin from drying out. Their texture<br />

lends itself to being massaged over skin under the shower, procuring an<br />

invigorating sensation of well-being.<br />

www.medical


issue 10 volume 12 • novemBeR 2010<br />

Prolia: unique new treatment for<br />

post-menopausal osteoporosis now<br />

reimbursed in Ireland<br />

Amgen Ireland and GlaxoSmithKline (Ireland) ltd (GSK) recently announced<br />

that denosumab has become available in Ireland to treat osteoporosis in postmenopausal<br />

women at increased risk of fracture and will be reimbursed under the<br />

General Medical Services and Drugs Payment Schemes.<br />

In Ireland, more than 300,000 people have osteoporosis. Despite the availability<br />

of treatment options, many of these women experience fractures due to poor<br />

compliance with therapy. With proven efficacy and a six-monthly injection, denosumab<br />

offers women with osteoporosis a new alternative to current treatments.<br />

Denosumab works in a different way from other osteoporosis treatments. It<br />

is the first and only approved therapy that specifically targets RAnK ligand, an<br />

essential regulator of osteoclasts (the cells that break down bone). Denosumab<br />

helps stop the process that causes bone loss throughout the skeleton, resulting in<br />

greater bone density, stronger bones, and reduced risk for fractures at the spine,<br />

hip and other non-vertebral sites.<br />

The reimbursement for denosumab follows a review of the therapy’s cost-effectiveness<br />

by the national Centre for Pharmacoeconomics (nCPE) for the prevention<br />

of osteoporotic fractures in postmenopausal women and will be available on both<br />

the GMS and DPS schemes as of October 1st.<br />

Discussing denosumab, specialist in bone health at St James’s Hospital, Professor<br />

Bernard Walsh said: “It is good to have another proven therapeutic arm available<br />

to us in the treatment of osteoporosis. The clinical study results are impressive and<br />

confirm the efficacy of the use of a monoclonal antibody treatment in this disease.”<br />

Dr Gillian Darling, GP Specialist in Women’s Health in leopardstown and the<br />

Dublin Well Woman Centres commented: “As most osteoporosis patients are treated<br />

in primary care it is an advantage to have a treatment that can be administered in the<br />

GP surgery as well as the hospital clinic setting.<br />

“Recent studies would seem to point to a strong efficacy and good tolerability profile<br />

of denosumab in the treatment of osteoporosis in post-menopausal women.”<br />

Denosumab, which is being co-marketed in Ireland by Amgen and GSK, marks<br />

an innovative approach to the treatment of post menopausal osteoporosis. Statistics<br />

show that 90 per cent of hip fractures in senior citizens are due to osteoporosis<br />

and that one in five patients suffering hip fracture die within four months and 30<br />

per cent within a year.<br />

For more information on denosumab’s reimbursement, please visit www.ncpe.ie<br />

ClonMedica now distributing Hedrin<br />

and Virasoothe<br />

Thornton & Ross ltd (T&R) are pleased to announce the appointment<br />

of ClonMedica, the OTC Division of Clonmel Healthcare Company ltd<br />

as its distributor in the Republic of Ireland for the Hedrin range of head<br />

lice treatments and Care Virasoothe Chicken Pox Relief Cooling Gel. The<br />

change is effective from 1st november after which all orders should be<br />

sent to Clonmel Healthcare. T&R would like to thank Allphar Services ltd<br />

for establishing these products in Ireland. Allphar will remain as T&R’s<br />

distributor for the rest of its pharmacy range including the market leading<br />

Galfer and Cerumol brands.<br />

Commenting on the change Rob Purkis, European Market Development<br />

Manager for T&R, says that the move reflects the synergy of Hedrin and<br />

Virasoothe with ClonMedica’s successful children’s product range and<br />

the Company’s contacts with a range of healthcare professionals. A<br />

similar approach in the UK has made Hedrin the market leading head lice<br />

treatment1 and is establishing the more recently launched Virasoothe which<br />

is clinically proven to relieve the symptoms of chicken pox. T&R is keen to<br />

communicate the clinically proven benefits of these products to a wider<br />

group of healthcare professionals than has been possible before and this has<br />

been a key factor in the appointment of ClonMedica.<br />

Martin Gallagher, Marketing and Sales Director of Clonmel Healthcare<br />

ltd, commenting on the appointment, expressed his enthusiasm for this<br />

new venture and is confident that this addition to the Company’s range of<br />

children’s product will result in greater understanding of the benefits of<br />

Hedrin and Virasoothe amongst healthcare professionals.<br />

pRoducT news<br />

Multaq – first-line option<br />

in new 2010 ESC Guidelines for the<br />

Management of Atrial Fibrillation<br />

Sanofi aventis announced recently that the European Society of Cardiology<br />

(ESC) 2010 new Guidelines for the Management of Atrial Fibrillation (AF)<br />

have been released and recommend that Multaq (dronedarone) should be<br />

used for maintenance of sinus rhythm as a first-line treatment option in all<br />

patients with paroxysmal and persistent AF (class of recommendation I, level<br />

of evidence A) other than those with CHF nyHA class III/IV or unstable CHF<br />

nyHA class II (class of recommendation III, level of evidence B).<br />

Multaq was granted a Class I recommendation, a designation assigned<br />

in the guidelines when “there is evidence and/or general agreement that a<br />

given procedure/therapy is beneficial, useful, and effective.” The Task Force<br />

for the Management of Atrial Fibrillation of the ESC recognised the extensive<br />

clinical development of Multaq, giving it their highest ranking A for level of<br />

evidence. Moreover, the guidelines recommend that Multaq may also be<br />

used to achieve rate control in non-permanent AF except for patients with<br />

nyHA class III – IV or unstable heart failure (class of recommendation IIa,<br />

level of evidence B).<br />

Importantly the new guidelines include, for the first time, a statement<br />

on the importance of reducing hospitalisation as a key therapeutic goal in<br />

the management of AF. They also state that Multaq should be considered<br />

in order to reduce cardiovascular hospitalisation in patients with nonpermanent<br />

AF and cardiovascular risk factors (Class of recommendation IIa,<br />

level of evidence B) as well as in patients with AF and stable heart failure<br />

(nyHA Class I, II) (Class of recommendation IIa, level of evidence C). 1<br />

The guidelines do not recommend use of Multaq in patients with nyHA<br />

class III and IV or with recently unstable (decompensation within the prior<br />

month) nyHA class II heart failure.<br />

“Sanofi-aventis is pleased with this first-line recommendation for Multaq<br />

in the AF guidelines which recognises the extensive clinical development for<br />

the product as well as the innovative outcome of reducing cardiovascular<br />

hospitalisation as demonstrated in the ATHEnA trial,” said Marc Cluzel,<br />

Executive Vice President, Research and Development, sanofi-aventis.<br />

Xamiol 60g Gel discontinued<br />

lEO Pharma has announced that Xamiol Gel 60g will be discontinued<br />

from november 2010. Please note that Dovobet Gel 60g will continue<br />

to be available. Dovobet Gel 60g contains the identical product form,<br />

active ingredients and strength as Xamiol (calcipotriol/bethamethasone<br />

dipropionate). Dovobet Gel is indicated for both scalp and mild to moderate<br />

body plaque psoriasis. The price is also identical.<br />

This discontinuation is not due to any safety or quality issues with Xamiol<br />

Gel, therefore pharmacists and patients may continue to dispense or use<br />

Xamiol Gel that they currently have.<br />

If you require any further information, please contact the Marketing<br />

Department at 01 4908924 or email paul.kirwan@lEO-Pharma.com<br />

independent.ie<br />

37


38<br />

classifieds/cRosswoRd<br />

DaTes For your Diary<br />

noveMber<br />

Tuesday 16 Nov 2010<br />

spectrum alliance<br />

Conference, red Cow Hotel,<br />

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The Spectrum Alliance is<br />

hosting a major conference at<br />

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For more information please<br />

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or Tel 083 322 6523.<br />

Organiser Spectrum Alliance<br />

Website www.<br />

spectrumalliance.ie<br />

Monday 15 Nov 2010 to<br />

Tuesday 16 Nov 2010<br />

science Foundation ireland’s<br />

(sFi) science summit 2010,<br />

Hodson bay Hotel, athlone<br />

Science Foundation Ireland’s<br />

(SFI) Science Summit 2010 will<br />

take place over two days in the<br />

Hodson Bay Hotel, Athlone.<br />

For more information please<br />

see: www.sfisummit.com<br />

Please note that this website<br />

name:<br />

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Website www.sfisummit.com<br />

Wednesday 24 Nov 2010<br />

Csi Mini-Med open Lecture<br />

series: ‘Life after stroke’,<br />

Dublin<br />

RCSI Mini-Med Open lecture<br />

series: “life after Stroke” by Dr<br />

Frances Horgan, School of<br />

Physiotherapy, RCSI.<br />

The RCSI Mini-Med Open<br />

lecture Series is free of charge;<br />

however registration is<br />

essential in order to guarantee<br />

a place.<br />

Previous lecture series have<br />

attracted widespread public<br />

interest with demand for<br />

places far outstripping<br />

availability.<br />

Register online at: www.rcsi.ie/<br />

minimed<br />

Organiser RCSI<br />

Website www.rcsi.ie/minimed<br />

Wednesday 26 Jan 201<br />

rCsi Mini-Med open Lecture<br />

series: ‘advanced Diagnostics<br />

in Cardiovascular Disease’,<br />

Dublin<br />

RCSI Mini-Med Open lecture<br />

series: ‘Advanced Diagnostics<br />

in Cardiovascular Disease’ by<br />

19<br />

21<br />

Professor Dermot Kenny,<br />

Clinical Research Centre,<br />

Beaumont Hospital, RCSI.<br />

The RCSI MiniMed Open<br />

lecture Series is free of charge;<br />

however registration is<br />

essential in order to guarantee<br />

a place.<br />

Register online at www.rcsi.ie/<br />

minimed<br />

Organiser RCSI<br />

Website www.rcsi.ie/minimed<br />

CLassiFieDs<br />

supervising Pharmacist –<br />

Munster area<br />

Supervising Pharmacist<br />

required in Co Waterford for<br />

Cover from end of October<br />

onwards for approx. 10<br />

months. There is a 2 week<br />

rota in operation Mon - Sat<br />

with an average of 35 hours<br />

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managing of staff required.<br />

Candidates should be PSI<br />

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aT irisH PHarMaCisT<br />

Please email your ad to<br />

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across<br />

1 Acetylsalicylic acid aspiring to lose its tail! (7)<br />

4 Strip, relief or book. That’s funny! (5)<br />

7 A divan identical to another? (4,3)<br />

8 learn treatment of kidney condition (5)<br />

9 Would such limbs enable a sailor to walk on water?<br />

(3,4)<br />

10 nelson’s went with a bang in O’Connell Street (6)<br />

12 What sounds like Becker & yeltsin may be found in<br />

Ossory (6)<br />

15 A vein in the throat sounds like a circus performer (7)<br />

17 Joint discovered in enamel bowl! (5)<br />

19 Confidential low ranking soldier? (7)<br />

20 Condensation found in momma’s tea mug (5)<br />

21 Try Hugo churning a dairy product (7)<br />

Down<br />

1 Subsequent to a broken fret (5)<br />

2 Measly complaint of German origin? (7)<br />

3 nakedness of dim sun exploding (6)<br />

4 Country porcelain? (5)<br />

5 Sam sure changes as he rubs away aches and pains (7)<br />

6 His sacs burst under the car (7)<br />

10 Does the cat wear them to bed? (7)<br />

11 Cases to lug a scrambled egg! (7)<br />

13 Aperture to go in pen disorder (7)<br />

14 Drop “C” we hear, for oedema (6)<br />

16 Colum comes around for a replacement (5)<br />

18 Ate W.H. ground for flour ingredient (5)<br />

issue 10 volume 12 • novemBeR 2010<br />

Please email letter and CV to<br />

dawn@greencrosspublishing.ie<br />

Medical<br />

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Reporter wanted for<br />

Medical Independent<br />

Interest in investigative journalism essential.<br />

Must be able to work on own initiative.<br />

Experience or interest in health beneficial but<br />

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Sub-Editor required:<br />

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Must be available Wed-Fri each week.<br />

Knowledge of layout and design an advantage<br />

but not essential, however must be familiar with<br />

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AnSWERS TO lAST MOnTH’S<br />

CROSSWORD<br />

Congratulations to the winner of last month’s crossword:<br />

Marie Mclaughlin, Pharmacy Department, University Hospital Galway,<br />

newcastle Rd, Galway.<br />

For a chance to win €70, please send completed entries to:<br />

the Editor, Irish Pharmacist, <strong>Green</strong><strong>Cross</strong> <strong>Publishing</strong>,<br />

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fax to (01) 478 9449 by 23 2010.<br />

Please note the winner's cheque will be issued 45 days after publication.<br />

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40<br />

opinion<br />

O’Sean’S eleven<br />

We’ve all seen the George<br />

Clooney movie Ocean’s Eleven,<br />

in which he plays the part<br />

of Danny Ocean, a very cool<br />

and sophisticated crook who<br />

assembles a gang of ten fellow<br />

criminals to carry out a complex multi-million dollar<br />

raid on three casinos. His celluloid achievements pale<br />

in comparison to the real life raid carried out in Ireland<br />

during the last decade. The title character, Dinny<br />

O’Sean, is unlikely to be as handsome as George<br />

Clooney – let’s face facts, the Americans can find<br />

prettier people for any role. They have Obama, we<br />

have Cowen. They had Monica lewinsky, we had Terry<br />

Keane. Enough said.<br />

The movie opens in the year 2000, in the small<br />

hours of the morning in the snug of an otherwise<br />

empty Dublin bar. O’Sean has brought together a<br />

renegade band of crooks, swindlers and chancers<br />

to unveil his master plan. They are the lowest of the<br />

outsIde edGe<br />

issue 10 volume 12 • novemBeR 2010<br />

low – nigerian customs officials in lagos airport have<br />

the mugshots of these guys pasted on the wall of the<br />

arrivals hall so that they can be stopped from entering<br />

the country and corrupting it. They are however,<br />

pillars of the establishment in Ireland.<br />

O’Sean calls a hush, and the gang listen wide-eyed<br />

as he begins to speak. ‘Right, lads, we are going to fINtAN Moore<br />

carry out the biggest heist in world history – we are<br />

going to rob 35 billion euro from the Irish people.’ After a sharp intake of breath followed by a gabble<br />

of excited voices, one crook pipes up – ‘But the<br />

country doesn’t have 35 billion euro.’<br />

O’Sean smiles benevolently upon him, and says ‘I<br />

know. And here’s the gas bit – we steal the money<br />

before they even have it, then they have to try and<br />

replace what we stole. And the really funny thing is that<br />

even when they find out, we’ll never see a day in jail.<br />

‘Here’s the plan. Paddy One – you set up a bank<br />

and you lend money to every gombeen in sight<br />

to buy land to develop. Ability to repay doesn’t<br />

matter. Paddy Two – you’re going to be one of those<br />

gombeens (laughter); you buy any land, anywhere, at<br />

any price as long as you can build on it. Paddy Three<br />

– you’re going to be a builder – you build houses,<br />

apartments, offices, shops and you’re to import tens<br />

of thousands of foreign workers to live in them as they<br />

build them. That’ll inflate the value. Paddy Four – you<br />

infiltrate the Department of Finance, and instil the<br />

mantra ‘light Touch Regulation’ into the thick skull of<br />

every fecker you meet. Paddy Five – you do the same<br />

in the Financial Regulator’s office. Paddy Six – you<br />

become an economist (more laughter), no not an<br />

ecologist, you gobshite, an economist, it’s okay – you<br />

don’t have to know anything, just keep repeating<br />

the phrase ‘continued growth’ until 2008, then ‘soft<br />

landing’ until we get the loot out of the country.<br />

Paddy Seven – you’ve got to spread the love – dirty<br />

job, but you gotta schmooze up the politicians, show<br />

them a good time and throw them lots of money.<br />

Make sure they know that it’s the Capital Gains Tax<br />

that’s keeping the show on the road. Paddy Eight – we<br />

need you to work on the trade unions – make sure<br />

the workers get payrises paid for by the Capital Gains<br />

Tax, then their extra money will inflate the price of<br />

property which makes more Tax for more payrises –<br />

sure it’ll end in tears, just not ours. Paddy nine – you<br />

become an estate agent, and advertise everywhere,<br />

big expensive glossy photos – all very pretty, stops<br />

anyone asking too many questions in case they lose<br />

their piece of the action. Paddy Ten – you become a<br />

property fund manager. It doesn’t matter what idiot<br />

scheme you put the investors’ money into as long as<br />

it’s made of brick, and make sure they pay too much<br />

for it – and don’t forget your commission.<br />

‘Remember, lads – we sell the bullshit to everyone,<br />

but don’t believe it yourselves – we keep sucking the<br />

money out and away to where they’ll never find it,<br />

and then we get out ourselves.’<br />

Then the old, the sick and the handicapped get to<br />

pay for the party.<br />

HObbS CHOiCe<br />

It was kind of funny to see Eddie Hobbs back on<br />

television with his ‘hard-hitting’ consumer show<br />

about the ‘extra markup’ we charge to private patients<br />

compared to what we charge the HSE. The last I<br />

saw of him was back in 2006 when he was pushing<br />

property on Cape Verde. Anybody who took that<br />

advice doesn’t read Eddie’s column in the Star – they<br />

wear it as a blanket as they sleep in a doorway. Given<br />

that jewellers have a 300 per cent markup, coffee<br />

shops 100 per cent, groceries 50 to 100 per cent and<br />

shoe shops 100 per cent then anybody thinking that<br />

50 per cent is high is deluded. It shows that the 20 per<br />

cent rate for the HSE is exceptionally low. I don’t like<br />

to engage in ‘whataboutery’ in any discussion, but<br />

given that newsagents have a markup of over 70 per<br />

cent, what should a fair price be for the RTE guide?<br />

Somehow, I doubt if Eddie’s going to tell us.

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