Wednesday Schedule - Biophysical Society

3260-PLAT 10:00 AMA WATER GRADIENT CAN BE USED TO REGULATE DRUGTRANSPORT ACROSS SKIN - A RESPONDING MEMBRANE.Emma Sparr, Sebastian Björklund, Johan Engblom, Krister Thuresson.8:15 AM–10:15 AM, Room 307PLATFORM BDMembrane Transporters & ExchangersCo-ChairsDavid Gadsby, Rockefeller UniversityPeter Larsson, University of Miami3261-PLAT 8:15 AMCOEVOLVING AMINO ACID POSITIONS IN EXPORTER-TYPEABC PROTEINS. Attila Gulyás-Kovács, David C. Gadsby.3263-PLAT 8:30 AMFUNCTIONAL ROTATION OF THE TRANSPORTER ACRB:INSIGHTS INTO DRUG EXTRUSION FROM SIMULATIONS.Attilio Vittorio Vargiu, Robert Schulz, Francesca Collu,Ulrich Kleinekathoefer, Paolo Ruggerone.3264-PLAT 8:45 AMPROTEIN DYNAMICS IN THE TRANSPORT CYCLE: NMRSTUDY OF THE MULTIDRUG RESISTANCE TRANSPORTER,EMRE. Katherine Henzler-Wildman, Emma Morrison,Greg Dekoster, Sonal Bansal.3265-PLAT 9:00 AMMOLECULAR BASIS OF THE “ALTERNATE ACCESS MODEL”IN THE CATION-SUBSTRATE SYMPORTER MHP1 FROMCOMPUTER SIMULATIONS AND X-RAY CRYSTALLOGRAPHY.Oliver Beckstein, Tatsuro Shimamura, Simone Weyand,Nicholas G. Rutherford, Jonathan M. Hadden, David Sharples,So Iwata, Peter J. F. Henderson, Alexander D. Cameron,Mark S. P. Sansom.3266-PLAT 9:15 AMSYMMETRY IN THE STRUCTURE OF THE GLUTAMATETRANSPORTER GLTPH SUGGESTS CONFORMATION OF ANALTERNATE STATE. Thomas J. Crisman, Shaogang Qu,Baruch Kanner, Lucy Forrest.3267-PLAT 9:30 AMOPPOSITE MOVEMENTS OF THE EXTERNAL GATE INGLUTAMATE TRANSPORTERS UPON BINDING DIFFERENTCOTRANSPORTED LIGANDS MEASURED BY EPR. Paul Focke,Pierre Moenne-Loccoz, Hans Koch, Peter Larsson.3268-PLAT 9:45 AMMECHANISM OF SELECTIVE UREA PERMEATION THROUGHA BACTERIAL UREA TRANSPORTER. Elena J. Levin,Matthias Quick, Ming Zhou.1488:15 AM–10:15 AM, Room 308PLATFORM BEProtein ConformationCo-ChairsSean Decatur, Oberlin CollegeAna Saraiva, Max Planck Institute, Germany3269-PLAT 8:15 AMSWITCHING AMYLOID -PEPTIDES OLIGOMERIZATIONAND CYTOTOXICITY WITH NANOPARTICLES. Ana M. Saraiva,Isabel Cardoso, Maria João Saraiva, M. Carmo Pereira,Manuel A. N. Coelho, Helmuth Moehwald, Gerald Brezesinski.3270-PLAT 8:30 AM-LACTALBUMIN, ENGINEERED TO BE NON-NATIVE ANDINACTIVE, KILLS TUMOR CELLS WHEN IN COMPLEX WITHOLEIC ACID: A NEW BIOLOGICAL FUNCTION RESULTINGFROM PARTIAL UNFOLDING. Jenny Pettersson-Kastberg,Ann-Kristin Mossberg, Maria Trulsson, Yeon Joong Yong,Soyoung Min, Yoongho Lim, John E. O’Brien, Catharina Svanborg,K. Hun Mok.3271-PLAT 8:45 AMNEUTRON SPIN ECHO STUDIES OF DYNAMICS INHEMOGLOBIN AND MYOGLOBIN. Jyotsana Lal, Peter Fouquet,Marco Maccarini, Lee Makowski.3272-PLAT 9:00 AMTEMPERATURE DEPENDENCE OF THE AMIDE I FREQUENCYAS A PROBE OF SOLVENT ACCESSIBILITY OF THE PROTEINBACKBONE. Dana M. Alessi, Sean M. Decatur.3273-PLAT 9:15 AMA HINGE REGION CIS-PROLINE IN BOVINE PANCREATICRNASE A ACTS AS A CONFORMATIONAL GATEKEEPER FORC-TERMINAL DOMAIN SWAPPING. Katherine H. Miller,Susan Marqusee, Jessica Karr.3274-PLAT 9:30 AMTHE IMPORTANCE OF PROTEIN-PROTEIN INTERACTIONSON THE PH-INDUCED CONFORMATIONAL CHANGES OFBOVINE SERUM ALBUMIN: A SMALL ANGLE X-RAYSCATTERING STUDY. Leandro R. S. Barbosa, Maria Grazia Ortore,Francesco Spinozzi, Paolo Mariani, Sigrid Bernstorff, Rosangela Itri.3275-PLAT 9:45 AMTHE MECHANICAL PROPERTIES OF PCNA: IMPLICATIONSFOR THE LOADING AND FUNCTION OF SLIDING CLAMPS.Joshua L. Adelman, John D. Chodera, I-Feng W. Kuo,Thomas F. Miller III, Daniel Barsky.3276-PLAT 10:00 AMCOORDINATION BETWEEN N- AND C-TERMINAL KINETICSOF HSP90 INVESTIGATED BY SMFRET. Thorsten Hugel,Christoph Ratzke, Moritz Mickler, Martin Hessling, Johannes Buchner.10:30 AM–11:15 AM, Hall DCOFFEE BREAK10:30 AM–12:30 PM, Hall DPOSTER PRESENTATIONS AND LATE POSTERS(For a complete listing of Wednesday Poster Presentations and postinginformation, see page 151.)1:00 PM–3:00 PM, Room 134SYMPOSIUM 20Single Molecules Meet Systems BiologyChairSunney Xie, Harvard University3919-SYMP 1:00 PMSINGLE MOLECULES IN SINGLE CELLS: A SYSTEM-WIDEQUANTIFICATION OF GENE EXPRESSION. Sunney Xie.3920-SYMP 1:30 PMPROBING INTRACELLULAR KINETICS AT THE LEVEL OFSINGLE MOLECULES. Johan Elf.3921-SYMP 2:00 PMERROR MINIZATION IN LATERAL INHIBITION CIRCUITS.Naama Barkai.3922-SYMP 2:30 PMBIOLOGICAL IMPORTANCE OF GENE CIRCUITINTERACTION PATTERNS. Gürol M. Süel, Unversity of TexasSouthwestern Medical Center.1:00 PM–3:00 PM, Room 135SYMPOSIUM 21Mechanism of Electromechanical Coupling inVoltage-gated Ion ChannelsChairWilliam Catterall, University of WashingtonBiophysical Society 54th Annual Meeting

3923-SYMP 1:00 PMTHE STRUCTURAL BASIS OF VOLTAGE SENSING.Roderick MacKinnon.3924-SYMP 1:30 PMTHE STRUCTURAL BASIS OF GATING CURRENTS: INSIGHTSFROM FLUORESCENCE SPECTROSCOPY. Francisco Bezanilla.3925-SYMP 2:00 PMDYNAMICS OF VOLTAGE-SENSOR MOVEMENT IN SODIUMCHANNELS. Todd Scheuer.3926-SYMP 2:30 PMMOLECULAR MOVEMENTS WITHIN THE VOLTAGE-SENSORDOMAIN OF A POTASSIUM CHANNEL. Fredrik Elinder.1:00 PM–3:00 PM, Room 303MINISYMPOSIUM 4New Chemical Modulators byRational DesignCo-ChairsYuan Chen, Beckman Research Institute of the City of HopeMarta Filizola, Mt. Sinai School of Medicine3927-MINISYMP 1:00 PMOPTIMIZING LIGAND-PROTEIN INTERACTIONS VIA SILCS:SITE IDENTIFICATION BY LIGAND COMPETITIVESATURATION. Alexander MacKerell.3928-MINISYMP 0:00 PMUSING MOLECULAR SIMULATIONS TO SCREEN FORANTIBIOTICS WITH ENHANCED PERMEATION PROPERTIESTHROUGH BACTERIAL PORES. Eric Hajjar.Author Name.3929-MINISYMP 1:40 PMCHEMICAL SYNTHESIS OF A HIGHLY SELECTIVE PROBE OFTHE RENAL OUTER MEDULLARY POTASSIUM CHANNEL(ROMK). Jerod S. Denton, Brian A. Chauder, Rishin Kadakia,Eric S. Dawson, Craig W. Lindsley, C. David Weaver, Gautam Bhave.3930-MINISYMP 2:00 PMGOLD NANOPARTICLES AS A PLATFORM FOR DESIGNINGPROTEIN-PROTEIN INTERACTION INHIBITORS:APPLICATION TO UBIQUITIN-LIKE MODIFICATIONS.Yang Su, Angela Perkins, Yi-Jia Li, Yuelong Ma, David Horne,Yuan Chen.3931-MINISYMP 2:20 PMNEW APPROACHES TO ANTI-INFECTIVE AND ANTI-CANCERTHERAPEUTICS TARGETING METALLOPROTEINS.Eric Oldfield.1:00 PM–3:00 PM, Room 304PLATFORM BFCardiac Muscle IICo-ChairsCristobal dos Remedios, University of Sydney, AustraliaHenk Granzier, University of Arizona3932-PLAT 1:00 PMPROTEOMICS OF THE HUMAN CARDIAC INTERCALATEDDISC: A MORE COMPLEX MULTI-FUNCTIONAL STRUCTURETHAN WAS PREVIOUSLY THOUGHT.Cristobal G. dos Remedios, Colleen Estigoy, Darryl Cameron,Joshua W. K. Ho, Benjamin Herbert, Matthew Padula, Russel Pickford,Michael Guilhaus, Jacob Odeberg, Fredrik Ponten.3933-PLAT 1:15 PMQUANTITATIVE ANALYSIS OF MYBP-C PHOSPHORYLATIONIN HUMAN HEART USING PHOSPHATE AFFINITY SDS-PAGE.Steven Marston, Sakthivel Sadayappan, O’neal Copeland.Wednesday, February 24, 2010, San Francisco, California3934-PLAT 1:30 PMIDENTIFICATION OF AMINO ACID RESIDUES IN THECARDIAC MYOSIN BINDING PROTEIN-C MOTIFIMPORTANT FOR ACTIN BINDING. Justin F. Shaffer,Samantha P. Harris.3935-PLAT 1:45 PMN-TERMINAL FRAGMENTS OF CARDIAC MYOSIN BINDINGPROTEIN-C INHIBIT ACTOMYOSIN MOTILITY BYTETHERING ACTIN. Abbey E. Weith, Sakthivel Sadayappan,Peter VanBuren, Jeffrey Robbins, David M. Warshaw.3936-PLAT 2:00 PMPKC PHOSPHORYLATION OF TITIN’S PEVK ELEMENT--ANOVEL AND CONSERVED PATHWAY FOR MODULATINGMYOCARDIAL STIFFNESS. Bryan D. Hudson, Carlos G. Hidalgo,Julius Bogomolovas, Yi Zhu, Brian Anderson, Marion Greaser,Siegfried Labeit, Henk L. Granzier.3937-PLAT 2:15 PMTITIN STRUCURE AND EXTENSIBILITY IN HEALTHY ANDFAILING HEARTS. Helen K. Graham, Michael J. Sherratt,Andrew W. Trafford.3938-PLAT 2:30 PMINSULIN SIGNALING REGULATES CARDIAC TITIN ISOFORMCOMPOSITION IN DEVELOPMENT AND DIABETICCARDIOMYOPATHY. Kamila Babicz, Wolfgang A. Linke,Martina Krueger.3939-PLAT 2:45 PMTHE EFFECT OF STIFFNESS AND BETA-ADRENERGICSTIMULATION ON NEONATAL CARDIOMYOCYTE CALCIUM-MEDIATED CONTRACTILE FORCE DYNAMICS.Anthony G. Rodriguez, Sangyoon Han, Michael Regnier,Nathan Sniadecki.1:00 PM–3:00 PM, Room 305PLATFORM BGNano-MaterialsCo-ChairHelen Hansma, University of California Santa Barbara3940-PLAT 1:00 PMBIONANOELECTRONIC DEVICES BASED ON 1D-LIPIDBILAYERS ON NANOTUBE AND NANOWIRE TEMPLATES.Nipun Misra, Julio Martinez, Alexander Artyukhin, Shih-Chieh Huang,Pieter Stroeve, Costas Grigoropoulos, Aleksandr Noy.3941-PLAT 1:15 PMMOLECULAR DYNAMICS STUDY OF CNT NANOPORESEMBEDDED IN LIPID BILAYERS. Elizabeth Jayne Wallace,John F. Ryan, Mark S. P. Sansom.3942-PLAT 1:30 PMSINGLE-STEP COATING AND BIFUNCTIONALIZATION OFGOLD NANOPARTICLES. Valerio Voliani, Stefano Luin,Fabio Beltram.3943-PLAT 1:45 PMBRANCHED, AMPHIPATHIC PEPTIDES THAT SELF ASSEMBLEINTO NANOVESICLES. Sushanth Gudlur, Yasuaki Hiromasa, TakeoIwamoto, John M. Tomich.3944-PLAT 2:00 PMEVALUATION OF SELECTED KISSING-LOOPS AS BUILDINGBLOCKS IN RNA NANO DESIGN. Wojciech K. Kasprzak,Eckart Bindewald, Tae-Jin Kim, Andrew Stephen, Robert Fisher,Bruce A. Shapiro.3945-PLAT 2:15 PMCHARACTERIZATION OF RNA NANO DESIGN STRUCTURESBY STEERED MOLECULAR DYNAMICS SIMULATIONSAPPROACH. Taejin Kim, Victor E. Marquez, Bruce A. Shapiro.3946-PLAT 2:30 PMNANOPATTERNING AT THE SERVICE OF SINGLEMOLECULE ASSAYS. Aline Cerf, Christophe Vieu.3947-PLAT 2:45 PMPOSSIBLE ORIGIN OF LIFE BETWEEN MICA SHEETS.Helen G. Hansma.149WEDNESDAY

1:00 PM–3:00 PM, Room 306PLATFORM BHProtein StructureCo-ChairsTimothy Fenn, Stanford UniversityMajid Minary-Jolandan, University of Illinois3948-PLAT 1:00 PMSTRUCTURE OF THE YELLOW FEVER VIRUS MEMBRANEFUSION ENVELOPE E. Eric Crampon, Stéphane Duquerroy,Giovanna Barba-Spaeth, Félix A. Rey.3949-PLAT 1:15 PMCRYSTAL STRUCTURES OF P. AERUGINOSA REVEAL ADYNAMIC TYPE IV PILUS MOTOR PROTEIN. Ana M. Misic,Kenneth A. Satyshur, Katrina T. Forest.3950-PLAT 1:30 PMSTRUCTURAL, BIOCHEMICAL, AND FUNCTIONAL STUDIESON THE REGULATION OF THE S. CEREVISIAE AMPKHOMOLOG SNF1. Gabriele A. Amodeo.3951-PLAT 1:45 PMINVESTIGATION OF PROTONATION EFFECTS ON ATPBINDING IN ABC TRANSPORTERS. Jussi Aittoniemi,Frances M. Ashcroft, Mark S. P. Sansom.3952-PLAT 2:00 PMNANO-MECHANICAL AND -ELECTROMECHANICALHETEROGENEITY IN SINGLE COLLAGEN FIBRILS.Majid Minary-Jolandan, Min-Feng Yu.3953-PLAT 2:15 PMSAXS: STRUCTURE VERIFICATION OF AN S-LAYER PROTEINUSING A FRACTAL MEAN FORCE POTENTIAL.Christine Horejs, Dietmar Pum, Uwe B. Sleytr, Rupert Tscheliessnig.3954-PLAT 2:30 PMIS THEORY LEADING NEUTRON DIFFRACTION INMACROMOLECULAR SOLVENT NETWORKS? Timothy Fenn,Michael Schnieders, Vijay Pande, Axel Brunger.3955-PLAT 2:45 PMIDENTIFICATION OF FUNCTIONAL SURFACES OF PROTEINSFROM SEQUENCES. Jieling Zhao, Sema Kachalo, Zheng Ouyang, JieLiang.1:00 PM–3:00 PM, ROOM 307PLATFORM BIImaging & Optical Microscopy IICo-ChairsMalte Wachsmuth, European Molecular Biology Laboratory, GermanyPaul Wiseman, McGill University, Montreal, Canada3956-PLAT 1:00 PMSELF-ORGANIZATION OF THE ESCHERICHIA COLICHEMOTAXIS NETWORK IMAGED WITH SUPER-RESOLUTION LIGHT MICROSCOPY. Ann McEvoy,Derek Greenfield, Hari Shroff, Gavin E. Crooks, Ned S. Wingreen,Eric Betzig, Jan Liphardt.3957-PLAT 1:15 PMK-SPACE IMAGE CORRELATION SPECTROSCOPY OFQUANTUM DOT LABELED T CELL RECEPTORSCHARACTERIZES THEIR NANOSCALE CLUSTERING INLIVING CELLS. Paul W. Wiseman, David L. Kolin, Sarah Boyle, JoanG. Bieler, Jonathan P. Schneck, Michael Edidin.3958-PLAT 1:30 PMTHE PAIR-CORRELATION APPROACH TO FCS.Enrico Gratton, Michelle A. Digman.3959-PLAT 1:45 PMSPATIALLY RESOLVED FLUORESCENCE FLUCTUATIONSPECTROSCOPY (FFS) IN LIVING CELLS. Jérémie Capoulade,Michael Knop, Malte Wachsmuth.3960-PLAT 2:00 PMMULTIPLEXED MEASUREMENT OF MOLECULARINTERACTIONS USING HYPER-SPECTRAL IMAGING ANDMULTI-PARAMETRIC DETECTION. Alessandro Esposito,Simon Schlachter, Arjen N. Bader, Lucio Pancheri, David Stoppa,Ashok R. Venkitaraman, Clemens F. Kaminski, Hans C. Gerritsen.3961-PLAT 2:15 PMANALYSIS OF CDC-42 MOBILITY AND DIMERIZATION INVIVO BY HIGHER ORDER FLUORESCENCE CORRELATIONCUMULANTS. Jay R. Unruh, Brian D. Slaughter, Boris Rubinstein,Rong Li, Winfried Wiegraebe.3962-PLAT 2:30 PMH33D GEN II: A NEW PHOTON COUNTING CAMERA FORSINGLE-MOLECULE IMAGING AND SPECTROSCOPY.Xavier Michalet, Ryan Colyer, Oswald Siegmund, Anton Tremsin,John Vallerga, Shimon Weiss.3963-PLAT 2:45 PMLIGHT SHEET MICROSCOPY OPTIMIZED FOR DEPTHPENETRATION TO STUDY EMBRYOGENESIS. Thai V. Truong,Willy Supatto, David S. Koos, John M. Choi, Scott E. Fraser.1:00 PM–3:00 PM, Room 308PLATFORM BJMember-organized SessionKinetics, Mechanisms and Regulation ofIon-Transporting ATPasesCo-ChairsHoward Kutchai, University of Virginia Health Sciences CenterJames Mahaney, Virginia College Osteophathic Medicine3964-PLAT 1:00 PMCHARACTERIZATION OF PARTIAL REACTIONS IN THECATALYTIC CYCLES OF CALCIUM AND COPPER ATPASES.Giuseppe Inesi, Yuta Hatori, David Lewis, Rajendra Pilankatta,Yueyong Liu.3965-PLAT 1:15 PMTHE INVOLVEMENT OF PROTEIN-PROTEIN INTERACTIONSIN THE MECHANISM OF THE NA+,K+-ATPASE.Ronald J. Clarke.3966-PLAT 1:30 PMTHE NA/K-ATPASE/SRC INTERACTION AND THE E1/E2TRANSITION. Qiqi Ye, Zhichuan Li, Zijian Xie.3967-PLAT 1:45 PMOLIGOMER STRUCTURE DETECTED IN NA/K- AND H/K-ATPASE. Kazuya Taniguchi, Yoshikazu Tahara, Hitoshi Takenaka,Yutaro Hayashi.3968-PLAT 2:00 PMSTRUCTURE-BASED DESIGN OF PHOSPHOLAMBANMUTANTS FOR GENE THERAPY. Simon J. Gruber, Kim N. Ha,Elizabeth L. Lockamy, Razvan L. Cornea, Roger J. Hajjar,Gianluigi Veglia, David D. Thomas.3969-PLAT 2:15 PMNITROXYL AND “FORBIDDEN DISULFIDES”:PHOSPHOLAMBAN CYSTEINES ARE TARGETED TOENHANCE SERCA2A ACTIVITY. Nazareno Paolocci,Carlo G. Tocchetti, James E. Mahaney, Gizem Keceli, Dong I. Lee,Jeff D. Ballin, Iain K. Farrance, Evangelia Kranias, Wei Dong Gao,Gerald M. Wilson, David A. Kass, John P. Toscano.3970-PLAT 2:30 PMPHOSPHOLABMAN REGULATION OF SERCA2A KINETICS, ASMODULATED BY NITROXYL. James E. Mahaney,David D. Thomas, Gizem Keceli, John P. Toscano, Carlo Tocchetti,Nazareno Paolocci.3971-PLAT 2:45 PMLOST IN TRANSLATION: REGULATION OF NA PUMPSUBUNIT ABUNDANCE. Jack H. Kaplan, Rebecca J. Clifford.150Biophysical Society 54th Annual Meeting

10:30 AM–12:30 PM, Hall DWEDNESDAY POSTER SESSIONSPosters should be mounted at 4:30 PM on the day preceding presentation and removed by 3:00 PM on the day of the presentation. Posters will be onview until 5:00 PM the night before presentation. Abstract numbers shown refer to the program order of abstracts as they appear in the on-lineAbstracts Issue. Board Numbers indicate where they are located in Hall D.Authors PresentODD-NUMBERED BOARDS10:30 AM–11:30 AMBOARD NUMBERSBoard #B1–Board #B14Board #B15–Board #B44Board #B45–Board #B69Board #B70–Board #B98Board #B99–Board #B115Board #B116–Board #B128Board #B129–Board #B140Board #B141–Board #B160Board #B161–Board #B171Board #B178–Board #B200Board #B201–Board #B213Board #B214–Board #B241Board #B242–Board #B256Board #B257–Board #B278Board #B279–Board #B282Board #B283–Board #B306Board #B307–Board #B314Board #B315–Board #B326Board #B327–Board #B346Board #B347–Board #B374Board #B375–Board #B397Board #B398–Board #B407Board #B408–Board #B419Board #B420–Board #B441Board #B442–Board #B470Board #B471–Board #B481Board #B482–Board #B498Board #B499–Board #B506Board #B507–Board #B535Board #B536–Board #B557Board #B558–Board #B563Board #B564–Board #B582Board #B583–Board #B595Board #B596–Board #B606Board #B607–Board #B631EVEN-NUMBERED BOARDS11:30 AM–12:30 PMPOSTER CATEGORIESProtein Dynamics IIIProtein Folding & Stability: Computational ApproachesHeme ProteinsMembrane Protein Structure IIProtein Aggregates IIIIntrinsically Disordered Proteins IIVirus Structure & AssemblyDNA, RNA Structure & Conformation IIIProtein-Nucleic Acid Interactions IIIMembrane Dynamics & Bilayer Probes Membrane Structure IIIMembrane Structure IIIMembrane FusionCalcium Signaling ProteinsExocytosis & Endocytosis IIIntracellular ChannelsMembrane Transporters & Exchangers IIMembrane Domains & Lipid DynamicsSignaling & Membrane TransformationsVoltage-gated Ca Channels IIInward Rectifier K ChannelsLigand-gated ChannelsCyclic Nucleotide-gated ChannelsIon Channels, Other IIExcitation-Contraction Coupling IICardiac Muscle IIIIntracellular Cargo TransportUnconventional Myosins IIMicrotubule Motors-DyneinCell & Bacterial Mechanics & Motility IIIOxidative Phosphorylation & Mitochondrial MetabolismRegulatory Networks & Systems BiologyVibrational SpectroscopyImaging & Optical Microscopy IVFluorescence Spectroscopy IIMolecular Mechanics & Force Spectroscopy IIWEDNESDAYWednesday, February 24, 2010, San Francisco, California151

10:30 AM–12:30 PM, Hall DPOSTER PRESENTATIONS(For a complete listing of Wednesday Poster Presentations, see page 151).Protein Dynamics III (Boards #B1-#B14)3277-POS BOARD #B1GREEN FLUORESCENT PROTEINS AGGREGATIONDYNAMICS EXPLORED WITH A MINIMALIST COARSEGRAINED MODEL. Fabio Trovato.3278-POS BOARD #B2ASYMMETRIC DYNAMICS OF THE ACYL-CARRIER PROTEININSIDE THE FUNGAL FATTY-ACID MEGA-SYNTHASE.Claudio Anselmi, José D. Faraldo-Gómez.3279-POS BOARD #B3INTERACTION OF CO/NO WITH THE APOPTOSIS-INDUCING CYTOCHROME C -CARDIOLIPIN COMPLEX.Ivan Husu, Sofia Kapetanaki, Gary Silkstone, Ursula Liebl,Michael T. Wilson, Marten Vos.3280-POS BOARD #B4METRIC SCALING FOR DIMENSIONALITY REDUCTION OFDISORDERED PROTEIN DYNAMICS. Joshua L. Phillips,Edmond Y. Lau, V. V. Krishnan, Michael Rexach, Shawn Newsam,Michael E. Colvin.3281-POS BOARD #B5DETECTION OF OXIDATION AND PALMITOYLATION INSNARE PROTEINS. April Adams, Liz C. Flores, Dixon J. Woodbury.3282-POS BOARD #B6APPLICATION OF GAUSSIAN NETWORK MODEL TOELUCIDATE FUNCTIONAL MODES OF MOTION IN AGLUTAMATE TRANSPORTER. Indira Shrivastava, Jie Jiang,Susan G. Amara, Ivet Bahar.3283-POS BOARD #B7SIMULATION OF MEMBRANE SCULPTING BY EFC F-BARDOMAIN LATTICES. Hang Yu, Ying Yin, Anton Arkhipov,Klaus Schulten.3284-POS BOARD #B8A DYNAMICAL MODEL FOR HEAT SHOCK PROTEIN (HSP)TRANSCRIPTION AND ITS CORRELATION WITH HSP70 INVITRO EXPERIMENTS. Yusheng Feng, Carolina Livi.3285-POS BOARD #B9TUNING PROTEIN DYNAMICS BY MODULATING SOLVENTMOTIONS THROUGH GLASSY MATRICES, SOL-GELS ANDREVERSE MICELLES. David Dantsker, Camille Roche,Mahantesh Navati, Joel M. Friedman.3286-POS BOARD #B10STRUCTURAL AND DYNAMICAL BEHAVIOR OF THE HIV-1NUCLEOCAPSID PROTEIN BY MOLECULAR DYNAMICS ANDQUANTUM MECHANICAL SIMULATIONS. Jooyeon Hong,Sihyun Ham.3287-POS BOARD #B11BIO-MECHANICAL AND BINDING EFFECTS IN CLEAVAGEOF VON WILLEBRAND FACTOR A2 DOMAIN BY ADAMTS13:MOLECULAR DYNAMICS, QUANTUM MECHANICS ANDFORCE DISTRIBUTION. Agnieszka K. Bronowska,Carsten Baldauf, Frauke Graeter.3288-POS BOARD #B12MAPPING THE PROTON CONDUCTION PATHWAYS IN THEINNER MEMBRANE MULTI-DRUG TRANSLOCASE ACRB.Nadine Fischer, Martin Raunest, Christian Kandt.3289-POS BOARD #B13APPLICATION OF AN INTER-PROTEIN COARSE-GRAINEDFORCE FIELD TO BINDING PROCESS OF ACTOMYOSIN.Kei-ichi Okazaki, Mitsunori Takano.3290-POS BOARD #B14FLUCTUATION THEOREM APPLIED TO F1-ATPASE.Kumiko Hayashi, Hiroshi Ueno, Ryota Iino, Hiroyuki Noji.Protein Folding & Stability: ComputationalApproaches (Boards #B15-#B44)3291-POS BOARD #B15COMPUTATIONAL SEARCH OF EVIDENCE FOR THEDIVISION OF AMINO ACIDS INTO TRANSITIONAL GROUPSIN A VIRTUAL STATE PROTEIN. PHASE I: EQUILIBRIUMFLUCTUATIONS. Svetlana Aroutiounian.3292-POS BOARD #B16MULTISCALE MODELING AND DESIGN OF MOLECULARCONFORMATIONAL STATES. Nikolay V. Dokholyan.3293-POS BOARD #B17 STUDENT TRAVEL AWARDEEIDENTIFYING TWO-STATE TRANSITIONS BYMICROCANONICAL ANALYSIS: COARSE-GRAINEDSIMULATIONS OF HELICAL PEPTIDES. Tristan Bereau,Michael Bachmann, Markus Deserno.3294-POS BOARD #B18TRYPTOPHAN FLUORESCENCE QUANTUM YIELDPREDICTIONS IN THE STUDY OF PROTEIN FOLDING. AC-TRP-ALA-ALA-ALA-HIS-NH2 AND VILLIN HEADPIECESUBDOMAIN. Jose R. Tusell, Patrik R. Callis.3295-POS BOARD #B19EXPLORING THE KINETICS AND FOLDING PATHWAYS OFTRP-CAGE USING A KINETIC NETWORK MODEL.Weihua Zheng, Emilio Gallicchio, Michael Andrec, Ronald M. Levy.3296-POS BOARD #B20INSIGHTS FROM MOLECULAR SIMULATIONS INTO THETEMPERATURE-INDUCED COLLAPSE OF UNFOLDEDPROTEINS. Robert B. Best.3297-POS BOARD #B21AN ALTERNATELY CHARGED RESIDUE CLUSTER AT THE N-TERMINAL END FORMS A RING SYSTEM ANDDYNAMICALLY REGULATES CALSEQUESTRINPOLYMERIZATION. Naresh C. Bal, Ashoke Sharon,Subash C. Gupta, Nivedita Jena, Sandor Gyorke, Muthu Periasamy.3298-POS BOARD #B22MODELING AND SIMULATION OF RODLET ASSEMBLY OFHYDROPHOBIN EAS IN AN ALL-ATOM FREE-ENERGYFORCEFIELD. Timo Strunk, Wolfgang Wenzel.3299-POS BOARD #B23MODELING PROTEIN STABILITY. Kingshuk Ghosh, Lucas Sawle.3300-POS BOARD #B24A TOY MODEL FOR CALCULATING THE RATE ANDPOSITION OF AMYLOID FIBRIL DISSOCIATION. Damien Hall.3301-POS BOARD #B25COOPERATIVE FOLDING KINETICS OF BBL PROTEIN ANDPERIPHERAL SUBUNIT-BINDING DOMAIN HOMOLOGUES.Wookyung Yu, Kwanghoon Chung, Mookyung Cheon, MuyoungHeo, Kyou-Hoon Han, Sihyun Ham, Iksoo Chang.3302-POS BOARD #B26FAST PREDICTION OF PROTEIN THERMODYNAMICS.Hui Wang, Chuanbin Du, Dennis R. Livesay, Donald J. Jacobs.3303-POS BOARD #B27 INTERNATIONAL TRAVELAWARDEENON-COVALENT INTERACTIONS INVOLVING AROMATICRESIDUES IN PROTEIN STRUCTURES: STABILITY ANDDYNAMICS IN MEMBRANE AND GLOBULAR PROTEINSUSING MOLECULAR DYNAMICS SIMULATIONS. Alok Jain,Ramasubbu Sankararamakrishnan.3304-POS BOARD #B28SIMPLIFIED GLOBAL NONLINEAR FUNCTION FOR FITNESSLANDSCAPE OF PROTEIN DESIGN. Yun Xu, ChangYu Hu,Yang Dai, Jie Liang.3305-POS BOARD #B29INVESTIGATIONS INTO ALPHA-HELIX TO BETA-SHEETPHASE TRANSITIONS. John S. Schreck, Jian-Min Yuan.152Biophysical Society 54th Annual Meeting

3306-POS BOARD #B30IMPORTANCE OF PROTEIN CONTEXT ON THE UNFOLDINGPATHWAYS OF -HAIRPINS. Amanda L. Jonsson, Valerie Daggett.3307-POS BOARD #B31MOLECULAR MODELING OF FOLDING IN LACTAM-MODIFIED CONOTOXINS. Brittany A. Kovacs, Pedro L. Muíño.3308-POS BOARD #B32IDENTIFICATION OF MULTIPLE FOLDING PATHWAYSSHARED BY THREE-HELIX BUNDLE PROTEINS.R. Dustin Schaeffer, Valerie Daggett.3309-POS BOARD #B33MOLECULAR DYNAMICS SIMULATIONS OF CONSENSUSTETRATRICOPEPTIDE REPEAT PROTEINS. Rudesh D.Toofanny, Aitziber L. Cortajarena, Lynne Regan, Valerie Daggett.3310-POS BOARD #B34AN FFT-BASED METHOD FOR MODELING CROWDINGEFFECTS WHEN BOTH TEST PROTEINS AND CROWDERSARE REPRESENTED AT THE ATOMIC LEVEL. Sanbo Qin,Huan-Xiang Zhou.3311-POS BOARD #B35NEGATIVE AND POSITIVE DESIGN IN PROTEIN FOLDINGAND THERMODYNAMIC STABILITY: INSIGHTS FROMCOMPUTATIONAL MUTAGENESIS AND SIMULATIONS.Huseyin Kaya, Igor N. Berezovsky.3312-POS BOARD #B36TOWARDS COMPREHENSIVE ANALYSIS OF PROTEIN FAMILYQUANTITATIVE STABILITY/FLEXIBILITY RELATIONSHIPS.Deeptak Verma, Donald J. Jacobs, Jun-tao Guo, Dennis R. Livesay.3313-POS BOARD #B37HUNTINGTIN: STABILITY AND INTERACTION WITHMOLECULAR PARTNER FROM COMPUTATIONALBIOPHYSICS STUDIES. Giulia Rossetti, Alessandra Magistrato,Annalisa Pastore, Suzanne Angeli, Jieya Shao, Marc I. Diamond,Paolo Carloni.3314-POS BOARD #B38ANALYSIS OF SITE-SPECIFIC FOLDING OF HELIX-TURN-HELIX PROTEINS WITH STATISTICAL-MECHANICALMODELS. Jason Lai, Krista E. Amunson, Jan Kubelka.3315-POS BOARD #B39A PHYSICS-BASED APPROACH FOR UNDERSTANDINGFOLDABILITY. TAISONG ZOU, SEFIKA BANU OZKAN.3316-POS BOARD #B40PREDICTION OF H EXCHANGE FROM PERFECTLYFUNNELED STRUCTURE BASED MODELS. Patricio O. Craig,Joachim Lätzer, Patrick Weinkam, Ryan Hoffman, Elizabeth Komives,Peter Wolynes.3317-POS BOARD #B41COMPUTATIONAL PREDICTION OF HOTSPOTS IN PROTEINMISFOLDING FOR RATIONAL IMMUNOTHERAPY.Steven Plotkin, Neil Cashman, Will Guest.3318-POS BOARD #B42PROTONATION/DEPROTONATION EFFECTS ON THESTABILITY OF TRP-CAGE MINIPROTEIN.Camilo A. Jimenez-Cruz, Angel E. Garcia.3319-POS BOARD #B43FORCE FIELD DEPENDENCE OF NEAR-EQUIILIBRIUMPROPERTIES IN A BETA HAIRPIN PEPTIDE. Natha R. Hayre.3320-POS BOARD #B44THE MECHANISM OF GEOMETRICAL FRUSTRATION IN SH3.Heiko Lammert, Jose N. Onuchic.Heme Proteins (Boards #B45-#B69)3321-POS BOARD #B45A BIOPHYSICAL-BIOCHEMICAL COMPARISON OFHEMOGLOBINS FROM MAMMOTH, ASIAN ELEPHANT, ANDHUMAN. Priyamvada Gupta, Nancy T. Ho, Tong-Jian Shen,Virgil Simplaceanu, Michael Hofreiter, Alan Cooper,Kevin L. Campbell, Chien Ho.3322-POS BOARD #B46THE USE OF GLASSY FILMS AND SOL-GEL MATRICES TOPROBE NITRITE MEDIATED REACTIONS OF METHEMOGLOBIN. Camille J. Roche, Mahantesh Navati,M. Belen Cassera, David Dantsker, Joel M. Friedman.3323-POS BOARD #B47GENERAL MECHANISMS FOR THE FOLDING AND ASSEMBLYOF MYOGLOBINS AND HEMOGLOBINS. David S. Culbertson,John S. Olson.3324-POS BOARD #B48TIME RESOLVED THERMODYNAMIC STUDIES OF LIGANDBINDING/RELEASE TO SOL-GEL ENCAPSULATED HORSEHEART MYOGLOBIN. Carissa M. Vetromile, Randy W. Larsen.3325-POS BOARD #B49THE ROLE OF THE INTERNAL DISULFIDE BOND IN THECONFORMATIONAL DYNAMICS OF NEUROGLOBIN.Luisana Astudillo, Pierre Sebban, Jaroslava Miksovska.3326-POS BOARD #B50DESIGN AND CHARACTERIZATION OF AN ENZYMATICALLYACTIVE AMPHIPHILIC MAQUETTE PROTEIN.Sarah E. Chobot, Gregory Wiedman, Christopher C. Moser,Bohdana M. Discher, P. Leslie Dutton.3327-POS BOARD #B51THE EFFECT OF NON-COORDINATED WATER IN THEHEME POCKET ON THE LIGAND BINDING DYNAMICS OFHEME PROTEINS. Rosa L. Nguyen, Benjamin W. Lintner,Ignacio L. Pena, Pooncharas Tipgunlakant, Jayashree Soman,Ivan Birukou, John S. Olson, Daniel E. Asarnow, David S. Kliger,Robert A. Goldbeck, Raymond M. Esquerra.3328-POS BOARD #B52EXPERIMENTAL AND COMPUTATIONAL STUDY OF THEMONOMER-DIMER EQUILIBRIUM IN DEHALOPEROXIDASEFROM AMPHITRITE ORNATA. Stefan Franzen, Vesna de Serrano,Ryan C. Oliver, Joanna Krueger.3329-POS BOARD #B53HEME PROTEINS: THE ROLE OF SOLVENT ON THEDYNAMICS OF GATES AND PORTALS REVEALED BY MDSIMULATIONS. Mariano Andrea Scorciapino, Arturo Robertazzi,Mariano Casu, Paolo Ruggerone, Matteo Ceccarelli.3330-POS BOARD #B54THE EFFECT OF DISTAL HEME POCKET MUTATIONS ONTHE WATER ACCESSIBLE AREAS IN MYOGLOBIN.Benjamin C. Rodriguez, Robert A. Goldbeck, Raymond M. Esquerra,Rosa L. Nguyen, David S. Kliger, Anton B. Guliaev.3331-POS BOARD #B55FERRYL INTERMEDIATES IN HEME-BASED DIOXYGENASES.Syun-Ru Yeh, Ariel Lewis-Ballester, Dipanwita Batabyal,Tsuyoshi Egawa, Changyuan Lu, Yu Lin, Marcelo A. Marti,Luciana Capece, Dario A. Estrin.3332-POS BOARD #B56MODULATION OF THE CONFORMATION OF CYTOCHROMEC OXIDASE FROM PARACOCCUS DENITRIFICANS BY ACTIVE-SITE MUTATIONS. Denis Rousseau, Hong Ji, Tapan Das,Anne Puustinen, Marten Wikstrom, Syun-Ru Yeh.3333-POS BOARD #B57CHARACTERIZATION OF THE RADICAL INTERMEDIATESOF DEHALOPEROXIDASE A AND B FROM AMPHITRITEORNATA. Reza A. Ghiladi, Jennifer D’Antonio, Rania Dumarieh.3334-POS BOARD #B58INVESTIGATION OF THE LOW FREQUENCY DYNAMICS OFHEME PROTEINS: NATIVE AND MUTANT CYTOCHROMESP450CAM AND REDOX PARTNER COMPLEXES.Karunakaran Venugopal, Ilia Denisov, Aditi Das, Stephen G. Sligar,Paul M. Champion.3335-POS BOARD #B59BLOCKING THE INHIBITOR BINDING SITE IN THEINTERIOR OF DEHALOPEROXIDASE FROM AMPHITRITEORNATA. Matthew K. Thompson, Jonathon M. Parnell,Stefan Franzen.WEDNESDAYWednesday, February 24, 2010, San Francisco, California153

3336-POS BOARD #B60CYTOCHROME C OXIDASE CUA AND HEME A: REDOXEQUILIBRIUM AND INTERACTIONS. Peter Nicholls,Maria G. Mason, Chris E. Cooper.3337-POS BOARD #B61THERMODYNAMIC PROFILES OF HETEROTROPICALLOSTERY OF HEMOGLOBIN (HB) BY ISOTHERMALTITRATION CALORIMETRY (ITC). Takashi Yonetani.3338-POS BOARD #B62ROLE OF HIS(E7) IN REGULATING LIGAND BINDING TOTHE SUBUNITS OF HUMAN HBA. Ivan Birukou,Rachel L. Schweers, John S. Olson.3339-POS BOARD #B63RESONANCE RAMAN SPECTRA OF AN O2-BINDING H-NOXDOMAIN REVEAL HEME RELAXATION UPON MUTATION.Rosalie Tran, Elizabeth M. Boon, Michael A. Marletta,Richard A. Mathies.3340-POS BOARD #B64CRYSTAL STRUCTURES OF PROTON UPTAKE MUTANTS OFCYTOCHROME C OXIDASE IN REDUCED AND OXIDIZEDFORMS: LOSS OF KEY WATERS ACCOUNT FORINACTIVATION. Jian Liu, Ling Qin, Carrie Hiser,R. Michael Garavito, Shelagh Ferguson-Miller.3341-POS BOARD #B65UNRAVELING THE MYSTERY OF FERRICYTOCHROME C: ANINVESTIGATION INTO INDUCED NON-NATIVECONFORMATIONAL CHANGES. Jonathan B. Soffer,Reinhard Schweitzer-Stenner.3342-POS BOARD #B66DYNAMIC CONTROL OF LIGAND ENTRY INTO THE HEMECLEFT OF CYTOCHROME C1 IN THE BC1 COMPLEX FROMRHODOBACTER SPHAEROIDES - A FOUR-SITE SAGA.Oleksandr Kokhan, Vladimir P. Shinkarev, Colin A. Wraight.3343-POS BOARD #B67ELECTRONIC AND GEOMETRICAL STRUCTURES OF HEMESA/A 3 OF THE BOVINE CYTOCHROME C OXIDASE IN THEFULLY-REDUCED AND OXIDIZED STATES REVEALED BY ABINITO CALCULATIONS. Mauro Boero, Jiyoung Kang,Masaru Tateno.3344-POS BOARD #B68EXAMINING OXYGEN ACCESSIBILITY IN H-NOX PROTEINSWITH A PHOSPHORESCENT RUTHENIUM PORPHYRIN.Michael B. Winter, Emily J. McLaurin, Steven Y. Reece, Charlie Olea,Jr., Daniel G. Nocera, Michael A. Marletta.3345-POS BOARD #B69STRUCTURAL DYNAMICS IN CHLOROPEROXIDASE: APHOTOACOUSTIC STUDY. Simona Horsa, Xiaotang Wang,Jaroslava Miksovska.Membrane Protein Structure II(Boards #B70-#B98)3346-POS BOARD #B70CHARGE-CHARGE INTERACTIONS PROMOTETRANSMEMBRANE HELIX-HELIX ASSOCIATION DEPENDINGON SEQUENCE CONTEXT. Dieter Langosch, Jana Herrmann,Angelika Fuchs, Johanna Panitz, Stephanie Unterreitmeier,Dmitrij Frishman.3347-POS BOARD #B71REVISITING HYDROPHOBIC MISMATCH WITH FREEENERGY CALCULATIONS OF TRANSMEMBRANE HELIXTILTING. Taehoon Kim, Wonpil Im.3348-POS BOARD #B72FROM IN SILICO PREDICTION TO IN ACTUCHARACTERIZATION OF A NOVEL TRANSMEMBRANE-BARREL. Thomas C. Freeman, William C. Wimley.3349-POS BOARD #B73A HIGHLY ACCURATE STATISTICAL APPROACH FOR THEPREDICTION OF TRANSMEMBRANE -BARRELS.Thomas C. Freeman, William C. Wimley.3350-POS BOARD #B74ACCURATE AB INITIO PREDICTION OF THREEDIMENSIONAL STRUCTURES OF BETA-BARREL MEMBRANEPROTEINS FROM SEQUENCES. Hammad Naveed,Ronald Jackups Jr., Jie Liang.3351-POS BOARD #B75SENSITIVITY OF COARSE GRAIN MODELS OF PEPTIDES TOTHE INTRODUCTION OF CHARGED RESIDUES IN MODELPEPTIDES AND BACTERIAL CHEMORECEPTORS.Benjamin A. Hall, Vitaly V. Vostrikov, Roger E. Koeppe,Mark S. P. Sansom.3352-POS BOARD #B76TRANSMEMBRANE HELIX ORIENTATION AND DYNAMICSEXAMINED BY ENSEMBLE DYNAMICS WITH SOLID-STATENMR OBSERVABLES AND POTENTIAL OF MEAN FORCECALCULATIONS. Sunhwan Jo, Wonpil Im.3353-POS BOARD #B77MEMBRANE INSERTION OF A VOLTAGE-SENSOR HELIX.Chze Ling Wee, Mark Sansom.3354-POS BOARD #B78STRUCTURAL MODEL OF THE VOLTAGE SENSING DOMAININ CI-VSP. Ernesto Vargas, Carlos A. Villalba-Galea, Benoit Roux,Francisco Bezanilla.3355-POS BOARD #B79COMPUTATIONAL STUDIES OF COLICIN INSERTION INTOMEMBRANES: THE CLOSED STATE. Lidia Prieto,Themis Lazaridis.3356-POS BOARD #B80MOLECULAR DYNAMICS SIMULATIONS OF A BACTERIALABC TRANSPORTER. Eoin P. Coll, D. P. Tieleman.3357-POS BOARD #B81STRUCTURAL QUALITY AND MD SIMULATIONS OFHOMOLOGY MODELS OF MAJOR FACILITATORSUPERFAMILY (MFS) TRANSPORTER PROTEINS.Azizah Mohd Asi, Mark S. P. Sansom.3358-POS BOARD #B82IN SILICO INVESTIGATIONS OF POSSIBLE ROUTES OFASSEMBLY OF 3A FROM SARS-CO VIRUS. Hao-Jen Hsu,Wolfgang B. Fischer.3359-POS BOARD #B83IRIS-LIKE MECHANISM OF PORE DILATION IN THE CORAMAGNESIUM TRANSPORT SYSTEM. Nilmadhab Chakrabarti,Chris Neale, Jian Payandeh, Emil F. Pai, Régis Pomès.3360-POS BOARD #B84HUMAN COPPER TRANSPORTER 1: MODEL-STRUCTURE,FUNCTION AND MOTION. Maya Schushan, Yariv Barkan,Turkan Haliloglu, Nir Ben-Tal.3361-POS BOARD #B85GPR35: STUDY OF CLASS A GPCR SEQUENCE DIVERGENCESUSING CONFORMATIONAL MEMORIES. Thomas Lane,Mary E. Abood, Patricia H. Reggio.3362-POS BOARD #B86CONSTRUCTION OF A -OPIOID RECEPTOR MODEL USINGCONFORMATIONAL MEMORIES. Elizabeth Poole, Dow Hurst,Patricia Reggio, Ping-Yee Law.3363-POS BOARD #B87CONCERTED MOTION AND HYDRATION OF THE BETA-2-ADRENERGIC RECEPTOR REVEALED BY MICROSECONDTIME SCALE MOLECULAR DYNAMICS. Tod D. Romo,Alan Grossfield, Michael C. Pitman.3364-POS BOARD #B88ACTIVATION PATHWAYS OF AGONISTS, PARTIAL AGONISTSAND INVERSE AGONIST IN BETA1 AND BETA2 ADRENERGICRECEPTORS. Supriyo Bhattacharya, Nagarajan Vaidehi.154Biophysical Society 54th Annual Meeting

3365-POS BOARD #B89FUNCTIONNAL ANALYSIS OF A CONSERVED HISTIDINERESIDUE OF THE EXTRACELLULAR LOOP OF ACID-SENSING-ION-CHANNEL-1A. Benoite Bargeton,Stephan Kellenberger.3366-POS BOARD #B90STRUCTURAL STUDIES OF THE INTEGRAL MEMBRANEPROTEIN HUMAN LTC4 SYNTHASE BY ELECTRONCRYSTALLOGRAPHY. Frederik Rudolph, Stefania Mari,Gengxiang Zhao, Matthew C. Johnson, Yoshihide Kanaoka,Daniel Müller, Ingeborg Schmidt-Krey.3367-POS BOARD #B91METAMORPHIC RESPONSE OF CLIC1 CHLORIDEINTRACELLULAR ION CHANNEL UPON INTERACTIONWITH THE MEMBRANE. Sophia C. Goodchild,Michael W. Howell, Kenneth A. Sale, Paul M. G. Curmi,Louise J. Brown.3368-POS BOARD #B92 STUDENT TRAVEL AWARDEESTRUCTURAL ANALYSIS OF HEPTAMERIC ALPHA-HEMOLYSIN UNDER EXTREME CONDITIONS THATFACILITATE NUCLEIC ACID TRANSLOCATION.Marsiyana M. Henricus, Deanpen Japrung, Qiuhong Li,Giovanni Maglia, Hagan Bayley.3369-POS BOARD #B93MTB MEMBRANE PROTEIN EXPRESSION , PURIFICATIONAND, STRUCTURE DETERMINATION : SOLID STATE NMRAPPROACH. Nabanita Das, Timothy A. Cross.3370-POS BOARD #B94FIRST STRUCTURAL CHARACTERIZATION OF A BON-DOMAIN IN A PROTEIN FROM MYCOBACTERIUMTUBERCULOSIS: OMPATB TRACKS TOWARD ANOLIGOMERIZATION PROCESS TO FORM A CELL WALLPORE. Daniel Auguin, Yinshan Yang, Stephane Delbecq,Emilie Dumas, Virginie Molle, Nathalie Saint.3371-POS BOARD #B95SP-C PALMITOYLATION IS CRUCIAL FOR STABILIZINGCHOLESTEROL-CONTAINING SURFACTANT FILMS DURINGCONTINUOUS COMPRESSION/EXPANSION CYCLING.Florian Baumgart, Olga Lucía Ospina, Leticia Gómez-Gil,Ignacio Rodríguez-Crespo, Jesús Pérez-Gil.3372-POS BOARD #B96NEW INSIGHTS INTO THE INTERFACIAL ACTIVATION OFSECRETED PHOSPHOLIPASE A2. Jeffrey L. Urbauer,Kathleen N. Nemec, Suren A. Tatulian.3373-POS BOARD #B97PEPTIDE-MEMBRANE AND PEPTIDE-PEPTIDEINTERACTIONS BETWEEN MYELIN BASIC PROTEIN ANDMYELIN-LIKE LIPIDS REVEALED BY COVALENTLYATTACHED VIBRATIONAL LABELS. Heather A. McMahon,Katherine N. Alfieri, Casey H. Londergan.3374-POS BOARD #B98STRUCTURAL CHARACTERIZATION OF HUMANPERIPHERAL MYELIN PROTEIN 22 USING NMR.Masayoshi Sakakura, Arina Hadziselimovic, Charles R. Sanders.Protein Aggregates III (Boards #B99-#B115)3375-POS BOARD #B99POSSIBLE PATHWAY BETWEEN ALPHA HELICAL AND BETAHELICAL STRUCTURES OF THE C-TERMINAL IN THEMAMMALIAN PRION PROTEIN. Shan Dai, Daniel L. Cox.3376-POS BOARD #B100MOLECULAR MECHANISM OF INHIBITION OF AMYLOIDFORMATION BY INOSITOL. Grace Li, Régis Pomès.3377-POS BOARD #B101SIDE CHAIN INTERACTIONS CAN IMPEDE AMYLOID FIBRILGROWTH:REPLICA EXCHANGE SIMULATIONS OF ABETAPEPTIDE MUTANT. Takako Takeda, Dmitri K. Klimov.3378-POS BOARD #B102ELUCIDATING THE ASSOCIATION AND DISSOCIATIONMECHANISM OF -AMYLOID PROTEIN BY TARGETEDMOLECULAR DYNAMICS SIMULATIONS. Chewook Lee,Sihyun Ham.3379-POS BOARD #B103CHARACTERING AMYLOID-BETA PROTEIN MISFOLDINGFROM MOLECULAR DYNAMICS SIMULATION WITHEXPLICIT WATER. Chewook Lee, Sihyun Ham.3380-POS BOARD #B104FIBER FORMATION OF SILK-LIKE PROTEINS. Marieke Schor,Peter G. Bolhuis.3381-POS BOARD #B105THE SPONTANEOUS AGGREGATION OF STERIC ZIPPERPEPTIDES STUDIED BY MOLECULAR DYNAMICSSIMULATIONS. Dirk Matthes, Bert L. de Groot.3382-POS BOARD #B106BETA-BARREL HYPOTHESIS: STRUCTURAL INSIGHTS TOOLIGOMERIC PRION CONFORMATION. Jiyong Park,Marcin I. Apostol, David Eisenberg.3383-POS BOARD #B107POLYMOPHISM OF A-BETA1-42 PEPTIDE OLIGOMER -MEMBRANE INTERACTIONS. Buyong Ma, Ruth Nussinov.3384-POS BOARD #B108MODELING AMYLOID OLIGOMERS WITH DIFFERENTSTRUCTURAL MORPHOLOGIES. Jie Zheng, Xiang Yu, Jun Zhao,Chao Zhao, Qiuming Wang.3385-POS BOARD #B109A SINGLE-MOLECULE APPROACH TO TAU. Andrew Dittmore,Omar A. Saleh.3386-POS BOARD #B110PRE-AMYLOID STATES OF ISLET AMYLOID POLYPEPTIDEEXAMINED BY SINGLE-PARTICLE FLUORESCENCE.Abhinav Nath, Andrew D. Miranker, Elizabeth Rhoades.3387-POS BOARD #B111N&B AND CROSS-N&B ANALYSIS DETECTOLIGOMERIZATION OF HUNTINGTIN IN LIVE CELLS.Giulia Ossato, Michelle A. Digman, Tamas Lukacsovich,J. Lawrence Marsh, Enrico Gratton.3388-POS BOARD #B112AMYLOID- AND -SYNUCLEIN AGGREGATE IN LIVE CELLSAT CONCENTRATIONS FAR BELOW THEIR IN VITROSOLUBILITY LIMITS. Suman Nag, Jiji Chen, Joseph Irudayaraj,Sudipta Maiti.3389-POS BOARD #B113AMYLOID BETA OLIGOMER STUDIED BY NEWLYDEVELOPED SINGLE MOLECULE ANALYSIS METHOD.Naofumi Terada, Tamotsu Zako, Masafumi Sakono, Mizuo Maeda.3390-POS BOARD #B114INVESTIGATING AMYLOID NUCLEATION AND GROWTHWITH FLUCTUATION MICROSCOPY. Keith Berland, Yan Liang,Neil Anthony.3391-POS BOARD #B115DETECTING AND CHARACTERIZING AMYLOID- 1-40OLIGOMERS USING SINGLE MOLECULE FLUORESCENCE.Priyanka Narayan, Angel Orte, Christopher M. Dobson,David Klenerman.Intrinsically Disordered Proteins II(Boards #B116-#B128)3392-POS BOARD #B116INTRINSIC DISORDER, SCAFFOLDS, AND STOCHASTICMACHINES. A. Keith Dunker.3393-POS BOARD #B117DISORDERNESS PROFILE OF SCAFFOLDING PROTEINS AS APREDICTOR OF SUPRAMOLECULAR ARCHITECTURE: TITINAND NEBULIN PROFILES CORRELATE WITH THESARCOMERE PROPORTION. Jeffrey G. Forbes, Kuan Wang.WEDNESDAYWednesday, February 24, 2010, San Francisco, California155

3394-POS BOARD #B118DYNAMICS OF A SKELETAL TROPONIN C - TROPONIN ICHIMERA PROBED BY COMPARISON OF EXPERIMENTALAND SIMULATED NMR RELAXATION PARAMETERS.Olivier Julien, Pascal Mercier, Claire N. Allen, Olivier Fisette,Carlos H. I. Ramos, Patrick Lagüe, Tharin M. A. Blumenschein,Brian D. Sykes.3395-POS BOARD #B119COMPETITION AND COMPLEX FORMATION BETWEEN P53,MDM2 AND THE P300 ZINC FINGER CH3. Sarah W. Burge,Eviatar Natan, Alan R. Fersht.3396-POS BOARD #B120STRUCTURAL DIFFERENCES BETWEEN APOLIPOPROTEINE3 AND E4 AS MEASURED BY 19 F- NMR. Kanchan Garai,Sourajit M. Mutafi, Berevan Baban, Carl Frieden.3397-POS BOARD #B121LIGHT CHAIN-MEDIATED SELF-ASSOCIATION OFINTRINSICALLY DISORDERED DYNEIN INTERMEDIATECHAIN. Afua Nyarko, Elisar Barbar.3398-POS BOARD #B122AQUIFEX AEOLICUS FLGM PROTEIN DOES NOT EXHIBITTHE DISORDERED CHARACTER OF THE SALMONELLATYPHIMURIUM FLGM PROTEIN. Rhett Malloy, Andrew Allen,Wai Kit Ma, Kevin Greenwood, Lynn Bryan, Rebecca Sacora,LaBrittney Williams, Matthew Gage.3399-POS BOARD #B123 INTERNATIONAL TRAVEL AWARDEEANALYZING THE SELF-ORGANIZING MECHANISM OFLYSOZYME AMYLOID FIBER FORMATION. Benjamin J. Burnett,Lisa M. Cole, Samuel T. Durrance, Shaohua Xu.3400-POS BOARD #B124EARLY OLIGOMER FORMATION OF ALPHA-SYNUCLEIN ASREVEALED BY FLUORESCENCE CORRELATIONSPECTROSCOPY. Sangeeta Nath, Jessica Meuvis, Jelle Hendrix,Yves Engelborghs.3401-POS BOARD #B125STRUCTURAL AND FUNCTIONAL INSIGHTS INTO LIPIDBINDING BY OLIGOMERIC ALPHA-SYNUCLEIN.Bart van Rooijen, Kirsten A. van Leijenhorst-Groener,Mireille M. A. E. Claessens, Vinod Subramaniam.3402-POS BOARD #B126STRUCTURAL PROPERTIES OF PORE FORMING OLIGOMERSOF ALPHA SYNUCLEIN. Hai-Young Kim, Min-Kyu Cho,Dietmar Riedel, Ashtosh Kurmar, Elke Maier, Carsten Siebenhaar,Stefan Becker, Claudio O. Fernandez, Hilar A. Lashuel, Roland Benz,Adam Lange, Markus Zweckstetter.3403-POS BOARD #B127USING COVALENTLY ATTACHED THIOCYANATE AS A SITE-SPECIFIC INFRARED PROBE TO CHARACTERIZE ADISORDER-TO-ORDER TRANSITION OF THEINTRINSICALLY DISORDERED C-TERMINAL DOMAIN OFTHE MEASLES VIRUS (NTAIL). Connor G. Bischak,Casey H. Londergan.3404-POS BOARD #B128ORIENTED PRION PROTEIN IMMOBILIZATION ATNANOSTRUCTURED INTERFACES. Barbara Sanavio,Christian Grunwald, Giuseppe Legname, Giacinto Scoles,Loredana Casalis.Virus Structure & Assembly(Boards #B129-#B140)3405-POS BOARD #B129DECIPHERING THE RELATIONSHIP BETWEEN HEPATITIS CVIRUS (HCV) P7 AND ITS FOES. Chee Foong Chew,Nicole Zitzmann, Philip C. Biggin.3406-POS BOARD #B130REVEALING THE STRUCTURAL INTEGRITY OF NOROVIRUSCAPSIDS BY NANOINDENTATION EXPERIMENTS.Marian Baclayon, Wouter Roos, Glen Shoemaker, Sue Crawford,Mary Estes, Ventakaram Prasad, Albert Heck, Gijs Wuite.3407-POS BOARD #B131TRACKING INFLUENZA A VIRUS RIBONUCLEOPROTEINCOMPLEX COMPONENTS BY PHOTOACTIVATABLEFLUOROPHORES. Chris T. Hoefer, Andreas Herrmann.3408-POS BOARD #B132EFFECTS OF SALTS ON INTERNAL DNA PRESSURE ANDMECHANICAL STABILITY OF PHAGES. Alex Evilevitch,Irena Ivanovska, Wouter Roos, Meerim Jeembaeva, Bengt Jönsson,Gijs A. Wuite.3409-POS BOARD #B133ROLE OF THE ELECTROSTATIC INTERACTIONS IN THEGENOME PACKAGING AND EJECTION OF DNA FROMBACTERIOPHAGES. Anton S. Petrov, Stephen C. Harvey.3410-POS BOARD #B134THE ENTROPIC PENALTY OF CONFINING A CHAINPOLYMER INTO A VERY SMALL SPACE. Stephen C. Harvey,Mark R. Smyda.3411-POS BOARD #B135TOWARD UNDERSTANDING THE EFFECT OF SINGLEAMINO ACID MUTATIONS ON VIRAL CAPSID STABILITY.Kuo Hao Lee, F. Marty Ytreberg.3412-POS BOARD #B136RESPIRATORY SYNCYTIAL VIRUS INTERACTIONS WITHNANOPARTICLES USING TRANSMISSION ELECTRONMICROSCOPY. Komal Vig, Seyhan Boyoglu, Vijaya Rangari,Michael Miller, Shreekumar Pillai, Shree R. Singh.3413-POS BOARD #B137CHARACTERIZATION OF RETROVIRAL GAG BEHAVIOR INTHE CYTOPLASM OF LIVING CELLS USING FLUORESCENCEFLUCTUATION SPECTROSCOPY. Keir Fogarty, Iwen Grigsby,Xiao Wang, Yan Chen, Jonathan Rawson, Joachim Mueller,Louis Mansky.3414-POS BOARD #B138A MECHANOCHEMICAL MODEL OF A VIRAL DNAPACKAGING MOTOR. Jin Yu, Jeffrey Moffitt, Craig Hetherington,Carlos Bustamante, George Oster.3415-POS BOARD #B139SWELLING AND SOFTENING OF THE CCMV PLANT VIRUSCAPSID IN RESPONSE TO PH SHIFTS. Bodo D. Wilts,Iwan A. T. Schaap, Mark J. Young, Trevor Douglas,Charles M. Knobler, Christoph F. Schmidt.3416-POS BOARD #B140DISSECTING LAMBDA TERMINASE: A VIRAL DNAPACKAGING MOTOR. Benjamin T. Andrews, Junqing Zhou,Jean S. Arens, Michael G. Feiss, Carlos E. Catalano.DNA, RNA Structure & Conformation III(Boards #B141-#B160)3417-POS BOARD #B141TARGETING DNA HAIRPIN LOOPS WITH THEIR PARTIALLYCOMPLEMENTARY STRANDS. Hui-Ting Lee, Carolyn Carr,Hollie Siebler, Irine Khutsishvilli, Luis A. Marky.3418-POS BOARD #B142EFFECT OF LOOP-CLOSING RESIDUES ON DNA HAIRPINSTABILITY. Nancy C. Stellwagen, Chun Yaw Chang.3419-POS BOARD #B143SPECTROSCOPIC STUDIES OF DNA-DRUG BINDINGAFFINITIES: SEQUENCE CONTEXT AND METHYLATIONEFFECTS. Mary E. Hatcher, Dianna Buckett, Stephanie McCarty.3420-POS BOARD #B144SOLUTION STRUCTURES AND ULTRAVIOLET RAMANSPECTRA OF PURINES REVEAL SYSTEMATIC SHIFTS WITHCHANGE IN PROTONATION STATE. Namrata Jayanth,Spriha Gogia, Mrinalini Puranik.156Biophysical Society 54th Annual Meeting

3453-POS BOARD #B177COUNTING RAD51 PROTEINS DISASSEMBLING FROMNUCLEOPROTEIN FILAMENTS UNDER TENSION.Joost van Mameren, Mauro Modesti, Ronald Kanaar, Wyman Clair,Erwin J. G. Peterman, Gijs J. L. Wuite.Membrane Dynamics & Bilayer Probes(Boards #B178-#B200)3454-POS BOARD #B178REVEALING THE MICROSTRUCTURAL CHANGES IN TISSUESIN-SITU WITH POSITRON ANNIHILATION SPECTROSCOPY.Petri Sane, Filip Tuomisto, Ilpo Vattulainen, Juha Holopainen.3455-POS BOARD #B179THE USE OF TIME-RESOLVED FLUORESCENCE ANISOTROPYTO REVEAL DOMAIN STRUCTURES IN MODEL MEMBRANEVESICLES: PROSPECTS FOR APPLICATIONS TO CELLMEMBRANES. Christopher D. Stubbs, Stanley B. Botchway.3456-POS BOARD #B180PROTEIN-INDUCED SHAPE CHANGES IN PHASE-SEPARATEDVESICLES. Jaime B. Hutchison, Aruni Karunanayake, Bob Weis,Tony Dinsmore.3457-POS BOARD #B181CERAMIDE GEL DOMAIN FORMATION IN A PHOSPHOLIPIDBILAYER: THE IMPACT OF CERAMIDE ACYL CHAIN.Sandra N. Pinto, Liana C. Silva, Rodrigo F. M. de Almeida,Manuel Prieto.3458-POS BOARD #B182PROBING CHOLESTEROL DEPENDENT LIPID PROPERTIESUSING MOLECULAR DYNAMICS SIMULATIONS OF BODIPY-PC IN EXPLICIT DMPC AND DPPC MEMBRANES.Phillip M. Morris, Danielle Stuhlsatz, Kevin Song, Wonpil Im.3459-POS BOARD #B183DYNAMICS OF PHASE SEPARATION IN LIPID MEMBRANES.Brian Camley, Frank L. H. Brown.3460-POS BOARD #B184MOLECULAR DYNAMICS SIMULATIONS OF IN-PLANEDENSITY FLUCTUATIONS IN PHOSPHOLIPID BILAYERS.Erik G. Brandt, Olle Edholm.3461-POS BOARD #B185AGE DEPENDENT DEFORMABILITY CHANGES OF RBCSEVALUATED USING A CYCLICALLY REVERSING SHEAR FLOWGENERATOR. Naoyuki Yokoyama, Daisuke Sakota,Toshitaka Yasuda, Setsuo Takatani.3462-POS BOARD #B186BIOMIMETIC METALLIC ELECTRODES FOR INTRACELLULARELECTRICAL MEASUREMENTS. Piyush Verma, Nick Melosh.3463-POS BOARD #B187CHARACTERIZING THE STRUCTURE AND DYNAMICS OFNANODISC LIPID BILAYERS OF DIFFERENT COMPOSITIONS.Taras Pogorelov, Y. Zenmei Ohkubo, Emad Tajkhorshid.3464-POS BOARD #B188INTER-MEMBRANE ADHESION MEDIATED BY MOBILELINKERS: EFFECT OF RECEPTOR SHORTAGE. Susanne F. Fenz,Rudolf Merkel, Kheya Sengupta.3465-POS BOARD #B189COLLECTIVE MEMBRANE DYNAMICS UNDER OSMOTICSTRESS. Avigdor Leftin, K. J. Mallikarjunaiah, Jacob J. Kinnun,Horia I. Petrache, Michael F. Brown.3466-POS BOARD #B190DIFFERENTIAL EFFECT OF ISOFLURANE ON THEANISOTROPY OF DIPHENYLHEXATRIENE AND ITSCATIONIC TRIMETHYLAMINE ANALOG. Steven C. Nelson,Steven Neeley, John D. Bell, David D. Busath.3467-POS BOARD #B191DEFORMATION OF VESICLES CONTROLLED BY LOCALSPONTANEOUS CURVATURES OF MEMBRANE. Yuka Sakuma,Masayuki Imai, Takashi Taniguchi, Toshihiro Kawakatsu.3468-POS BOARD #B192A BIOMOLECULAR PHOTODIODE FOR IMAGING OF CELLMEMBRANE POTENTIAL. Daniel R. Cooper, Jay Nadeau.3469-POS BOARD #B193SUB-DIFFUSION AND SUPER-DIFFUSION OF HYDRATIONWATER MOLECULES AT BIOLOGICAL INTERFACES.Jhuma Das, Elijah Flenner, Maikel Rheinstadter, Ioan Kosztin.3470-POS BOARD #B194TWO-DIMENSIONAL CONTINUUM PERCOLATIONTHRESHOLD AS A FUNCTION OF THE RADIUS OF THEDIFFUSING PARTICLES. Michael J. Saxton.3471-POS BOARD #B195 STUDENT TRAVEL AWARDEECOMPARISON OF LIPID MONOLAYERS AND BILAYERS BYCOMPARATIVE MOLECULAR DYNAMICS SIMULATIONS OFA LIPID-LIKE DYE MOLECULE. Kevin C. Song, Phillip W. Livanec,Robert C. Dunn, Wonpil Im.3472-POS BOARD #B196MEMBRANE INTERACTIONS IN IONIC SOLUTIONS.Natalie E. Stenzoski, Adriana L. Rogozea, Megan M. Koerner,Bruce D. Ray, Horia I. Petrache.3473-POS BOARD #B197CORRELATING OBSTRUCTED DIFFUSION WITH OBSTACLEMORPHOLOGY USING SINGLE MOLECULE TRACKING ANDAFM IN SUPPORTED LIPID BILAYERS. Michael J. Skaug,Roland Faller, Marjorie L. Longo.3474-POS BOARD #B198NOVEL PROBES FOR SENSING LATERAL STRESS INMEMBRANES. Natalia Goehring, Anca Margineanu,Richard Templer, Oscar Ces.3475-POS BOARD #B199 STUDENT TRAVEL AWARDEELIPID DIFFUSION IN TETHERED BILAYER LIPIDMEMBRANES (TBLMS). Siddharth Shenoy, Radu Moldovan,Samuel Rauhala, David Vanderah, Mathias Loesche.3476-POS BOARD #B200MONITORING SUBMICRON AND MICRON-SIZE MEMBRANECOMPARTMENTS USING QUANTUM DOTSMONOVALENTLY CONJUGATED TO TRACER MOLECULES.Amanda P. Siegel, Daniel E. Minner, Michael J. Murcia,Jeffrey S. Elmendorf, Kenneth Ritchie, Christoph A. Naumann.Membrane Structure III(Boards #B201-#B213)3477-POS BOARD #B201PHASE BEHAVIOR AND MOLECULAR INTERACTIONS OFMEMBRANES CONTAINING PHOSPHATIDYLCHOLINES ANDSTEROL: A DEUTERIUM NMR STUDY. Ya-Wei Hsueh,Ming-Yen Kuo, Mei-Ting Chen.3478-POS BOARD #B202EVIDENCE OF COEXISTING PHASES IN BINARY MIXTURESOF POPC/CERAMIDE3. Raghu S. Masala, Cristiano L. P. Oliveira,Jan S. Pedersen, Beate Klösgen.3479-POS BOARD #B203PHYSICAL PROPERTIES OF THE LIPID DIPHYTANOYLPHOSPHATIDYLCHOLINE (DPHPC) USED FOR IONCHANNEL MEASUREMENTS. Dino J. Dieudonné,Philip A. Gurnev, Adriana L. Rogozea, Bruce D. Ray, Horia I. Petrache.3480-POS BOARD #B204PROTEIN-LIPID INTERACTION AND DOMAIN FORMATIONIN ASYMMETRIC MEMBRANES. Salvatore Chiantia,Petra Schwille, Erwin London.3481-POS BOARD #B205THERMAL ENERGIES AND INVARIANT LIPID STRUCTURES.Pat DeMoss, Horia I. Petrache.3482-POS BOARD #B206SPECIFIC SPATIAL AND ORIENTATIONAL ORDER INPHOSPHOLIPID MEMBRANES INDUCED BY CHOLESTEROL.Hector Martinez-Seara, Tomasz Rog, Mikko Karttunen,Ramon Reigada, Ilpo Vattulainen.158Biophysical Society 54th Annual Meeting

3483-POS BOARD #B207NEAR-FIELD STRUCTURAL STUDIES OF LIPID BILAYERS.Merrell A. Johnson, Ricardo Decca.3484-POS BOARD #B208CALGARY LIPIDS: A LIPID FORCE FIELD FOR MOLECULARSIMULATIONS. Luca Monticelli, Emppu Salonen,D. Peter Tieleman.3485-POS BOARD #B209VISCOELASTIC PROPERTIES OF PLASMA MEMBRANESVARIES WITH CHOLESTEROL LEVEL. Nima Khatibzadeh,Sharad Gupta, George Durm, William Brownell, Bahman Anvari.3486-POS BOARD #B210THE PROGRESSION OF A NOVEL LIPOSOME-BASEDDELIVERY VEHICLE TOWARD IN VIVO DRUG DELIVERY.Benjamin Wong, Jason Schmidt, Joseph Zasadzinski.3487-POS BOARD #B211A PLATFORM TO STUDY CURVATURE EFFECTS OFPROTEINS ON MEMBRANES. Hector H. Huang,Joseph B. Pesavento, Sharon Rozovsky, Kenneth H. Downing,Jay T. Groves.3488-POS BOARD #B212INVESTIGATION OF MITOCHONDRIAL CRISTA MEMBRANEMORPHOLOGIES IN TERMS OF MINIMIZING THE FREEENERGY OF THE CONFIGURATION. Mariam Ghochani,Avinoam Rabinovitch, Terry Frey, Jim Nulton, Peter Salamon,Arlette R. Baljon.3489-POS BOARD #B213DOMAIN ASSEMBLY IN GIANT UNILAMELLAR VESICLESPREPARED FROM MYELIN LIPIDS. Nicoletta Kahya,Dick Hoekstra.Membrane Fusion (Boards #B214-#B241)3490-POS BOARD #B214FAST SINGLE VESICLE SNARE-MEDIATED MEMBRANEFUSION ASSAY IN PLANAR SUPPORTED BILAYERS REVEALSDETAILS ABOUT FUSION MECHANISM. Marta K. Domanska,Volker Kiessling, Lukas K. Tamm.3491-POS BOARD #B215IMAGING THE DISASSEMBLY OF SYNTXIN CLUSTERDURING THE EXOCYTOSIS OF SINGLE SECRETORYGRANULES. Mitsuharu Midorikawa, Wolfhard Almers.3492-POS BOARD #B216SINGLE MOLECULE STUDY OF DISASSEMBLY OF SNARECOMPLEX BY NSF/-SNAP. Jaemyeong Jung, Timothy D. Fenn,Steven Chu, Axel T. Brunger.3493-POS BOARD #B217A PRE-DOCKING ROLE FOR MICROTUBULES IN INSULIN-STIMULATED GLUCOSE TRANSPORTER 4 TRANSLOCATION.Yu Chen, Yan Wang, Wei Ji, Pingyong Xu, Tao Xu.3494-POS BOARD #B218A SHORT LIPOPEPTIDE DERIVED FROM THE N-HEPTADREPEAT REGION INHIBITS HIV-1 GP41 MEDIATED FUSIONVIA AN ALTERED MODE OF ACTION. Avraham Ashkenazi,Yael Wexler-Cohen, Yechiel Shai.3495-POS BOARD #B219HIV-1 ENV-MEDIATED MEMBRANE FUSION MONITORED BYFLUORESCENCE MICROSCOPY OF SYNCYTIUMFORMATION BETWEEN CLONE69T1REVENV AND SUPT1CELLS. Michael Yee, Krystyna Konopka, Jan Balzarini,Nejat Düzgünefl.3496-POS BOARD #B220FUSION ACTIVITY OF HIV GP41 FUSION DOMAIN ISRELATED TO ITS SECONDARY STRUCTURE. Alex L. Lai,Yinling Li, Ania Cieslinska, Lukas K. Tamm.3497-POS BOARD #B221VOLTAGE ACROSS THE TARGET CELL MEMBRANE IS ASTRONG REGULATOR OF FUSION OF VIRUS CONTAININGCLASS II OR CLASS III PROTEINS. Ruben Markosyan,Fred S. Cohen.3498-POS BOARD #B222CONFORMATIONAL SAMPLING OF INFLUENZA FUSIONPEPTIDE IN MEMBRANE BILAYERS AS A FUNCTION OFTERMINI AND PROTONATION STATES. Afra Panahi,Michael Feig.3499-POS BOARD #B223MEMBRANE FUSION ENHANCED! Herre Jelger Risselada,Helmut Grubmueller.3500-POS BOARD #B224INACCURACY OF THE HELFRICH EQUATION FOR THECURVATURE ENERGY OF FUSION INTERMEDIATES.David P. Siegel.3501-POS BOARD #B225FUSOGENIC ACTIVITY OF CATIONIC LIPIDS CORRELATESWITH LIPID SHAPE DISTRIBUTION. Caroline Lonez,Marc F. Lensink, Jean-Marie Ruysschaert, Michel Vandenbranden.3502-POS BOARD #B226MEMBRANE TENSION DRIVES EXPANSION OF HEMIFUSIONDIAPHRAGMS NUCLEATED BY INFLUENZAHEMAGGLUTININ. Jason M. Warner, Ben O’Shaughnessy.3503-POS BOARD #B227MULTI-SCALE MODELING OF THE “CONTACT-FACILITATED” DELIVERY MECHANISM OFPERFLUOROCARBON-BASED NANOEMULSIONS. Sun-Joo Lee,Brett N. Olsen, Paul H. Schlesinger, Nathan A. Baker.3504-POS BOARD #B228FUSION BETWEEN INTRALUMINAL VESICLES OF LATEENDOSOMES AS A POSSIBLE MECHANISM OF ENDOSOMALESCAPE BY CELL-PENETRATING PEPTIDES. Sung-Tae Yang,Leonid Chernomordik, Kamran Melikov.3505-POS BOARD #B229FISSION OF MEMBRANE NANOTUBES CAUSED BY OSMOTICSTRESS. Alexey Evseev, Pavel Bashkirov.3506-POS BOARD #B230DECREASING TEMPERATURE BELOW T T OR INCREASINGCHOLESTEROL ENHANCE VESICLE-BILAYER MEMBRANEFUSION. Kevin J. Tuttle, David E. Lee, Reed A. Doxey,Dixon J. Woodbury.3507-POS BOARD #B231MEMBRANE FUSION ASSAY BASED ON PORE-SPANNINGLIPID BILAYERS. Ines Höfer, Claudia Steinem.3508-POS BOARD #B232DIRECT OBSERVATION OF INTERMEDIATE STATES INMEMBRANE FUSION BY PHOTONIC FORCE MICROSCOPY.Andrea Keidel, Tobias F. Bartsch, Ernst-Ludwig Florin.3509-POS BOARD #B233LIPID BILAYER RIGIDITY AFFECTS THE FUSION KINETICSOF INDIVIDUALLY OBSERVED INFLUENZA PARTICLES.Jason J. Otterstrom, Daniel L. Floyd, John J. Skehel,Stephen C. Harrison, Antoine M. van Oijen.3510-POS BOARD #B234SITE-SPECIFIC DNA-CONTROLLED FUSION OF SINGLE LIPIDVESICLES TO SUPPORTED LIPID BILAYERS. Lisa V. Simonsson,Peter Jönsson, Gudrun Stengel, Fredrik Höök.3511-POS BOARD #B235DNA-MEDIATED FUSION BETWEEN INDIVIDUALTETHERED VESICLES. Robert J. Rawle, Bettina van Lengerich,Steven G. Boxer.3512-POS BOARD #B236COVALENT TETHERING OF LIPID VESICLES TO ASUPPORTED LIPID BILAYER BY A DNA-TEMPLATED CLICKREACTION. Bettina van Lengerich, Robert J. Rawle, Steven G. Boxer.3513-POS BOARD #B237ROLE OF CURVATURE IN PEG-MEDIATED FUSIONBETWEEN HIGHLY CURVED AND UN-CURVEDMEMBRANES. Michael J. Bruno, Mayur Temgire, M. J. Costello,Barry R. Lentz.WEDNESDAYWednesday, February 24, 2010, San Francisco, California159

3514-POS BOARD #B238VSV TRANS-MEMBRANE DOMAIN PROMOTES CONTENTMIXING TO OCCUR EARLY IN THE FUSION PROCESS.Tanusree Sengupta, Barry R. Lentz.3515-POS BOARD #B239EFFECT OF HIV GP41 FUSION PEPTIDE AND ITS CROSS-LINKED OLIGOMERS IN MEMBRANE FUSION.Myriam Diaz-Martinez, Hirak Chakraborty, Wei Qiang,David Weliky, Barry R. Lentz.3516-POS BOARD #B240FUSOGENIC ACTIVITY OF PLA2-IIA AND SMASE IN PEG-MEDIATED MEMBRANE FUSION. Jose L. Alejo, Chad Leidy.3517-POS BOARD #B241MEMBRANE FUSION IS SPATIALLY CONTROLLED BYMODIFICATION OF PHOSPHOINOSITIDES. Fabrice Dumas,Richard D. Byrne, Ben Vincent, Laurence Salome, Dominic L. Poccia,Banafshé Larijani.Calcium Signaling Proteins(Boards #B242-#B256)3518-POS BOARD #B2421CHARACTERIZATION OF CONFORMATIONAL TRANSITIONSIN DREAM PROTEIN USING FLUORESCENCESPECTROSCOPY. Gangadhar Dhulipala, Jaroslava Miksovska.3519-POS BOARD #B243 INTERNATIONAL TRAVEL AWARDEENEW ASPECTS OF LIPID-PROTEIN INTERACTIONSREVEALED BY CALMODULIN BINDING TO THE LIPIDMEDIATOR SPHINGOSYLPHOSPHORYLCHOLINE.Erika Kovacs, Veronika Harmat, Judit Toth, Beata G. Vertessy,Karoly Modos, Jozsef Kardos, Karoly Liliom.3520-POS BOARD #B244SUBSTITUTIONS FOR A SEMI-CONSERVED IQ MOTIFGLYCINE DIFFERENTIALLY AFFECT THE STABILITIES OFDIFFERENT CA 2+ -BOUND STATES OF A CALMODULIN-IQDOMAIN COMPLEX. Anthony Persechini, D. J. Black.3521-POS BOARD #B245CONFORMATIONAL CHANGES OF CAMKII: A MODEL OFACTIVATION. Laurel Hoffman, Kristian Kaufmann, Roger Colbran,Jens Meiler, Hassane Mchaourab.3522-POS BOARD #B246ANOMALOUS CALCIUM DEPENDENT BINDING OFCALMODULIN TO KCNQ2 POTASSIUM CHANNELS.Alessandro Alaimo, Pilar Areso, Alvaro Villarroel.3523-POS BOARD #B247INTERPLAY BETWEEN CALMODULIN AND THE CA 2+CHANNEL BETA SUBUNIT IN CA 2+ -DEPENDENTINACTIVATION OF THE L-TYPE CHANNEL CA V 1.2.Zulfiqar A. Malik, Madeline Shea, Mark E. Anderson,Johannes W. Hell.3524-POS BOARD #B248ROLE OF AKAP150 IN THE REGULATION OF THE SYNAPTICL-TYPE CHALCIUM CHANNEL CAV1.2. Mingxu Zhang,Hai Qian, Johannes W. Hell.3525-POS BOARD #B249THE SECOND LOOP OF ORAI CHANNELS FINE-TUNES CA 2+FEEDBACK REGULATION. Rainer Schindl, Irene Frischauf,Judith Bergsmann, Christoph Romanin.3526-POS BOARD #B250POSITIVELY CHARGED AS WELL AS HYDROPHOBIC AMINOACIDS IN ORAIS’ CONSERVED N-TERMINAL DOMAINCONTRIBUTE TO ORAI FUNCTION. Isabella Derler,Barbara Lackner, Judith Bergsmann, Marc Fahrner, Klaus Groschner,Christoph Romanin.3527-POS BOARD #B251REGULATORY ROLE OF N-TERMINAL ORAI DOMAINS INCURRENT ACTIVATION. Judith Bergsmann, Isabella Derler,Marc Fahrner, Klaus Groschner, Christoph Romanin.3528-POS BOARD #B252CONFORMATIONAL REARRANGEMENT WITHIN STIM1 C-TERMINUS CRUCIAL FOR COUPLING TO ORAI1.Martin Muik, Marc Fahrner, Rainer Schindl, Isabella Derler,Irene Frischauf, Judith Bergsmann, Reinhard Fritsch, Klaus Groschner,Christoph Romanin.3529-POS BOARD #B253CCH1 RESTORES INTRACELLULAR CALCIUM IN FUNGALCELLS DURING ER STRESS. Min-Pyo Hong, Kiem Vu,Jennifer Bautos, Angie Gelli.3530-POS BOARD #B254SERCA AND IP3R EXPRESSION AND FUNCTION INVASCULAR SMOOTH MUSCLE IS ALTERED THROUGHOUTATHEROSCLEROTIC PROGRESSION. Marie-Ann Ewart,John G. McCarron, Simon Kennedy, Susan Currie.3531-POS BOARD #B255EXTRACELLULAR CA2+ AND GLUTAMATE MODULATINGTHE FUNCTION OF METABOTROPIC GLUTAMATERECEPTOR 1 ALPHA (MGLUR1·). Yusheng Jiang.3532-POS BOARD #B256EXPRESSION AND REGULATION OF SHARK NCX GENE INTRANSGENIC MOUSE HEART. Sarah Haviland, Lars Cleemann,Tim McQuinn, Michael Kern, Martin Morad.Exocytosis & Endocytosis II(Boards #B257-#B278)3533-POS BOARD #B257CHEMOMECHANICAL REGULATION OF SNARE PROTEINSSTUDIED WITH MOLECULAR DYNAMICS SIMULATIONS.Lars Bock, Brian Hutchings, Helmut Grubmüller, Dixon J. Woodbury.3534-POS BOARD #B258SNARE COMPLEX ASSEMBLY IN RETINAL BIPOLAR NEURONEXOCYTOSIS. Proleta Datta, Leigh Beth Curtis, Roger Janz,Ruth Heidelberger.3535-POS BOARD #B259ROLE OF THE SYNAPTOBREVIN C-TERMINUS IN FUSIONPORE FORMATION. Annita Ngatchou, Kassandra Kisler,Qinghua Fang, Alexander M. Walter, Ying Zhao, Dieter Bruns,Jakob B. Sørensen, Manfred Lindau.3536-POS BOARD #B260EFFECTS OF RAB3 AND RAB27 ON EXOCYTOTIC ACTIVITYAND DOCKING IN MOUSE CHROMAFFIN CELLS.Widmann W. Hoerauf, Stephen A. Ernst, Arasakumar Subramani,Edward L. Stuenkel.3537-POS BOARD #B261LINK BETWEEN STRUCTURE AND COOPERATIVITY IN THEC2A DOMAINS OF SYNAPTOTAGMIN. Kerry Fuson,Kristofer Knutson, Austin Meyer, Jake W. Gauer, Jesse Murphy,Anne Hinderliter, R. Bryan Sutton.3538-POS BOARD #B262QUANTITATIVE ANALYSIS OF DOMAIN FORMATION AFTERSNARE MEDIATED FUSION OF SYNAPTIC VESICLES.Fabio Fernandes, Matthew Holt, Geert Bogaart, Erwin Neher.3539-POS BOARD #B263PRIMED VESICLES OF THE READILY RELEASABLE POOLAPPEAR TO BE IN A HEMIFUSED STATE.Svetlana N. Melnikova, Jurgen Klingauf.3540-POS BOARD #B264TOWARDS REAL TIME ANALYSIS IN PHOTOACTIVATIONLOCALIZATION MICROSCOPY. Martin Wiemhoefer,Daniel Boening, Julia Trahe, Jürgen Klingauf.3541-POS BOARD #B265SYNTAXIN1A DISPERSION AND ASSESSMENT OF CIS-SNARE-COMPLEX FORMATION-DISASSEMBLY DURING SYNAPTICTRANSMISSION IN HIPPOCAMPAL NEURONS.Vadim E. Degtyar, Robert S. Zucker.160Biophysical Society 54th Annual Meeting

3542-POS BOARD #B266SYNAPTOTAGMIN-1 AND COMPLEXIN-2 WORKCOOPERATIVELY TO PROMOTE EXOCYTOSIS FROMADRENAL CHROMAFFIN CELLS. Chad P. Grabner,Gustavo Guzman, Paanteha Kamalimoghadam, Yvonne Schwarz,Dieter Bruns.3543-POS BOARD #B267COMPLEXIN AND SYNAPTOTAGMIN IN SYNAPTICFUNCTION AND PLASTICITY. Ramon A. Jorquera,Richard W. Cho, Sarah Huntwork, Lauren Barr, J. Troy Littleton.3544-POS BOARD #B268A ROLE FOR DYSFERLIN AND AGATOXIN SENSITIVECALCIUM CHANNELS IN THE CALCIUM-TRIGGEREDSECRETION OF ATP FOLLOWING PLASMA MEMBRANEWOUNDING. Srinagesh V. Koushik, Jose Fernando Covian-Nares,Henry L. Puhl III, Steven S. Vogel.3545-POS BOARD #B269EVOKED CATECHOLAMINE RELEASE FROM SYMPATHETICNERVE TERMINALS IN CARDIAC SLICES. J. Lu, Y. Xiu, Y. Mu,S. Guo, X. Y. Zhang, H. D. Xu, H. Q. Dou, Q. Li, X. J. Kang,L. N. Liu, Y. T. Yang, C. X. Zhang, L. H. Li, J. M. Cao, Zhuan Zhou.3546-POS BOARD #B270A PERMISSIVE ROLE FOR PROTEIN KINASE A IN SUPPORTOF EPAC AGONIST-STIMULATED HUMAN ISLET INSULINSECRETION. George G. Holz, Oleg G. Chepurny, Colin A. Leech,Igor Dzhura, Grant G. Kelley, Michael W. Roe, Elvira Dzhura,Xiangquan Li, Frank Schwede, Hans-G Genieser.3547-POS BOARD #B271TIRF MICROSCOPY STUDY OF EXOCYTOTIC ATP RELEASEFROM A549 EPITHELIAL CELLS. Irina Akopova, Sabina Tatur,Mariusz Grygorczyk, Ignacy Gryczynski, Zygmunt Gryczynski,Julian Borejdo, Ryszard Grygorczyk.3548-POS BOARD #B272ARACHIDONIC ACID/PPARA ENHANCEMENT OF CA2+-REGULATED EXOCYTOSIS IN ANTRAL MUCOUS CELLS OFGUINEA PIG. Takashi Nakahari.3549-POS BOARD #B273DOPAMINE PRODUCTION IN THE PANCREATIC ‚-CELLS: APOSSIBLE AUTOCRINE REGULATORY MECHANISM FORINSULIN SECRETION. Alessandro Ustione, David W. Piston.3550-POS BOARD #B274CHOLESTEROL STABILIZES THE FUSION PORE OF RATCHROMAFFIN GRANULES BEFORE ITS RAPID DILATION.Frederick W. Tse, Nan Wang, Christina Kwan, Xiandi Gong,Elena Posse de Chaves, Amy Tse.3551-POS BOARD #B275INTEGRATION OF ELECTRICAL STIMULATION TOGETHERWITH ELECTROCHEMICAL MEASUREMENT OF QUANTALEXOCYTOSIS ON MICROCHIPS. Jaya Ghosh, Kevin Gillis.3552-POS BOARD #B276QUANTITATIVE MODELING OF SYNAPTIC RELEASE AT THEPHOTORECEPTOR SYNAPSE. Gabriel Duncan, Katalin Rabl,Ian Gemp, Wallace B. Thoreson, Ruth Heidelberger.3553-POS BOARD #B277INERTIA OF SYNAPTIC VESICLE EXOCYTOSIS. Oliver Welzel,Teja W. Groemer, Jasmin Jung, Armin M. Stroebel, Katrin Ebert,Johannes Kornhuber, Andreas W. Henkel.3554-POS BOARD #B278SIMULTANEOUS OPTICAL-ELECTRICAL MEASUREMENT OFTHE DELAY BETWEEN FORMATION OF THE FUSION POREAND PROTON EQUILIBRATION IN EXOCYTOSIS OF SINGLEVESICLES. Daniel Steinbrenner, Nadine Harmel, Nikolaj Klöcker,Jan C. Behrends.Intracellular Channels (Boards #B279-#B282)3555-POS BOARD #B279FUNCTIONAL PROPERTIES OF SR CL - AND K + CHANNELSDURING POSTNATAL DEVELOPMENT OF CARDIACMUSCLE. Maura Porta, Kristin Harris, Eric Winkel,Josefina Ramos-Franco, Rafael Mejia-Alvarez.3556-POS BOARD #B280ROLE OF TRIC-A CHANNEL IN CIRCULATORY FUNCTION.Daiju Yamazaki, Satomi Kita, Shinji Komazaki, Aya Mishima,Miyuki Nishi, Takahiro Iwamoto, Hiroshi Takeshima.3557-POS BOARD #B281TIC110 A CHANNEL-FORMING PROTEIN AT THE INNERENVELOPE OF CHLOROPLASTS ELECTROPHYSIOLOGY ANDREGULATION. Tom A. Goetze, Richard Wagner, Monica Balsera,Bettina Bölter, Jürgen Soll.3558-POS BOARD #B282LUMINAL CA 2+ IS A MAJOR SENSITISER OF TWO-PORECHANNELS TO NAADP. Samantha Jane Pitt, Tim Funnell,Michael X. Zhu, Mano Sitsapesan, Elisa Venturi, John Parrington,Magarida Ruas, Antony Galione, Rebecca Sitsapesan.Membrane Transporters & Exchangers II(Boards #B283-#B306)3559-POS BOARD #B283FUNCTIONAL RECONSTITUTION OF INFLUENZA A M2 (22-62). Ted J. Ryser, Daniel Inouye, Spencer Funk, Emily Peterson,Mukesh Sharma, Timothy A. Cross, David D. Busath.3560-POS BOARD #B284YERSINIA TRANSLOCON COMPLEXES ARE STABILIZED INNANOLIPOPROTEIN PARTICLES (NLPS). Jenny A. Cappuccio,Craig D. Blanchette, Erin S. Arroyo, Angela K. Hinz,Feliza A. Bourguet, Todd A. Sulchek, Brent W. Segelke,Paul D. Hoeprich, Brett A. Chromy, Matthew A. Coleman.3561-POS BOARD #B285LOCATION OF TRANSMEMBRANE SEGMENTS OF NA + /CA 2+EXCHANGER NCX1 INVESTIGATED WITH CHEMICALCROSSLINKERS. Xiaoyan Ren, Debora A. Nicoll,Kenneth D. Philipson.3562-POS BOARD #B286CA 2+ -INDUCED CONFORMATIONAL CHANGES OF NA + -CA 2+EXCHANGER DIMERS: ROLE OF CA 2+ BINDING DOMAINS.Michela Ottolia, Bernard Ribalet, John Scott, Kenneth D. Philipson.3563-POS BOARD #B287THE ROLE OF MICROSCOPIC INTERACTIONS FOREFFECTIVE ANTIBIOTIC DELIVERY ACROSS THE BACTERIALOUTER MEMBRANE. Brigitte Ziervogel,Balasundaresan Dhakshnamoorthy, Lydia Blachowicz, Benoit Roux.3564-POS BOARD #B288TOWARDS A CELL-FREE ASSAY TO INVESTIGATE LIPIDBILAYER PERMEATION AND EFFLUX TRANSPORT OFTHERAPEUTIC AGENTS. Denise I. Ilgen, Sara Belli, Klaus Eyer,Vivianne Hermann, Stefanie D. Krämer.3565-POS BOARD #B289CLASSIFICATION OF HUMAN SOLUTE CARRIERSUPERFAMILY MEMBERS REVEALS FUNCTIONALSIMILARITIES ACROSS FAMILIES. Avner Schlessinger, Andrej Sali.3566-POS BOARD #B290MODEL-STRUCTURE, MUTAGENESIS AND FUNCTIONALCHARACTERISTICS OF THE HUMAN TRANSPORTER, NHA2.Maya Schushan, Minghui Xiang, Etana Padan, Rajini Rao,Nir Ben-Tal.3567-POS BOARD #B291FUNCTIONAL RECONSTITUTION OF A BICOMPONENT ABCTRANSPORTER. Mohammad M. Mohammad, David J. Niedwiezki,Xianming Lin, Richard D. Veenstra, Liviu Movileanu.WEDNESDAYWednesday, February 24, 2010, San Francisco, California161

3568-POS BOARD #B292NEW IMMOBILIZED PROTEOLIPOSOME-BASED BIOSENSORSYSTEM FOR INVESTIGATING HUMAN ATP-BINDINGCASSETTE TRANSPORTERS. Patrick Seelheim, Michael Seifert,Hans-Joachim Galla.3569-POS BOARD #B293FUNCTIONALLY ROTATING MECHANISM OF A MULTIDRUGTRANSPORTER STUDIED BY COARSE-GRAINEDSIMULATION. Xin-Qiu Yao, Hiroo Kenzaki, Shoji Takada.3570-POS BOARD #B29 4ALL-ATOM MOLECULAR DYNAMICS SIMULATION OFBACTERIAL MULTIDRUG EFFLUX TRANSPORTERS ACRB.Tsutomu Yamane, Mitsunori Ikeguchi.3571-POS BOARD #B295STRUCTURE-FUNCTION ANALYSIS OF ABCB1PHARMACOGENOMICS AND ALTERATIONS IN P-GLYCOPROTEIN TRANSPORT. Alana A. White,J. B. Alexander Ross, Erica L. Woodahl.3572-POS BOARD #B296FUNCTIONAL ROTATION OF THE TRANSPORTER ACRB: THEESSENTIALS OF PERISTALTIC MOTION AND SUBSEQUENTSUBSTRATE EXTRUSION. Robert Schulz, Attilio Vittorio Vargiu,Francesca Collu, Ulrich Kleinekathöfer, Paolo Ruggerone.3573-POS BOARD #B297TRANSPORT INHIBITORS CAUSE CONFORMATIONALCHANGES IN THE YEAST MITOCHONDRIAL CITRATETRANSPORT PROTEIN RECONSTITUTED IN LIPOSOMES ASDEMONSTRATED BY EPR SPECTROSCOPY. Ronald S. Kaplan,June A. Mayor, Jiakang Sun, Rusudan Kotaria, Kyoung Joon Oh.3574-POS BOARD #B298CHARACTERIZATION OF SUBSTRATE BINDING BY THEBACTERIAL ASPARTATE TRANSPORTER GLT PH THROUGHEQUILIBRIUM AND STOPPED-FLOW TRYPTOPHANFLUORESCENCE MEASUREMENTS. David Ewers, Toni Becher,Rabea Krefft, Patricia Hidalgo, Christoph Fahlke.3575-POS BOARD #B299DETECTION OF SUBSTRATE-DEPENDENTCONFORMATIONAL CHANGES IN HP1 OF THE GLUTAMATETRANSPORTER GLTPH. Derek Francis, David S. Cafiso,Joseph A. Mindell.3576-POS BOARD #B300MECHANISM OF INTERACTION OF THE GLUTAMATETRANSPORTER EAAC1 WITH K+. Christof Grewer.3577-POS BOARD #B301SEQUENCE OF EVENTS IN THE EXTRACELLULAR HALF OFTHE TRANSPORT CYCLE IN GLUTAMATE TRANSPORTER.Zhijian Huang, Emad Tajkhorshid.3578-POS BOARD #B302STRUCTURAL TRANSITION BETWEEN THE ION-RELEASINGAND ION-BINDING STATES OF A SECONDARY MEMBRANETRANSPORTER. Jing Li, Emad Tajkhorshid.3579-POS BOARD #B303MODELING OF THE INWARD-FACING STATE OF LEUT ANDDYNAMICS OF THE OUTWARD-TO-INWARD TRANSITION.Saher A. Shaikh, Emad Tajkhorshid.3580-POS BOARD #B304MOLECULAR DETERMINANTS OF THE STOICHIOMETRY OFTRANSPORT IN GLPT. Giray Enkavi, Emad Tajkhorshid.3581-POS BOARD #B305CONFORMATIONAL CHANGES IN THE APCT AMINO ACIDTRANSPORTER: MONTE CARLO NORMAL MODEFOLLOWING. Gennady V. Miloshevsky, Ahmed Hassanein,Peter C. Jordan.3582-POS BOARD #B306THE ALLOSTERIC ROLE OF ION BINDING IN THEFUNCTIONAL MECHANISMS OF TRANSPORTERS WITHLEUT FOLD. Lei Shi, Harel Weinstein.Membrane Domains & Lipid Dynamics(Boards #B307-#B314)3583-POS BOARD #B307NEUROLIGIN-1 OLIGOMERIZATION INDUCES CELLMORPHOLOGY CHANGES VIA LIPID DOMAINNUCLEATION. Nicole Mende, Sophie Pautot.3584-POS BOARD #B308DON’T FENCE ME IN: EVIDENCE FOR A ‘FENCE’ THATIMPEDES THE DIFFUSION OF PIP2 INTO AND OUT OFNASCENT PHAGOSOMES IN MACROPHAGES.Urszula P. Golebiewska, Jason Kay, Sergio Grinstein, Wonpil Im,Richard Pastor, Suzanne Scarlata, Stuart McLaughlin.3585-POS BOARD #B309HARD TO FENCE YOU IN: COMPUTATIONAL APPROACHESTO EXPLORE THE HYPOTHESIS THAT ACTIN FILAMENTSIMPEDE PIP2 DIFFUSION IN MEMBRANES. Wonpil Im,Stuart McLaughlin, Richard W. Pastor.3586-POS BOARD #B310REGIONS OF CORRELATED FLUCTUATIONS IN MEMBRANELIPID CONCENTRATIONS AS A CONSEQUENCE OFCHARGED CYTOPLASMIC LIPIDS. Michael Schick,Gregory G. Putzel.3587-POS BOARD #B311PROBING SPATIAL ORGANIZATION IN CELL MEMBRANE ATTHE IMMUNOLOGICAL SYNAPSE. Yan Yu, Jay T. Groves.3588-POS BOARD #B312THE EFFECTS OF HIGH VOLTAGES ON THE MORPHOLOGYOF A DPPC LIPID BILAYER. Kasper E. Feld.3589-POS BOARD #B313LYSOPHOSPHATIDIC ACID INTERACTIONS WITH MODELMEMBRANES: A NOVEL CELL SIGNALING REGULATORYMECHANISM? Evan Mintzer.3590-POS BOARD #B314MOLECULAR HYDRATION INVESTIGATED USINGEXTENDED MEMBRANE SURFACES. Adriana L. Rogozea,Matthew J. Justice, Horia I. Petrache.Signaling & Membrane Transformations(Boards #B315-#B326)3591-POS BOARD #B315DETERMINATION OF THRESHOLD FORCES FOR TETHERFORMATION IN VESICLES. Daniel Stark, Thomas Killian,Robert Raphael.3592-POS BOARD #B316QUANTIFYING PATHOGEN RECOGNITION OF THE CELLMEMBRANE: SIMPLE SUGARS SIMULATE THE FUNCTIONSOF COMPLEX GLYCANS. Xiaoyang Zhu, Athena Guo.3593-POS BOARD #B317DYNAMICAL BASIS OF THE ENHANCEMENT OF THEENZYMATIC ACTIVITY OF FACTOR VIIA BY TISSUE FACTOR.Y. Zenmei Ohkubo, Emad Tajkhorshid.3594-POS BOARD #B318REGULATION OF PHOSPHOLIPASE C BETA - RAC1CYTOSKELETAL PATHWAYS BY GAMMA SYNUCLEIN.Urszula P. Golebiewska, Jason-Flor Sisante, Jaak Raudsepp,Gyongyi Mihalyne, Suzanne Scarlata.3595-POS BOARD #B319PTEN AND CI-VSP SHOW SIMILAR PHOSPHOINOSITIDEBINDING PREFERENCES. Arne Gericke, Roberta E. Redfern,Alonzo Ross, Carlos A. Villalba-Galea, Ernesto Vargas,Francisco Bezanilla, Jerome Lacroix.3596-POS BOARD #B320MEMBRANE PHOSPHATIDYLSERINE AND PLASMA CA2+LEVELS SWITCH FACTOR XA FROM AN INACTIVE DIMERTO AN ACTIVE MONOMER. Tilen Koklic, Rinku Majumder,Barry R. Lentz.162Biophysical Society 54th Annual Meeting

3597-POS BOARD #B321QUANTITATIVE ANALYSIS OF BINDING AFFINITIES OFPI(4,5)P2 SENSOR DOMAINS IN LIVING CELLS BY USING THEVOLTAGE-CONTROLLED PI(4,5)P2-5’-PHOSPHATASE, CI-VSP.Christian R. Halaszovich, Daniela N. Schreiber, Dominik Oliver.3598-POS BOARD #B322OPTICAL CONTROL OF CELL DEATH: TRANSLATION OF ATEMPORAL PROCESS TO A SPATIAL DISPLAY. Ann E. Oliver,Viviane Ngassam, Atul N. Parikh.3599-POS BOARD #B323PATCH CLAMPED GIANT UNILAMELLAR VESICLESCONTAINING RECONSTITUTED ION CHANNELS.Marcus D. Collins, Sharona E. Gordon.3600-POS BOARD #B324PH DOMAIN MUTATION ALTERS MEMBRANE TARGETINGSPECIFICITY OF GRP1 AND AKT. Carissa Pilling.3601-POS BOARD #B325ENGINEERED NANOLIPOPROTEINS AS BIOSYNTHETICDECOYS FOR PATHOGEN-BINDING. Atul N. Parikh,Daniel Bricarello, Emily J. Mills, Jitka Petrlova, John Voss.3602-POS BOARD #B326CRYSTALLIZATION OF CALCIUM CARBONATE VATERITEASSOCIATED WITH LIQUID CRYSTAL IN EMBRYONIC YOLKSACS. Xuehong Xu, MengMeng Xu, Odell Jones, Guanliang Cao,Bryant Joseph, Guifang Yan, Chuyu Zhang.Voltage-gated Ca Channels II(Boards #B327-#B346)3603-POS BOARD #B327STIM1 BINDS TO AND INHIBITS CAV1.2 VOLTAGE GATEDCALCIUM CHANNELS. Chan Young Park, Aleksandr Shcheglovitov,Ricardo E. Dolmetsch.3604-POS BOARD #B328OXYGEN-SENSING OF L-TYPE CALCIUM CHANNELS IN RATCARDIOMYOCYTES: THE POSSIBLE ROLE OFHEMOXYGENASE. Angelo O. Rosa, Lars Cleemann, Martin Morad.3605-POS BOARD #B329A NEW PARADIGM FOR GEM REGULATION OF VOLTAGE-GATED CA 2+ CHANNELS. Mingming Fan, Jian Yang.3606-POS BOARD #B330THE SUBUNIT OF VOLTAGE-GATED CA 2+ CHANNELSACTS AS A TRANSCRIPTIONAL REGULATOR. Yun Zhang,Yoichi Yamada, Mingming Fan, Saroja D. Bangaru, Bochao Lin,Jian Yang.3607-POS BOARD #B331INCREASED INTRACELLULAR MAGNESIUM ATTENUATES-ADRENERGIC STIMULATION OF THE CARDIAC CAV1.2CHANNEL. Sylvain Brunet, Todd Scheuer, William A. Catterall.3608-POS BOARD #B332LOCALIZED CALCINEURIN IN CALCIUM- DEPENDENTINACTIVATION OF L-TYPE CALCIUM CHANNELS.William A. Sather, Seth F. Oliveria, Mark L. Dell’Acqua.3609-POS BOARD #B333 MINORITY BIOPHYSICISTS TRAVELAWARDEESUMOYLATION OF VOLTAGE-GATED ALPHA1A CALCIUMCHANNELS. Maria A. Davila, Haiyan Chen,Erika S. Piedras-Renteria.3610-POS BOARD #B334REM2 REDISTRIBUTES IN RESPONSE TO NEURONALSTIMULATION. Robyn Flynn, Michael A. Colicos,Gerald W. Zamponi.3611-POS BOARD #B335PLASMA MEMBRANE TARGETING OF HIGH-VOLTAGEACTIVATED CALCIUM CHANNELS. Benoîte Bourdin,Florian Le Coz, Fabrice Marger, Alexandra Raybaud, Yolaine Dodier,Hélène Klein, Rémy Sauvé, Lucie Parent.3612-POS BOARD #B336ASSOCIATION OF VOLTAGE-GATED CALCIUM CHANNELSUBUNIT 2 -3 WITH LIPID RAFTS: STRUCTURAL ANDFUNCTIONAL IMPLICATIONS. Ivan Kadurin, Anthony Davies,Anita Alvarez Laviada, Leon Douglas, Annette C. Dolphin.3613-POS BOARD #B337CABP1 REGULATES BOTH CA AND BA CURRENTSTHROUGH CA(V)1.2 (L-TYPE) CALCIUM CHANNELS.Shimrit Oz, Adva Benmocha, Amy Lee, Nathan Dascal.3614-POS BOARD #B338MOLECULAR BASIS OF A C TERMINAL MODULATORYMECHANISM IN CA V 1.3 VOLTAGE-GATED CA 2+ CHANNELS.G. Juhasz-Vedres, F. Hechenblaikner, A. Lieb, M. Gebhart,J. Cimerman, M. J. Sinnegger-Brauns, J. Striessnig, A. Koschak.3615-POS BOARD #B339THE REGULATION OF N-TYPE (CA V 2.2) VOLTAGE-GATEDCALCIUM CHANNELS BY CA V SUBUNIT N- AND C-TERMINAL VARIABLE DOMAINS. Lele Song, Laura Roberts,Elizabeth Fitzgerald.3616-POS BOARD #B340GAMMA1 SUBUNIT RENDERS CAV1.2 CHANNELSDEPENDENT ON CELL CYCLE. Anna Angelova,Alexandra Ulyanova, Roman Shirokov.3617-POS BOARD #B341REMODELLING CA 2+ RESPONSIVENESS OF CA V 2.3 BY CA V BSUBUNITS: ROLE OF AN N-TERMINAL POLYACIDIC MOTIF.Vicenta Salvador-Recatala, Robert M. Greenberg.3618-POS BOARD #B342OLIGOMERIZATION OF CA V SUBUNITS IS AN ESSENTIALCORRELATE OF CA 2+ CHANNEL ACTIVITY. Qi Zong Lao,Evgeny Kobrinsky, Nikolai Soldatov.3619-POS BOARD #B343INTERACTION OF THE CALCIUM CHANNEL 2 / 1 SUBUNITWITH AN ATP SYNTHASE IN THE PLASMA MEMBRANE OFMUSCLE CELLS. Jesus Garcia-Martinez.3620-POS BOARD #B344ACTIVITY-DEPENDENT CAV1.2 CLUSTER SURFACEEXPRESSION IN INSULIN-SECRETING CELLS. Enming Zhang,Pawel Buda, Taman Mahdi, Thomas Reinbothe, Jörg Striessnig,Erik Renström.3621-POS BOARD #B345VASCULAR CAV1.2 EXPRESSION IS INCREASED INATHEROSCLEROSIS. Wenze Wang, Sung W. Rhee,Jawahar L. Mehta, Philip Palade.3622-POS BOARD #B346EXPRESSION OF CALCIUM CHANNEL SUBUNITS INMESENCHYMAL STEM CELLS UNDERGOING MUSCLEDIFFERENTIATION. Liliana Grajales, David Geenen, Jesus Garcia.Inward Rectifier K Channels(Boards #B347-#B374)3623-POS BOARD #B347RADIOLYTIC FOOTPRINTING REVEALS CONFORMATIONALCHANGES DURING POTASSIUM CHANNEL GATING.Sayan Gupta, Rhijuta D’Mello, Mark R. Chance, Vassiliy N. Bavro,Catherine Venien-Bryan, Stephen J. Tucker.3624-POS BOARD #B348STRUCTURAL DYNAMICS OF KIRBAC1.1 PROBED BYFLUORESCENT LABELING AND FRET. Shizhen Wang,Sarah Heyman, Decha Enkvetchakul, Colin G. Nichols.3625-POS BOARD #B349NOVEL INSIGHTS INTO THE OUTER PORE DOMAINSTRUCTURE IN INWARD RECTIFIER CHANNELS KIR 2.3.Oana N. Ureche, Ravshan Baltaev, Liviu Ureche,Nathalie Strutz-Seebohm, Florian Lang, Guiscard Seebohm.WEDNESDAYWednesday, February 24, 2010, San Francisco, California163

3626-POS BOARD #B350A CONSERVED ARGININE NEAR THE SELECTIVITY FILTEROF KIR1.1 CONTROLS RB/K SELECTIVITY. Henry Sackin,Mikheil Nanazashvili, Hui Li, Lawrence G. Palmer.3627-POS BOARD #B351CHARACTERIZATION OF THE LIPOSOMAL RUBIDIUMUPTAKE ASSAY. Ninder Panesar, Decha Enkvetchakul.3628-POS BOARD #B352CHANGES IN T-TUBULAR POTASSIUM REVEALED BYINWARD RECTIFIER I K1 TAIL CURRENTS IN MOUSEVENTRICULAR MYOCYTES. Lufeng Cheng, Fuzhen Wang,Tiffany Yang, Anatoli N. Lopatin.3629-POS BOARD #B353A STRUCTURAL MODEL OF A KIR CHANNEL IN THE OPENSTATE DERIVED FROM MUTAGENIC SCANNING OF THEPORE GATING ENERGETICS. Murali K. Bollepalli, Philip Fowler,Markus Rapedius, Man-Jiang Xie, Lijun Shang, Hariolf Fritzenschaft,Mark Sansom, Stephen J. Tucker, Thomas Baukrowitz.3630-POS BOARD #B354PH-DEPENDENT GATING MECHANISM OF KIR2.1 INWARDRECTIFIER K+ CHANNEL INDEPENDENT OF POLYAMINEAND MAGNESIUM BLOCK. Keiko Ishihara, Ding-Hong Yan,Tsuguhisa Ehara.3631-POS BOARD #B355THE SITE FOR DOCKING CATIONS IN CYTOPLASMICDOMAIN OF INWARD RECTIFIER K + CHANNELS.Atsushi Inanobe, Atsushi Nakagawa, Yoshihisa Kurachi.3632-POS BOARD #B356VOLTAGE DEPENDENCE OF KIR2.1 BLOCK BYINTRACELLULAR SPERMINE. Hyeon-Gyu Shin, Yanping Xu,Zhe Lu.3633-POS BOARD #B357A MULTICISTRONIC 2A-PEPTIDE-BASED VECTORENCODING FOR CI-VSP AND A PAIR OF FRET SENSORS TOSTUDY EFFECTS OF PIP 2 -DEPLETION ON RECEPTOR-ACTIVATED GIRK CURRENT. Fabian Hertel, Agathe Switalski,Kirsten Bender, Marie-Cecile Kienitz, Lutz Pott.3634-POS BOARD #B358CAVEOLIN-1 INHIBITS VASCULAR KATP CHANNELS BYMODULATING CHANNEL SENSITIVITY TO MGADP.Lowri M. Davies, Gregor I. Purves, Richard Barrett-Jolley,Caroline Dart.3635-POS BOARD #B359DIFFERENTIAL PKC ISOFORM REGULATION OF K ATPCHANNEL TRAFFICKING AND FUNCTION. Paul T. Manna,Andrew J. Smith, Sarah Fletcher, Asipu Sivaprasadarao.3636-POS BOARD #B360INTRACELLULAR MECHANISMS RESPONSIBLE FOR PKGSTIMULATION OF ATP-SENSITIVE POTASSIUM CHANNELS.Yong-ping Chai, Yu-Fung Lin.3637-POS BOARD #B361INVESTIGATING THE PIP2 BINDING SITE IN KIR CHANNELSVIA MULTI-SCALE BIOMOLECULAR SIMULATIONS.Phillip J. Stansfeld, Richard J. Hopkinson, Frances M. Ashcroft,Mark S. P. Sansom.3638-POS BOARD #B362FUNCTIONAL CHARACTERIZATION OF THE ANDERSEN-TAWIL SYNDROME ASSOCIATED MUTATION (M307I) INKCNJ2. Bi-Hua Tan, Chunhua Song, Stacie L. Kroboth, Qing Zhou,Sinisa Dovat, Michael J. Ackerman, Janathan C. Makielski,Lee L. Eckhardt.3639-POS BOARD #B363EXPLORING THE INWARDLY RECTIFYING POTASSIUMCHANNEL KIR2.1 AND ANDERSEN’S SYNDROME IN THESKELETAL MUSCLE. Dina Simkin, Nicolas Guy, Frederic Brau,Jacques Barhanin, Alain Lacampagne, Said Bendahhou.3640-POS BOARD #B364FUNCTIONAL CHARACTERIZATION OF MUTATIONS INKIR4.1 (KCNJ10) ASSOCIATED WITH THE SESAMESYNDROME. Monica Sala-Rabanal, Misty J. Eaton,Colin G. Nichols.3641-POS BOARD #B365IDENTIFICATION OF A HETEROZYGOUS SULFONYLUREARECEPTOR 1 MUTATION THAT EXERTS A STRONGDOMINANT-NEGATIVE EFFECT ON K ATP CHANNELRESPONSE TO MGADP. Qing Zhou, Carmit Avnon Ziv,Benjamin Glaser, David H. Zangen, Show-ling Shyng.3642-POS BOARD #B366SULFONYLUREA RECEPTOR TRANSMEMBRANE DOMAINZERO MUTATIONS THAT DISRUPT FULL LENGTH ANDMINIMAL ATP-SENSITIVE POTASSIUM CHANNELPROPERTIES. Emily B. Pratt, Paul Tewson, Show-Ling Shyng.3643-POS BOARD #B367HOW DO MUTATIONS IN M0 OF KCNJ11 PRODUCEDIABETES? Andrey P. Babenko.3644-POS BOARD #B368IDENTIFICATION OF THE ALCOHOL ACTIVATION SITE INGIRK CHANNELS. Prafulla Aryal, Hay Dvir, Senyon Choe,Paul A. Slesinger.3645-POS BOARD #B369THE OUTER TRANSMEMBRANE DOMAIN IS INVOLVED IN ASLOW VOLTAGE-DEPENDENT GATE IN A K+ CHANNEL.Gerhard Thiel, Dirk Baumeister, Mattia DiFrancesco, Stefan M. Kast,Anna Moroni.3646-POS BOARD #B370THE LIPID DEPENDENCE OF PURIFIED ANDRECONSTITUTED KIR2.1 AND KIR2.2. Wayland W. L. Cheng,Nazzareno D’Avanzo, Decha Enkvetchakul, Colin G. Nichols.3647-POS BOARD #B371DIRECT REGULATION OF PROKARYOTIC KIR CHANNEL BYCHOLESTEROL. Dev K. Singh, Avia Rosenhouse-Dantsker,Colin G. Nichols, Decha Enkvetchakul, Irena Levitan.3648-POS BOARD #B372FUNCTIONAL RECONSTITUTION OF A GIRK1-CHIMERAAND ITS REGULATION BY THE SUBUNITS OF GPROTEINS. Edgar Leal-Pinto, Yacob Gomez-Llorente,Shobana Sundaram, Qiong-Yao Tang, Iban Ubarretxena,Diomedes E. Logothetis.3649-POS BOARD #B373EXPRESSION AND PURIFICATION OF RECOMBINANTHUMAN INWARD RECTIFIER K + (KCNJ) CHANNEL.Nazzareno D’Avanzo, Wayland W. L. Cheng, Liang Dong,Colin G. Nichols, Declan A. Doyle.3650-POS BOARD #B374PURIFIED HETERO-TETRAMERS OF THE POTASSIUMCHANNEL KCV REVEALING INDEPENDENT SUBUNITCONTRIBUTION TO THE TEA BLOCK. Qiulin Tan, Li-Qun Gu.Ligand-gated Channels (Boards #B375-#B397)3651-POS BOARD #B375DESENSITIZATION CONTRIBUTES TO THE POSTSYNAPTICRESPONSE OF IONOTROPIC RECEPTORS; A COMPARATIVESTUDY OF CYS-LOOP, PURINERGIC, AND GLUTAMATERECEPTOR-CHANNELS. David Papke,Giovanni Gonzalez-Gutierrez, Claudio Grosman.3652-POS BOARD #B376EFFECTS OF PROTONS ON MACROSCOPIC AND SINGLE-CHANNEL CURRENTS MEDIATED BY THE HUMAN P2X7RECEPTOR. Bente Flittiger, Manuela Klapperstueck,Guenther Schmalzing, Fritz Markwardt.3653-POS BOARD #B377P2X7 RECEPTOR-MEDIATED DISRUPTION OF THE PLASMAMEMBRANE AND ENDOPLASMIC RETICULUMMORPHOLOGY AND CELL SURVIVAL. Melanija Tomic,Zonghe Yan, Suo Li, Arthur Sherman, Stanko S. Stojilkovic.164Biophysical Society 54th Annual Meeting

3654-POS BOARD #B378REDOX MODULATION OF ATP-GATED P2X7 CURRENTS.Damien S. K. Samways, Terrance M. Egan.3655-POS BOARD #B379IDENTIFYING THE ION ACCESS PATHWAY TO THETRANSMEMBRANE PORE IN P2X RECEPTORS.Toshimitsu Kawate, Mufeng Li, Shai D. Silberberg, Kenton J. Swartz.3656-POS BOARD #B380CHARACTERIZATION OF SHARK ASIC1B, AN ANCIENTFORM OF AN ACID-SENSING ION CHANNEL.Andreas Springauf, Stefan Gründer.3657-POS BOARD #B381THE 1-2 LINKER IN THE EXTRACELLULAR DOMAIN OFASIC1 DETERMINES DESENSITIZATION OF ASIC1.Tianbo Li, Cecilia M. Canessa.3658-POS BOARD #B382MULTISITE BINDING OF ANESTHETICS TO GLIC, APENTAMERIC LIGAND-GATED ION CHANNEL. Qiang Chen,Mary Hongying Cheng, Hilary Stevenson, Yan Xu, Pei Tang.3659-POS BOARD #B383MUTATIONAL ANALYSIS OF THE PROKARYOTICPENTAMERIC LIGAND-GATED ION CHANNEL GLIC.Borna Ghosh, Susan Hanson, Cynthia Czajkowski.3660-POS BOARD #B384MOLECULAR DYNAMICS INVESTIGATION OF ANESTHETICHALOTHANE INTERACTIONS WITH THE PROTON-GATEDION CHANNEL GLIC. Mary Hongying Cheng, Yan Xu,Rob D. Coalson, Pei Tang*.3661-POS BOARD #B385PACKING OF THE EXTRACELLULAR DOMAINHYDROPHOBIC CORE IS EVOLUTIONARILY OPTIMIZED TOFACILITATE PENTAMERIC LIGAND-GATED ION CHANNELACTIVATION. Cosma D. Dellisanti, Sonya M. Hanson, Lin Chen,Cynthia Czajkowski.3662-POS BOARD #B386SITE-SPECIFIC FLUORESCENCE REVEALS DISTINCTSTRUCTURAL CHANGES INDUCED IN THE HUMAN 1 GABARECEPTOR BY INHIBITORY NEUROSTEROIDS.Gustav Akk, Ping Li, Alpa Khatri, John Bracamontes, David S. Weiss,Joe Henry Steinbach.3663-POS BOARD #B387MOLECULAR DYNAMICS SIMULATIONS OF THE GABA TYPEA RECEPTOR. Timothy Carpenter, Felice Lightstone.3664-POS BOARD #B388AN ELECTROPHYSIOLOGY ASSAY FOR THE FASTCHARACTERIZATION OF GABAA ION CHANNELMODULATORS. Qin Chen, Ian Spencer, Juliette Johnson,Cristian Ionescu-Zanetti.3665-POS BOARD #B389CHARACTERIZATION OF THE ETOMIDATE BINDING SITEIN EXPRESSED ALPHA1BETA3 GABAAR BY PHOTOAFFINITYLABELING. David C. Chiara, Zuzana Dostalova, Aiping Liu,Xiaojuan Zhou, Stuart A. Forman, Keith W. Miller, Jonathan B. Cohen.3666-POS BOARD #B390EFFECT OF GABA CONCENTRATION ON CURRENT-VOLTAGE PROPERTIES OF THE GABA(A) RECEPTOR.Kate O’Toole, Andrew Jenkins.3667-POS BOARD #B391MOLECULAR DETERMINANTS IN GLYCINE AND GABA-ARECEPTORS THAT SENSE INTRACELLULAR CHLORIDECONCENTRATION. Mirko Moroni, Marco Beato, Lucia G. Sivilotti.3668-POS BOARD #B392MICROSECOND SIMULATIONS SHOW THAT ETHANOLBINDS BETWEEN SUBUNITS AND STABILIZES THE OPENFORM OF A GLYCINE RECEPTOR MODEL. Samuel Murail,Björn Wallner, James R. Trudell, Edward Bertaccini, Erik Lindahl.3669-POS BOARD #B393THE ACTIVATION MECHANISM OF THE RAT HOMOMERICALPHA2 GLYCINE RECEPTOR. Paraskevi Krashia, Remigijus Lape,Lucia Sivilotti.3670-POS BOARD #B394TRANSIENT CURRENTS FROM GLYCINE RECEPTORSDEPEND ON INTRACELLULAR CHLORIDE. Ewa Nurowska,James P. Dilger.3671-POS BOARD #B395A NOVEL MECHANISM FOR THE INHIBITORY ACTION OFHYDROCORTISONE AT 5-HT 3 A RECEPTOR. Natalia Andersen,Jeremias Corradi, Cecilia B. Bouzat.3672-POS BOARD #B396ANALYSIS OF CORA-CATALYZED MG2+ SELECTIVECURRENTS IN XENOPUS OOCYTES. Olivier Dalmas,Walter Sandtner, Jose S. Santos, Ludivine Frezza, Luis G. Cuello,Francisco Bezanilla, Eduardo Perozo.3673-POS BOARD #B397MECHANISM OF REGULATION OF KEF CHANNELS BYCHEMICALLY DIVERSE GLUTATHIONE MOLECULES.Tarmo P. Roosild, Samantha Castronovo, Jess Healy, Samantha Miller,Tim Rasmussen, Wendy Bartlett, Stuart Conway, Ian R. Booth.Cyclic Nucleotide-gated Channels(Boards #B398-#B407)3674-POS BOARD #B398LIGAND BINDING AND ACTIVATION GATING INCNGA2A4B1B CHANNELS. Vasilica Nache, Jana Kusch,Christoph Biskup, Thomas Zimmer, Eckhard Schulz, Volker Hagen,Frank Schwede, Wolfgang Bönigk, Klaus Benndorf.3675-POS BOARD #B399SITE-SPECIFIC PROTEIN LABELING USING REVERSIBLETRANSITION METAL ION BINDING. Michael C. Puljung,William N. Zagotta.3676-POS BOARD #B400CYCLIC NUCLEOTIDE GATED CHANNELS HAVE AFUNCTIONAL VOLTAGE SENSOR DISABLED BYHYDROPHOBIC INTERACTIONS. Arin S. Marchesi,Monica Mazzolini, Vincent Torre.3677-POS BOARD #B401INTERACTION ENERGIES BETWEEN INTRACELLULARREGIONS IN CNG CHANNEL ACTIVATION. Jana Kusch,Thomas Zimmer, Josh Holschuh, Christoph Biskup, Eckhard Schulz,Vasilica Nache, Klaus Benndorf.3678-POS BOARD #B402STRUCTURAL INSIGHT INTO THE ION SELECTIVITY ANDCA 2+ BLOCKAGE IN CYCLIC NUCLEOTIDE GATEDCHANNELS. Mehabaw Derebe, Weizhong Zeng, Youxing Jiang.3679-POS BOARD #B403SUBUNIT-SPECIFIC REGULATION OF PHOTORECEPTORCNG CHANNELS BY PHOSPHOINOSITIDES. Gucan Dai,Elizabeth Rich, Lane Brown, Michael Varnum.3680-POS BOARD #B404TRANSFERRING S3-S4 MOTIF FROM KV CHANNELS TO THECNG CHANNEL. Angelica Lopez-Rodriguez, Miguel Holmgren.3681-POS BOARD #B405CAESIUM PERMEATION REVEALS AN UNUSUAL VOLTAGEDEPENDENT GATING AT THE SELECTIVITY FILTER OFCNGA1 CHANNELS. Arin S. Marchesi, Monica Mazzolini,Vincent Torre.3682-POS BOARD #B406FUNCTIONAL EXPRESSION AND SUBCELLULARLOCALIZATION OF F-CHANNELS IN HUMAN VENTRICULARAND HESC-DERIVED CARDIOMYOCYTES. Laura Sartiani,Alexis Bosman, Valentina Spinelli, Martina Del Lungo,Alessandro Mugelli, Marisa Jaconi, Elisabetta Cerbai.WEDNESDAYWednesday, February 24, 2010, San Francisco, California165

3683-POS BOARD #B407VOLTAGE GATED TRAPPING OF FCAMP IN HCN2CHANNELS. Jana Kusch, Susanne Thon, Christoph Biskup,Eckhard Schulz, Thomas Zimmer, Klaus Benndorf.Ion Channels, Other II (Boards #B408-#B419)3684-POS BOARD #B408DESCENT OF THE PRION PROTEIN GENE FAMILY FROMTHE EXTRACELLULAR DOMAIN OF AN ANCESTRAL ZIPMETAL ION TRANSPORTER. Holger Wille, Sepehr Ehsani,Joel C. Watts, David Westaway, Gerold Schmitt-Ulms.3685-POS BOARD #B40996 PARALLEL GIGASEAL PATCH CLAMP RECORDINGS.Andrea Bruggemann, Cecilia Farre, Timo Stengel, Claudia Haarmann,Christian Patzig, Christian Grad, Corinna Voll, Bertholt Heintzel,Stephanie Simmel, Juergen Steindl, Niels Fertig, Michael George.3686-POS BOARD #B410ACID EXTRUSION FROM HUMAN SPERMATOZOA ISMEDIATED BY FLAGELLAR HV1 PROTON CHANNEL.Polina V. Lishko, Andriy Fedorenko, Inna L. Botchkina,Yuriy Kirichok.3687-POS BOARD #B411ION CHANNEL RECONSTITUTION ON A PORE-SUSPENDINGMEMBRANE ON MICROSTRUCTURED GLASS CHIP:TOWARDS ARTIFICIAL GAP JUNCTION FORMATIONBETWEEN BILAYERS AND CELLS. Mohamed Kreir,Christoph Methfessel, Michael Habig, Mathias Winterhalter,Niels Fertig.3688-POS BOARD #B412VIRAL AND HOST CHANNELS: A COMPARISON.Wolfgang B. Fischer.3689-POS BOARD #B413CHANNELRHODOPSIN-2 VARIANTS WITH ACCELERATEDAND DECELERATED CHANNEL KINETICS. Andre Berndt,Katja Stehfest, Dietrich Gradmann, Peter Hegemann.3690-POS BOARD #B414VSOP/HV1 PROTON CHANNELS SUSTAIN SUPEROXIDEPRODUCTION, CALCIUM ENTRY, AND CELL MIGRATION BYLIMITING THE DEPOLARIZATION AND ACIDIFICATION OFACTIVATED NEUTROPHILS. Antoun El Chemaly,Yoshifumi Okochi, Mari Sasaki, Serge Arnaudeau, Yasushi Okamura,Nicolas Demaurex.3691-POS BOARD #B415DESIGN OF A POTENT AND SELECTIVE SMALL MOLECULEKV1.5 BLOCKER. Ananthakrishnan Sankaranarayanan.3692-POS BOARD #B416USING DOMAIN BASED DISCOVERY METHODS TOIDENTIFY PROKARYOTIC COUNTERPARTS TO EUKARYOTICPROTEIN ION CHANNELS. Eric Jakobsson, Gloria Rendon,Ruth Kantorovitz, Jeffrey Tilson, Mao-Feng Ger.3693-POS BOARD #B417A NOVEL FLUORESCENCE ASSAY FOR VOLTAGE-GATED IONCHANNELS BASED UPON LIGHT INDUCED VOLTAGECLAMP. Ulrich Pehl, Sonja Kleinlogel, Ingo Janausch, Bela Kelety,Ernst Bamberg.3694-POS BOARD #B418FUNCTIONAL STUDIES OF VOLVOX CHANNELRHODOPSINCHIMERAS. Matthias Prigge, Franziska Schneider,Satoshi S. P. Tsunoda, Peter Hegemann.3695-POS BOARD #B419K2P1 ASSEMBLES WITH K2P3 OR K2P9 TO FORM SUMO-REGULATED TASK BACKGROUND CHANNELS.Leigh D. Plant, Leandro Zúñiga, Sonia Olikara, Jeremy D. Marks,Steve A. N. Goldstein.Excitation-Contraction Coupling II(Boards #B420-#B441)3696-POS BOARD #B420THE EFFECT OF APELIN ON SINGLE ISOLATED CARDIACMYOCYTES FROM WILD-TYPE AND APELIN / APJ KO MICE.Christian Bollensdorff, David Charo, Michael Ho, Giovanni Fajardo,Daniel Bernstein, Thomas Quertermous, Euan Ashley, Peter Kohl.3697-POS BOARD #B421MECHANISM OF THE SPONTANEOUS BEATING OFSKELETAL-BASED PRECURSOR OF CARDIOMYOCYTES(SPOC). Takayuki Miyanishi, Takao Shioya, Nagomi Kurebayashi,Takashi Murayama, Masahiro Oono.3698-POS BOARD #B422CARDIAC ACTION POTENTIAL MODEL WITH SPATIALSUBCELLULAR CALCIUM CYCLING AND PHYSIOLOGICALTRANSMEMBRANE CURRENTS. Daisuke Sato, Donald M. Bers.3699-POS BOARD #B423ROLE OF MICROSCOPIC HETEROGENEITIES IN THEORGANIZATION OF CARDIAC SARCOPLASMIC RETICULUMIN THE GENESIS OF CALCIUM ALTERNANS. Andriy Belevych,George E. Billman, Sandor Gyorke.3700-POS BOARD #B424ACTIVATION OF REVERSE NA+-CA2+ EXCHANGE BY THENA+ CURRENT DURING AN ACTION POTENTIALAUGMENTS THE CALCIUM TRANSIENT: EVIDENCE FROMNCX KNOCKOUT MICE. Robert K. Larbig, Natalia Torres,John H. B. Bridge, Joshua I. Goldhaber, Kenneth D. Philipson.3701-POS BOARD #B425MODULATION OF L-TYPE CALCIUM CURRENT BYCALCIUM-DEPENDENT MECHANISM IN TROUTVENTRICULAR MYOCYTES. Cros Caroline, Sallé Laurent,Warren E. Daniel, Shiels A. Holly, Fabien Brette.3702-POS BOARD #B426OSMOLARITY MODULATION OF CA2+ ENTRY IN DEPLETEDAND NON-DEPLETED, CPA POISONED, MURINE SKELETALMUSCLE FIBERS. Pura Bolaños, Alis Guillen, Carlo Caputo.3703-POS BOARD #B427PROPERTIES OF STORE OPERATED CA 2+ ENTRY INMALIGNANT HYPERTHERMIA SUSCEPTIBLE HUMANSKELETAL MUSCLE FIBRES. Adrian M. Duke, Philip M. Hopkins,Jane P. Halsal, Derek S. Steele.3704-POS BOARD #B428PASSIVE ACTIVATION OF STORE-OPERATED CA2+ ENTRY INMYOTUBES DEPENDS ON THE RATE OF RYR1-DEPENDENTCA2+ LEAK. Viktor Yarotskyy, Robert T. Dirksen.3705-POS BOARD #B429EXPRESSION OF FUNCTIONAL TRANSGENIC ALPHA1S-DHPRCHANNELS IN ADULT MAMMALIAN SKELETAL MUSCLEFIBERS. Marino G. Di Franco, Marbella Quinonez, Philip Tran,Julio L. Vergara.3706-POS BOARD #B430AN IMPORTANT FRACTION OF THE MAMMALIANSKELETAL MUSCLE CHLORIDE CONDUCTANCE ISLOCATED IN THE TRANSVERSE TUBULES. Alvaro Herrera,Marino DiFranco, Julio L. Vergara.3707-POS BOARD #B431SKELETAL MUSCLE FIBERS OF COLD-ACCLIMATED MICEDISPLAY INCREASES IN BASAL CALCIUM, MITOCHONDRIALCONTENT AND FATIGUE RESISTANCE. Håkan Westerblad,Takashi Yamada, Joseph D. Bruton.3708-POS BOARD #B432ALLELE SPECIFIC GENE SILENCING IN AUTOSOMAL-DOMINANT SKELETAL MYOPATHIES. Ryan E. Loy,Mohammed A. Mostajo-Radji, John D. Lueck, Robert T. Dirksen.3709-POS BOARD #B433INCREASED FATIGUE IN SARCOGLYCAN KNOCK OUTMOUSE SKELETAL MUSCLE FIBERS. Jorge A. Sanchez,Maria C. Garcia, Ramon Coral, Alhondra Solares.166Biophysical Society 54th Annual Meeting

3710-POS BOARD #B434NUCLEAR TRANSLOCATION AND POSSIBLETRANSCRIPTIONAL REGULATION IN SKELETAL MUSCLE BYCAV‚1A. Jackson Taylor, Tan Zhang, Claudia Hereñú,Osvaldo Delbono.3711-POS BOARD #B435EFFECTS OF DOMAIN PEPTIDE DP4 ON DEPOLARIZATION-INDUCED CALCIUM TRANSIENTS AND CALCIUMCURRENTS IN VOLTAGE-CLAMPED FIBERS FROM MOUSEFDB SKELETAL MUSCLE. Rotimi O. Olojo,Erick O. Hernández-Ochoa, Noriaki Ikemoto, Martin F. Schneider.3712-POS BOARD #B436SMALL ANKYRIN 1 ORGANIZES THE CA2+ STORES OF THESARCOPLASMIC RETICULUM IN SKELETAL MUSCLE.Andrew P. Ziman, Maegen A. Ackermann, W. J. Lederer,Robert J. Bloch.3713-POS BOARD #B437INCREASED CA SPARKS AND WAVES FREQUENCY ANDUNCHANGED [NA] I IN HEARTS FROM ANKYRIN-BHETEROZYGOUS MICE. Emmanuel Camors, Peter J. Mohler,Donald M. Bers, Sanda Despa.3714-POS BOARD #B438REGULATION OF E-C COUPLING VIA TRI AND FKBP12.Cheng Long, JianJun Xu, Johanna Lanner, KeKe Dong,Susan L. Hamilton.3715-POS BOARD #B439EXPOSURE TO HIGH GLUCOSE ALTERS ACTIONPOTENTIAL-INDUCED CA2+ TRANSIENTS AND ENHANCESNFAT5 EXPRESSION AND NUCLEAR TRANSLOCATION INCULTURED ADULT MOUSE SKELETAL MUSCLE FIBERS.Erick O. Hernández-Ochoa, Minerva Contreras, Patrick Robison,Tiansheng Shen, Martin F. Schneider.3716-POS BOARD #B440ASSOCIATION OF THE ALPHA1S I/II LOOP PEPTIDE WITHBETA1A RESULTS IN TRANSLOCATION OF THE COMPLEXTO THE CELL SURFACE AND IN CLUSTERING.Alexander Polster, Symeon Papadopoulos.3717-POS BOARD #B441IN VITRO INTERACTIONS BETWEEN THE BETA 1A SUBUNITOF THE SKELETAL MUSCLE DHPR AND RYR1. Robyn Rebbeck,Yamuna Karunasekara, Esther M. Gallant, Llara Weaver,Nicole A. Beard, Marco G. Casarotto, Angela F. Dulhunty.Cardiac Muscle III (Boards #B442-#B470)3718-POS BOARD #B442HEART FAILURE SWITCHES RV INOTROPIC RESPONSESFROM NEGATIVE TO POSITIVE. Guanying Wang,Che-Chung Yeh, Brian C. Jensen, Michael J. Mann, Paul C. Simpson,Anthony J. Baker.3719-POS BOARD #B443IN VITRO MOTILITY STUDIES OF C-TERMINAL MYOSINREGULATORY LIGHT CHAIN MUTANTS IMPLICATED INFAMILIAL HYPERTROPHIC CARDIOMYOPATHY.William M. Schmidt, James Watt, Katarzyna Kazmierczak, Jeff Moore,Danuta Szczesna-Cordary.3720-POS BOARD #B444SINGLE MOLECULE KINETICS IN THE FAMILIALHYPERTROPHIC CARDIOMYOPATHY RLC-R58Q MUTANTMOUSE HEART. Prasad Mettikolla, Rafal Luchowski, Shande Chen,Zygmunt Gryczynski, Ignacy Gryczynski, Danuta Szczesna-Cordary,Julian Borejdo.3721-POS BOARD #B445CONTRACTION-MEDIATED DAMAGE IN MDX MICETRABECULAE: A MODEL FOR CARDIOMYOPATHY INDUCHENE MUSCULAR DYSTROPHY. Ying Xu,Jill A. Rafael-Fortney, Paul M. L. Janssen.3722-POS BOARD #B446MYOFILAMENT FORCE DEVELOPMENT IS LESS ECONOMICIN POST-INFARCT REMODELED MYOCARDIUM.Jolanda van der Velden, Nicky M. Boontje, Daphne Merkus,Ger J. M. Stienen, Dirk J. Duncker.3723-POS BOARD #B447MYOSIN HEAVY CHAIN ISOFORM EXPRESSION ANDCONTRACTILE FUNCTION IN MECHANICALLY UNLOADEDLEFT VENTRICLES FOLLOWING LEFT VENTRICULAR ASSISTDEVICE (LVAD) IMPLANTATION. Matthew R. Locher,Holly S. Norman, Satoru Osaki, Takushi Kohmoto, Nancy K. Sweitzer,Richard L. Moss.3724-POS BOARD #B448MYOFIBRILLAR PROTEIN EXPRESSION ANDCONTRACTILITY IN NEONATES AND INFANTS WITHCONGENITAL RIGHT VENTRICULAR OUTFLOWOBSTRUCTION. Fatiha Elhamine, Bodgan Iorga, Gerardus Bennink,Konrad Brockmeier, Robert Stehle, Gabriele Pfitzer.3725-POS BOARD #B449SEX DIMORPHIC MYOFILAMENT FUNCTION AND AMPKEXPRESSION IN R403Q HEARTS. John P. Konhilas.3726-POS BOARD #B450INTRALIPID PROTECTS CARDIAC FUNCTION OF LATEPREGNANT MICE AGAINST ISCHEMIA/REPERFUSIONINJURY. Jingyuan LI, Andrea Ciobotaru, Soban Umar,Parisa Partownavid, Siamak Rahman, Mansoureh Eghbali.3727-POS BOARD #B451INTRALIPID INDUCES CARDIOPROTECTION AGAINSTISCHEMIA-REPERFUSION INJURY BY INHIBITING THEMITOCHONDRIAL PERMEABILITY TRANSITION POREOPENING VIA THE PI3K/AKT PATHWAY. Siamak Rahman,Jean Chrisostome Bopassa, Jingyuan Li, Soban Umar,Andrea Ciobotaru, Parisa Partownavid, Mansoureh Eghbali.3728-POS BOARD #B452PROTEASOME ACTIVITY IS REDUCED AT THE END OFPREGNANCY AND FULLY RESTORED TO NON-PREGNANTLEVELS ONE WEEK POSTPARTUM IN THE MURINE HEAR.Andrea Ciobotaru, Shannamar Dewey, Soban Umar, Aldrin V. Gomes,Mansoureh Eghbali.3729-POS BOARD #B453SEPSIS RELATED C5A PEPTIDE CAUSES CALCIUMOVERLOAD IN ADULT CARDIAC MYOCYTES. Todd J. Herron,Gelareh Atefi, Jose Jalife, Peter A. Ward.3730-POS BOARD #B454SHORT-RANGE MECHANICAL PROPERTIES OFMYOCARDIUM FROM DIABETIC RATS. Mihail I. Mitov,Leigh Ann Callahan, Kenneth S. Campbell.3731-POS BOARD #B455INCREASED PHOSPHORYLATION OF MYOFILAMENTPROTEINS AFTER STRETCH IN RABBIT VENTRICULARMYOCARDIUM. Michelle M. Monasky, Paul M. L. Janssen.3732-POS BOARD #B456A SYSTEMS BIOLOGY APPROACH TO RESTRICTIVECARDIOMYOPATHY IN DROSOPHILA. Anthony Cammarato,Nakissa N. Alayari, Marjan Gucek, Mary C. Reedy, Jasma Rucker,Jennifer E. Van Eyk, Robert N. Cole, Brian O’Rourke, Rolf Bodmer,Sanford I. Bernstein, D. Brian Foster.3733-POS BOARD #B457MESENCHYMAL STEM CELLS PROTECT CARDIOMYOCYTES.Dushon DeVere Riley, Terry B. Rogers, Aarif Y. Khakoo,Cecilia A. Frederick, Shibani Pati, Shirley A. Gaa, W. Jonathan Lederer.3734-POS BOARD #B458MECHANICAL AND BIOCHEMICAL CHARACTERISTICS OFHUMAN STEM CELL-DERIVED CARDIOMYOCYTES.Scott D. Lundy, Marieke J. Bloemink, Samantha C. Lynn,Michael A. Geeves, Michael A. Laflamme, Michael Regnier.WEDNESDAYWednesday, February 24, 2010, San Francisco, California167

3735-POS BOARD #B459CELL-SEEDED FIBRIN SCAFFOLDS FOR CARDIAC TISSUEENGINEERING. Kassandra S. Thomson, Gabrielle Robinson,F. Steven Korte, Cecilia Giachelli, Buddy D. Ratner, Marta Scatena,Michael Regnier.3736-POS BOARD #B460CARDIAC SPECIFIC OVEREXPRESSION OF N-RAP INTRANSGENIC MICE. Garland Crawford, Shajia Lu, Justin Dore,Robert Horowits.3737-POS BOARD #B461EXTRACELLULAR MATRIX REMODELLING IN AN OVINEMODEL OF AGEING AND HEART FAILURE. Margaux A. Horn,Helen K. Graham, Mark Hall, Mark A. Richards, Jessica D. Clarke,Katharine M. Dibb, Andrew W. Trafford.3738-POS BOARD #B462INVOLVEMENT OF CALCINEURIN/STAT3 PATHWAYS INHEART HYPERTROPHY DURING PREGNANCY. Soban Umar,Andrea Ciobotaru, Humann Matori, Jingyuan Li, Mansoureh Eghbali.3739-POS BOARD #B463GPER ACTIVATION INHIBITS MITOCHONDRIAPERMEABILITY TRANSITION PORE OPENING VIA ERKPHOSPHORYLATION AND PROVIDES CARDIOPROTECTIONAFTER ISCHEMIA-REPERFUSION. Jean Chrisostome Bopassa,Ligia Toro, Enrico Stefani.3740-POS BOARD #B464OPPOSITE PRODUCTION OF REACTIVE OXYGEN SPECIES BYCOMPLEXES I AND III DURING HEARTISCHEMIA/REPERFUSION. Jean Chrisostome Bopaassa,Netanel Feivel Zilberstein, Ligia Toro, Enrico Stefani.3741-POS BOARD #B465SUB-PROTEOMIC FRACTIONATION OF RAT CARDIACTISSUE: COMPARING ISCHEMIC VS NORMAL REMOTEREGION WITH IN-SOLUTION BASED PROTEOMICS.Chad M. Warren, MS, David L. Geenen, PhD,Donald L. Helseth, Jr., PhD, R. John Solaro, PhD.3742-POS BOARD #B466CONTRACTILE FUNCTION IS ALTERED BY REGULATION OFHO-1 ACTIVITY IN SINGLE ADULT RAT CARDIOMYOCYTES.Sarah Nowakowski, F. Steven Korte, Jun Luo, Margaret Allen,Michael Regnier.3743-POS BOARD #B467STUDY OF O-GLCNACYLATION OF CONTRACTILEPROTEINS IN CARDIAC MYOFIBRILS BY ENZYMATICLABELLING. Man Ching Leung, Andrew E. Messer,O’Neal Copeland, Steven B. Marston.3744-POS BOARD #B468CANNABINOID (CB) RECEPTORS ARE NOT INVOLVED IN A-955840 INDUCED NEGATIVE INOTROPIC EFFECTS INISOLATED CARDIAC MYOCYTES. Zhi Su, Gilbert Diaz,Lee Preusser, Xiaoqin Liu, Michael Dart, Betty Yao, Michael Meyer,James Limberis, Jonathon Green, James Polakowski, Ruth L. Martin,Bryan F. Cox, Gary A. Gintant.3745-POS BOARD #B469EFFECTS OF DEVELOPMENT OF COMPENSATORYHYPERTROPHY ON FORCE FREQUENCY AND BETA-ADRENERGIC RESPONSES. Kaylan M. Haizlip, Paul M. L. Janssen.3746-POS BOARD #B470A NOVEL PLEIOTROPIC EFFECT OF STATINS: ENHANCEDCARDIOMYOCYTE 2-ADRENOCEPTOR RESPONSIVENESS.Sara D. Pugh, Karen E. Porter, Sarah Calaghan.Intracellular Cargo Transport(Boards #B471-#B481)3747-POS BOARD #B471REAL TIME VISUALIZATION OF AXONAL TRANSPORT OFGTPASE RAB7 IN RAT EMBRYONIC DORSAL ROOT GANGLIA.Kai Zhang, Chengbiao Wu, Harsha Mudrakola, Yasuko Osakada,Bianxiao Cui.3748-POS BOARD #B472MODELING CYTOSKELETAL DYNAMICS AND VESICLEMOVEMENTS IN GROWING POLLEN TUBES. Jens Kroeger,Firas Bou Daher, Anja Geitmann.3749-POS BOARD #B473VELOCITIES OF MICROTUBULE-BASED MOTORS IN LIVINGCHLAMYDOMONAS. Jeneva A. Laib, Bela Dhamankar,Robert A. Bloodgood, William H. Guilford.3750-POS BOARD #B474HOW THE FLAGELLUM MEASURES ITS LENGTH.William B. Ludington, Benjamin D. Engel, Wallace F. Marshall.3751-POS BOARD #B475ON THE MOVEMENT OF CARGO DRIVEN BY MOLECULARMOTORS AND THE ASYMMETRIC EXCLUSION PROCESSES.Carla Goldman.3752-POS BOARD #B476SURFACE ADSORPTION OF PROTEIN CORONA CONTROLSTHE CELL INTERNALIZATION MECHANISM OFMULTICOMPONENT LIPOPLEXES IN SERUM.Giulio Caracciolo, Luciano Callipo, Sofia Candeloro De Sanctis,Chiara Cavaliere, Daniela Pozzi, Giuseppe Caruso, Michelle Digman,Susana Sanchez, Enrico Gratton.3753-POS BOARD #B477MORE FREIGHT, MORE ENGINES: FORCE SCALES WITHCARGO SIZE IN A LIVING CELL. Bela Dhamankar, Jeneva A. Laib,Robert A. Bloodgood, William H. Guilford.3754-POS BOARD #B478IN VIVO ORGANELLE TRACKING, CALIBRATION, ANDFORCE MEASUREMENT WITH AN OPTICAL TRAP.Benjamin H. Blehm, Yann R. Chemla, Paul R. Selvin.3755-POS BOARD #B479EFFECTS OF ACTIN FILAMENTS ON NGF RETROGRADETRANSPORT. Yasuko Osakada, Harsha Mudrakola, Kai Zhang,Bianxiao Cui.3756-POS BOARD #B480MEAN TIME AND PROBABILITY TO REACH A STRUCTUREDTARGET. Thibault Lagache, David Holcman.3757-POS BOARD #B481 INTERNATIONAL TRAVEL AWARDEEANOMALOUS DIFFUSIVE BEHAVIOR IN INTRACELLULARTRANSPORT MEDIATED BY MOLECULAR MOTORS.Luciana Bruno, Valeria Levi, Maia Brunstein, Marcelo Despósito.Unconventional Myosins II(Boards #B482-#B498)3758-POS BOARD #B482ELECTRON MICROSCOPY OF MYOSIN 6 MOLECULES.Chun Feng Song, Howard D. White, Folma Buss,John Kendrick-Jones, John Trinick.3759-POS BOARD #B483PROBING MYOSIN-VI PROCESSIVITY USING ARTIFICIALLEVER ARMS. Mary W. Elting, Zev D. Bryant, Jung-Chi Liao,James A. Spudich.3760-POS BOARD #B484COUPLED MYOSIN VI MOTORS FACILITATEUNIDIRECTIONAL MOVEMENT ON AN F-ACTIN NETWORK.Sivaraj Sivaramakrishnan, James Spudich.3761-POS BOARD #B485A MODEL FOR MYOSIN VI KINETICS UNDER LOAD.Peiying Chuan, James A. Spudich, Alexander R. Dunn.3762-POS BOARD #B486SHREC MEASUREMENT OF MYOSIN-VI STEPPING MOTION.Keigo Ikezaki, Mitsuhiro Sugawa, So Nishikawa, Tomotaka Komori,Atsuko Hikikoshi Iwane, Toshio Yanagida.168Biophysical Society 54th Annual Meeting

3763-POS BOARD #B487STEERED MOLECULAR DYNAMICS SIMULATION OFUNFOLDING OF MYOSIN VI PROXIMAL TAIL DOMAIN.Yanxin Liu, Jen Hsin, HyeongJun Kim, Anne Houdusse,H. Lee Sweeney, Paul R. Selvin, Klaus Schulten.3764-POS BOARD #B488DIMERIZATION IS ESSENTIAL FOR THE LARGE STEP SIZE OFMYOSIN VI. Monalisa Mukherjea, Paola Llinas, Daniel Safer,Anne Houdusse, H. Lee Sweeney.3765-POS BOARD #B489CARGO BINDING PROTEINS TRIGGER MYOSIN VIDIMERIZATION. Denis Phichith, Mirko Travaglia, Zhaohui Yang,Daniel Safer, Lee Sweeney.3766-POS BOARD #B490SINGLE-MOLECULE AND MOLECULAR DYNAMICS STUDYOF THE DIMERIZATION OF MYOSIN VI MEDIAL TAILDOMAIN. HyeongJun Kim, Jen Hsin, Yanxin Liu,Monalisa Mukherjea, Daniel Safer, Anne Houdusse, H. Lee Sweeney,Klaus Schulten, Paul R. Selvin.3767-POS BOARD #B491MOUSE MYOSINVIIA IS A MONOMERIC, “SLOW” MOTORWITH AN INTERMEDIATE DUTY RATIO. Jessica Haithcock,Jennifer C. Pinder, Attila Nagy, Walter Stafford, Suzanne Cartwright,Betty Belknap, James R. Sellers, Howard D. White, Eva Forgacs.3768-POS BOARD #B492A COMPARISON OF MECHANICAL PROPERTIES OFDROSOPHILA AND MOUSE MYOSIN 7A. Verl Siththanandan,Andras Kengyel, Yasuharu Takagi, Eva Forgacs, Davin Hong,James Sellers.3769-POS BOARD #B493KINETIC ANALYSIS REVEALS DIFFERENCES IN THE BINDINGMECHANISM OF CALMODULIN AND CALMODULIN-LIKEPROTEIN TO THE 3 IQ MOTIFS IN MYOSIN-10. Ariel J. Caride,Richard D. Bennett, Emanuel E. Strehler.3770-POS BOARD #B494THE MOLECULAR ADAPTATIONS OF MYOSIN X FORBUNDLED ACTIN FILAMENT TRACKS. Ronald S. Rock,Stanislav Nagy, Benjamin Ricca.3771-POS BOARD #B495A STRUCTURED DOMAIN IS RESPONSIBLE FOR BUNDLESELECTION OF MYOSIN X. Stanislav Nagy, Ronald Rock.3772-POS BOARD #B496A RECEPTOR MEDIATED DELIVERY SYSTEM FOR SINGLEMOLECULE IMAGING IN LIVE CELLS. Alicja Janik,Crista M. Brawley, Ronald S. Rock.3773-POS BOARD #B497THE DYNAMICS FOR MYOSIN-X INDUCED FILOPODIAPROTRUSION. Tomonobu M. Watanabe, Hiroshi Tokuo,Kohsuke Gonda, Hideo Higuchi, Mitsuo Ikebe.3774-POS BOARD #B498THE EFFECT OF THE INTERACTION BETWEEN THEMYOSIN-X FERM DOMAIN AND INTEGRIN ON FILOPODIAPROTRUSION. Shugo Nishiyama, Tomonobu Watanabe,Toshio Yanagida, Mitsuo Ikebe.Microtubule Motors-Dynein(Boards #B499-#B506)3775-POS BOARD #B499CYSTEINE MAPPING OF CYTOPLASMIC DYNEIN MOTORDOMAIN. Hikmat N. Daghestani, James F. Conway, Billy W. Day.3776-POS BOARD #B500CYTOPLASMIC DYNEIN IS NOT A CLASSICAL DUTY RATIOMOTOR. Wilhelm Walter, Bernhard Brenner, Walter Steffen.3777-POS BOARD #B501COLLECTIVE DYNAMICS OF CYTOPLASMIC DYNEINMOTORS IN VITRO. Manuel Neetz, Stefan Diez,Iva Toliç-Nørrelykke.3778-POS BOARD #B502 STUDENT TRAVEL AWARDEELIS1 AND NUDE PERMIT MULTIPLE DYNEIN MOTORS TOCOOPERATE TO TRANSPORT HIGH LOADS.Richard J. McKenney, Micahel Vershinin, Ambarish Kunwar,Shahrnaz Kemal, Richard B. Vallee, Steven P. Gross.3779-POS BOARD #B503DYNAMIC REGULATION OF BIDIRECTIONAL VESICLETRANSPORT. Adam G. Hendricks, Jennifer L. Ross, Eran Perlson,Harry W. Schroeder III, Mariko Tokito, Erika L. F. Holzbaur.3780-POS BOARD #B504 INTERNATIONAL TRAVEL AWARDEESTEADY STATES OF A TUG-OF-WAR MODEL FORORGANELLE TRANSPORT. Yunxin Zhang.3781-POS BOARD #B505NON-MONOTONIC FORCE-DISSOCIATION RATE RELATIONIMPROVES ENSEMBLE PERFORMANCE OF MULTIPLEMOLECULAR MOTORS. Ambarish Kunwar, Michael Vershinin,Steven P. Gross, Alexander Mogilner.3782-POS BOARD #B506THE BIREFRINGENCE AND MOLECULAR FINE- STRUCTUREOF AXONEMES. Noda Naoki, Rudolf Oldenbourg.Cell & Bacterial Mechanics & Motility III(Boards #B507-#B535)3783-POS BOARD #B507PHYSICS OF PHAGOCYTOSIS IN SELF RECOGNITION:PARTICLE SIZE AND MYOSIN FORCES. Dennis E. Discher,Pia Rodriguez, Richard Tsai, Kevin Hsu.3784-POS BOARD #B508GROWTH PROCESS AND MECHANICS OF CELL ADHESIONINVESTIGATED BY OPTICAL TWEEZERS. Hideaki Miyoshi,Tadao Sugiura, Kotaro Minato.3785-POS BOARD #B509H2-CALPONIN REGULATES ADHESION AND MIGRATION OFMACROPHAGES. Euy-Myoung Jeong, J.-P. Jin.3786-POS BOARD #B510NUCLEATION AND GROWTH OF INTEGRIN ADHESIONS.Erdinc Atilgan, Ben Ovryn.3787-POS BOARD #B511ADIPOGENIC COMMITMENT OF MESENCHYMAL STEMCELLS REGULATED BY ERM PROTEINS-MEDIATEDCELLULAR BIOMECHANICS. Igor Titushkin, Michael Cho.3788-POS BOARD #B512MECHANICS OF MOLECULAR BOND CLUSTERS BETWEENELASTIC MEDIA: STOCHASTIC-ELASTIC COUPLING IN CELL-MATRIX ADHESION. Jin Qian, Jizeng Wang, Yuan Lin,Huajian Gao.3789-POS BOARD #B513MAPPING ADHESION TURNOVER IN MIGRATING CELLS: ANIMAGE CROSS-CORRELATION STUDY. Tim Toplak,Miguel Vicente Manzanares, Lingfeng Chen, Rick Horwitz,Paul Wiseman.3790-POS BOARD #B514NANOSCALE PROTEIN ARCHITECTURE OF FOCALADHESIONS. Pakorn Kanchanawong, Gleb Shtengle,Erika B. Ramko, Michael W. Davidson, Harald F. Hess,Clare Waterman.3791-POS BOARD #B515MECHANICAL COUPLING THROUGH ENDOTHELIAL CELLADHESIONS DETERMINED USING A NOVEL LIVE-CELLSTRAIN DEVICE. Lawrence Huang, Pattie S. Mathieu,Brian P. Helmke.3792-POS BOARD #B516MIMICKING THE CELLULAR ENVIRONMENT: EFFECTS OFELASTIC NANOPATTERNED SUBSTRATES ON INTEGRIN-MEDIATED CELLULAR INTERACTIONS. Ilia Louban,Christine Selhuber-Unkel, Roberto Fiammengo, Joachim P. Spatz.WEDNESDAYWednesday, February 24, 2010, San Francisco, California169

3793-POS BOARD #B517DEVELOPMENT OF MICROPATTERNED ELASTICGELATINOUS GELS TO CONTROL CELL MECHANOTAXIS.Satoru Kidoaki, Takahito Kawano, Hiroyuki Sakashita.3794-POS BOARD #B518A NOVEL MULTISCALE MODEL OF CELL ADHESION ANDMIGRATION ON DEFINED EXTRACELLULAR MATRICES.Amit Pathak, Sanjay Kumar.3795-POS BOARD #B519MATRIX RIGIDITY MEDIATES GROWTH FACTOR RESPONSEDURING 3D ENDOTHELIAL CELL SPROUTING.Amir Shamloo, Sarah C. Heilshorn.3796-POS BOARD #B520MICROPATTERNING BIOMANUFACTURED SINGLE-DOMAINNANOPARTICLES USING SELF-ASSEMBLY TO FORMARTIFICIAL MAGNETOSOME CHAINS. Warren C. Ruder,Chia-Pei Hsu, Szu-Yuan Chou, Joel T. Dawson, Lina M. Gonzalez,James F. Antaki, Philip R. LeDuc.3797-POS BOARD #B521ON THE MECHANICS OF CELL ADHESION ANDPROLIFERATION ON FRACTAL SURFACES. Francesco Gentile,Luca Tiritano, Edmondo Battista, Enzo Mario Di Fabrizio,Paolo Decuzzi.3798-POS BOARD #B522STUDYING CANCER CELL INVASION IN 3D MICRO-STRUCTURAL MATRICES. Wei Sun, Nicholas Agung Kurniawan,Choon Nam Ong, Raj Rajagopalan, Chwee Teck Lim.3799-POS BOARD #B523A GENETIC STRATEGY FOR GRADED AND DYNAMICCONTROL OF CELL-MATRIX MECHANOBIOLOGY.Joanna L. MacKay, Albert Keung, Sanjay Kumar.3800-POS BOARD #B524TUMOR AND MICRO-ENVIRONMENT: THE ROLE OFPRESSURE IN CANCER PROLIFERATION. Fabien Montel,Markus Basan, Danijela Vignjevic, Laurent Malaquinj, Thomas Risler,Bernard Cabane, Jacques Prost, Giovanni Cappello,Jean-François Joanny.3801-POS BOARD #B525REACTION OF PRIMARY FIBROBLASTS TO WELLCONTROLLED EXTERNAL STRAIN. Uta Zedler, Nico Hampe,Simone Born, Wolfgang Rubner, Sebastian Houben,Norbert Kirchgeßner, Bernd Hoffmann, Samuel Safran, Rudolf Merkel.3802-POS BOARD #B526CELL RESPONSE TO A LOCALLY APPLIED FORCE:MECHANICAL STIFFENING CORRELATED TO ACTINRECRUITMENT. Delphine Arcizet, Francois Gallet, Sylvie Henon.3803-POS BOARD #B527DOES THE EXTERNAL ENVIRONMENT OF CELLS, INADDITION TO THEIR GENETIC PROGRAMS, PLAY A ROLEIN THE LOCALIZATION OF THEIR DIVISION SITES?Stephanie Deboeuf, Maria Kilfoil.3804-POS BOARD #B528CROSSLINKED COLLAGEN FILMS AFFECT CELL STATE.Irena L. Ivanovska, Dennis Discher.3805-POS BOARD #B529BREAST CANCER CELLS REDUCE THE STIFFNESS OFENDOTHELIAL CELLS. Claudia Tanja Mierke, Ben Fabry.3806-POS BOARD #B530FEELING FOR CELLS WITH LIGHT: ILLUMINATING THEROLE OF BIOMECHANICS FOR CANCER METASTASIS.Josef A. Käs, Anatol Fritsch, Franziska Wetzel, Tobias Kiessling,David Nnetu, Mareike Zink.3807-POS BOARD #B531REFRIGERATED VERSUS FRESH HUMAN RED BLOOD CELLSRESPONSE TO SHEER STRESS. Keaten Holley, Daniel B. Erenso,Evan Scott, Anthony L. Farone, Mary B. Farone.3808-POS BOARD #B532HOW DEEP CELLS FEEL. Amnon Buxboim, Shamik Sen,Dennis E. Discher.3809-POS BOARD #B533FIBROBLASTS SENSE SUBSTRATE VISCOSITY.Daniel E. Minner, Phillip Rauch, Joseph Käs, Christoph A. Naumann.3810-POS BOARD #B534 MINORITY BIOPHYSICISTSTRAVEL AWARDEECONTROL OF EXTRACELLULAR MATRIX ORGANIZATIONTHROUGH COUPLED MECHANICAL AND CHEMICALINPUTS. Robert L. Steward Jr., Chao-Min Cheng, Philip LeDuc.3811-POS BOARD #B535CELL-MATRIX DE-ADHESION DYNAMICS REFLECTCONTRACTILE MECHANICS. Shamik Sen, Sanjay Kumar.Oxidative Phosphorylation & MitochondrialMetabolism (Boards #B536-#B557)3812-POS BOARD #B536COUPLED ELECTRON AND PROTON TRANSFER INCOMPLEX I AND COMPLEX IV OF THE RESPIRATORYCHAIN: INSIGHTS FROM COMPUTER SIMULATIONS.Alexei Stuchebrukhov.3813-POS BOARD #B537ELECTROPHYSIOLOGY OF FUNCTIONAL COUPLING OFELECTRON TRANSPORT CHAIN COMPLEXES.Kerstin Diekert, Natalie Watzke, Petr Obrdlik.3814-POS BOARD #B538FLASH INITIATED REDOX EVENTS WITHIN CYTOCHROMEBC1 SUGGEST EQUILIBRATION BETWEEN HEMES B:EFFECTS OF TEMPERATURE, VISCOSITY, INHIBITORS ANDSUBSTRATES. Jeffrey Havens, Quan Yuan, Shaoqing Yang,Chang-An Yu, Linda Yu, Bill Durham, Frank Millett.3815-POS BOARD #B539IN YARROWIA LIPOLITYCA MITOCHONDRIA THEASSOCIATION OF NADH DEHYDROGENASE TYPE II WITHTHE CYTOCHROME COMPLEXES DEPENDS ON THEGROWTH PHASE. Salvador Uribe-Carvajal,Sergio Guerrero Castillo.3816-POS BOARD #B540HALOPHILIC PROPERTIES OF MITOCHONDRIA FROM THESALT-TOLERANT YEAST DEBARYOMYCES HANSENII.Alfredo Cabrera, Sergio Guerrero Castillo, Antonio Peña,Salvador Uribe-Carvajal.3817-POS BOARD #B541“STRUCTURE AND DYNAMICS OF THE EXTERNAL STALK OFTHE FOF1-ATP SYNTHASE”. Oleg A. Volkov, Tassilo Hornung,Susan J. Pandey, Tarek M. Zaida, John G. Wise, Pia D. Vogel.3818-POS BOARD #B542PARTIAL REACTIONS OF THE ATP SYNTHESIS REACTION INTHE E. COLI D380C MUTANT F1FO-ATP SYNTHASE.Mikhail Galkin, Robert Nakamoto.3819-POS BOARD #B543ELECTRIC FIELD DRIVEN TORQUE IN ATP SYNTHASE.John H. Miller, Sladjana Maric, Hans L. Infante, M. Scoppa,M. S. Cheung, James R. Claycomb.3820-POS BOARD #B544CARDIAC PACEMAKER CELLS UNIQUELY MATCH ATPSUPPLY TO DEMAND. Yael Yaniv, Magdalena Juhaszova,Alexey E. Lyashkov, Harold A. Spurgeon, Steven J. Sollott,Edward G. Lakatta.3821-POS BOARD #B545ANALYSIS OF INTRACELLULAR ADP COMPARTMENTATIONREVEALS FUNCTIONAL COUPLING BETWEEN PYRUVATEKINASE AND ATPASES IN RAT CARDIOMYOCYTES.Mervi Sepp, Marko Vendelin, Heiki Vija, Rikke Birkedal.170Biophysical Society 54th Annual Meeting

3822-POS BOARD #B546DIFFUSION RESTRICTIONS IN CARDIOMYOCYTES FROMLOW-PERFORMANCE HEART. Nina Sokolova, Marko Vendelin,Rikke Birkedal.3823-POS BOARD #B547NOVEL METHOD FOR INVESTIGATION OF INTERACTIONSBETWEEN MITOCHONDRIAL CREATINE KINASE ANDADENINE NUCLEOTIDE TRANSLOCASE. Minna Varikmaa,Madis Metsis, Rita Guzun, Tuuli Käämbre, Alexei Grichine,Valdur Saks.3824-POS BOARD #B548VDAC PHOSPHORYLATION REGULATES INTERACTIONWITH TUBULIN. Kely L. Sheldon, Sergey M. Bezrukov,Tatiana K. Rostovtseva.3825-POS BOARD #B549FREE TUBULIN AND CAMP-DEPENDENTPHOSPHORYLATION MODULATE MITOCHONDRIALMEMBRANE POTENTIAL IN HEPG2 CELLS: POSSIBLE ROLEOF VDAC. Eduardo N. Maldonado, Jyoti R. Patnaik,John J. Lemasters.3826-POS BOARD #B550HYPOTHERMIC CARDIOPROTECTION ATTENUATESMITOCHONDRIAL PERMEABILITY TRANSITION POREOPENING AND CALCIUM LOADING IN ISOLATED CARDIACMITOCHONDRIA. Johan Haumann, James S. Heisner,Age D. Boelens, Mohammed Aldakkak, David F. Stowe,Amadou K. S. Camara.3827-POS BOARD #B551BUFFER MAGNESIUM LIMITS MITOCHONDRIAL CALCIUMUPTAKE BUT NOT MATRIX CALCIUM BUFFERING INRESPONSE TO ADP. Age D. Boelens, Ranjan K. Dash,Johan Haumann, Amadou K. S. Camara, Mohammed Aldakkak,Ashish K. Gadicherla, David F. Stowe.3828-POS BOARD #B552COMPLEX I AND F 0 F 1 -ATP SYNTHASE MEDIATE MEMBRANEDEPOLARIZATION AND MATRIX ACIDIFICATION BYISOFLURANE IN MITOCHONDRIA. Danijel Pravdic,Naoyuki Hirata, David F. Stowe, Zeljko J. Bosnjak,Martin Bienengraeber.3829-POS BOARD #B553CA 2+ ENHANCES ROS GENERATION FROM INHIBITEDCOMPLEX I BUT NOT FROM INHIBITED COMPLEX III WITHNADH-LINKED SUBSTRATE. Mohammed Aldakkak,David F. Stowe, Age D. Boelens, Johan Haumann, Ranjan K. Dash,Matthias L. Riess, Amadou K.S. Camara.3830-POS BOARD #B554 INTERNATIONAL TRAVELAWARDEEIDENTIFICATION OF THE MITOCHONDRIAL CARRIERTHAT PROVIDES YARROWIA LIPOLYTICA WITH A FATTYACID- INDUCED AND NUCLEOTIDES- SENSITIVEUNCOUPLING PROTEIN- LIKE ACTIVITY. Luis AlbertoLuévano, Eva Moyano, Mario García de Lacoba, Eduardo Rial,Salvador Uribe- Carvajal.3831-POS BOARD #B555SILYBIN DERIVATIVES MODULATE THYROID HORMONE-MEDIATED UCP2 EXPRESSION IN NEONATAL RATCARDIOMYOCYTES. Martin Modriansky, Eva Gabrielova,Radek Gazak, Martin Jaburek, Pavel Kosina, Jan Vacek, Vladimir Kren.3832-POS BOARD #B556UNCOUPLING AND INWARD MIGRATION OFSUBSARCOLEMMAL MITOCHONDRIA IN RAT HEARTDURING EARLY DIABETES. Chun-Hong Shao, Ming Li, AydinTay, Matthew C. Zimmerman, Lyudmila S. Shlyakhtenko,William G. Mayhan, Gisela Beutner, Shey-Shing Sheu, Keshore Bidasee.3833-POS BOARD #B557FGF21 AND PANCREATIC ISLET FATTY ACID METABOLISM.Mark Y. Sun, Dawn M. Kilkenny, Jonathan V. Rocheleau.Computational Methods III(Boards #B558-#B563)3834-POS BOARD #B558A NEW SEMI-EXPLICIT SOLVATION MODEL: FAST PHYSICSFOR BETTER RESULTS. Charles Kehoe, Christopher Fennell,Ken Dill.3835-POS BOARD #B559NON-LINEAR ANALYSIS OF VOLTAGE CLAMP DATA IN THEINVESTIGATION OF MECHANISMS OF INHERITEDARRHYTHMIAS. Ashley Raba, Jacques Beaumont.3836-POS BOARD #B560MISTY MOUNTAIN CLUSTERING: APPLICATION TO FASTUNSUPERVISED FLOW CYTOMETRY GATING. Istvan P. Sugar,Stuart C. Sealfon.3837-POS BOARD #B561AN INVESTIGATION OF GLUTAMIC ACID 242 AS A PROTONPUMP VALVE IN BOVINE CYTOCHROME C OXIDASE USINGQM/MM MONTE CARLO SIMULATIONS.Benjamin M. Samudio.3838-POS BOARD #B562IONIC EFFECT ON MD-SAXS PROFILE. Tomotaka Oroguchi,Mitsunori Ikeguchi.3839-POS BOARD #B563PARAMETERIZATION OF CB1 NEGATIVE ALLOSTERICMODULATORS FOR CHARMM MOLECULAR DYNAMICS.Hadley A. Iliff, Diane L. Lynch, Evangelia Kotsikorou,Patricia H. Reggio.Regulatory Networks & Systems Biology(Boards #B564-#B582)3840-POS BOARD #B564A SYSTEMS BIOLOGY APPROACH TO UNDERSTANDINGALZHEIMER’S DISEASE. Christina R. Kyrtsos, John S. Baras.3841-POS BOARD #B565A RATCHET MECHANISM FOR LOW-FREQUENCY HEARINGIN MAMMALS. Tobias Reichenbach, A. J. Hudspeth.3842-POS BOARD #B566MODEL OF THE DROSOPHILA CIRCADIAN CLOCK: LOOPREGULATION AND TRANSCRIPTIONAL INTEGRATION.Hassan M. Fathallah-Shaykh.3843-POS BOARD #B567CELLULAR DYNAMICS OF EMBRYOMAS WITHIN ADULTNEOPLASMS. John H. Frenster, Jeannette A. Hovsepian.3844-POS BOARD #B568ANALYTIC PARAMETER FITTING IN STOCHASTIC STEMCELL MODELS. Joshua L. Phillips, Jennifer O. Manilay,Michael E. Colvin.3845-POS BOARD #B569THE OSCILLATORY RHYTHMIC ACTIVITY OF RETINALGANGLION CELL SPIKES MIGHT BE INDUCED BY SLOWWAVE COMPONENT IN RD1 MICE RETINA. Yong Sook Goo,Jang Hee Ye, Sang Baek Ryu, Kyung Hwan Kim.3846-POS BOARD #B570AN ACCELERATED ALGORITHM FOR STOCHASTICSIMULATION OF REACTION-DIFFUSION SYSTEMS USINGGRADIENT-BASED DIFFUSION AND UNIFIED TAU-LEAPING.Wonryull Koh, Kim T. Blackwell.3847-POS BOARD #B571CHOLESKY-LANGEVIN MODEL FOR BIOCHEMICALNETWORKS WITH ACCURATE ACCOUNT OF STOCHASTICEFFECTS OF COUPLINGS BETWEEN MOLECULAR SPECIES.Youfang Cao, Jie Liang.WEDNESDAYWednesday, February 24, 2010, San Francisco, California171

3848-POS BOARD #B572PREDICTING THE TOGGLE SWITCH BISTABILITY FROMMAXIMUM UNCERTAINTY PRINCIPLES. Steve Presse,Kingshuk Ghosh, Ken A. Dill.3849-POS BOARD #B573ON THE EQUIVALENCE OF THE EQUILIBRIUMCORRELATION AND NON-EQUILIBRIUM RESPONSE INSTOCHASTIC BIOCHEMICAL KINETICS.Chao-Ping (Cherri) Hsu, Ching-Cher Sanders Yan.3850-POS BOARD #B574MODULARITY AND CENTRALITY IN METABOLIC NETWORKEVOLUTION. Craig C. Jolley, Aurélien Mazurie, Mark Young,Trevor Douglas.3851-POS BOARD #B575USING EFFECTIVE EMPIRICAL SUB-NETWORKS TO MOVEEQUILIBRIA OF GENE NETWORKS. Gemunu Gunaratne.3852-POS BOARD #B576INVESTIGATING CO-REGULATION NETWORKS USINGGENERATIVE MODELS. Matthew B. Carson, Nitin Bhardwaj,Hui Lu.3853-POS BOARD #B577EVOLUTIONARY SPEED OF ENZYMES FUNCTIONALSURFACES AND THEIR RELATIONSHIP WITH METABOLICFLUXES IN NETWORKS OF CENTRAL CARBON METABOLISMOF BACTERIA. David Jimenez-Morales, Rudong Li, Zhuo Wang,Yingzi Li, Lei Liu, Jie Liang.3854-POS BOARD #B578FUNCTIONAL ASSIGNMENT OF HYPOTHETICAL PROTEINSFROM PROTEIN-PROTEIN INTERACTION NETWORKS.Matthias Meier, Doron Gerber, Stephen Quake.3855-POS BOARD #B579HYDRATION PRESSURE INCREASES IN HEAT-DAMAGEDSKIN:OSMOTIC-STRESS AND HIGH-RESOLUTIONMAGNETIC RESONANCE DATA IMPLICATE LOCALSUPRAMOLECULAR MECHANISMS. Maria P. McGee,Michael Morykwas, Louis Argenta.3856-POS BOARD #B580REACTIVITY OF HUMAN HOLOCARBOXYLASE SYNTHETASETOWARD BIOTIN-ACCEPTING SUBSTRATES. Maria Ingaramo,Dorothy Beckett.3857-POS BOARD #B581BIOLOGICAL FAILURE MODEL FOR PANCREATIC -CELLDYSFUNCTIONS. Hyuk Kang, Kyungreem Han, Jinwoong Kim,Moo Young Choi.3858-POS BOARD #B582NOISE CAN INDUCE STEADY-STATE BIMODALITY INPOSITIVE FEEDBACK LOOPS WITHOUT COOPERATIVITY.Tsz-Leung To, Narendra Maheshri.Vibrational Spectroscopy(Boards #B583-#B595)3859-POS BOARD #B583MICRO-SPECTROSCOPY OF BIOMOLECULES AND CELLS ATVARIABLE PRESSURE IN A MICRO-CAPILLARY.Sang Hoon Park, Silki Arora, Alfons Schulte.3860-POS BOARD #B584RAMAN SPECTROSCOPIC SIGNATURES OF THE METABOLICSTATES OF ESCHERICHIA COLI CELLS AND THEIRDEPENDENCE ON ANTIBIOTICS TREATMENT.Tobias J. Moritz, Douglas S. Taylor, Christopher R. Polage,Denise M. Krol, Stephen M. Lane, James W. Chan.3861-POS BOARD #B585DATA PROCESSING IN FTIR IMAGING OF CELLS ANDTISSUES: TOWARDS PROTEIN SECONDARY STRUCTUREIMAGING. Erik Goormaghtigh, Audrey Bénard, Allison Derenne,Régis Gasper.3862-POS BOARD #B586INTER-RESIDUE COUPLING OF MODEL PPII HELICES USING13C ISOTOPIC LABELING. Heng Chi, Ahmed Lakhani, Anjan Roy,Timothy A. Keiderling.3863-POS BOARD #B587EXPERIMENTAL AND THEORETICAL SPECTROSCOPICSTUDY OF 3 10 HELICAL PEPTIDES USING ISOTOPICLABELING. Ahmed A. Lakhani.3864-POS BOARD #B588ULTRAFAST INTERCONVERSION BETWEEN PROTEINCONFORMATIONAL SUBSTATES: DIRECTLY OBSERVED BY2D IR VIBRATIONAL ECHO SPECTROSCOPY. Sayan Bagchi,Michael D. Fayer.3865-POS BOARD #B589LOW FREQUENCY VIBRATIONS OF BIOLOGICAL SOLIDS:TERAHERTZ, FTIR, INS, RAMAN, DFT, AND BOMDMOLECULAR DYNAMICS OF THE L-SERINE CRYSTAL.Robert W. Williams, Edwin J. Heilweil.3866-POS BOARD #B590STUDYING ELECTROSTATIC FIELDS IN HUMAN ALDOSEREDUCTASE WITH NEW INHIBITOR AS PROBE. Lin Xu.3867-POS BOARD #B591USING DIFFERENCE INFRARED SPECTROSCOPY TOINVESTIGATE THE EFFECTS OF PH ON PGK-SUBSTRATECOMPLEXES. Adam E. Colbert, Gina MacDonald.3868-POS BOARD #B592DETERMINATION OF THE ISOMERIZATION DYNAMICSAND TRANSIENT RING D ORIENTATION CHANGES OF THEPHYTOCHROME PFR FORM IN SOLUTION BYPOLARIZATION RESOLVED FEMTOSECOND VIS PUMP - IRPROBE SPECTROSCOPY. Karsten Heyne, Yang Yang,Martin Linke, Janina Hahn, Peter Schmieder.3869-POS BOARD #B593EFFECTS OF HYDRATION LEVELS ON THE BANDWIDTH OFMICROWAVE RESONANT ABSORPTION INDUCED BYCONFINED ACOUSTIC VIBRATIONS. Tzu-Ming Liu,Hung-Pin Chen, Shih-Chia Yeh, Chih-Yu Wu, Chung-Hsiung Wang,Tang-Nian Luo, Yi-Jan Chen, Shen-Iuan Liu, Chi-Kuang Sun.3870-POS BOARD #B594RAMAN SPECTROSCOPIC DETECTION OF AN OPTICALLYTRAPPED SINGLE DNA MOLECULE. Satish K. Rao, Saurabh Raj,Dmitri Petrov.3871-POS BOARD #B595SINGLE-CELL DIESEL MINING ON MICROALGAE: DIRECTAND QUANTITATIVE MONITORING OF MICROALGAL OILPRODUCTION IN VIVO BY RAMAN SPECTROSCOPY.Huawen Wu, Joanne V. Volponi, Seema Singh.Imaging & Optical Microscopy IV(Boards #B596-#B606)3872-POS BOARD #B596 INTERNATIONAL TRAVELAWARDEEHOW TO USE CONFOCAL MICROSCOPY IN SEARCH OF AHIGHLY RESOLVED HOLOGRAM. Aura I. Moreno-Vega,Carlos Saldaña, Veronica Morales-Tlalpan, Mauricio Diaz-Muñoz,Victor M. Castaño Meneses.3873-POS BOARD #B597IMAGING CONTRAST AND BIOMECHANICS USING OPTICALCOHERENCE TOMOGRAPHY TO SENSESUPERPARAMAGNETIC IRON OXIDE LABELED PLATELETS.Amy L. Oldenburg, Thomas H. Fischer, Caterina M. Gallippi.3874-POS BOARD #B598IMAGING ON NANO-RESOLUTION SCALE OF CARRIERMODIFICATIONS CAUSED BY THERAPEUTICS &DIAGNOSTICS BY FREEZE-FRACTURE TEM.Brigitte Papahadjopoulos-Sternberg.172Biophysical Society 54th Annual Meeting

3875-POS BOARD #B599SYNCHROTRON X-RAY FLUORESCENT IMAGING ANDSPECTROSCOPY STUDIES OF THE ROLE OF COPPER IN THESTEM CELL NICHE ARCHITECTURE OF ADULT NEURALSTEM CELLS. Yulia Pushkar.3876-POS BOARD #B600MRI OF THROMBUS PROPOGATION AFTER PLAQUERUPTURE. James A. Hamilton, Alkystis Phinikaridou.3877-POS BOARD #B601DEVELOPMENT OF AN ORGANOTYPIC SYSTEM TO IMAGEMETASTASIS OF CARCINOID TUMORS IN SITU.Sasi Arunachalam, Riaz Nasim, David Giovannucci.3878-POS BOARD #B602IN VIVO CHONDROCYTE MECHANICS. Ziad Abusara,Andre Leumann, Ruth Seerattan, Walter Herzog.3879-POS BOARD #B603DIFFRACTION PATTERNS OF LIVE C. ELEGANS:ACQUISITION AND ANALYSIS. Jenny Magnes,Kathleen M. Raley-Susman, Rahul Khakurel, Alicia Sampson,Margo Kinneberg, Rebecca Eels.3880-POS BOARD #B604DETECTION OF ANTI-OXIDANT MARKER IN NORMALSUBJECTS AND PATIENTS WITH NEURODEGENERATIVEDISORDERS USING IN VIVO MAGNETIC RESONANCESPECTROSCOPY. Ishima Badhwar, Pravat K. Mandal.3881-POS BOARD #B605FREEZE-FRACTURE TEM ON DOMAINS IN LIPID MONO-AND BILAYER AND PROMOTED BY ANTIMICROBIALPEPTIDES AS A NEW GENERATION OF ANTIBIOTICS.Brigitte Papahadjopoulos-Sternberg, Raquel F. Epand,Richard M. Epand.3882-POS BOARD #B606BIOMETALLIC NANO-STRUCTURES: A THOUSAND-FOLDFLUORESCENCE ENHANCEMENT WITH NANOPETALS.Michelle A. Digman, Chi-Cheng Fu, Giulia Ossato, Luke P. Lee,Enrico Gratton, Michelle Khine.Fluorescence Spectroscopy II(Boards #B607-#B631)3883-POS BOARD #B607THE CONFORMATIONAL CYCLE OF MITOCHONDRIALHSP70. Martin Sikor, Koyeli Mapa, Volodymyr Kudryavtsev,Karin Waegemann, Stanislav Kalinin, Claus AM Seidel, Walter Neupert,Dejana Mokranjac, Don C. Lamb.3884-POS BOARD #B608ACTIN NUCLEATION AND POLYMERIZATIONINVESTIGATED USING FLUORESCENCE FLUCTUATIONSPECTROSCOPY. Nikolaus Naredi-Rainer, Alvaro H. Crevenna,Matthias Höller, Roland Wedlich-Söldner, Don C. Lamb.3885-POS BOARD #B609ALEX SINGLE MOLECULE THREE COLOR IN TIRFMICROSCOPY. Jinwoo Lee, Sungchul Hong Hohng.3886-POS BOARD #B610STRUCTURAL REARRANGEMENTS OF THE MOTORPROTEIN PRESTIN REVEALED BY FLUORESCENCERESONANCE ENERGY TRANSFER. Kristin Rule Gleitsman,Michihiro Tateyama, Yoshihiro Kubo.3887-POS BOARD #B611BINDING KINETICS AND FRACTION OF IMMOBILEENZYMES BOUND TO CELLULOSE FIBRILS STUDIEDTHROUGH CONFOCAL LASER SCANNING FLUORESCENCEMICROSCOPY AND FRAP. Jacob C. Bolewski,Jose M. Moran-Mirabal, Larry P. Walker.3888-POS BOARD #B612EFFECT OF TRIFLUOROETHANOL ON THE TRYPTOPHANSIDE CHAIN ORIENTATION IN THE HYDROPHOBIC COREOF TROPONIN C STUDIED BY NMR AND TIME RESOLVEDFLUORESCENCE. Guoli Wang, Olivier Julien, Abel Jonckheer,Brian D. Sykes, Yves Engelborghs.3889-POS BOARD #B613SINGLE MOLECULE STUDIES OF POLYMERASE DNAINTERACTION WITH TIRF MICROSCOPY. Gregor Heiss,Stephanie Schorr, Thomas Carell, Don C. Lamb.3890-POS BOARD #B614INVESTIGATIONS OF CALMODULIN CONFORMATIONSRESOLVED BY SINGLE MOLECULE MICROSCOPY.Matthew S. DeVore, E. Shane Price, Carey K. Johnson.3891-POS BOARD #B615A FRET-FLIM STUDY REVEALS THE INTERACTIONBETWEEN ALCAM AND ACTIN AS A POTENTIALREGULATOR OF ALCAM BINDING ACTIVITY. Cicerone Tudor,Agnieszka Esseling-Ozdoba, Carl G. Figdor, Hans Kanger,Vinod Subramaniam.3892-POS BOARD #B616SURFACE DIFFUSION OF CELLULASES ON CELLULOSEFIBRILS STUDIED THROUGH FLUORESCENCESPECTROSCOPY. Jose M. Moran-Mirabal, Jacob C. Bolewski,Larry P. Walker.3893-POS BOARD #B617INVESTIGATION OF THE EFFECTS OF CELLULOSEMORPHOLOGY ON SYNERGISM IN CELLULASE MIXTURESUSING QUANTITATIVE FLUORESCENCE MICROSCOPY.Marie K. Donnelly, Jose M. Moran-Mirabal, Stephane C. Corgie,Harold G. Craighead, Larry P. Walker.3894-POS BOARD #B618LIVE CELL FLUORESCENCE ANALYSIS AND MATHEMATICALMODELING OF DUAL MECHANISMS OF CDC42 RECYCLINGIN YEAST: RELATIONSHIP OF INTERNALIZATION RATE ANDMORPHOLOGY. Brian D. Slaughter, Arupratan Das,Boris Rubinstein, Jay Unruh, Joel W. Schwartz, Rong Li.3895-POS BOARD #B619SELF-REFERENCING DIFFERENTIAL SPECTROSCOPYANALYSIS IN BREAST TRANSLATIONAL RESEARCH.Shanshan Xu, Albert Cerussi, Enrico Gratton.3896-POS BOARD #B620DETERMINATION OF REGIONAL DIFFUSION COEFFICIENTSOF FLUORESCENT ATP IN RAT CARDIOMYOCYTES.Ardo Illaste, Martin Laasmaa, David Schryer, Rikke Birkedal,Pearu Peterson, Marko Vendelin.3897-POS BOARD #B621APPLICATION OF PHASOR PLOTS TO ANALYSIS OFFLUOROPHORE HETEROGENEITY, EXCITED STATEREACTIONS AND PROTEIN CONFORMATIONS.Nicholas G. James, Martin ·tefl, Justin A. Ross, David M. Jameson.3898-POS BOARD #B622RECEPTOR-LIGAND INTERACTIONS IN THE PLASMAMEMBRANE OF LIVE CELLS RESOLVED IN SPACE AND TIMEBY N&B ANALYSIS. Christian Hellriegel, Valeria R. Caiolfa,Nicolai Sidenius, Enrico Gratton, Moreno Zamai.3899-POS BOARD #B623ANOMALOUS DIFFUSION AS A READOUT FOR THEFOLDING STATUS OF TRANSMEMBRANE PROTEINS.Nina Malchus, Laura Weimann, Matthias Weiss.3900-POS BOARD #B624COUNTING UP THE MOLECULES IN LIVE BACILLUSSUBTILIS BY FLUCTUATION IMAGING AND ANALYSIS: AN INVIVO STUDY OF TRANSCRIPTIONAL REGULATION.Matthew L. Ferguson, Matthieu Jules, Dominique Le Coq,Stéphane Aymerich, Nathalie Declerck, Catherine A. Royer.WEDNESDAYWednesday, February 24, 2010, San Francisco, California173

3901-POS BOARD #B625AUTOMATED SCREEN OF IN VIVO MOLECULARINTERACTIONS USING FLUORESCENCE CROSS-CORRELATION SPECTROSCOPY (FCCS). William A. Marshall,Christopher Wood, Jay R. Unruh, John T. Dirnberger,Hans-Martin Herz, Winfried Wiegraebe.3902-POS BOARD #B626APPLICATION OF FLUORESCENCE CORRELATIONSPECTROSCOPY TO MEASURE HIGH-DENSITYLIPOPROTEIN (HDL) METABOLISM. Russell Deitrick,Hamid Razzaghi, Emily A. Gibson.3903-POS BOARD #B627IN VIVO IMAGING OF SINGLE-MOLECULETRANSLOCATION THROUGH NUCLEAR PORE COMPLEXESBY PAIR CORRELATION FUNCTIONS. Francesco Cardarelli,Enrico Gratton.3904-POS BOARD #B628FLUORESCENCE CORRELATION SPECTROSCOPY FORCLINICAL TESTING IN VON WILLEBRAND DISEASE.Richard Torres, Michael Levene.3905-POS BOARD #B629DYNAMIC IMAGING AND FLUCTUATION SPECTROSCOPYON SINGLE MICROVILLI IN OPOSSUM KIDNEY CELLS BYTHE MODULATION TRACKING METHOD. Luca Lanzano,Peter Fwu, Hector Giral, Moshe Levi, Enrico Gratton.3906-POS BOARD #B630REGULATION OF CFTR ON THE PLASMA MEMBRANE.Asmahan Abu-Arish, Ian R. Bates, Elvis Pandzic, Angela Ho,John W. Hanrahan, Paul W. Wiseman.3907-POS BOARD #B631PREDICTING PROTEIN CO-EXPRESSION FRACTIONS INLIVING CELLS. Elizabeth M. Smith, Yan Chen, Joachim Mueller.Molecular Mechanics & Force Spectroscopy II(Boards #B632-#B642)3908-POS BOARD #B632DNA STRETCHING KINETICS AND ENTROPICBOTTLENECKS. Lorenzo Bongini, Pasquale Bianco,Vincenzo Lombardi.3909-POS BOARD #B633MULTIPLE BINDING MODES OF ACTINOMYCIN D REVEALTHE BASIS FOR ITS POTENT HIV-1 AND CANCER ACTIVITY.Thayaparan Paramanathan, Ioana D. Vladescu, Micah J. McCauley,Ioulia Rouzina, Mark C. Williams.3910-POS BOARD #B634ATOMISTIC SIMULATION OF ESTROGEN RECEPTOR-COACTIVATOR PEPTIDE COMPLEXES TO IDENTIFYSPECIFIC BINDING SITES. Pradip K. Biswas,Rajendram Rajnarayanan.3911-POS BOARD #B635SOURCES OF HETEROGENEITY IN THE FORCEDUNFOLDING PATHWAY OF STREPTOKINASE BETAREVEALED THROUGH HIGH-TEMPERATURE STEERED MDSIMULATIONS. K. Maria Mills, Dora Guzman, Zhibin Guan,Ioan Andricioaei.3912-POS BOARD #B636EXPLORING THE FUNCTION OF TITIN KINASE BYMECHANICAL SINGLE-MOLECULE PUMP-AND-PROBE.Elias M. Puchner, Hermann E. Gaub.3913-POS BOARD #B637SINGLE MOLECULE STUDY OF THE MOTION OF MATRIXMETALLOPROTEASE MMP1 ON TYPE I COLLAGEN FIBERSHOWS PROTEOLYSIS DRIVEN HINDERED BIASEDDIFFUSION. Susanta K. Sarkar, Barry Marmer, Gregory Goldberg,Keir C. Neuman.3914-POS BOARD #B638HIGH FREQUENCY ASYNCHRONOUS ROTATION OFMAGNETIC MICROSPHERES AND BIOPHYSICALAPPLICATIONS - HIGHER SENSITIVITY REGIME FORMAGNETIC BEAD BIOSENSORS. Paivo Kinnunen.3915-POS BOARD #B639MEASUREMENT OF THE ELASTIC MODULUS OFINDIVIDUAL TYPE I COLLAGEN FIBRILS. Garrett Matthews,Erin Cropper.3916-POS BOARD #B640HOW DO OSMOLYTES AFFECT THE STABILITY OFPOLYCYSTIN-1 PKD DOMAINS? Meixiang Xu, Liang Ma,Andres Oberhauser.3917-POS BOARD #B641REAL TIME DETECTION OF MECHANICAL STRESS INSPECIFIC CYTOSKELETAL PROTEINS. Fanjie Meng,Thomas Suchyna, Frederick Sachs.3918-POS BOARD #B642UNFOLDING AND REFOLDING DYNAMICS OF FILAMIN APROTEIN UNDER CONSTANT FORCES. Hu Chen,Fumihiko Nakamura, Hongxia Fu, Peiwen Cong, Michael P. Sheetz,Jie Yan.174Biophysical Society 54th Annual Meeting