Betty Ford Lecture Sharon Walsh - AMERSA

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General Methods Enroll as inpatients healthy adult volunteers withappropriate drug use histories Include tests of the appropriate control (positiveand negative if available) agents for comparisonwith the test drug of interest Collect of broad array of responses Physiological (safety) Subjective measures (abuse liability) Cognitive/psychomotor Self-administration14
RADARS System Opioid Abuse Trends,Populations Rates (Ranked Highest-Lowest)2010RankPoisonCenterOpioidTreatmentSKIPDrugDiversionCollegeSurvey1 Hydrocodone Oxycodone Oxycodone Oxycodone Oxycodone2 Oxycodone Hydrocodone Hydrocodone Hydrocodone Hydrocodone3 Tramadol Methadone Methadone Methadone Fentanyl4 Methadone Morphine Morphine Morphine Methadone5 Morphine Hydromorphone Hydromorphone Buprenorphine Morphine6 Buprenorphine Fentanyl Fentanyl Tramadol Tramadol7 Fentanyl Buprenorphine Buprenorphine Hydromorphone Buprenorphine8 Hydromorphone Tramadol Tramadol Fentanyl HydromorphoneCourtesy Dr. Richard Dart from Fifth Annual RADARS System Scientific Meeting, April 28, 2011.15
Page 1 and 2: Prescription Opioid Abuse: Translat
Page 3 and 4: OutlineEpidemiology of prescription
Page 5 and 6: Number of New Nonmedical Users of P
Page 7 and 8: Opioid AnalgesicPrescriptions in th
Page 9 and 10: Broward Palm Beach New Times, Volum
Page 11: Abuse Potential vs. Abuse Liability
Page 16 and 17: RADARS System Opioid Abuse Trends,P
Page 18 and 19: “How HIGH Are You Right Now?”Or
Page 20 and 21: “How Much Do You LIKE the Drug?In
Page 22 and 23: Treatment Admissions InvolvingOpioi
Page 24 and 25: “How Much Do You Like the Drug?
Page 26 and 27: Oxycodone Plasma ConcentrationsConc
Page 28 and 29: Oral Opioid Self-Administration:Pro
Page 30 and 31: Development of Abuse-Deterrent orAb
Page 32 and 33: Buprenorphine Sublingual buprenorph
Page 34 and 35: Buprenorphine Implementation Benefi
Page 36 and 37: Broward Palm Beach New Times, Volum
Page 38 and 39: RADARS System Opioid Abuse Trends,P
Page 40 and 41: How Do Prescribing Practices Increa
Page 42 and 43: Definitions Diversion: an unauthori
Page 44 and 45: Methods - The Curriculum Gather all
Page 46 and 47: Results CME attendees:Boardcertific
Page 48 and 49: Buprenorphine has an average half-l
Page 50 and 51: What % of your patients are in opio
Page 52 and 53: 100Average Daily Maintenance Dose#B
Page 54 and 55: Confessions of X-Licensed Doctors H
Page 56 and 57: Conclusions Prescription opioid abu

Betty Ford Lecture Sharon Walsh - AMERSA

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