Betty Ford Lecture Sharon Walsh - AMERSA

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“How Much Do You Like the Drug?”605040Oxycontin® (intranasal)0 mg/70 kg15 mg/70 kg30 mg/70 kgOxycodone (p.o.)Placebo10 mg20 mg40 mgScore3020100B0 .25 .5 .75 1 1.25 1.5 BTime (hrs)0 .25 .5 .75 1 1.25 1.5Time (hrs)Lofwall, Nuzzo & Walsh (2011) under review.#Walsh, Nuzzo, Lofwall and Holtman (2008) Drug and Alcohol Dependence, 98: 191-202. 24
Oxycodone Plasma Concentrations6050IN OxyContin® 30 mg/70 kgIN OxyContin® 15 mg/70 kgIV oxycodone 5 mg/70 kgConcentration (ng/mL)403020100-0.50 0.5 1 1.5 24 8 1224Time (hrs)Lofwall, Moody, Fang, Nuzzo and Walsh (2011) Journal of Clinical Pharmacology, e-pub ahead of print 25
Page 1 and 2: Prescription Opioid Abuse: Translat
Page 3 and 4: OutlineEpidemiology of prescription
Page 5 and 6: Number of New Nonmedical Users of P
Page 7 and 8: Opioid AnalgesicPrescriptions in th
Page 9 and 10: Broward Palm Beach New Times, Volum
Page 11: Abuse Potential vs. Abuse Liability
Page 14 and 15: General Methods Enroll as inpatient
Page 16 and 17: RADARS System Opioid Abuse Trends,P
Page 18 and 19: “How HIGH Are You Right Now?”Or
Page 20 and 21: “How Much Do You LIKE the Drug?In
Page 22 and 23: Treatment Admissions InvolvingOpioi
Page 26 and 27: Oxycodone Plasma ConcentrationsConc
Page 28 and 29: Oral Opioid Self-Administration:Pro
Page 30 and 31: Development of Abuse-Deterrent orAb
Page 32 and 33: Buprenorphine Sublingual buprenorph
Page 34 and 35: Buprenorphine Implementation Benefi
Page 36 and 37: Broward Palm Beach New Times, Volum
Page 38 and 39: RADARS System Opioid Abuse Trends,P
Page 40 and 41: How Do Prescribing Practices Increa
Page 42 and 43: Definitions Diversion: an unauthori
Page 44 and 45: Methods - The Curriculum Gather all
Page 46 and 47: Results CME attendees:Boardcertific
Page 48 and 49: Buprenorphine has an average half-l
Page 50 and 51: What % of your patients are in opio
Page 52 and 53: 100Average Daily Maintenance Dose#B
Page 54 and 55: Confessions of X-Licensed Doctors H
Page 56 and 57: Conclusions Prescription opioid abu

Betty Ford Lecture Sharon Walsh - AMERSA

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