Betty Ford Lecture Sharon Walsh - AMERSA

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“How Much Do You LIKE the Drug?Intravenous AdministrationMorphine Oxycodone HydrocodoneConcentration (ng/mL)6050403020100 mg5 mg10 mg20 mg0BL 0 5 10 15 95185275 365 BL 0 5 10 15 95185 275 365 BL 0 5 10 15 95185 275 365Time (min)Time (min)Time (min)Stoops, Hatton, Lofwall, Nuzzo & <strong>Walsh</strong> (2010) Psychopharmacology, 212: 193-203.20
Summary All three drugs produced a similar profile of euphoriceffects in the absence of unpleasant effects Relative potency estimates suggest that oxycodone andhydrocodone are roughly equipotent with respect toabuse potential Oral hydromorphone was less than two-fold as potent asoxycodone and hydrocodone inconsistent with analgesicestimates These data suggest that relative potency estimatesbased upon analgesic response may not be comparableto those assessing relative abuse potential21
Page 1 and 2: Prescription Opioid Abuse: Translat
Page 3 and 4: OutlineEpidemiology of prescription
Page 5 and 6: Number of New Nonmedical Users of P
Page 7 and 8: Opioid AnalgesicPrescriptions in th
Page 9 and 10: Broward Palm Beach New Times, Volum
Page 11: Abuse Potential vs. Abuse Liability
Page 14 and 15: General Methods Enroll as inpatient
Page 16 and 17: RADARS System Opioid Abuse Trends,P
Page 18 and 19: “How HIGH Are You Right Now?”Or
Page 22 and 23: Treatment Admissions InvolvingOpioi
Page 24 and 25: “How Much Do You Like the Drug?
Page 26 and 27: Oxycodone Plasma ConcentrationsConc
Page 28 and 29: Oral Opioid Self-Administration:Pro
Page 30 and 31: Development of Abuse-Deterrent orAb
Page 32 and 33: Buprenorphine Sublingual buprenorph
Page 34 and 35: Buprenorphine Implementation Benefi
Page 36 and 37: Broward Palm Beach New Times, Volum
Page 38 and 39: RADARS System Opioid Abuse Trends,P
Page 40 and 41: How Do Prescribing Practices Increa
Page 42 and 43: Definitions Diversion: an unauthori
Page 44 and 45: Methods - The Curriculum Gather all
Page 46 and 47: Results CME attendees:Boardcertific
Page 48 and 49: Buprenorphine has an average half-l
Page 50 and 51: What % of your patients are in opio
Page 52 and 53: 100Average Daily Maintenance Dose#B
Page 54 and 55: Confessions of X-Licensed Doctors H
Page 56 and 57: Conclusions Prescription opioid abu

Betty Ford Lecture Sharon Walsh - AMERSA

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