Surfactant replacement therapy in acute respiratory ... - RM Solutions
Surfactant replacement therapy in acute respiratory ... - RM Solutions
Surfactant replacement therapy in acute respiratory ... - RM Solutions
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Cl<strong>in</strong>ical trial adult• 4 RCT• Failed to demonstrate a mortality benefit.- Anzueto A, et al. Aerosolized surfactant <strong>in</strong> adults with sepsis-<strong>in</strong>duced <strong>acute</strong> <strong>respiratory</strong>distress syndrome: Exosurf Acute Respiratory Distress Syndrome Sepsis Study Group.N Engl J Med 1996; 334:1417–1421- Gregory TJ, Ste<strong>in</strong>berg KP, Spragg R, et al. Bov<strong>in</strong>e surfactant <strong>therapy</strong> for patients with<strong>acute</strong> <strong>respiratory</strong> distress syndrome. Am J Respir Crit Care Med 1997; 155:1309–1315- Lewis JF, Walmrath HD, et al. Effect of recomb<strong>in</strong>ant surfactant prote<strong>in</strong> C-basedsurfactant on the <strong>acute</strong> <strong>respiratory</strong> distress syndrome. N Engl J Med 2004; 351:884–892- Jozef Kesecioglu1 et al, Exogenous Natural <strong>Surfactant</strong> for Treatment of Acute LungInjury and the Acute Respiratory Distress Syndrome Am J Respir Crit Care Med Vol180. pp 989–994, 2009-
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