Surfactant replacement therapy in acute respiratory ... - RM Solutions

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Surfactant• Type II pneumocytes.• Lower alveolar surface tension.• 80% phospholipids (dipalmitoyl phosphatidylcholine 85% ).• 8% neutral lipids.• 12% proteins SP –A,B,C, and D- Surface tension (A,B,C )- Immune defense , particle clearance- Modulate lung inflammation ( D , A )
Type of SurfactantPed criti care medicine basic science and clinical evidence Derrk 2007
Page 1 and 2: Surfactant Replacement Therapyin Ch
Page 3 and 4: Case 1• 2 yrs boy 50% flam burn ,
Page 5 and 6: Case 2• Preterm 24/52, CA 10 days
Page 10: Type of SurfactantPhLip SPA SPB SPC
Page 13 and 14: Clinical trial adult• 4 RCT• Fa
Page 15 and 16: Clinical trial in pediatrics ALI/AR
Page 17 and 18: Clinical trial in pediatrics• Pha
Page 19 and 20: Clinical trial in pediatrics• Tre
Page 21 and 22: Clinical trial in pediatrics• Sub
Page 23 and 24: Ventilator-free daysDuffett M, choo
Page 25 and 26: Duration PCCU stayDuffett M, choong
Page 27 and 28: Clinical trial in pediatricsInitial
Page 29 and 30: Summery• Surfactant not recommend

Surfactant replacement therapy in acute respiratory ... - RM Solutions

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