Surfactant replacement therapy in acute respiratory ... - RM Solutions

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Clinical trial in pediatrics ALI/ARDS• Douglas F. Willson et al. JAMA, January 26, 2005—Vol 293.- Improve oxygenation and mortality.- Minor transient hypoxia , hypotension around instillation
Clinical trial in pediatrics• Phase 3 multicenteral trail, randomized, blinded• Natural lung surfactant (calfactant) vs placebo .• 21 centers.• 153 patient.• 3 years study period.Wilson etal jama 293: 470-476, 2005
Page 1 and 2: Surfactant Replacement Therapyin Ch
Page 3 and 4: Case 1• 2 yrs boy 50% flam burn ,
Page 5 and 6: Case 2• Preterm 24/52, CA 10 days
Page 8 and 9: Surfactant• Type II pneumocytes.
Page 10: Type of SurfactantPhLip SPA SPB SPC
Page 13 and 14: Clinical trial adult• 4 RCT• Fa
Page 15: Clinical trial in pediatrics ALI/AR
Page 19 and 20: Clinical trial in pediatrics• Tre
Page 21 and 22: Clinical trial in pediatrics• Sub
Page 23 and 24: Ventilator-free daysDuffett M, choo
Page 25 and 26: Duration PCCU stayDuffett M, choong
Page 27 and 28: Clinical trial in pediatricsInitial
Page 29 and 30: Summery• Surfactant not recommend

Surfactant replacement therapy in acute respiratory ... - RM Solutions

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