nanosymposium - Society for Neuroscience

8:00 Y13 353.17 Peptidyl-prolyl isomerase pin1-binding
to cdk5-phosphorylated tau. T. KIMURA*; K. TSUTSUMI;
T. SAITO; K. ISHIGURO; T. UCHIDA; M. HASEGAWA; S.
HISANAGA. Tokyo Metropolitan Univ., Mitsubishi Kagaku
Iustitute of Life Sci., Dept. of Biol., Grad. Sch.of Sci, Tohoku
Univ., Tokyo Inst.Psych.
9:00 Y14 353.18 Lysine methylation of tau protein in
Alzheimer’s disease: Identification of sites and potential
for modification crosstalk. K. E. FUNK*; S. N. THOMAS; Y.
WAN; Z. LIAO; P. DAVIES; J. KURET; A. J. YANG. The Ohio
State Univ., Univ. of Maryland, Albert Einstein Col. of Med.
10:00 Y15 353.19 Antisense to GSK-3beta improves
learning and memory in aged SAMP8 mice. S. A. FARR*;
V. B. KUMAR; M. L. NIEHOFF; J. E. MORLEY. St. Louis
University/VA Med.
11:00 Y16 353.20 • Inhibition of Phosphoprotein
Phosphatase 2A demethylation reduces tau dysfunction. S.
P. BRAITHWAITE*; D. HE; M. VORONKOV; D. C. LO; J. B.
STOCK. Signum Biosci., Duke Univ., Princeton Univ.
8:00 Y17 353.21 GSK3b and cdk5 promote tau proteolysis
and aggregation. S. LEE*; T. B. SHEA. UMass Lowell.
POSTER
354. Beta and Gamma Secretase, BACE, and Presenilin I
Theme C: Disorders of the Nervous System
Mon. 8:00 AM – Walter E. Washington Convention
Center, Hall A-C
8:00 Y18 354.01 Secreted beta amyloid levels and cell
cycle regulation differentiate Alzheimer’s disease mutations
in presenilin1 but do not correlate with age of disease onset.
U. WOJDA*; E. BIALOPIOTROWICZ; A. SZYBINSKA; J.
KUZNICKI. IIMCB.
9:00 Y19 354.02 PS1Δ8 familial Alzheimer’s mutation
results in motor deficits, region specific cell loss, and a total
loss of all detectable γ-secretase activity. H. BRAUTIGAM*;
D. L. DICKSTEIN; S. GANDY; P. R. HOF; M. E. EHRLICH.
Mount Sinai Sch. of Med., Mount Sinai Sch. of Med., Mount
Sinai Sch. of Med., James J. Peters VA Med. Ctr., Mount
Sinai Sch. of Med.
10:00 Y20 354.03 Lys203 and Lys382 are essential for the
proteasomal degradation of BACE1. Y. ZHANG; R. WANG;
Z. YING; J. ZHAO; R. WANG; Y. DENG; W. SONG; H.
QING*. Beijing Inst. Technol., Univ. of British columbia, Univ.
of British columbia.
11:00 Y21 354.04 γ-secretase modulation properties of
soluble amyloid precursor protein-α. D. DARLINGTON*.
Univ. of South Florida.
8:00 Y22 354.05 Investigating the regional expression of
gamma secretase in the human brain. P. A. LEWIS*, Jr.; M.
RYTEN; D. TRABZUNI; J. HARDY. UCL Inst. of Neurol.
9:00 Y23 354.06 • Vascular factor LPA may contribute to
Alzheimer’s disease. J. SHI*; G. MAO; M. CUI; X. XU. Univ.
of Tennessee.
10:00 Y24 354.07 Chop-induced nf-κb activation increases
bace1 in hippocampal slices treated with the oxysterol
27-hydroxycholesterol. O. GHRIBI*; G. MARWARHA. UND
Med. Sch., Univ. of North dakota.
11:00 Y25 354.08 Characterization of nectin processing
mediated by presenilin-dependent gamma-secretase. S.
T. LIM*; J. KIM; A. DUDAK; A. CHANG; H. J. FEDEROFF.
Georgetown Univ. Med. Ctr.
8:00 Y26 354.09 • Hair follicle mRNA signature finds the
GSI SCH900229 to be Notch sparing in humans. K. Q.
TANIS*; A. A. PODTELEZHNIKOV; J. K. LUNCEFORD;
J. HING; J. CLEMENTS; E. M. FINNEY; A. ALBRIGHT; A.
LOBODA; S. S. BLACKMAN; R. IANNONE; R. MARGOLIN.
Merck, Merck, Merck, Merck, Merck, Merck, Merck, Merck.
9:00 Y27 354.10 The effect of fatty acids on γ-secretase
activity. O. HOLMES*; S. PATURI; W. YE; D. SELKOE; M.
WOLFE. Brigham and Women’s Hospital/Harvard Med. Sch.
10:00 Y28 354.11 Structural analysis of the transmembrane
domain 4 of Presenilin 1 by substituted cysteine accessibility
method. A. TOMINAGA*; S. TAKAGI; T. TOMITA; T.
IWATSUBO. Dept Neuropathol & Neurosci, Univ. Tokyo Grad
Sch. Pharmaceu Sci., Dept Neuropathol, Univ.Tokyo Grad
Sch. Med.
11:00 Y29 354.12 • GSI-1, a presenilin 1 selective
γ-secretase inhibitor with improved side effect profile in
preclinical models. L. ZHANG*; L. A. HYDE; W. WU; D.
BURNETT; M. COHEN-WILLIAMS; R. DEL VECCHIO; N.
JONES; J. LEE; L. SONG; G. TERRACINA; Q. ZHANG;
J. CLADER; W. GREENLEE; A. NOMEIR; M. BERADI; C.
MAHON; R. MARGOLIN; M. HU; E. M. PARKER. Merck
Res. Labs.
8:00 Y30 354.13 • Unable to Attend BACE1 inhibitors:
In vitro-in vivo correlation of Aβ effect in brain. J. JANSON;
S. EKETJÄLL; K. TUNBLAD; F. JEPPSSON; S. BRIEM;
A. RADESÄTER; K. ELIASON; J. FÄLTING*; S. VISSER.
Astrazeneca R&D, AstraZeneca R&D, AstraZeneca R&D,
AstraZeneca R&D.
9:00 Y31 354.14 Familial Alzheimer’s disease-associated
presenilin mutants suppress calcium influx through TRPM7
channels. H. OH; Y. CHUN; S. YOUN; T. KIM; S. CHUNG*.
Sungkyunkwan Univ., Columbia Univ. Med. Ctr.
10:00 Y32 354.15 Age-dependent synaptic dysfunctions
in APPswe;PS1deltaE9 mice. A. MEGILL; P. C. WONG;
H. LEE*. Univ. of Maryland, Johns Hopkins Univ., Johns
Hopkins Sch. of Med.
11:00 Y33 354.16 BACE2 tissue expression and β-amyloid
precursor protein processing in multiple BACE2-targeted
mouse lines. R. W. TERRY*; G. VASSILEVA; W. HU; X.
CHEN; R. DELVECCHIO; L. HYDE; B. G. SALISBURY; E.
PARKER; M. E. KENNEDY. Merck Res. Labs., Merck Res.
Labs., Union County Col.
8:00 Y34 354.17 BACE1 elevation is involved in amyloid
plaque pathogenesis in the triple transgenic model of
Alzheimer’s disease: Profiling an early-onset axonal
accumulation of putative APP β-carboxyl terminal fragments.
X. YAN*; Y. CAI; X. ZHANG; L. N. MACKLIN; H. CAI; X.
LUO; R. G. STRUBLE; G. M. ROSE; P. R. PATRYLO.
Central South Univ., Central South Univ., Harbin Med. Univ.,
Southern Illinois Univ. Sch. of Med., Natl. Inst. on Aging,
Southern Illinois Univ. Sch. of Med., Southern Illinois Univ.
Sch. of Med., Southern Illinois Univ. Sch. of Med.
9:00 Y35 354.18 Presenilin 1 regulates cellular distribution
and neuroprotective function of Trk and EphB receptors.
Z. XUAN*; G. BARTHET; J. DUNYS; J. XU; Z. SHAO; N.
ROBAKIS. Mount Sinai Sch. of Med.
10:00 Y36 354.19 • Gamma-secretase/Notch signaling in
insulin resistance. S. YANG*; D. JO. Sungkyunkwan Univ.
11:00 Z1 354.20 • Adiponectin signaling in Alzheimer’s
disease. S. KIM*; D. JO. Sungkyunkwan Univ.
30 | Society for Neuroscience • Indicated a real or perceived conflict of interest, see page 162 for details.
� Indicates a high school or undergraduate student presenter.