The only quantitative data available in cattle indicates 138mg Ba/kg BW, as BaCO 3, in dry feedstuffs was acutelytoxic to steers, whereas 69 mg Ba/kg BW was not. 117 Assumingwater consumption of 20% BW, this translates to690 mg Ba 2+ /L in drinking water as being acutely toxic or345 mg Ba 2+ /L as the NOAEL. This contrasts with thereport of Richards et al. 116 that 2 mg soluble Ba 2+ /L water,plus some undetermined amount of Ba from sediment,was immediately toxic to cows and calves. It is also muchhigher than the toxic dose reported in goats, where 7 mg/kg BW BaCl 2(4.6 mg Ba/kg BW) was lethal. 115 It is likelythat BaCO 3in feed is not as bioavailable as the Ba 2+ ionin water. The acutely lethal dose in the goat study translatesto 23 mg Ba 2+ /L under the assumptions outlined inthe Introduction.Obviously, much more research needs to be donewith Ba in ruminants, but, given the current state ofknowledge, soluble Ba 2+ concentrations should be heldto well below 23 mg/L to avoid acute toxicity. There isabsolutely no data on chronic Ba 2+ ion toxicity in anyof our species of interest. This, plus the limited andconflicting data from chronic studies in other animals,makes it impossible to postulate a long-term “safe”level of the Ba 2+ ion in drinking water <strong>for</strong> domesticlivestock and/or wildlife species with any degree ofcertainty.We do not recommend using water containing morethan 10 mg Ba 2+ /L even <strong>for</strong> short periods. Untilthere is better data, it is impossible to make anyrecommendations regarding chronic exposure.14
4 FluorideFluorine (F) is the most electronegative and reactive ofknown elements. It rarely occurs free in nature, chemicallycombining to <strong>for</strong>m fluorides. Fluorides are widelydistributed throughout the environment in variousanthropogenic and natural <strong>for</strong>ms. Mineral <strong>for</strong>ms of F includecryolite (Na 3AlF 6), fluorite (CaF 2), and fluorapatite(Ca 5(PO 4) 3F). Vegetation can accumulate fluoride fromsoil, water, and the atmosphere. 146 In aqueous environments,F occurs as the free fluoride ion (F - ) and is mobile,especially in alkaline waters. 95 Unless surface waters arecontaminated by a F - source, ground waters tend to havehigher concentrations of F - than surface waters.EssentialityThe NRC 147 describes F - as an “important constituent” ofbones and teeth, and, although essentiality has not beenproven, small amounts have been added to municipalwater supplies to improve dental health <strong>for</strong> decades. Apparently,even if F is essential, the dietary requirement isso small it is easily met by even highly purified diets. Asnoted by Ammerman, 148 “Whether or not it is essential<strong>for</strong> animals may be open to debate… The fact that it istoxic is more easily confirmed.”MetabolismFluoride is readily absorbed by the stomach, rumen, andsmall intestine. The efficiency of absorption dependsupon the solubility of the specific F compound, otherdietary components, and the species, sex, and age ofthe animal. 147,149 Conditions that result in very low pHfavor the <strong>for</strong>mation of hydrogen fluoride (HF), which islipophilic and thus diffuses easily across lipid membranes.The F - ion is absorbed in the small intestine via a pHindependent process. 147 Soluble fluorides, i.e. the F - ionin water, are almost 100% absorbed. Less soluble sourcessuch as F compounds in bone meal are relatively poorlyabsorbed. Ca, Mg, Al, NaCl, and high lipid concentrationsare known to depress F uptake. 147,150Two mechanisms are responsible <strong>for</strong> removal of F - fromthe systemic circulation: renal excretion and depositionin calcified tissues. After absorption, most F - circulatesin plasma as ionic F - . To a lesser extent, it circulates asCaF 2or HF, or it is bound to protein. 150-152 CirculatingF - represents a relatively small portion of the total bodyburden but is the <strong>for</strong>m most easily exchanged with othertissues and/or eliminated via renal filtration. 151,152 Urinaryexcretion is the primary route of elimination andis directly related to urinary pH; thus, factors that affecturinary pH influence how much F- is excreted. 150,153Under “normal” circumstances, roughly 50% of ingestedF - is eliminated immediately, and the remainder is incorporatedinto bony tissues 147 ; however, these percentagesmay be significantly modified by physiologic factors suchas age, sex, or other factors. Calcified tissues such asteeth and bone have a great affinity <strong>for</strong> F - , incorporatingit as fluorapatite in place of hydroxyapatite in the calcifiedmatrix. 147,153 To a certain extent, bone depositionrepresents a <strong>for</strong>m of detoxication by decreasing the F -exposure of other tissues. Fluorapatite crystals, however,are less soluble than the hydroxyapatite they replace andthus 1) persist <strong>for</strong> long periods in bone, and 2) interferewith normal turnover (remodelling) of bone. There<strong>for</strong>e,at higher concentrations, bone F - interferes with normalphysiological processes like growth and healing. Since F -deposition in skeletal tissues is related to the turnover ofbone minerals, young, rapidly growing animals are morelikely to accumulate it. 147ToxicityAnimals can ingest potentially toxic doses of F - from avariety of sources. In the past, <strong>for</strong>ages contaminated byaluminum smelters or grown in naturally high F - soils,rock phosphate fed nutritional supplements, and/or consumptionof naturally high F - water have resulted in F -poisoning. 147,149,154-156 Large doses of soluble F - can <strong>for</strong>mcorrosive HF, interfere with ion gradients in excitablecells, and/or precipitate divalent cations from serum. 157,158Thus, acute fluorosis is manifested as gastroenteritis,cardiac arrhythmias, and/or collapse. 157 Chronic or subchronicexposure to somewhat lower doses results in kidneydamage, 157,159,160 neurologic damage, or reproductivefailure. 161-163 The most sensitive (i.e. occur at the lowestdose) clinical manifestations of F - toxicosis in livestockand wildlife under real-world conditions are tooth andbone de<strong>for</strong>mities. 149,164-169 These bony tissue lesions often15
- Page 1 and 2: Water Qualityfor Wyoming Livestock
- Page 3: AbbreviationsADG - average daily ga
- Page 6 and 7: 7 pH 31Function. . . . . . . . . .
- Page 8 and 9: animal drinks. Water intake is tech
- Page 10 and 11: ter or “mg X/L”. If the substan
- Page 12 and 13: tion between the erythrocytic and p
- Page 14 and 15: in diseases such as cancer. 10,20,2
- Page 17 and 18: 3 BariumBarium (Ba), an alkaline ea
- Page 19: exposed to 100 mg Ba 2+ /L had depr
- Page 23 and 24: lost weight and many died at the hi
- Page 25: Our search of the literature pertai
- Page 28 and 29: elatively stable; however, once unb
- Page 30 and 31: supplementing with 17 ppm Cu for si
- Page 32 and 33: not transport oxygen from the lungs
- Page 34 and 35: Winter and Hokanson 381 fed varying
- Page 37 and 38: 7 pHpH is defined as “the negativ
- Page 39: for basic drinking water. From a pu
- Page 42 and 43: efficiency. 436,437 Absorption of S
- Page 44 and 45: significantly impaired in the same
- Page 47 and 48: 9 Sodium ChlorideSodium chloride (N
- Page 49 and 50: containing 15,000 mg NaCl/L for 21
- Page 51 and 52: 10 SulfurSulfur (S) occurs in natur
- Page 53 and 54: in feed or water consumption. The a
- Page 55 and 56: 11 Total Dissolved Solids (TDS)Tota
- Page 57: 12 SummaryElementShort (days - week
- Page 61 and 62: 14 Bibliography1. National Research
- Page 63 and 64: 35. Klug H.L., Lampson G.P. and Mox
- Page 65 and 66: 69. Harding J.D., Lewis G. and Done
- Page 67 and 68: 104. Choudhury H. and Cary R. (2001
- Page 69 and 70: 136. Boyd E.M. and Abel M. (1966).
- Page 71 and 72:
171. Mullenix P.J., Denbesten P.K.,
- Page 73 and 74:
203. Schultheiss W.A. and Van Nieke
- Page 75 and 76:
237. Tolgyesi G. and Elmoty I.A. (1
- Page 77 and 78:
269. ANZECC (2000). Australian and
- Page 79 and 80:
301. Huber J.T., Price N.O. and Eng
- Page 81 and 82:
332. Crowley J.W., Jorgensen N.A.,
- Page 83 and 84:
366. Walker R. (1990). Nitrates, ni
- Page 85 and 86:
399. Wu L., Kohler J.E., Zaborina O
- Page 87 and 88:
432. Naftz D.L. and Rice J.A. (1989
- Page 89 and 90:
464. Glenn M.W., Jensen R. and Grin
- Page 91 and 92:
498. Knott S.G. and McCray C.W.R. (
- Page 93 and 94:
532. Harvey R.W., Croom J. WJ, Pond
- Page 95 and 96:
567. Koletsky S. (1959). Role of sa
- Page 97 and 98:
602. Gooneratne S.R., Olkowski A.A.
- Page 99 and 100:
633. McAllister M.M., Gould D.H., R