Tramadol – interaction with SSRIs and with Morphine

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A Double-blind, RCT - addition of a Tramadol Infusion to MorphinePCA in 69 patients after Abdominal Surgery:(Webb AR et al. Anesth Analg 2002;95:1713-8)end surgery initialloading dose ofTramadol (1 mg/kg)end surgery initialloading dose ofSalinepostoperative infusionof Tramadol at 0.2 mgkg -1 · h -1postoperative infusionof Salinemorphine B 1mg; LO 5 minvia PCA
Mean (95% CI) Values for analgesic Efficacy four hourly (1 =excellent, 2 = good, 3 = satisfactory, 4 = poor, and 5 = very poor)and PCA Morphine Consumption 48 h after Surgery(Webb AR et al. Anesth Analg 2002;95:1713-8)no evidence of increased adverse effects in patients receiving tramadol
Page 2 and 3: Serotonin Syndrome (SS)• all drug
Page 4 and 5: Neuromuscular hyperactivityClonus,m
Page 6 and 7: Drugs associated with SerotoninToxi
Page 8 and 9: Cyproheptadine (5-HT 2Aantag)to red
Page 10 and 11: Tramadol and SSRIs• Tramadol - at
Page 13 and 14: Tramadoland Morphine• Multimodal
Page 15 and 16: TramadolCYP2D6(sparteineoxidase)250
Page 17 and 18: TramadolMorphine• Does combinatio
Page 19 and 20: Median (and interquartile range) of
Page 21 and 22: Pain Intensity in Three groups by N
Page 23: Median Effective Dose of Tramadol a
Page 27 and 28: Mean Post-operative Pain Scores (±

Tramadol – interaction with SSRIs and with Morphine

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