Pharmacology of Antiretroviral Agents An Emphasis on Drug ...
Pharmacology of Antiretroviral Agents An Emphasis on Drug ...
Pharmacology of Antiretroviral Agents An Emphasis on Drug ...
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Reverse Transcriptase Inhibitors2 Types• Nucleoside (NRTI) and Nucleotide (NtRTI) ReverseTranscriptase Inhibitors• Structurally similar to purine or pyrimidine nucleosides• Lack 3’-OH group• Phosphorylated & incorporated into growing DNA strand “CHAINTERMINATORS”• N<strong>on</strong>-nucleoside (NNRTI)• Structurally dissimilar to NRTIs• No phosphorylati<strong>on</strong>• Direct binding to RT enzyme
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