Pharmacology of Antiretroviral Agents An Emphasis on Drug ...

More documents

Recommendations

Info

Risk Factors for Drug Interactions AmongOlder Adults with HIV• Adherence issues and concerns• Longterm adherence• Pill burden and fatigue• More likely to be on less tolerable regimens with higher pill burden• Adverse effects• COST $$$• Treatment adherence (multiple providers and appointments)• Neurocognitive impairment• Depression• Health literacy
Risk Factors for Drug Interactions AmongOlder Adults with HIV• Pharmacokinetic changes• Comorbidities• Cardiovascular disease, renal failure, diabetes, bone fractures aremore prevalent among HIV-infected individuals• Polypharmacy• Use <strong>of</strong> multiple pharmacies• Use <strong>of</strong> over-the-counter and natural products• Adherence Issues and concerns• Pill burden and fatigue• Hospital admissions
Page 1 and 2: PHARMACOLOGY OFANTIRETROVIRAL AGENT
Page 3 and 4: Introduction- Patient Case• SY is
Page 5 and 6: 1. Centers for Disease Control and
Page 7 and 8: 3. Luther VP, Wilken AL. HIV Infect
Page 9 and 10: Incident cases in 2009 approx 48,00
Page 11 and 12: ANTIRETROVIRALTHERAPYPharma
Page 13 and 14: 7. Pomerantz RJ and Horn DL. 20 Yea
Page 15 and 16: Step 1: Binding & Attachment9. AIDS
Page 17 and 18: Enfuvirtide- Mechanism of</
Page 19 and 20: NRTI Mechanism of
Page 21 and 22: Integration12. Pommier Y, Johnson A
Page 23 and 24: Protease Inhibitors11. Brunton, L.
Page 25 and 26: When to Start ART in Older Adults
Page 27 and 28: OLDER ADULTSPharmacokineticsAdverse
Page 29 and 30: Drug MetabolismCytochrome P450 Enzy
Page 31 and 32: P-glycoprotein• Efflux transporte
Page 33 and 34: Risk Factors for Drug Interactions
Page 39 and 40: 19. Marzolini C, Back D, Weber R, e
Page 41: Risk Factors for Drug Interactions
Page 45 and 46: 21. Rastegar DA, Knight AM, and Mon
Page 47 and 48: RECOGNIZINGPREVENTABLE ADVERSEEVENT
Page 49 and 50: Preventable Adverse Events:CCR5 Inh
Page 51 and 52: Preventable Adverse EventsNNRTIs•
Page 53 and 54: Pharmacoenhancers• Cobicistat•
Page 55 and 56: Drug Interactions Involving Proteas
Page 57 and 58: Pharmacokinetic Interactions withPr
Page 59 and 60: HMG-CoA Reductase Inhibitors andPro
Page 61 and 62: Lipid-Lowering Agents</stro
Page 63 and 64: Neuropsychiatric• An</str
Page 65 and 66: Other P450 interactions•
Page 67 and 68: PREVENTING DRUGINTERACTIONS
Page 69 and 70: Back to our patient case…• SY i
Page 71 and 72: Patient Case• Drug Interactions
Page 73 and 74: References1. Centers for Disease Co

Pharmacology of Antiretroviral Agents An Emphasis on Drug ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?