Pharmacology of Antiretroviral Agents An Emphasis on Drug ...

Drug MetabolismCytochrome P450 Enzymes• Substrate: metabolized by enzyme to end product whichis eliminated• Inducer: increases production <strong>of</strong> enzymes that metabolizea substrate• Often leads to reduction in concentration <strong>of</strong> the substrate• May take 1-2 weeks for it to occur• Inhibitor: interferes with ability <strong>of</strong> enzyme to metabolizesubstrate• Often leads to increase in concentration <strong>of</strong> substrate• Occurs quickly