Pharmacology of Antiretroviral Agents An Emphasis on Drug ...
Pharmacology of Antiretroviral Agents An Emphasis on Drug ...
Pharmacology of Antiretroviral Agents An Emphasis on Drug ...
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Preventable Adverse EventsNNRTIs• <strong>Drug</strong>-disease interacti<strong>on</strong>s• Reduced hepatic functi<strong>on</strong>: potential for hepatic dysfuncti<strong>on</strong>• Reduced clearance• Neuropsychiatric: EFV• Gastric acid: ? RPV• <strong>Drug</strong>-drug Interacti<strong>on</strong>s• Pharmacokinetic• ABSORPTION: H2RAs or PPIs: RPV• METABOLISM: CYP3A4 substrate cauti<strong>on</strong> with inducers• Most are inducers <str<strong>on</strong>g>of</str<strong>on</strong>g> CYP system• EFV can inhibit/induce• RPV: not significant inducer/inhibitor• Etravirine: mild inducer <str<strong>on</strong>g>of</str<strong>on</strong>g> CYP3A4 & mild inhibitor <str<strong>on</strong>g>of</str<strong>on</strong>g> 2C9, 2C19