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52. The association between cannabis use and depression: a meta-analysis of longitudinal studiesLev-Ran S. 1,2 , Roerecke M. 2 , Le Foll B. 2,3 , George T. 2,3 , McKenzie K. 2,3 and Rehm J. 2,3,41 Addiction Medicine Services, Department of Psychiatry, Sheba Medical Center, Tel Hashomer, Israel; 2 Centre for Addiction and Mental Health, Toronto, ON, Canada; 3 University ofToronto, Toronto, ON, Canada; 4 Technische Universitat Dresden, Dresden, Germany;53. Dominant and Submissive mice show differential expression of genes involved in regulation of the HPA axis and different pattern of synapticplasticity in the hippocampusNesher E. 1,2 , Gross M. 1,3 , Lisson S. 1,2 , Sadvakassova G. 1,4 , Sheinin A. 3 , Tikhonov T. 1,2 , Michaelevski I. 3 , Yadid G. 2 and Pinhasov A. 11 Department of Molecular Biology, Ariel University Center, Ariel, Israel; 2 Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel; 3 Department of Biochemistry and MolecularBiology, Tel-Aviv University, Tel-Aviv, Israel; 4 Kazakh National Medical University, Almaty, Kazakhstan;54. What is considered abnormal sustaining of attention? A survey among teachers and parents of elementary school children1 yael segal trivitz; 2 Tal Shani Sherman; 3 Miriam Levav; 4 Doron Gothelf ;55. Physiological and endocrine responses to environmental and visceral stressors indicate diminished stress reactivity of Ahi1 (Abelson helperintegration site 1) gene heterozygous knockout mice.Lifschytz T. 1 , Lotan A. 1 , Slonimsky A. 1 , Greenbaum L. 1 and Lerer B. 1Biological Psychiatry Laboratory, Hadassah- Hebrew University Medical Center, Jerusalem;56. Neural mechanisms underlying stress resilience in the Ahi1 knockout mouse: Relevance to neuropsychiatric disordersLotan A. 1 , Lifschytz T. 1 , Slonimsky A. 1 , Broner E.C. 1 , Greenbaum L. 1 , Abedat S. 2 , Fellig Y. 3 , Cohen H. 4 , Lory O. 5 and Goelman G. 5 and Lerer B. 11 Biological Psychiatry Laboratory, Hadassah-Hebrew University Medical Center, Jerusalem; 2 Cardiovascular Research Center, Hadassah-Hebrew University Medical Center,Jerusalem; 3 Dept of Pathology, Hadassah- Hebrew University Medical Center, Jerusalem; 4 Mental Health Center, Beersheba; 5 MRI Lab, Medical Biophysics, Hadassah-Hebrew UniversityMedical Center, Jerusalem;9