Inpatient Hyperglycemia

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Study Type:Patient Population:Prospective, multicenter, randomized,open-label trial130 subjects with DM2Diet and/or oral hypoglycemic agentsUmpierrez et al, Diabetes Care 30:2181–2186, 2007
Randomized Basal Bolus versus Sliding Scale RegularInsulin in patients with type 2 Diabetes Mellitus(RABBIT-2 Trial)‣ D/C oral antidiabetic drugs on admission‣ Starting total daily dose (TDD):• 0.4 U/kg/d x BG between 140-200 mg/dL• 0.5 U/kg/d x BG between 201-400 mg/dL‣ Half of TDD as insulin glargine and half as rapidactinginsulin (glulisine)• Insulin glargine - once daily, at the same time/day.• Glulisine- three equally divided doses (AC)Umpierrez et al, Diabetes Care 30:2181–2186, 2007
Page 1 and 2: Inpatient Management ofMedical and
Page 3 and 4: Clinical Guidelines for theManageme
Page 5 and 6: Case Presentation:‣ 48 y/o male w
Page 7 and 8: Point-of-Care BloodGlucose Readings
Page 9 and 10: Hyperglycemia*: A Common Comorbidit
Page 11 and 12: Epidemiology of Inpatient Hyperglyc
Page 13 and 14: Comparison of sensitivity and speci
Page 15 and 16: Patients (%)IGT and Undiagnosed T2D
Page 17 and 18: Epidemiology of Inpatient Hyperglyc
Page 19 and 20: Community Acquired Pneumonia Outcom
Page 21 and 22: Thirty Day Mortality and Inhospital
Page 23 and 24: AACE/ADA Target Glucose Levelsin No
Page 25 and 26: Recommendations for Managing Patien
Page 27: Management of Hyperglycemia andDiab
Page 31 and 32: BG, mg/dLRabbit 2 Trial: Changes in
Page 33 and 34: Basal-Bolus Insulin Therapy vs Slid
Page 35 and 36: DEAN Trial: Changes in Mean DailyBl
Page 37 and 38: DEAN Trial: Insulin DoseThe mean to
Page 39 and 40: Summary of Univariate Analysesp-val
Page 41 and 42: Primary outcome:• Differences bet
Page 43 and 44: Basal Bolus Insulin Regimen‣ D/C
Page 45 and 46: Blood Glucose (mg/dL)Rabbit Surgery
Page 47 and 48: Hospital Complications: Primary out
Page 49 and 50: Basal-Bolus Insulin Therapy vs Slid
Page 51 and 52: RABBIT-2 vs. DEAN TrialsBasal Bolus
Page 53 and 54: Hypoglycemia: Univariate Analysesp-
Page 55 and 56: Clinical Guidelines for the Managem
Page 57 and 58: Insulin ActionBasal-PLUS Insulin Re
Page 59 and 60: Discharge insulin AlgorithmDischarg

Inpatient Hyperglycemia

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