Inpatient Hyperglycemia

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Study Type:Patient Population:Study Sites:Prospective, randomized, open-label trial130 subjects with DM2Oral hypoglycemic agents or insulin therapyGrady Memorial Hospital, Atlanta, GARush University Medical Center, Chicago, ILUmpierrez et al, J Clin Endocrinol Metab 94: 564–569, 2009
DEAN Trial: Changes in Mean DailyBlood Glucose ConcentrationBG, mg/dL240Detemir + aspart220NPH + regular200180P=NS160140120100Pre-RxBG0 1 2 3 4 5 6-10Duration of Therapy, dData are means SEM.Basal-bolus regimen: detemir was given once daily; aspart was given before meals.NPH/regular regimen: NPH and regular insulin were given twice daily, two thirds in AM, one third in PM.Umpierrez GE, et al. J Clin Endocrinol Metab. 2009;94(2):564-569.
Page 1 and 2: Inpatient Management ofMedical and
Page 3 and 4: Clinical Guidelines for theManageme
Page 5 and 6: Case Presentation:‣ 48 y/o male w
Page 7 and 8: Point-of-Care BloodGlucose Readings
Page 9 and 10: Hyperglycemia*: A Common Comorbidit
Page 11 and 12: Epidemiology of Inpatient Hyperglyc
Page 13 and 14: Comparison of sensitivity and speci
Page 15 and 16: Patients (%)IGT and Undiagnosed T2D
Page 17 and 18: Epidemiology of Inpatient Hyperglyc
Page 19 and 20: Community Acquired Pneumonia Outcom
Page 21 and 22: Thirty Day Mortality and Inhospital
Page 23 and 24: AACE/ADA Target Glucose Levelsin No
Page 25 and 26: Recommendations for Managing Patien
Page 27 and 28: Management of Hyperglycemia andDiab
Page 29 and 30: Randomized Basal Bolus versus Slidi
Page 31 and 32: BG, mg/dLRabbit 2 Trial: Changes in
Page 33: Basal-Bolus Insulin Therapy vs Slid
Page 37 and 38: DEAN Trial: Insulin DoseThe mean to
Page 39 and 40: Summary of Univariate Analysesp-val
Page 41 and 42: Primary outcome:• Differences bet
Page 43 and 44: Basal Bolus Insulin Regimen‣ D/C
Page 45 and 46: Blood Glucose (mg/dL)Rabbit Surgery
Page 47 and 48: Hospital Complications: Primary out
Page 49 and 50: Basal-Bolus Insulin Therapy vs Slid
Page 51 and 52: RABBIT-2 vs. DEAN TrialsBasal Bolus
Page 53 and 54: Hypoglycemia: Univariate Analysesp-
Page 55 and 56: Clinical Guidelines for the Managem
Page 57 and 58: Insulin ActionBasal-PLUS Insulin Re
Page 59 and 60: Discharge insulin AlgorithmDischarg

Inpatient Hyperglycemia

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