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viContents12. Streptogramins and Ox
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viiiContributorsElizabeth D. Hermse
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2 Craigconcentrations. With this pa
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4 Craigaminoglycosides decreases an
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6 CraigLog 10 CFU/Thigh at 24 hours
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8 Craig10080CephalosporinsPenicilli
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10 Craig50Cephalosporins40T>MIC (%)
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12 Craigor fluoroquinolones has a p
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14 CraigTABLE 3 Pharmacodynamic and
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16 Craig14. Andes D, van Ogtrop M.
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18 Craig55. Heffelfinger JD, Dowell
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2 Applying Pharmacodynamics for Sus
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Applying Pharmacodynamics for Susce
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Applying Pharmacodynamics for Susce
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Applying Pharmacodynamics for Susce
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Applying Pharmacodynamics for Susce
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≥Applying Pharmacodynamics for Su
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Applying Pharmacodynamics for Susce
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Applying Pharmacodynamics for Susce
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Applying Pharmacodynamics for Susce
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Applying Pharmacodynamics for Susce
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Applying Pharmacodynamics for Susce
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Applying Pharmacodynamics for Susce
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Section II: Non-clinical Models of
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In Vitro Dynamic Models as Predicti
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In Vitro Dynamic Models as Predicti
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In Vitro Dynamic Models as Predicti
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In Vitro Dynamic Models as Predicti
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In Vitro Dynamic Models as Predicti
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In Vitro Dynamic Models as Predicti
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In Vitro Dynamic Models as Predicti
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In Vitro Dynamic Models as Predicti
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In Vitro Dynamic Models as Predicti
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In Vitro Dynamic Models as Predicti
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In Vitro Dynamic Models as Predicti
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In Vitro Dynamic Models as Predicti
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In Vitro Dynamic Models as Predicti
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In Vitro Dynamic Models as Predicti
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In Vitro Dynamic Models as Predicti
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In Vitro Dynamic Models as Predicti
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4 Animal Models of Infection for th
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Animal Models of Infection for the
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Animal Models of Infection for the
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Animal Models of Infection for the
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Animal Models of Infection for the
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Animal Models of Infection for the
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Animal Models of Infection for the
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Animal Models of Infection for the
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Animal Models of Infection for the
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Animal Models of Infection for the
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Animal Models of Infection for the
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Animal Models of Infection for the
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5 The Predictive Value of Laborator
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Predictive Value of Laboratory Test
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Predictive Value of Laboratory Test
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Predictive Value of Laboratory Test
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Predictive Value of Laboratory Test
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Predictive Value of Laboratory Test
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Predictive Value of Laboratory Test
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Predictive Value of Laboratory Test
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Predictive Value of Laboratory Test
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Predictive Value of Laboratory Test
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Predictive Value of Laboratory Test
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- Page 139 and 140: 130 Tozuka and Murakawacharacterist
- Page 141 and 142: 132 Tozuka and Murakawa(cephem, oxa
- Page 143 and 144: 134 Tozuka and MurakawaInfusion pha
- Page 145 and 146: 136 Tozuka and Murakawapoorly into
- Page 147 and 148: 138 Tozuka and Murakawasix hours (3
- Page 149 and 150: 140 Tozuka and Murakawadosing inter
- Page 151 and 152: 142 Tozuka and MurakawaIntestinal b
- Page 153 and 154: 144 Tozuka and Murakawa16. Tozuka Z
- Page 155 and 156: 146 Tozuka and Murakawa59. Nicolau
- Page 157 and 158: 148 Kim and Nicolauand 23S) and fro
- Page 159 and 160: 150 Kim and Nicolaudetectable amino
- Page 161 and 162: 152 Kim and Nicolauactivity (26). B
- Page 163 and 164: 154 Kim and Nicolaucalculated as th
- Page 165 and 166: 156 Kim and Nicolauoverestimate of
- Page 167 and 168: 158 Kim and Nicolauit will likely m
- Page 169 and 170: 160 Kim and Nicolautrough concentra
- Page 171 and 172: 162 Kim and NicolauTABLE 1 Selectio
- Page 173 and 174: 164 Kim and NicolauConcentration (
- Page 175 and 176: 166 Kim and NicolauAdoption of cont
- Page 177 and 178: 168 Kim and Nicolau18. Swenson C, C
- Page 179 and 180: 170 Kim and Nicolau61. Karlowsky J,
- Page 181 and 182: 172 Kim and Nicolau103. Beaubien AR
- Page 183: 174 Kim and Nicolau146. Marik PE, L
- Page 187 and 188: 178 Ambrose et al.microorganism. Ad
- Page 189 and 190: 180 Ambrose et al.Human PK-PD DataI
- Page 191 and 192: 182 Ambrose et al.10080Mortality (%
- Page 193 and 194: 184 Ambrose et al.prevention concen
- Page 195 and 196: 186 Ambrose et al.Human PK-PD DataC
- Page 197 and 198: 188 Ambrose et al.27. Tam VH, Louie
- Page 199 and 200: 190 Hermsen et al.compound consists
- Page 201 and 202: 192 Hermsen et al.Drug elimination
- Page 203 and 204: 194 Hermsen et al.ability to select
- Page 205 and 206: 196 Hermsen et al.only represent co
- Page 207 and 208: 198 Hermsen et al.time for an antib
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- Page 211 and 212: 202 Hermsen et al.be considered at
- Page 213 and 214: 204 Hermsen et al.healthy volunteer
- Page 215 and 216: 206 Hermsen et al.TABLE 2Estimated
- Page 217 and 218: 208 Hermsen et al.regimen significa
- Page 219 and 220: 210 Hermsen et al.Pharmacotherapy:
- Page 221 and 222: 212 Hermsen et al.65. Knudsen JD, F
- Page 223 and 224: 214 Hermsen et al.109. Saunders NJ,
- Page 226 and 227: 10 Macrolide, Azalide, and Ketolide
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- Page 230 and 231: TABLE 1 The In Vitro Activities of
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Macrolide, Azalide, and Ketolides 2
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Macrolide, Azalide, and Ketolides 2
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Macrolide, Azalide, and Ketolides 2
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11 Metronidazole and Clindamycin fo
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Metronidazole and Clindamycin for A
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Metronidazole and Clindamycin for A
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Metronidazole and Clindamycin for A
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240 Abbanat et al.HOOHNOO NHNONONOO
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242 Abbanat et al.TABLE 1In Vitro A
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244 Abbanat et al.TABLE 1In Vitro A
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246 Abbanat et al.79GP 80 , or a 21
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248 Abbanat et al.TABLE 2 Steady-St
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250 Abbanat et al.TABLE 4 Pharmacok
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252 Abbanat et al.antibiotic-suscep
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254 Abbanat et al.TABLE 5 In Vitro
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256 Abbanat et al.TABLE 5 In Vitro
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258 Abbanat et al.TABLE 6Pharmacoki
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260 Abbanat et al.enrolled under th
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262 Abbanat et al.35. Tait-Kamradt
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264 Abbanat et al.antimicrobials ag
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13 Pharmacokinetics and Pharmacodyn
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Pharmacokinetics and Pharmacodynami
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Pharmacokinetics and Pharmacodynami
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Pharmacokinetics and Pharmacodynami
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Pharmacokinetics and Pharmacodynami
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Pharmacokinetics and Pharmacodynami
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280 Kiser and FletcherThe resistanc
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282 Kiser and Fletcherthe clinicall
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284 Kiser and Fletcheroccurred in 8
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286 Kiser and FletcherCLINICAL PHAR
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288 Kiser and Fletcherwhich would a
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Table 2 FDA-Approved Dosing Regimen
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292 Kiser and Fletcher4. De Clercq
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15 Pharmacodynamics of AntiviralsGe
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Pharmacodynamics of Antivirals 297P
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Pharmacodynamics of Antivirals 2991
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Pharmacodynamics of Antivirals 301A
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Pharmacodynamics of Antivirals 303P
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Pharmacodynamics of Antivirals 3052
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Pharmacodynamics of Antivirals 3071
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Pharmacodynamics of Antivirals 309c
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Pharmacodynamics of Antivirals 3111
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Pharmacodynamics of Antivirals 313v
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Section V: Antifungal Agents16 Anti
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Antifungal Agents Pharmacokinetics
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Antifungal Agents Pharmacokinetics
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Antifungal Agents Pharmacokinetics
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Antifungal Agents Pharmacokinetics
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Antifungal Agents Pharmacokinetics
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17 Pharmacokinetics and Pharmacodyn
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TABLE 1 Overview of Pharmacokinetic
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Pharmacokinetics and Pharmacodynami
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Pharmacokinetics and Pharmacodynami
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Pharmacokinetics and Pharmacodynami
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Pharmacokinetics and Pharmacodynami
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Pharmacokinetics and Pharmacodynami
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Pharmacokinetics and Pharmacodynami
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Pharmacokinetics and Pharmacodynami
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Pharmacokinetics and Pharmacodynami
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Pharmacokinetics and Pharmacodynami
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Pharmacokinetics and Pharmacodynami
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Pharmacokinetics and Pharmacodynami
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Pharmacokinetics and Pharmacodynami
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356 Gumbo et al.TABLE 1 MIC 90 (mg/
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358 Gumbo et al.Cytoplasmicmembrane
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360 Gumbo et al.outcome is expected
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362 Gumbo et al.TABLE 2Ref.Pharmaco
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364 Gumbo et al.products become mar
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366 Gumbo et al.echinocandin HMA 32
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368 Gumbo et al.TABLE 5 Pharmacokin
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370 Gumbo et al.TABLE 6 Pharmacokin
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372 Gumbo et al.plasma C max ,AUC 0
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374 Gumbo et al.steady-state AUC of
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376 Gumbo et al.for fluconazole, it
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378 Gumbo et al.67. Matsumoto F. Ef
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380 Ashley and WhiteAD340 Qinghaosu
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382 Ashley and WhiteHalofantrineHal
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384 Ashley and Whiteway rapidly to
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386 Ashley and WhiteAminoquinolines
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388 Ashley and WhiteAtovaquone-Prog
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390 Ashley and WhiteAQ and its meta
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392 Ashley and Whiteindividual dose
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394 Ashley and Whiteactivity. This
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396 Ashley and Whitelactate dehydro
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398 Ashley and Whiteresponses appea
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400 Ashley and White10 12Total para
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402 Ashley and WhiteTABLE 3 Treatme
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404 Ashley and WhiteTABLE 4 Treatme
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406 Ashley and White19. White N. Ma
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408 Ashley and White64. Phillips RE
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Section VII: Pharmacodynamics in Dr
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Human Pharmacodynamics of Anti-infe
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Human Pharmacodynamics of Anti-infe
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Human Pharmacodynamics of Anti-infe
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Human Pharmacodynamics of Anti-infe
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Human Pharmacodynamics of Anti-infe
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Human Pharmacodynamics of Anti-infe
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Human Pharmacodynamics of Anti-infe
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Human Pharmacodynamics of Anti-infe
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Human Pharmacodynamics of Anti-infe
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Human Pharmacodynamics of Anti-infe
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434 BhavnaniBRIDGING DATA AND BRIDG
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436 Bhavnaniin PKs (5). As with pol
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438 Bhavnaniinfection models, and (
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440 BhavnaniPhase Iepoxidehydrolase
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442 Bhavnaniand Asia are similar to
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444 BhavnaniTABLE 2 Percent Probabi
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446 Bhavnani10. Nilchaikovit T, Hil
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448 Bhavnani52. Cirincione B, Lobek
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450 Forrest and DrusanoKeeping drug
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452 Forrest and Drusanosignificant.
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454 Forrest and DrusanoTABLE 2 Mont
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456 Forrest and DrusanoRayner et al
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458 Forrest and Drusano120100Durati
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460 Forrest and DrusanoUsing Classi
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462 Forrest and Drusano12. Meagher
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464 Lister et al.TABLE 1 Emerging R
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466 Lister et al.The mechanism of p
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468 Lister et al.Although ESBLs wer
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470 Lister et al.Acquired Vs. Mutat
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472 Lister et al.the emergence of r
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474 Lister et al.emergence of resis
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476 Lister et al.to emerge during t
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478 Lister et al.10Pseudomonas aeru
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480 Lister et al.11Pseudomonas aeru
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482 Lister et al.23. Kislak JW, Raz
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484 Lister et al.68. Shlaes DM, Bou
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Section IX: Application of PK-PD to
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The Principles of Pharmacoeconomics
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The Principles of Pharmacoeconomics
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The Principles of Pharmacoeconomics
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The Principles of Pharmacoeconomics
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The Principles of Pharmacoeconomics
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The Principles of Pharmacoeconomics
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The Principles of Pharmacoeconomics
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The Principles of Pharmacoeconomics
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506 Index[Animal models of infectio
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508 Index[Antimalarial agents]uncom
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510 IndexContinuous infusion (CI),
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512 Index[b-Lactam pharmacodynamics
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514 Index[Pharmacoeconomics, princi
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516 IndexSusceptibility testingfila