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Streptogramins and Oxazolidinones 253TABLE 5 In Vitro Activities of the Oxazolidinones Linezolid and DA-7867 withComparative AgentsMIC (mg/mL)Organism Compound N Range MIC 50 MIC 90Percentagesusceptible Refs.VS-EnterococcusfaecalisVancomycin 121 2–4 2 2 100 28Teicoplanin 121 0.5 0.5 0.5 100 28Ampicillin 121 1–64 1 1 99.2 28Doxycycline 121 1–32 8 16 38 28Ciprofloxacin 121 1–64 2 64 47.9 28Linezolid 121 0.5–2 2 2 100 28DA-7867 49 0.06 to 0.12 0.12 0.12 NB a 71VR-E. faecalis Vancomycin 81 16–512 512 512 0.0 28Teicoplanin 81 0.5–128 64 128 43.2 28Ampicillin 81 1–128 1 2 97.5 28Doxycycline 81 1–32 8 16 35.8 28Ciprofloxacin 81 1–64 32 64 1.2 28Linezolid 81 1–2 1 2 100 28DA-7867 10 0.06 to 0.12 0.06 0.12 NB 71VS-EnterococcusfaeciumVancomycin 42 2 2 2 100 28Teicoplanin 42 0.5–1 0.5 1 100 28Ampicillin 42 1–128 64 128 21.4 28Doxycycline 42 1–32 1 8 73.8 28Ciprofloxacin 42 1–64 64 64 9.5 28Linezolid 42 0.25–4 2 2 97.6 28DA-7867 29 0.06 to 0.12 0.12 0.12 NB 71VR-E. faecium Vancomycin 616 8–512 256 512 0.0 28Teicoplanin 616 0.5–128 32 32 22.2 28Ampicillin 616 1–256 64 128 3.2 28Doxycycline 616 1–32 4 16 60.7 28Ciprofloxacin 616 8–64 64 64 0.0 28Linezolid 616 0.25–16 1 2 99.5 28DA-7867 30 0.06 to 0.12 0.12 0.12 NB 71Staphylococcus aureus bCA-MSSA Vancomycin 1592 0.12 to 2 1 1 100 23Penicillin 1592 0.016 to >32 4 32 17.7 23Doxycycline 1592 0.5 to >4 0.5 0.5 99.0 23Ciprofloxacin 1592 0.25 to >4 0.25 1 91.3 23TMP-SFX c 1592 0.5 to >2 0.5 0.5 96.8 23Linezolid 1592 0.12–4 2 2 100 23CA-MRSA Vancomycin 652 0.5–4 1 1 100 23Penicillin 652 0.016 to >32 32 >32 0.5 23Doxycycline 652 0.5 to >4 0.5 2 96.1 23Ciprofloxacin 652 0.25 to >4 >4 >4 15.2 23TMP-SFX 652 0.5 to >2 0.5 0.5 92.2 23Linezolid 652 0.5–16 2 2 99.8 23N-MSSA Vancomycin 706 0.5–2 1 1 100 23Penicillin 706 0.016 to >32 4 32 17.4 23(Continued)