SK Gupta* et al. /International Journal Of Pharmacy&Technology
SK Gupta* et al. /International Journal Of Pharmacy&Technology
SK Gupta* et al. /International Journal Of Pharmacy&Technology
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S.K.<strong>Gupta*</strong> <strong>et</strong> <strong>al</strong>. /Internation<strong>al</strong> Journ<strong>al</strong> <strong>Of</strong> Pharmacy&<strong>Technology</strong>and sodium v<strong>al</strong>proate (antiepileptic). Plant <strong>al</strong>coholic extract, formotidine and sodium v<strong>al</strong>proate showed a dosedependent reduction of a gastric ulceration 25 .Dombeya bu<strong>et</strong>tneri The effects of an aqueous extract of leaves of D. b<strong>et</strong>ween on gastric acid secr<strong>et</strong>ion and <strong>et</strong>hanolinduced gastric mucos<strong>al</strong> damage studied in rats. Gastric acid secr<strong>et</strong>ion measure by continuous perfusion in ur<strong>et</strong>haneanaesth<strong>et</strong>izedIntragastric perfusion with extract caused significant reduction in bas<strong>al</strong> and histamine stimulated gastric acidsecr<strong>et</strong>ion. Pr<strong>et</strong>reatment with extract <strong>al</strong>so reduced the extent of gastric mucos<strong>al</strong> damage induced by or<strong>al</strong> <strong>et</strong>hanol (75%V/V) but have no effect on mucus secr<strong>et</strong>ion.Therefore, consumption of an extract of the leaves of D. bu<strong>et</strong>tneri may be benefici<strong>al</strong> prevention andtreatment of peptic ulcer disease 26 .Neurolaena lobata: The hexane fraction (H X F) chloroform fraction (CIF) and aqueous fraction (H 2 OF) fractions ofa hydro <strong>al</strong>coholic extract (HE) of N. lobata aeri<strong>al</strong> parts were investigation there ability to prevent ulceration gastricmucosa. The pylorus ligature experiment demonstrated that HE, H X F and CIF fraction changed significantly thegastric juice param<strong>et</strong>ers such as pH v<strong>al</strong>ue (increase to 5.4, 4.9. and 4.8 respectively) and acid output (decreases by4.6, 5.3 and 6.2 (--) 4th respectively) and gastric content (increased by 400, 410 and 390 mg, respectively) inanim<strong>al</strong>s.M. lobata present significant antiulcer effect when assessed in this ulcer, induced models by increasedactivity of defensive mechanism of stomach, such as prostaglandin synthesis and mucus production 27 .Ezanatia chlorantha: Antiulcer action of novel protoberberine type <strong>al</strong>k<strong>al</strong>oid [7,8-dihdro-8 –Hydroxy p<strong>al</strong>matine (1)],obtained from bark of E.chlorantha using the HCl <strong>et</strong>hanol, absolute <strong>et</strong>hanol and pylorus ligation techniques. Thehe<strong>al</strong>ing effect on chronic ac<strong>et</strong>ic acid induced gastric ulcer that, dose dependently inhibited the formation of gastriculcer induced by HCl/ <strong>et</strong>hanolThe significant inhibition of pylorus-ligated ulcers occurs at gastric acid concentration previously known toinduce severe gastric ulceration in rats.IJPT | March-2011 | Vol. 3 | Issue No.1 | 824-853 Page 840
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