SK Gupta* et al. /International Journal Of Pharmacy&Technology

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S.K.Gupta* et al. /International Journal Of Pharmacy&Technologyin cultured rat hepatocytes. These constituents also showed a significant stimulatory effect on liver cell regeneration.Evidence suggests that trailing eclipta exerts its protective action through a reduction in GSH depletion 40 .Indian Gall Fruit (Terminalia chebula): Traditionally used in chronic diarrhea and dysentery, flatulence, vomiting,colic, and enlarged spleen and liver. In a study conducted on rabbits, Indian gall fruit had a hypocholesterolemiceffect on cholesterol inducedhypercholesterolemia 40Chicory Seed (Cichorium intybus): Traditionally used for hepatic conditions and liver rejuvenation and has shownprotective effects in mice with high levels of liver damaging enzymes 40 .Long Pepper Fruit (Piper longum): Piperine, an active alkaloid constituent, has been shown to exert a significantprotection against liver toxicity induced by tert-butyl hydro peroxide and carbon tetrachloride by reducing in bothvitro and vivo lipid peroxidation by decreasing the reduction of GSH 40 .Arjuna Myrobalan Bark (Terminalia arjuna): The powdered bark is traditionally used as a diuretic and generaltonic in cases of cirrhosis of the liver 41 .Amla Fruit (Emblica officinalis): Traditionally used for enlarged liver and for liver revitalizing 42 .Spreading Hog Weed Whole Plant (Boerhaavia diffusa): Traditionally used for hepatic disorders and for internalinflammation 43 .Phylanthus Aerial Parts (Phyllanthus niruri): The fresh root is traditionally given in peptic ulcer 44 .SUMMARY AND CONCLUSION:Peptic ulcer is common gastro intestinal disorder and includes gastro esophageal reflux peptic ulcer and ZEsyndrome.It is usually arising due to imbalance in aggressive (gastric juice, pepsin production, H. pylori, alcohol,NSAID’S) and defensive factor (endogenous prostaglandin, gastrial mucosal barriers). To treat this disease twocategories of the drugs are used: Synthetic drugs, Herbal drugs. Herbal drugs in case of this disease play animportant role owing to various protective and curing effects on stomach. These are not only effective in the pepticulcer but also show different associated activities.• Antistress activity: Abiexs pindrowIJPT | March-2011 | Vol. 3 | Issue No.1 | 824-853 Page 845
S.K.Gupta* et al. /International Journal Of Pharmacy&Technology• Increase mucin secretion and life span of mucosa cell: Bacopa monniera.• Increase PG production: Flueggea microcarpa.• Cytoprotective action: Zingiber officinale, capsaicin.• Acid neutralizing capacity: Beninecosa lispida.• Decrease volume acidity of gastric juice: Garcina Cambogia.• Antibacterial action against H. pylori: Rabdosia trichocarpas.• H + K + ATPase activity inhibitor: Kampo formulation.• Anti histamines: Atractylodes lancea.• Inhibition of 5- Lipoxygenase: Calotropis procera.The drugs from the plant origin play very important role to treat the peptic ulcer.To conclude it may be said that herbal drugs have provided us with potent weapons like atropine, codeine,taxol, vincristine and vinblastine. In the modern scenario, diseases are becoming drug-resistant and scientists arestudying possible roles of plant based drugs for screening life saving drugs. The herbal system of medicine is a fullyfledged system of medicine and it cannot be ruled out as quackery. Backing up this system is the fact that ancientfindings and documentation have through the centuries provided us with leads on the development of life-savingdrugs.Liver disease appears to be on the increase. Part of this increase may be due to our frequent contact withchemicals and other environmental pollutants. The amount of medicine consumed has increased greatly withresulting dangers to the liver. The liver, the detoxifying factory in the body, has become an increasingly overworkedorgan. While those who smoke, abuse alcohol and drugs and live in severely polluted environments are at greatestrisk, we all suffer some threat of damage or disease to the liver.Several hundred plants have been examined for use in a wide variety of liver disorders. Just handfuls havebeen fairly well researched. The latter category of plants include: Silybum marianum (milk thistle), Picrorhizakurroa (kutkin), Curcuma longa (turmeric), Camellia sinensis (green tea), Chelidonium majus (greater celandine),Glycyrrhiza glabra (licorice), and Allium sativa (garlic). Silybum marianum, Picrrorhiza kurroa, Andrographispaniculata, Phyllanthus niruri, and Eclipta Alba are proven hepatoprotective medicinal herbs, which have shownIJPT | March-2011 | Vol. 3 | Issue No.1 | 824-853 Page 846
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SK Gupta* et al. /International Journal Of Pharmacy&Technology

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