Chronisch Vermoeidheidssyndroom: diagnose, behandeling en ...

10 Chronic Fatigue Syndrome KCE reports 88
• The management of children and young people who may be
chronically tired but who have a diagnosis of another medical or
psychiatric illness which is causing the fatigue
• The management of co-morbid disorders
• Appraisal of the evidence underpinning theories of aetiology and
biological/immunological markers of CFS or health economics of the
condition.
The search strategy used for the guideline was based on that developed in the most
recent evidence review undertaken by the Centre for Reviews and Dissemination 15
although the search was updated (until February 2004) and restricted to papers on
children and young people.
Both CRD Report 35, NICE Clinical Guideline 53 for adults and RCPCH guideline for
children and young people were considered as the base for our literature review, as
well as the Cochrane Systematic Review about the effectiveness of exercise therapy.
Additional studies published after the search strategy used in these publications were
specifically searched in our own literature search strategy. However, we have searched
the literature for material published from 2004 onwards, to avoid any missing in
relevant publications.
2.1.2.4 HTA reports
No additional report was found.
2.1.2.5 Studies in progress
Our search found 10 controlled trials completed or in progress (but not yet published)
with chronic fatigue syndrome. The list of these trials can be found in appendix 2.
2.1.2.6 Literature review (period 2004-2007)
The primary search in Medline (search window: 2004 - Nov 2007) yielded 210 citations
and the primary search in Embase (search window: 2004 - Nov 2007) yielded 96
additional citations (excluding duplicates). A total of 306 abstracts identified from
electronic searches were screened against protocol-defined exclusion criteria. After
screening of abstracts for exclusion criteria (Level I screening), 64 were accepted and
these full-text papers were retrieved for more in-depth screening (Level II). During
Level II screening of full-text papers, 41 were rejected, resulting in a total of 23
accepted studies (Figure 1). The most common reason for rejection was inappropriate
design.