Bioinformatics History and Introduction - Chagall

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Examining bioinformatics approaches to abiological problemmiRNA target prediction24 January 2013 Luce Skrabanek
miRNAs: an introduction• Small RNA molecules, 19-24 bases in length,that are involved in regulation of numerousbiological processes– Target mRNA for degradation– Repress translation• Derived from longer primary miRNA transcripts24 January 2013 Luce Skrabanek
Page 1 and 2: BioinformaticsHistory and Introduct
Page 3 and 4: Required skills• Biology• Compu
Page 5 and 6: Applications of bioinformatics• M
Page 7 and 8: The scales of knowledge• Historic
Page 9 and 10: Biology of Systems• Huge amounts
Page 11 and 12: 24 January 2013 Luce SkrabanekRavi
Page 13 and 14: Where do we get our data from?• E
Page 15 and 16: Caution!• Errors in the databases
Page 17 and 18: My protein doesn’t begin with an
Page 19 and 20: Some sample error rates• GenBank:
Page 21: Propagation of errors• The qualit
Page 25 and 26: miRNA3’ UTR24 January 2013 Luce S
Page 27 and 28: Indirect experimental identificatio
Page 29 and 30: Computational prediction of miRNA t
Page 31 and 32: Pipeline to identify miRNA targets
Page 33 and 34: Sequence matching algorithm• Modi
Page 35 and 36: Control sequences• 100 sets of ra
Page 37 and 38: Pipeline to identify mammalian targ
Page 39 and 40: Validation• Luciferase reporter a
Page 41 and 42: 24 January 2013 Luce SkrabanekLewis
Page 43 and 44: Many other programs…• Many prog
Page 45 and 46: Evaluation comparison5 miRNAs vs. S
Page 47 and 48: SVMs: Brief introduction• Positiv
Page 49 and 50: TargetMiner• Used the 289 negativ
Page 51 and 52: Further evaluation• Trained other
Page 53: Important points• This type of an

Bioinformatics History and Introduction - Chagall

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