Formulation and Evaluation of Perindopril Sublingual Tablets
Formulation and Evaluation of Perindopril Sublingual Tablets
Formulation and Evaluation of Perindopril Sublingual Tablets
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International Journal <strong>of</strong> Research in Pharmaceutical <strong>and</strong> Biomedical Sciences ISSN: 2229-3701Table 3: Water absorption ratio, Wetting time, Disintegration time <strong>and</strong> Drug content <strong>of</strong><strong>Perindopril</strong> sublingual tablets<strong>Formulation</strong> code Water absorption ratioWetting time(Sec.)Disintegration time (sec) Drug contentF1 27 132 237 99.13F2 35 88 181 98.82F3 41 68 145 99.05F4 55 45 98 100.87Table 4: Regression analysis <strong>of</strong> formulations F1-F4Release KineticsS. No. <strong>Formulation</strong>KorsemeyerZero-Order First-Order HiguchiPeppas1 F 1 0.9032 0. 9834 0.9654 0.96492 F 2 0.8891 0. 8954 0.9875 0.94853 F 3 0.9110 0. 9750 0.9679 0.96364 F 4 0.9159 0. 9452 0.9863 0.9830Fig. 1: Wetting time pr<strong>of</strong>ile <strong>of</strong> <strong>Perindopril</strong> formulations F1-F4Fig. 2: Water absorption ratio pr<strong>of</strong>ile <strong>of</strong> <strong>Perindopril</strong> formulations F1-F4Fig. 3: Comparison <strong>of</strong> Dissolution pr<strong>of</strong>ile <strong>of</strong> <strong>Perindopril</strong> formulations F1-F41197Vol. 2 (3) Jul – Sep 2011www.ijrpbsonline.com