Peter Tontonoz, M.D., Ph.D.

Peter Tontonoz, M.D., Ph.D.Howard Hughes Medical Institute416 Beirut Avenue675 Charles Young Dr., MRL 5-748 Pacific Palisades, CA 90272University of Californiaptontonoz@mednet.ucla.eduLos Angeles, CA 90095 (310) 206-4546Place of Birth:Worcester, MassachusettsEducation: M.D., Harvard Medical School, Boston, MA (1996)Ph.D., Harvard University, Cambridge, MA (1996)Department of GeneticsB.A., Wesleyan University, Middletown, CT (1989)High Honors in Molecular Biology and BiochemistryExperience:Professor (2006-present)Department of Pathology and Laboratory Medicine, UCLAInvestigator (2000-present)Howard Hughes Medical InstituteAssociate Professor with Tenure (2002-2006)Department of Pathology and Laboratory Medicine, UCLAAssistant Professor (1999-2002)Department of Pathology and Laboratory Medicine, UCLAHonors:Editorial Boards:2010 Hoeg Award for Basic and Clinical Research, AHA2008 Leadership Council, ASCI2005 Weitzman Memorial Award, Endocrine Society2004 Bristol-Myers Squibb Freedom to Discover Award2004 American Society for Clinical Investigation1999 Damon Runyon Scholar Award1994 Dana-Farber Smith Prize for Outstanding Research,1988 Phi Beta Kappa, Wesleyan UniversityJournal of Clinical InvestigationMolecular and Cellular BiologyMolecular EndocrinologyJournal of Lipid Research

Selected Publications:Pei, L., Waki, H., Vaitheesvaran, B., Wilpitz, D.C., Kurland, I., and Tontonoz, P. (2006). NR4A orphannuclear receptors are transcriptional regulators of hepatic glucose metabolism. Nature Medicine.12:1048-55.Waki, H., Park, K.W., Mitro, N., Pei, L., Damoiseaux, R., Wilpitz, D., Reue, K., Saez, E., Tontonoz, P.(2007). The small molecule harmine is an anti-diabetic cell-type-specific regulator of PPARγexpression. Cell Metabolism. 5:357-370. Cover Article.Zelcer, N., Khanlou, N., Clare, R., Jiang, Q., Reed-Geaghan, E.G., Landreth, G.E., Vinters, H.V.V.,and Tontonoz, P. (2007). Attenuation of neuroinflammation and Alzheimer’s disease pathology byLXRs. Proc. Natl. Acad. Sci. U.S.A. 104:10601-10606.Bradley, M.N., Hong, C., Joseph, S.B., Chen, M., Wang. X., Lusis, J., Collins, A., Hseuh, W.A. Collins,J.L., Tangirala, R. and Tontonoz, P. (2007). Ligand activation of LXRβ reverses whole body cholesteroloverload and atherosclerosis in LXRα-/-apoE-/- mice. J. Clin. Invest. 117:2337-2346.Chao, L.C., Zhang, Z., Tsugumichi, S., Tontonoz, P. and Pilch, P. (2007). Nur77 coordinately regulatesexpression of genes linked to glucose metabolism in skeletal muscle. Molecular Endocrinology.21:2152-2163.Park, K.W., Waki, H., Villanueva, C.J., Monticelli, L., Hong, C., Kang, S., MacDougald, O.A., Goldrath,A.W., and Tontonoz, P. (2008). Id2 is a small molecule-inducible modulator of PPARγ expression andadipocyte differentiation. Molecular Endocrinology. 22:2038-48.Bensinger, S.J., Bradley, M.N., Joseph, S.B., Zelcer, N., Janssen, E.M., Hausner, M.A., Shih, R.,Parks, J., Edwards, P.A., Jamieson, B.D., and Tontonoz, P. (2008). LXR signaling couples sterolmetabolism to proliferation in the acquired immune response. Cell. 134:97-111.Chao, L.C., Bensinger, S.J., Wroblewski, K., and Tontonoz, P. (2008). Inhibition of adipocytedifferentiation by Nur77, Nurr1 and Nor-1. Molecular Endocrinology. 22:2596-608. Cover Article.Bensinger, S.J. and Tontonoz, P. (2008). Integration of metabolism and inflammation by lipid-activatednuclear receptors. Nature. 454:470-477.Zelcer, N., Hong, C., Boyadjian, R., and Tontonoz, P. (2009). LXR regulates cholesterol uptakethrough Idol-dependent ubiquitination of the LDL receptor. Science. 325:100-104.A-Gonzalez, N., Bensinger, S.J., Bradley, M.N., Zelcer, N., Beceiro, S., Hong, C., Deniz, J., Ramirez,C.M., Gallardo, G., Galarreta, C., Salazar, J., Lopez, F., Parks, J., Edwards, P.A., Andujar, M.,Tontonoz, P. and Castrillo, A. (2009). Apoptotic cells promote their own clearance and immunetolerance through activation of LXR signaling. Immunity. 31:245-258.Chao, L.C., Wroblewski, K., Zhang, Z., Pei, L., Vergnes, L., Reue, K., Watt, M.J., Newgard, C.B., Pilch,P.F., Hevener, A.L. and Tontonoz, P. (2009). Insulin resistance and altered systemic glucosemetabolism in mice lacking Nur77. Diabetes. 58:2788-96.