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documented to possess both highly anti-tumor and pesticidal properties.Active compounds from Graviola and other Annona plants have been submitted to the NIH anti-AIDS screen by Purdue University and their work is continuing with a number of other activeplant species in the Annona plant family. Thus far, Purdue and/or it's staff have filed at least 9U.S. and/or international patents on their work around the antitumorous and insecticidalproperties and uses of these acetogenins. Three separate research groups have isolated novelcompounds in the seeds and leaves of Graviola which have demonstrated significant antitumorous,anticancerous and selective toxicity against various types of cancer cells, publishing 8clinical studies on their findings. One study demonstrated that an acetogenin in Graviola wasselectively cytotoxic to colon adenocarcinoma cells in which it was 10,000 times the potency ofadriamycin (a chemotherapy drug). Cancer research is ongoing on Graviola, and four newstudies have been published in 1998 which further narrow down the specific phytochemicalswhich are demonstrating the strongest anticancerous and antiviral properties.In the June issue of Cancer Letters, Purdue researchers reported that the Annonaceousacetogenin, bullatacin, preferentially killed multi-drug resistant cancer cells because it blockedproduction of adenosine triphosphate, ATP, the chief energy-carrying compound in the body. In1997, Purdue University published information with promising news that several of theAnnonaceous acetogenins are not only are effective in killing tumors that have proven resistantto anti-cancer agents, but also seem to have a special affinity for such resistant cells. Cancercells that survive chemotherapy may develop resistance to the agent originally used againstthem as well as to other, even unrelated, drugs. The term multi-drug resistance (MDR) has beenapplied to this phenomenon. Cancer research will obviously be ongoing on these importantplants and plant chemicals as several pharmaceutical companies continue to research, test andattempt to synthesize these chemicals into new chemo-theraputic drugs.Graviola is safe enough that it protects healthy cells instead of killing them, doesn't causeextreme nausea or hair loss and this treatment doesn't make cancer patients drop huge amountsof weight, get weak, or compromise their immune systems.Herbal Secrets of the Rainforest, "Tropical Plant Database," Ms. Leslie Taylor, PrimaPublishing, September, 1998.GOTU KOLALEAVES(CENTELLAASIATICA)Code: BHSN-BTH-006Weight: 8 OuncesGOTU KOLA24