Curriculum Vitae and Publications - Isped

Curriculum Vitae and PublicationsJacqmin-Gadda HélèneInserm Research DirectorInserm Research Center U897, Biostatistics team, Bordeaux, FranceBirth date: May 10, 1968EDUCATION:University Bordeaux II HDR 2002 Biostatistics/Public HealthUniversity Paris VII PhD 1994 BiostatisticsUniversity Paris VII Master 2 1990 BiomathématicsUniversity Paris IV MST 1989 Social Science/ StatisticUniversity Bordeaux II DEUG 1987 Applied MathematicsRESEARCH AND PROFESSIONAL EXPERIENCE:2007- … DR2 Inserm U897, Biostatistic team2000-2007 CR1 Inserm U 875, (ex EMI 0338, ex “Biostatistic” team of U330)1996-2000 CR2 Inserm U330, Biostatistic teamResearch interest: Biostatistics.My main field of research is statistical methods for the analysis of longitudinal data andespecially, models for multivariate longitudinal data and joint models for longitudinal data andtime-to-event. The main motivation and application are the study of cognitive aging and riskfactors and natural history of Alzheimer’s disease. Other fields of application are HIV andcancer. On these subjects, I have directed 10 master students and 3 PhD students.EXPERT AND CONSULTING ACTIVITIES2002-2003 : Member of the « Action Coordonnée n°7 » of the ANRS (National agency forAIDS research) on epidemiological cohort (2002/2003).2003 – … : Associate Editor of Biometrics.2009 : AERES expert2009 : Member of the Advisory Board of the GuidAge StudyCONFERENCE ORGANIZATIONCo-organizator of the Inserm workshops :« Modelling of incomplete observations : sensitivity analyses» ( Mai 2007) ;« Latent class models for longitudinal data» (Mai 2010)Member of the scientific commitee of the following conferences : ADELF 2008 (Paris), IBSChannel Network 2009 (Ghent, Belgique 6-8/4/2009), Journées de Statistiques de la SFDS2009 (Bordeaux), ISCB 2010 (Montpellier),…

PHD STUDENTS :Rodolphe Thiebaut : Longitudinal modelling of HIV markers. PhD thesis in Biological andMedical Sciences speciality Epidemiology and Biostatistics, Bordeaux II University. (2002).Cécile Proust-Lima : Mixed model with latent structure for heterogeneous multivariatelongitudinal data: application to cognitive aging and dementia. PhD thesis in Biological andMedical Sciences speciality Epidemiology and Biostatistics, Bordeaux II University. (2006).Etienne Dantan : Modelling of pre-diagnostic phase of Alzheimer’s disease. PhD thesis inBiological and Medical Sciences speciality Epidemiology and Biostatistics, Bordeaux IIUniversity. (2006).

99-1 Baldy I, Tessier JF, Kauffman F, Jacqmin-Gadda H, Nejjari C, Salamon R. Prevalenceof asthma and mean levals of air pollution : results from the French PAARK survey..European Respiratory Journal, 1999, 14 : 132-138.99-2 Jacqmin-Gadda H, Commenges D, Dartigues JF. Analyse de données longitudinalesgaussiennes comportant des données manquantes sur la variable à expliquer. Rev. Epidem. etSanté Publ., 1999, 47,525-534.200000-1 Jacqmin-Gadda H, Fabrigoule C, Commenges D, Letenneur L, Dartigues JF (2000). Acognitive screening battery for dementia in the elderly. J clin epidemiol, 53, 980-987.00-2 Jacqmin-Gadda H, Thiébaut R, Chêne G, Commenges D (2000). Analysis of leftcensoredlongitudinal data with application to viral load in HIV infection. Biostatistics 1, 355-368.00-3 Rondeau V, Commenges D, Jacqmin-Gadda H, Dartigues JF (2000). Relationshipbetween aluminum concentrations in drinking water and Alzheimer’s disease. Am JEpidemiol, 152, 59-66.00-4 Thiébaut R, Dabis F, Malvy D, Jacqmin-Gadda H, Mercié P, Daucourt V for the GECSA(2000). Serum triglycerides, HIV infection and highly active antiretroviral therapy. Aquitainecohort, France, 1996-1998. J Acquir Immune Defic Syndr, 23, 261-265.00-5 Thiébaut R, Morlat P, Jacqmin-Gadda H, Neau D, Mercié P, Dabis F, Chêne G, for theGECSA (2000). Clinical progression of HIV-1 infection according to the viral responseduring the first year of antiretroviral treatment. AIDS, 14, 971-978.00-6 Commenges D, Scotet V, Renaud S, Jacqmin-Gadda H, Barberger-Gateau P, DartiguesJF (2000). Intake of Flavonoids and risk of dementia. Eur J Epidemiol, 16, 357-363.00-7 Goldberg M, Clavel-Chapelon F, Derriennic F, Jacqmin-Gadda H, Larroque B, Meyer L,Moulin JJ, Tirmarche M (2000). Les Cohortes épidémiologiques : aspects méthodologiques,éthiques et pratiques. Compte-rendu d’un Colloque scientifique de l’adelf.(Nancy, 12-14janvier 2000). Rev Epidemiol Sante Publique, 48, 503-508.200101-1 Binquet C, Chêne G, Jacqmin-Gadda H, Journot V, Saves M, Lacoste D, Dabis F and theGECSA. Modeling changes in CD4+ lymphocyte counts after starting HAART and therelationship with the risk of apportunistic infections, Aquitaine Cohort, 1996-1997. Am JEpidemiol 2001, 153 , 386-393.01-2 Rondeau V, Jacqmin-Gadda H, Commenges D, Dartigues JF. Aluminum in drinkingwater and cognitive decline in elderly subjects: the Paquid cohort. Am J Epidemiol 2001,154:288-290 (lettre).

01-3 Journot V, Chêne G, Joly P, Saves M, Jacqmin-Gadda H, Molina JM, Salamon R and theALBI study group. Viral load as a primary outcome in human immunodeficiency virus trials:a review of statistical analysis methods. Control Clin Trials 2001, 22 , 639-658.01-4 Auriacombe S, Fabrigoule C, Lafont S, Amieva H, Jacqmin-Gadda H, Dartigues JF.Letter and category fluency in normal elderly participants : a population-based study. Aging,neuropsychology and cognition 2001, 8(2) , 98-108.200202-1 Jacqmin-Gadda H, Joly P, Commenges D, Binquet C, Chêne G. Penalized likelihoodapproach to estimate smooth mean curve on longitudinal data. Statistics in Medicine 2002,21:2391-240202-2 Thiébaut Rodolphe, Jacqmin-Gadda H, Commenges D, Chêne G. Bivariate linear mixedmodels using SAS proc mixed. Computer Methods and Programs in Biomedicine 2002,69:249-256.02-3 Winnock M, Letenneur L, Jacqmin-Gadda H, Dallongeville J, Amouyel P, Dartigues JF.Longitudinal analysis of the effect of apolipoprotein E ε4 and education on cognitiveperformance in elderly subjects : The paquid study. J Neurol Neurosurg Psychiat 2002,72 :794-797.200303-1 Thiébaut R, Jacqmin-Gadda H, Leport C, Katlama C, Costagliola D, Le Moing V,Morlat P, Chêne G, and the APROCO study group. Bivariate longitudinal model for theanalysis of the evolution of HIV RNA and CD4 cell count in HIV infection taking intoaccount left censoring of HIV RNA measures Journal of Biopharmaceutical Statistics 2003,13(2) : 271-282.03-2 Marque Sébastien, Jacqmin-Gadda H, Dartigues JF, Commenges D. Cardiovascularmortality and calcium and magnesium in drinking water: an ecological study in elderlypeople. European Journal of Epidemiology 2003, 18 (4), 305-309.03-3 Thiébaut R, Chêne G, Jacqmin-Gadda H, Morlat P, Mercié P, Dupon M, Neau D,Ramaroson H, Dabis F, Salamon R and the GECSA. Time updated CD4+ T lymphocytecount and HIV RNA as prognostic factors in HIV-1 infected patients naive of antiretroviralsand newly treated with an highly active antiretroviral therapy. JAIDS 2003, 33 :380-386.03-4 Hashemi R, Jacqmin-Gadda H, Commenges D. A Latent process model for jointmodeling of events and marker. Lifetime Data Analysis, 2003,9 : 331-343.03-5 Thiébaut R, Jacqmin-Gadda H., Journot V, Ferchal F, Rancinan C, Molina JM, Chêne Gand the ALBI study group. Analysis of undetectable HIV RNA using survival analysis: resultsmust be interpreted carefully. HIV Clinical Trials 2003, 4(6) :417-420.

200404-1 Thiébaut R, Jacqmin-Gadda H. Mixed models for longitudinal left-censored repeatedmeasures. Computer Methods and Programs in Biomedicine, 2004, 74 : 255-260.04-2 Lewden C, Jacqmin-Gadda H, Vildé JL, Bricaire F, Waldner-Combernoux A, May T,Cuzin L, Lang JM, Leport C, Chêne G and the APROCO Study Group. An example of nonrandommissing data for hepatitis C virus (HCV) status in a prognostic study among humanimmunodeficiency virus (HIV)-infected patients. HIV Clinical Trial 2004; 5 : 224-31.04-3 Jacqmin-Gadda H, Thiebaut R, Dartigues JF. Modélisation conjointe de donnéeslongitudinales quantitatives et de délais censurés, Revue d’Epidémiologie et Santé Publique2004, 52 : 502-510.04-4 Jacqmin-Gadda H, Thiébaut R. Modèles de selection pour données longitudinalesgaussiennes : application à l’étude du vieillissement cognitif. Journal de la Société Françaisede Statistiques 2004,145 (2) : 19-32.04-5 Thiébaut R, Jacqmin-Gadda H. Modélisation longitudinale de données incomplètes :Exemple de la charge virale plasmatique du VIH: Journal de la Société Française deStatistiques 2004,145 (2) : 33-48.200505-1 Thiébaut R, Jacqmin-Gadda H, Babiker A, Commenges D and the CASCADEcollaboration. Joint modelling of bivariate longitudinal data with informative dropout and leftcensoring with application to the evolution of CD4+ cell count and HIV RNA viral load inresponse to treatment of HIV infection, Statistics in Medicine 2005,24(1):65-82.05-2 Proust C, Jacqmin-Gadda H. Estimation of linear mixed models with a mixture ofdistribution for the random effects. Computer Methods and Programs in Biomedicine 2005,78, 165-173.05-3 Pérès K, Helmer C, Letenneur L, Jacqmin-Gadda H, Barberger-Gateau P. Ten-yearchange in disability prevalence and related factors in two generations of French elderlycommunity dwellers: data from the PAQUID study. Aging Clinical and ExperimentalResearch 2005, 17(3) : 229-35.05-4 Amieva H., Jacqmin-Gadda H , Orgogozo JM, LeCarret N, Helmer,C, Letenneur L,Barberger-Gateau P, Fabrigoule C, Dartigues JF. The nine year cognitive decline beforedementia of the Alzheimer type: a prospective population-based study. Brain 2005, 128 :1093-1101.200606-1 Jacqmin-Gadda H, Commenges D, Dartigues JF .Random changepoint model for jointmodeling of cognitive decline and dementia. Biometrics 2006, 62, 254-260.

06-2 Thiebaut R, Jacqmin-Gadda H, Walker S, Sabin C, Prins M, Del Amo J, Porter K, DabisF, Chêne G 2 and CASCADE Collaboration. Determinants of response to first HAARTregimen in antiretroviral-naïve patients with an estimated time since HIV seroconversion. HIVMedicine 2006, 7, 1-9.06-3 Proust C, Jacqmin-Gadda H, Taylor J, Ganiayre J, Commenges D (2006). A nonlinearmodel with latent process for cognitive evolution using multivariate longitudinal data.Biometrics 2006,62, 1014-1024.06-4 Thiébaut R, Guedj J, Jacqmin-Gadda H, Chêne G, Trimoulet P, Neau D, Commenges D.Estimation of dynamical model parameters taking into account undetectable marker values.BMC Medical Research Methodology 2006, 6:38.06-5 Montagnier D, Barberger-Gateau P, Jacqmin-Gadda H, Dartigues JF, Rainfray M, PeresK, Lechevallier-Michel N, Fourrier-Réglat A. Evolution of prevalence of depressivesymptoms and antidepressant use between 1988 and 1999 in a large sample of French elderly:results from the PAQUID study. Journal of the American Geriatric Society 2006, 54, 1839-1845.200707-1 Jacqmin-Gadda H , Sibillot S, Proust C, Molina JM, Thiebaut R. Robustness of thelinear mixed model to misspecified error distribution. Computational Statistics and DataAnalysis 2007, 51, 5142-54.07-2 Proust-Lima C, Letenneur L, Jacqmin-Gadda H. A nonlinear latent class model for jointanalysis of multivariate longitudinal data and a binary outcome, Statistics in Medicine 2007 ,26(10), 2229-45.07-3 Proust-Lima C, Amieva H, Dartigues JF, Jacqmin-Gadda H. Properties of fourpsychometric tests to measure cognitive changes in brain aging population-based studies.American Journal of Epidemiology 2007, 165, 344-50.07-4 Rondeau V, Mathoulin-Pelissier S, Jacqmin-Gadda H, Brouste V, Soubeyran P. Jointfrailty models for recurring events and death using maximum penalized likelihood estimation: application on cancer events. Biostatistics 2007, 8, 708-721.200808-1 Proust-Lima C, Amieva H, Letenneur L, Orgogozo JM, Jacqmin-Gadda H, Dartigues JF.Gender and education impact on brain aging: a general cognitive factor approach. Psychologyand Aging 2008;23(3):608-620.08-2 Dantan E, Proust-Lima C, Letenneur L, Jacqmin-Gadda H. Pattern mixture models andlatent class models for the analysis of multivariate longitudinal data with informative dropout.International Journal of Biostatistics 2008, 4, issue 1, article 14.08-3 Amieva H, Le Goff M, Millet X, Pérès K, Orgogozo JM, Bargerger-Gateau P, Jacqmin-Gadda H, Dartigues JF. Evidencing the beginning of the predementia phase of Alzheimer’s

disease: emergence of cognitive deficits, memory complaints, depressive symptoms andfunctional decline, Annals of Neurology 2008;64:492-498.200909-1 Proust-Lima C, Joly P, Dartigues JF, Jacqmin-Gadda H. Joint analysis of multiplelongitudinal outcomes and a time to event by a nonlinear latent class model: application tocognitive ageing. Computational Statistics and Data Analysis 2009, 53:1142-54.09-2 Rondeau V, Jacqmin-Gadda H, Helmer C, Dartigues JF. Aluminum and silica intake indrinking water and the risk of Alzheimer's disease or cognitive decline: findings of the 15-year follow-up PAQUID cohort. American Journal of Epidemiology 2009;169 (4):489-496.09-3 Jacqmin-Gadda H, Proust-Lima C, Taylor JMG, Commenges D. Score test forconditional independence between longitudinal outcome and time-to-event given the classesin the joint latent class model, Biometrics, sous presse.