The Human Microbiome - Bioconductor

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The bacterial 16S rRNA genePresent in all bacteriaVariableLittle evidence ofhorizontal gene transferAccurate phylogeniesConserved
Why Study the Vaginal Microbiota?• The vaginal microbiota affects the health of womenand impacts the success of pregnancy– E. coli colonization of the vagina may precede UTI– Group B streptococcus and neonatal sepsis• The vagina hosts unique consortia of microbessuggesting selection for these key organisms• Bacterial vaginosis (BV) is a condition linked tonumerous health problems, including: Preterm birth Pelvic inflammatory disease (infection of upper tract) HIV acquisition and shedding Increased risk of other sexually transmitted diseases (GC, CT, Trich, HSV, HPV) Post hysterectomy vaginal cuff cellulitis and other surgical infectionsEpidemiology. 2007;18:702-8.Sobel JD. Infect Dis Clin N Am 2005;19:387-406
Page 1 and 2: The Human MicrobiomeDavid N. Fredri
Page 3 and 4: Human Genome Project (HGP)• 3.16
Page 5 and 6: The Human Microbiome Project Peter
Page 7: Science. 2006 Jun 2;312(5778):1355-
Page 10 and 11: The gut microbiome affects…• Vi
Page 14 and 15: Bacterial VaginosisThe most prevale
Page 16 and 17: Schematic for Pyrosequencing Approa
Page 18 and 19: BACTERIAL DIVERSITY - PYROSEQUENCIN
Page 21 and 22: 16S rRNA gene copies/swab16S rRNA g
Page 23 and 24: 16S rRNA gene copies/swabRecurrent
Page 25 and 26: The Human Microbiome and Omics• S

The Human Microbiome - Bioconductor

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