Wet Lungs Dry lungs - PULSION Medical Systems SE

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� Lung is a fairly dry place � Needed for proper gas exchange � Surfactant function � Recruitment � Diffusion of gases � Increase EVLW by only 200-300ml - ALI � In ALI mortality approaches 100% if EVLW > 14.3 ml/kg PBW on day 1
Acute lung injury
Page 1 and 2: Wet Lungs Dry lungs Impact on Outco
Page 3: Disclosures � Advisor for Pulsion
Page 10 and 11: Gap formation Endothelium Vessel Lu
Page 12 and 13: EVLW Calfee, C. S. et al. Chest 200
Page 14 and 15: 40 pts with ARDS
Page 16 and 17: EVLW goal directed Rx of ALI � Pr
Page 18 and 19: � Prospective, randomized study
Page 20 and 21: � 1000 patients with ALI/ARDS pro
Page 22 and 23: � 37 with ALI and serum protein
Page 24 and 25: The Case for Measuring EVLW in ARDS
Page 26 and 27: CO EVLW Preload “Optimal”Preloa
Page 29 and 30: � ARDSNet ventilation � RR 35,
Page 31 and 32: What would you do? � Fluid long,
Page 33 and 34: Gave 500 ml bolus of NS � MAP = 5
Page 35 and 36: 12 hours later on norepinephrine
Page 37 and 38: � MAP = 65 mmHg � CI = 4.1 L/mi

Wet Lungs Dry lungs - PULSION Medical Systems SE

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