Control of Continuous Flow Chemical Reactors: - CPAC - University ...

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Reaction Monitoring with Ramann Spectrum cropped toregion <strong>of</strong> interestbelow, with a 1 st orderpolyfit appliedn Standards <strong>of</strong>0% to 100%productn Responsivein RamanRaman Signal (A.U.)54.543.532.521.510.5x 10 4Raman Signal (A.U.)120001000080006000400020000ProductReagent720 740 760 780 800 820 840 860Raman Shift (cm^-^1)0400 600 800 1000 1200 1400 1600 1800Raman Shift (cm^-^1)
PLS Raman Validation ModelYield Predicted by Raman (%)100908070605040PLS Model - Raman Yield Prediction vs. HPLCHigh Catalyst ConcentrationR 2 = 0.9992 Latent VariablesRMSEC = 0.91141RMSEP = 2.1617Calibration Bias = 0Prediction Bias = 0High T, Low R tHigh T, High R t30Y Predicted 120CalibrationTest10Low T, High R t1:10Low T, Low R tfit0 20 40 60 80 100Yield Measured by HPLC (%)
Page 1 and 2: Control of ContinuousFlow Chemical
Page 3 and 4: Analytical Control System DesignOpt
Page 5 and 6: Sampling Systems• NeSSI Component
Page 7 and 8: NeSSI Sampling System for ReactorRa
Page 9 and 10: NeSSI Reagent Sampling SystemNeSSI
Page 11 and 12: Corning ® Advanced-Flow TM LFLow-F
Page 13 and 14: Full Reactor System w/Control2.5 ft
Page 15 and 16: Chemical Reactionn Esterification o
Page 17 and 18: Temperature vs. Reaction Progress
Page 19: Catalyst Conc. Vs. Reaction Progres
Page 23 and 24: Real-Time Quantitative Yieldn Able
Page 25 and 26: Real-Time Quantitative Analysisn Ra
Page 27 and 28: Moffat Swern Oxidation of Alcoholn
Page 29 and 30: Experimental Batch - Developmentn R
Page 31 and 32: IR Reaction Progressn Reaction prog
Page 33 and 34: Infrared Conclusionsn Spectral chan
Page 35 and 36: Pre-processed Raman Data7000Reactio
Page 37 and 38: Raman Reaction PlotRAMAN SCORE PLOT
Page 39 and 40: Concluding Remarks onSpectroscopic
Page 41 and 42: Swern Reactor w/sampling + Analytic
Page 43 and 44: Data Fusionn There is no one perfec
Page 45 and 46: ResultsComparison of Individual Mod

Control of Continuous Flow Chemical Reactors: - CPAC - University ...

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