Control of Continuous Flow Chemical Reactors: - CPAC - University ...

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100PLS Model - Raman Yield Prediction vs. HPLCReal-Time Quantitative AnalysisYield Predicted by Raman (%)908070605040302010Validation of Real-Time Yield Model00 20 40 60 80 100Yield Measured by HPLC (%)1 mL/min2 mL/min4 mL/minManuscript in Preparation24
Real-Time Quantitative Analysisn Rapid online quantitative real-time analysisconclusively demonstrated with Ramanspectroscopy¨ 20 s from start of spectrum acquisition to chemicalconversion informationn Less than 1 second to model spectrumn ~19 seconds Raman spectral acquisition¨ Continuous information output with no moving parts,operators, or supplies25
Page 1 and 2: Control of ContinuousFlow Chemical
Page 3 and 4: Analytical Control System DesignOpt
Page 5 and 6: Sampling Systems• NeSSI Component
Page 7 and 8: NeSSI Sampling System for ReactorRa
Page 9 and 10: NeSSI Reagent Sampling SystemNeSSI
Page 11 and 12: Corning ® Advanced-Flow TM LFLow-F
Page 13 and 14: Full Reactor System w/Control2.5 ft
Page 15 and 16: Chemical Reactionn Esterification o
Page 17 and 18: Temperature vs. Reaction Progress
Page 19 and 20: Catalyst Conc. Vs. Reaction Progres
Page 21 and 22: PLS Raman Validation ModelYield Pre
Page 23: Real-Time Quantitative Yieldn Able
Page 27 and 28: Moffat Swern Oxidation of Alcoholn
Page 29 and 30: Experimental Batch - Developmentn R
Page 31 and 32: IR Reaction Progressn Reaction prog
Page 33 and 34: Infrared Conclusionsn Spectral chan
Page 35 and 36: Pre-processed Raman Data7000Reactio
Page 37 and 38: Raman Reaction PlotRAMAN SCORE PLOT
Page 39 and 40: Concluding Remarks onSpectroscopic
Page 41 and 42: Swern Reactor w/sampling + Analytic
Page 43 and 44: Data Fusionn There is no one perfec
Page 45 and 46: ResultsComparison of Individual Mod

Control of Continuous Flow Chemical Reactors: - CPAC - University ...

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