oXiris membrane - CRRT Online

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oXiris: Unique Membrane Technologyheparinwith a 3-Fold Mode of Action**PEI=PolyEthylene Imine‣ Pre-coating w/heparin Heparin reduces at surface membraneremainsthrombogenicityactive for Inibition of Thrombinby formation of Thrombin –Anti –Thrombin (TAT) complex‣ Surface treatment provides Absorbed on ability PEI**: the toadsorb molecules endotoxins*that are negativelycharged like Endotoxins &Heparin‣ AN69 core membrane efficient renalSelectively absorbed into thesupport membrane bulk: by diffusion all molecules &convection, which can access the as membrane well ascytokine pores (MW
Comparison of AN69ST membrane& oXiris membrane• Membrane core material: AN69 for both• Surface treatment: PEI bound to AN69 forboth but 3 times more PEI for oXiris vs ST• Heparin coating:During priming with heparinized salinefor AN69ST: 600UI/m² adsorbed heparinDuring manufacturing process for oXiris:4500UI/m² adsorbed heparin for oXiris
Page 1: AVOIDING ANTICOAGULATION in CRRT: A
Page 4 and 5: Patient at high risk of bleeding•
Page 6 and 7: Heparin or CitrateSaline FlushesHep
Page 10: ‗Bio-activity‘ of the Grafted H
Page 14 and 15: Clinical studies resultsposter - SR
Page 16 and 17: Reported average filter life withAN
Page 18 and 19: AN69ST compatibility of use with ci
Page 20 and 21: EndotoxinEU/mlDoes the surface coat
Page 22 and 23: Clots in deaeration chamber• Like
Page 25: Conclusions & Perspectives‣ Modif

oXiris membrane - CRRT Online

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