l(CK-MB), and troponin. TotalCK levels are elevated inpatients with CRF, but CK-MB levels are not; thus, elevationin CK-MB levels is dueto myocardial injury. Elevationof troponin levels withouta corresponding elevationin total CK levels has beenshown to reflect enzymeelimination kinetics due torenal failure or cross-reactivityof the troponin I assaywith noncardiac antigens.Therefore, any enzyme elevationsare not diagnostic in andof themselves. The diagnosisof postoperative MI shouldbe made based on a combinationof clinical, laboratory,and ECG evidence. The preoperativeuse of beta-blockertherapy (eg, atenolol) may bebeneficial, though at the riskof developing or worseninghyperkalemia.Patients already on dialysis-Forpatients already ondialysis, dialysis adequacy,preoperative dialysis needs,postoperative dialysis timing,and dosage requirements forall medications should be determined.Patients on hemodialysisusually require preoperativedialysis within 24hours before surgery to reducethe risk of volume overload,hyperkalemia, and excessivebleeding. Patients withperitoneal dialysis who areundergoing abdominal surgeryshould be switched tohemodialysis until woundhealing is complete. Peritonealdialysis should be continuedfor those undergoingnon-abdominal surgery.lPatients who already havea renal transplant -Because of complicated druginteractions and immunosuppressivedosing, monitoring,and adjustment, a nephrologistwith specializedknowledge of renal transplantationshould be involvedin the preoperative evaluationof patients with CRF whohave received kidney transplantation.Cyclosporine ortacrolimus taken by renaltransplant recipients for immunosuppressionare metabolizedby the cytochromeP-450 system in the liver andthus interact with a wide varietyof agents. Diltiazem,hepatic 3-methylglutaryl coenzymeA reductase inhibitors,macrolides, and antifungaldrugs inhibit the system,elevate drug levels, and canprecipitate nephrotoxicity.Others, such a scarbamazepine,barbiturates, and theophylline,induce the hepaticenzyme system, reduce druglevels, and can precipitate rejection.Drug levels must bemonitored in this setting.Intravenouscy closp-orine ortacrolimus should be given atone-third the oral dose untilthe patient is able to tolerateoral medications. A thoroughpre-operative evaluation ofthe patient is mandatory toassess the functions of thedifferent systems. Both generaland regional anaesthetictechniques can be used, dependingupon the functionalstatus.References1. Wolfe RA, Ashby VB, MilfordEL, et al: Comparison ofmortality in all patients ondialysis, patients on dialysiswaiting transplantation, andrecipients of the firstcadaveric transplant. N EnglJ Med 341: 1725-1730, 1999.2. Gaston RS, Alveranga DY,Becker BN, et al: Kidney andpancreas transplantation. AmJ Transplant 3 (Supp 4): 64-77, 2003.3. Legendre C, Saltiel C, KriesH, Grunfeld J-P. Hypertensionin kidney transplantation.Klin Wochenschr 1989;67: 919-22.4. Gunnarsson R, Lofmark R,Norlander R, et al. Acutemyocardial infarction in renaltransplant recipients: incidenceand prognosis. EurHeart J 1984; 5: 218-21.5. Hambley H, Mufti GH.Erythropoietin: an old friendrevisited. Br Med J 1990; 300:621-2.6. Goldfarb S, Cox M, Suiger I,Goldbert M. Acutehyperkalaemia induced byhyperglycaemia; hormonalmechanisms. Ann Intern Med1976; 84: 426-32.7. Vandam LD, Harrison JH,Murray JE, et al: Anaestheticaspects of renal homotransplantationin man. Anesthesiology23: 783-92, 1962.8. Linke CL, Merin RG: Aregional anaesthetic approach56Journal of Postgraduate Medical Education, Training & ResearchVol. II, No. 5, September-October 2007
for renal transplantation.Anesth Analg 55: 69-73,1976.9. Kirvela M, Yli-Hankala A,Lindgren L: Comparison ofpropofol/alfentanil anaesthesiawith isoflurane/N 2O/fentanylanaesthesia for renaltransplantation. Acta AnaesthesiolScand 30: 574-580,1986.10. Dawidson I, Berglin E,Brynger H, et al: Intravascularvolumes and colloid dynamicsin relation to fluidmanagement in living relatedkidney donors and recipients.Crit Care Med 15: 631-6,1987.11. Koning OH, Ploeg RJ, vonBockel JH, et al: Risk factorsfor delayed graft function incadaveric organ transplantation:A prospective study ofrenal function and graft survivalafter preservation withUniversity of Wisconsin solutionin multi- organ donors.European Multicentre StudyGroup. Transplantation 63:1620-8, 1997.12. Grundmann R, Kindler J,Meider G, et al: Dopaminetreatment of human cadaverkidney graft recipients: Aprospectively randomizedtrial. Klin Wochenschr 60:193-7, 1982.13. Kadieva VS, Friedman L,Margolius LP, et al: The effectof dopamine on graftfunction in patients renaltransplantation. Anesth Analg76: 362-5, 1993.The “Bomb” EtherApparatusEther Apparatus, Wilson andPinson’s, steel, nickel-platedcomplete with rubber tubing,attachment for the mask, fillingfunnel, and spanner. (a)Ether in a closed space at atemperature of 100°C. is at apressure of 97 lb. per squareinch - its saturation vapourpressure at that temperature.With each fall of temperaturethere is a corresponding fallof pressure, until at its boilingpoint ( 35°C.) the effectivepressure is nil. (b) Etheras a liquid expands as the temperaturerises, and as liquidsare very incompressible, roommust be left in the closedspace for this expansion. Aspecial filler plug (A) is fittedwhich ensures that such roomis left. A Safety Blow-off (C)is provided which prevents allpossibility of the apparatusbursting.It is intended for use withether only.The ether keepsperfectly well inside the steelcontainer.Always have thefiller-plug (A) screwed uptightly (to prevent leakagewhen in use). See that thefaces of the filler-plug andcontainer are quite clean beforetightening up.To Fill.-Unscrew and remove thefiller-plug, and pour in etheruntil it begins to run over.Ifthe container is hot, immersethe apparatus in cold water fora few seconds before unscrewingthe filler-plug.Seethat the valve is turned off.Place in a large bowl of boilingwater, which may cover itcompletely. The valve-top (B)is graduated like a clock dial,the largest red dot marking thezero or “off ” position.The pointer is set to the zerodot when the valve is shut off,and is also adjustable, so thatit can be reset to this positionwhen the valve has worn alittle. This resetting will beseldom needed.If. the valvegets very loose, tighten thegland-nut, i.e. the little nut inthe middle of the valve.Thespanner provided is for theseadjustments. The small attachment(D) is for the administrationof open warm ether,the method of giving whichis described below.Journal of Postgraduate Medical Education, Training & Research57
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