ALPHA LIPOIC ACID

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ALPHA LIPOIC ACID ver.2.0 HS/SMpigmentation, proving that it performs skin-lightening activity with oral intake both in vitro andin vivo.Start of AdministrationMeasurement of the color valueUV ray exposureUV ray exposureUV ray exposureUV ray exposureMeasurement of the color valueUV ray exposureEnd of Administration-2 0 2 4 6 8 10 120Change L in the color value(L Dark Light-2-4-6-8-10-12-14Day after first UV ray exposure(Day)0 mg/kg1 mg/kg25 mg/kg50 mg/kgFig. 10 Effect of α-Lipoic Acid on Pigmentation Formation caused by UV rays in BrownGuinea Pigs (average value +/- SD, n=3)MethodBrown guinea pigs (male, 4 weeks old)were given α-lipoic acid daily from 2 days before (day -2) UV rayradiation (day 0). UV rays (UV-B, 2,000 mJ/cm 2 ) ware radiated to the hair-shaved back of the guinea pigs usinga UV-ray radiator (Solar Simulator manufactured by Ushio, Inc, Japan.) 4 times from day 0 to day 3. α-lipoicacid was given orally from day -2 to day 10 including the period of UV ray radiation. The color value (L*value) of the radiation area was measured using a spectro-color-difference meter (Nippon DenshokuIndustries Co., Ltd.) before UV ray radiation (day 0) and 8th and 10th days after starting the radiation.11
ALPHA LIPOIC ACID ver.2.0 HS/SM Fig. 11 Radiation Area on the 8th Day after Starting the Radiation12
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ALPHA LIPOIC ACID

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