ALPHA LIPOIC ACID

ALPHA LIPOIC ACID ver.2.0 HS/SMexcessive glucose-derived energy in fat cells. We studied the activity of-lipoic acid on crudeGPDH prepared from 3T3-L1 adipocytes and discovered that it has inhibitory activity (Fig. 6).Namely, --lipoic acid prevents fat accumulation converted from excessive sugar.GPDH Activity(Unit/mL) Concentration(g/L)Fig. 6 Effect of -Lipoic Acid on Fat Cell-derived GPDH activity (n=2-3)MethodThe lysate prepared from differentiated 3T3-L1 cells was used as the enzyme source. GPDHactivity was measured by commercioally available kit (Primary Cell), Japan.(4)Preventive effect on body weight gain in miceWe examined how-lipoic acid influences weight gain in which were fed diet mice freely for13 days with mild exercise. As shown in Fig. 7, the effect to prevent weight gain was weak byoral administration of-lipoic acid (0.1%) only. However, -lipoic acid supplementation withmild exercise significantly boosted its effect to prevent weight gain.Change in mice Weight (g) Control-lipoic acid 0.1%Only exercising-lipoic acid 0.1% with exercising DayFig. 7 Change in Mice Weight Fed -Lipoic Acid Continuously with or without Exercise (n=5)6