UNC School of Dentistry - The University of North Carolina at ...

# 71 Pulp revascularization through exposed dentin matrix with collagen scaffold on immatureteeth with apical periodontitisN YAMAUCHI , S YAMAUCHI , M YAMAUCHI M and F TEIXEIRADepartment of Endodontics, University of North Carolina at Chapel HillStrategies and biological basis for pulp revascularization treatment on immature teeth with apical periodontitis iscurrently limited. The purpose of this study is to evaluate whether, after disinfection of immature dog teeth withapical periodontitis, the exposure of dentin matrix and a collagen scaffold with an induced blood clot will aid inpulp revascularization and root canal development. Apical periodontitis will be induced in immature dog teeth.After disinfection of the teeth, four treatments and a negative control will be evaluated: blood clot alone, bloodclot with a collagen scaffold, blood clot with exposure of dentin matrix, blood clot with exposure of dentin matrixcombined with a collagen scaffold, and negative control teeth with no treatment. Radiographic and histologicalanalysis will be used to examine tissue growth and root development. This study will provide preliminary dataneeded to develop a novel strategy for the effective treatment of immature teeth with apical periodontitis.#72 Association Between Oral Health And Risk For Oral/Oropharyngeal Cancer: A Population-Based StudyK. DIVARIS, A.F. OLSHAN, M.C. WEISSLER, and W.K. FUNKHOUSERDepartments of Pediatric Dentistry, Epidemiology, Otolaryngology/Head and Neck Surgery, and Pathology andLaboratory MedicineObjective: Recent research has linked periodontal disease with an increased of several cancers. Previousepidemiologic reports have associated tooth loss and other oral health indicators such as oral hygiene andmouthwash use with increased risk for oral/oropharyngeal cancer (OOPC), but evidence has been inconsistent.Furthermore, no study has examined OOPC risk factors among African-Americans. The aims of the presentinvestigation were to: a) examine the association of tooth loss with risk for oral, pharyngeal and laryngeal cancer,b) determine whether African-Americans have a distinct oral health risk profile and c) evaluate interactionsbetween tooth loss and other factors such as tobacco and alcohol use. Methods: Analyses were conducted using theCHANCE study dataset, which contains interview data of incident OOPC cases diagnosed between 2002-2006 in46 counties in North Carolina. In this population-based study, controls (N=1,396) were frequency matched withcases (N=1,390) on age, race and gender. A total of 350 African-American cases are included. Multivariatelogistic regression modeling was employed to obtain odds ratios (OR) and 95% confidence intervals (CI), whileadjusting for demographic and lifestyle factors. Results: The age, sex, and race-adjusted estimate of tooth loss(>15 teeth lost compared to =15) related to OOPC risk was (OR=1.74;CI=1.58, 1.92). The full model that alsocontrolled for alcohol consumption, tobacco use, education level and other covariates, yielded no material increasein risk (ORadj=1.05;CI=0.93, 1.19). Although some variability was observed, there were no appreciabledifferences between gender and racial groups for this exposure. One or more preventive dental visits the lastdecade were associated with almost 40% risk reduction (OR=0.62;CI=0.49, 0.78), whereas self-reported ‘looseteeth’ emerged as a weak but consistent association (OR= 1.31;CI=1.06, 1.62). Conclusions: These data providesupport for a possible modest association of periodontal disease, as evidenced by self-reported tooth loss indicatorsbut not tooth loss per se, with OOPC risk. The finding that preventive dental visits were associated with a markedrisk decrease adds to the oral-systemic health interaction hypothesis and underlines the importance of oral diseaseprevention from a public health perspective. The development and application of more comprehensive indicatorsof oral health for population-based studies is warranted. Supported in part by R01-CA9073144