Guidelines and Handbook for IBSCs - Department of Biotechnology
Guidelines and Handbook for IBSCs - Department of Biotechnology
Guidelines and Handbook for IBSCs - Department of Biotechnology
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<strong>Guidelines</strong> <strong>for</strong> <strong>IBSCs</strong>• Ensure that measures are in place to prevent the accidental escape <strong>of</strong> regulatedGMOs/LMOs <strong>and</strong> rDNA materials.• Undertake periodic laboratory inspections.• Assist Investigator in developing emergency plans <strong>for</strong> containment <strong>and</strong>clean up accidental spills; investigates <strong>and</strong> reviews recombinant DNA labaccident• A report from the <strong>of</strong>ficer may <strong>for</strong>m part <strong>of</strong> the <strong>IBSCs</strong> annual report.9.5 Principal InvestigatorAll recombinant research projects carried out by an organisation involving theuse <strong>of</strong> GMOs/LMOs or rDNA materials should have a Principal Investigator(PI). It is the duty <strong>of</strong> the PI to apprise the IBSC about the nature <strong>of</strong> theexperiments being carried out. Depending upon the risk category, the PI has toin<strong>for</strong>m the IBSC, seek permission <strong>of</strong> IBSC be<strong>for</strong>e starting the experiments orseek permission <strong>of</strong> the RCGM through its IBSC.Based on the nature <strong>of</strong> the GMOs/LMOs <strong>and</strong> rDNA materials, the PI determinesthe proper containment level <strong>for</strong> the project <strong>and</strong>, in accordance withthe guidelines, develops the necessary experimental protocols. Thisin<strong>for</strong>mation is then submitted to IBSC <strong>for</strong> review. The responsibilities <strong>of</strong> PI aresummarized below:• to make an initial determination <strong>of</strong> the required levels <strong>of</strong> physical <strong>and</strong>biological containment in accordance with the stipulated guidelines.• to submit the initial research protocol <strong>and</strong> any subsequent changes (suchas changes in the source <strong>of</strong> DNA or host vector system) to the IBSC <strong>for</strong>review <strong>and</strong> approval.• to ensure that no work is initiated until the research project has beenapproved by the IBSC <strong>and</strong> has met all requirements <strong>of</strong> DBT guidelines.• to communicate with IBSC throughout the conduct <strong>of</strong> the project.• to ensure safe conduct <strong>of</strong> the rDNA experiments in his laboratory.• to make available the protocols that describe the potential biohazards <strong>and</strong>the precautions to be taken to all laboratory staff.• to instruct laboratory staff about the practices <strong>and</strong> techniques required to10<strong>Guidelines</strong> <strong>and</strong> H<strong>and</strong>book <strong>for</strong> Institutional Biosafety Committees (<strong>IBSCs</strong>)
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