research day 2013 - UBC Dentistry - University of British Columbia

MESSAGE FROM THE DEANWelcome to the Sixth UBC Faculty of Dentistry Research Day.All of the previous Research Days have been very successfuland we are pleased to have an outstanding program for today.The 2013 Research Day continues the approach of using aclinical case to introduce the need to conduct basic researchand the translation of research findings into patient careapplications. Research is the investment that the professionmakes for the future. Basic research findings will becomenew diagnostic and therapeutic approaches for our patientsand so it is critical to keep pushing the envelope of knowledgeforward. UBC is a research-intensive university and theFaculty of Dentistry is committed to playing a critical rolein oral health research. We hope that this day highlights thelinks between basic research and clinical dentistry.The overall theme for Research Day 2013 is TechnologicalAdvances in Dentistry. The rate of change in technology hasincreased at an incredible rate. Approaches that could nothave even been imagined 25 years ago are now becomingcommon and in fact approaching the standard of care. At thistime, many of the technological advances are quite expensiveand decisions to invest need to be carefully considered.The clinical decision-making required to use a new technologyneeds to take the best interests of the patient into account.UBC Dentistry faculty members and the people working intheir laboratories are at the cutting edge of both developingand implementing these technologies, which makes thespeakers in today’s program particularly valuable. They willbe resources for the dental profession in British Columbia formany years and understanding their programs of research shouldbe very beneficial.We are delighted to have a keynote speaker who is internationallyrecognized for his research in composite resins. Professor JackFerracane is from just down the coast in Oregon and we hopehe will become a much more frequent visitor to Vancouver andthe UBC Faculty of Dentistry. I have heard him speak on severaloccasions and always come away with new insights aboutcomposite resins.I hope you enjoy the program and gain additional awareness ofthe new technologies that are entering the practice of dentistry.I further hope you gain perspective on the considerations forusing new technology on your patients and the clinicaldecision-making that is required. Future research technologicaladvances are certain to make a difference in our approachesto diagnosis and treatment.Thank you for your participation.Charles F. Shuler, DMD, PhDProfessor and Dean, UBC Faculty of Dentistry3

UBC Dentistry Research Day 2013Technological Advances in Dentistry: Decision-Making in Clinical UseTuesday, January 22, 2013 · 8:00 am – 3:00 pmUBC Student Union Building Ballroom8:00 — 8:40 REGISTRATION & CONTINENTAL BREAKFAST8:40 — 8:50 WELCOMEDr. Charles Shuler, Professor and DeanINTRODUCTION & OVERVIEW OF THE DAYDr. Edward Putnins, Professor and Associate Dean of Research, Graduate & Postgraduate Studies8:50 — 9:15 IMAGE QUALITY AND DOSIMETRY IN CONE BEAM CTDr. Nancy Ford, Assistant Professor, Division of Oral Biology, Department of Oral Biological & Medical Sciences“What are the compromises between image quality and radiation dose?”9:20 — 9:40 USE OF CONE BEAM CT IN THE PEDIATRIC PATIENTDr. Ella Choi, MSc/Diploma in Pediatric Dentistry Student, Division of Pediatric Dentistry, Department of Oral Health Sciences“What is the radiation dose in pediatric patients receiving cone beam CT imaging?”9:45 — 10:10 A COMPARISON OF THE RADIATION DOSE FROM DIFFERENT DENTAL IMAGING PROCEDURESDr. Pierre Deman, Postdoctoral Research Fellow, Department of Oral Biological & Medical Sciences“How do radiation doses in cone beam CT compare to other X-ray procedures?”10:10 — 10:30 COFFEE BREAK10:35 — 11:00 ANALOG TO DIGITAL: PARADIGM SHIFT IN RESTORATIVE DENTISTRYDr. Mark Fogelman, Clinical Assistant Professor, Department of Oral Health Sciences“How can CAD/CAM dentistry benefit the practitioner and patient?”11:05 — 11:30 DENTAL MATERIALS SELECTION FOR CAD/CAM SYSTEMSDr. N. Dorin Ruse, Professor and Chair, Division of Biomaterials, Department of Oral Biological & Medical Sciences“What dental materials are available for CAD/CAM systems and what should be considered when making a choice?”11:35 — 11:50 RESEARCH POSTER AWARDS PRESENTATIONDr. Ravindra Shah, Associate Professor and Director, International RelationsUndergraduate & Graduate Students11:50 — 1:00 LUNCH (BOX LUNCH PROVIDED) & RESEARCH POSTER VIEWINGPosters by undergraduate students, graduate students, postdoctoral fellows, research associates, visiting scientists,and faculty members1:05 — 1:25 DIGITAL SCAN, DIGITAL DESIGN, DIGITALLY-CONTROLLED MILLING—A PARADIGM CHANGEIN PROSTHODONTICSDr. Jonathan Ng, MSc/Diploma in Prosthodontics Student, Division of Prosthodontics & Dental Geriatrics, Departmentof Oral Health Sciences“What is the marginal fit accuracy of crowns fabricated using intraoral scanning, digital design, and 5-axis milling?”1:30 — 2:45 RESIN COMPOSITES—STATE-OF-THE-ART (KEYNOTE ADDRESS)Dr. Jack Ferracane, Department of Restorative Dentistry, Oregon Health & Science University, Portland, Oregon“What formulation changes are being made to enhance properties and performance?”2:45 — 3:00 CASE WRAP-UP & DISCUSSIONUBC Dentistry Thanks the Following Research Day Sponsors:PRESENTING GOLD SPONSORSILVER BREAKFAST SPONSORSILVER LUNCH SPONSOR5

MESSAGE FROM THE ASSOCIATE DEAN OF RESEARCHThank you for attending the Sixth Annual UBC DentistryResearch Day.As novel technologies and materials are developed with thepremise that they will enhance the standard of care and willbe utilized in health care offices, it is crucial for professionalsto not only embrace them with cautious optimism but tocritically evaluate them in relation to patient safety and theirrelative improvement over established technologies/materials.Research Day 2013 aims to examine some key aspectsassociated with cone beam computed tomography, CAD/CAM technologies, dental material selection for CAD/CAM,and a review of state-of-the-art resin composites.To begin the day, we will have three presentations from thelaboratory of Dr. Nancy Ford focusing on cone beam CT.They will address the relationship between radiationdosimetry and image quality, the use of cone beam CT forpediatric patient assessment, and a comparison of this newimaging modality with traditional radiographic techniques.As the day progresses, we will transition to a review ofCAD/CAM technologies and how digital imaging and millingis transforming crown preparation. Three presentationswill cover the use of CAD/CAM machines in dental offices,aspects related to dental material selection for CAD/CAM,and the results of an assessment of marginal crown fitachieved via CAD/CAM. We are delighted and honouredto have Dr. Jack Ferracane, a world-class authority indental materials, present the keynote address on state-ofthe-artdental resin composites. I would like to express ourappreciation to the outstanding faculty, graduate students,postdoctoral research fellow, invited presenter, and oursponsors, all of whom have agreed to participate and supportResearch Day 2013.In addition, please do read through this Research Dayprogram booklet to see the other exciting research that iscurrently being done by our faculty and students here at theUBC Faculty of Dentistry. In closing, this Research Day andthe book that you all have received were made possible bythe efforts of many people on the Research Day OrganizingCommittee. I would like to personally thank Ingrid Ellis,Nancy Ford, Alison Kovacs, Jane Merling, Dorin Ruse,Nik Williams-Walshe, and Terry Wintonyk, who have workedvery hard to ensure that all aspects of this day are successful.Do enjoy Research Day 2013.Edward E. Putnins, DMD, PhD, Dip PerioProfessor and Associate Dean of Research,Graduate & Postgraduate Studies6

NANCY L. FORD, BSc, PhDDr. Nancy Ford completed her PhD inMedical Biophysics at the University ofWestern Ontario. Her initial academicappointment was in the Departmentof Physics at Ryerson University inToronto, Ontario. Dr. Ford joined theUniversity of British Columbia in2011 as the Director of the Centrefor High-Throughput Phenogenomicsand an Assistant Professor in theDepartment Oral Biological & MedicalSciences. Her research has focusedon optimizing and assessing imagingprotocols for preclinical and clinicalcomputed tomography.IMAGE QUALITY ANDDOSIMETRY IN CONE BEAMCOMPUTED TOMOGRAPHYAdvances in imaging technology haveenabled affordable three-dimensionalX-ray imaging techniques specificallytargeting dental imaging. Cone beamcomputed tomography (CBCT)technology is available in dental officesworldwide and can produce 3D imagesof the maxillofacial region that werepreviously unattainable using 2Dtechnologies. These images can beacquired with high spatial resolution tovisualize the internal structures of theteeth and underlying bone. However,these high-quality 3D images come ata price—an increased radiation doseto the patient. In this presentation, thecompromises between image quality andpatient dose in CBCT will be discussed.ELLA CHOI, BSc, DDSDr. Ella Choi is currently a secondyear student in the combined MScand Diploma in Pediatric DentistryProgram at the UBC Faculty ofDentistry. She obtained her Doctor ofDental Surgery from the Universityof Alberta. Her research focuses onunderstanding the radiation dose inpediatric patients receiving cone beamCT imaging. She has received theArthur Cumming Award for excellencein pediatric dentistry and the AmericanAssociation of Pediatric DentistryStudent Award.USE OF CONE BEAM COMPUTEDTOMOGRAPHY IN THEPEDIATRIC PATIENTThe frequency of use of cone beamcomputed tomography (CBCT) indentistry is increasing every year.CBCT provides valuable informationto dentists that cannot otherwise beobtained. However, there are a limitednumber of studies on CBCT radiationand its cumulative lifetime effect inchildren. Children are more sensitiveto radiation and they have a longerpost-radiation lifespan than adults:the younger the child, the higher theirrisk of cancer. The radiation dosefrom a single CT scan is relatively low.However, doses to pediatric patients areoften higher than necessary. As part ofmy research, I have measured radiationdoses using adult head phantomsand conducted population studies todetermine the specifics for designingpediatric head phantoms.8

PIERRE DEMAN, PhDDr. Pierre Deman performed lifescience imaging studies at the InstitutPolytechnique du Grenoble (DiplômeD’Ingénieur, Grenoble, France) andthe University of Grenoble (Master’sDegree). He did his doctoral trainingat the Grenoble NeurosciencesInstitute and the European SynchrotronRadiation Facility on a new method ofbrain tumour radiation therapy andtreatment follow-up with functionalimaging (perfusion measurement).Dr. Deman completed a postdoctoralfellowship at the French Health Defenseon lung immune system imaging usingin vivo two-photon microscopy.A COMPARISON OF THERADIATION DOSE FROMDIFFERENT DENTALIMAGING PROCEDURESDental cone beam computed tomographyscanners were introduced to performthree-dimensional high resolutionimaging. As they are dedicated to highcontrast imaging, a low radiation doseto the patient is achievable. But thereis currently no accepted method ofconfirming the dose as it is too differentfrom narrow slice computed tomographyand fluoroscopy, which have protocols tomeasure an indicator of the dose (CTDIand DAP, respectively). Dose distribution(dose free-in-air, in a phantom, beamprofiles) and a new method compatiblewith every X-ray source has been testedand shows that the radiation received froma CBCT is two times lower than from amulti-slice CT and around 20 times higherthan from a panoramic system.MARK FOGELMAN, DMD, FCPDr. Mark Fogelman received his DMDdegree from the Hebrew University inJerusalem, Israel. He practiced generaldentistry for 20 years prior to joiningthe University of British Columbia asa Clinical Assistant Professor. In 2008,he introduced the CEREC CAD/CAMdentistry program for undergraduateand graduate students. Soft tissue LEDlasers were later integrated to addsupport to soft tissue management inthe Integrated Clinical Care clinic.Dr. Fogelman’s areas of special interestinclude incorporating technologicaladvances in dental education and he ispassionately involved in establishing aDigital Clinical Learning Centre at theUBC Faculty of Dentistry.ANALOG TO DIGITAL:PARADIGM SHIFT INRESTORATIVE DENTISTRYInnovations in dental laboratorytechnology through the digitalizationof manufacturing indirect restorationswere the catalysts to the integration ofemerging technologies in restorativedentistry. Change in dentistry iscontinuous and is traditionallyevolutionary in nature. However, therapidly developing field of technologyis transforming dentistry at anunprecedented pace—more revolutionthan evolution. For many who arepracticing and teaching dentistry, this isa paradigm shift that challenges manywell-established practices. Consequently,we are required to make the rightdecisions for our patients, students,and the future of the dental profession.This presentation will review digitalrestorative technologies, some of themCAD/CAM, which are now availableto dentists and which will continue totransform the practice of dentistry.9

KEYNOTE ADDRESSJACK L. FERRACANE, PhDDr. Jack Ferracane is Professor andChair of Restorative Dentistry, andDivision Director of Biomaterials &Biomechanics at the Oregon Health &Science University School of Dentistry. Hehas a BS in Biology from the University ofIllinois, and an MS and PhD in BiologicalMaterials from Northwestern University,Chicago, Illinois. Dr. Ferracane is afounding fellow and Past President ofthe Academy of Dental Materials. He isa Past President of the Dental MaterialsGroup of the International Association forDental Research. He serves on the editorialboard of ten journals, and is currentlyan Associate Editor of the “Journal ofDental Research” and “Odontology.”Dr. Ferracane has authored a textbookentitled “Materials in Dentistry:Principles and Applications,” now in itssecond edition. He has published andlectured extensively on dental materials,including dental composites, adhesives,and dental amalgam.Dr. Ferracane’s current researchinterests are in dental composites andthe use of bioactive glasses in resin-baseddental materials. He also is activelyinvolved in the establishment andoperation of networks designed toconduct clinical research in the privatepractice setting. His research is fundedby the NIH/NIDCR as well as privateindustry. Dr. Ferracane routinelypresents at the IADR and the Academyof Dental Materials annual meetings.He has provided continuing education atannual meetings of the American DentalAssociation, British Dental Association,California Dental Association, ChicagoMidwinter, Midwest Dental Conference,Oregon Dental Conference, PacificNorthwest Dental Conference, SouthwestDental Conference, Yankee DentalCongress, Korean Academy of PediatricDentistry, and to other professionaldental organizations.RESIN COMPOSITES—STATE-OF-THE-ARTThe current state-of-the-art of dentalcomposites includes a wide varietyof materials with a broad range ofmechanical properties, handlingcharacteristics, and esthetic possibilities.There is no one ideal material availableto the clinician, but the commercialmaterials that comprise the currentarmamentarium are of high qualityand, when used appropriately, haveproven to deliver excellent clinicaloutcomes of adequate longevity. Thishighly competitive market continuesto evolve, with the major emphasis inthe past being to produce materialswith adequate mechanical properties,and high wear resistance and polishretention. The more recent research anddevelopment efforts have addressedthe issue of polymerization shrinkageand its accompanying stress, whichmay have a deleterious effect on thecomposite–tooth interfacial bond.Current efforts are focused on thedelivery of materials with self-adhesiveproperties, as well as those that can beplaced in bulk, thus leading to trulysimplified placement in the mouth. Thispresentation will review the current stateof dental composites with an eye towardfuture developments and improvements.11

POSTER ABSTRACTSPoster Competition JudgesDR. RAVINDRA SHAH (Chair)DR. MAZEN ALOTAIBIDR. DIETER BRÖMMEDR. S. ROSS BRYANTDR. RICARDO CARVALHODR. LARI HÄKKINENDR. KAVITA MATHU-MUJUDR. CAROLINE NGUYENDR. BENJAMIN PLISKADR. CATHERINE POHDR. JOY RICHMANDR. CLIVE ROBERTSDR. N. DORIN RUSEDR. YA SHENDR. RANA TARZEMANY12

Fibroblasts/Epithelial Cell Confrontations on Microgrooved SubstrataAbdollahzadeh N*, Moon H, Brunette DMDepartment of Oral Biological & Medical Sciences, Faculty of Dentistry, The University of British Columbia,Vancouver, CanadaMicro-CT Measurement of the Internal Fit of Lithium Disilicate CrownsAlfaro D* 1 , Wyatt C 1 , Ruse D 2 , Carvalho R 3 , Ng J 11Division of Prosthodontics & Dental Geriatrics, Department of Oral Health Sciences, Faculty of Dentistry,The University of British Columbia, Vancouver, Canada (UBC); 2 Division of Biomaterials, Department of OralBiological & Medical Sciences, Faculty of Dentistry, UBC; 3 Frontier Clinical Research Centre, Department ofOral Biological & Medical Sciences, Faculty of Dentistry, UBCeMax CAD vs eMax Press: a Fracture Mechanics CharacterizationAl-Kadi L*, Ruse NDDepartment of Oral Biological & Medical Sciences, Faculty of Dentistry, The University of British Columbia,Vancouver, CanadaThe Role of Smad2 Overexpression and the Progression of PeriodontitisAlotaibi M*, Kitase Y, Mills K, Shuler CDepartment of Oral Biological & Medical Sciences, Faculty of Dentistry, The University of British Columbia,Vancouver, CanadaCraniofacial Morphology and Sleep Disordered Breathing in ChildrenAran R*, Almeida F, Pliska B, Chen H, Lowe ADepartment of Oral Health Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, CanadaBonding of FRC-Posts: Influence of Post SizeBerthold C* 1,2 , Mitterhuber B 1 , Powers JM 3,4 , Haapasalo M 2 , Petschelt A 11Dental Clinic 1: Operative Dentistry & Periodontology, Friedrich-Alexander Universität Erlangen-Nürnberg,Germany; 2 Department of Oral Biological & Medical Sciences, Faculty of Dentistry, The University of BritishColumbia, Vancouver, Canada; 3 Restorative Dentistry & Prosthodontics, The University of Texas Health ScienceCenter at Houston, Houston, Texas, USA; 4 Dental Consultants, Inc., Ann Arbor, Michigan, USAIn Vitro Retrieval Time Comparison of Three Endodontic Obturation MaterialsBraniste M*, Coil MJ, Shen Y, Haapasalo MDepartment of Oral Biological & Medical Sciences, Faculty of Dentistry, The University of British Columbia,Vancouver, CanadaCraniopagus Conjoined Twins: Challenges and Considerations for Dental RehabiliationCampbell KM*, Johnston DHDepartment of Oral Health Sciences, Faculty of Dentistry, The University of British Columbia and Department ofDentistry, BC Children’s Hospital, Vancouver, CanadaEffect of Fatigue on Nickel–Titanium Controlled Memory Instrument Torsional FailureCampbell L* 1 , Shen Y 1 , Zhou H 2 , Haapasalo M 11Division of Endodontics, Department of Oral Biological & Medical Sciences, Faculty of Dentistry,The University of British Columbia, Vancouver, Canada; 2 Center for Biomedical Materials & Engineering,College of Material Science & Chemical Engineering, Harbin Engineering University, Harbin, ChinaThe Functional Effects on Mandibular Growth of Klearway TM versus Twin-BlockChen H*, Yagi K, Almeida F, Pliska B, Lowe ADepartment of Oral Health Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, CanadaFor full abstracts see http://www.dentistry.ubc.ca/ResearchDay/201 3/Abstracts.pdf13

Neural Crest and Stemness Gene Expression by Human Gingival FibroblastsCheung G* 1 , Fournier B 1,2 , Jiang G 1 , Larjava H 1 , Häkkinen L 11Department of Oral Biological & Medical Sciences, Faculty of Dentistry, The University of British Columbia,Vancouver, Canada; 2 Cordeliers Research Center, Descartes University, Paris, FranceSoft and Hard Tissue Changes After Correction of Jaw MalocclusionChou BK* 1 , Liew XL 2 , Kao CT 21Faculty of Dentistry, The University of British Columbia, Vancouver, Canada; 2 Orthodontic Department,College of Dentistry, Chung Shan Medical University, Taichung, TaiwanNickel–Titanium Rotary Instruments After Graduate Endodontic Clinical UseShen Y 1 , Coil JM 1 , Coil AJ* 1 , Zhou H 2 , Haapasalo M 11Division of Endodontics, Department of Oral Biological & Medical Sciences, Faculty of Dentistry,The University of British Columbia, Vancouver, Canada; 2 Center for Biomedical Materials & Engineering,College of Material Science & Chemical Engineering, Harbin Engineering University, Harbin, ChinaEffects of Endodontic Irrigation Solutions After Instrumentation with WaveOneCrisanti M*, Shen Y, Haapasalo MDivision of Endodontics, Department of Oral Biological & Medical Sciences, Faculty of Dentistry,The University of British Columbia, Vancouver, CanadaThe Effect of Agitation on Sodium Hypochlorite Penetration into DentinDavis S*, Shen Y, Haapasalo MDivision of Endodontics, Department of Oral Biological & Medical Sciences, Faculty of Dentistry,The University of British Columbia, Vancouver, CanadaDental Cone Beam: What Dose for the Patient?Deman P* 1 , Thakur Y 2 , Ford NL 11Department of Oral Biological & Medical Sciences, Centre for High-Throughput Phenogenomics,Faculty of Dentistry, The University of British Columbia, Vancouver, Canada; 2 Department ofRadiology, Vancouver General Hospital, Vancouver, CanadaDeprived Oral Health Status Among Low-Incomes in Vancouver’s Downtown EastsideHau K* 1,2 , Ng S 2,3 , Littlejohn D 3 , Poh C 1,2,31Cancer Control Research, BC Cancer Agency/Research Centre, Vancouver, Canada; 2 Department of OralBiological & Medical Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, Canada;3Vancouver Hospital & Health Science Centre, Vancouver Coastal Health Authority, Vancouver, CanadaEffectiveness of Bonding Agents Used at the UBC Dentistry ClinicsHieawy AT* 1 , Wang ZJ 1 , Fogelman M 2 , Carvalho RM 1,3 , Manso AP 11Department of Oral Biological & Medical Sciences, Faculty of Dentistry, The University of British Columbia,Vancouver, Canada (UBC); 2 Department of Oral Health Sciences, Faculty of Dentistry, UBC; 3 FrontierClinical Research Centre, Faculty of Dentistry, UBCExperimental Perturbation of Tooth Regeneration in a Polyphyodont LizardHolmes SN*, Richman JMDepartment of Oral Health Sciences, Faculty of Dentistry, Life Sciences Institute, The University of BritishColumbia, Vancouver, CanadaWnt5a Induces Enzymatic Degradation of Craniofacial Cartilage via JNK SignallingHosseini-Farahabadi S*, Geetha-Loganathan P, Fu K, Richman JMDepartment of Oral Health Sciences, Faculty of Dentistry, Life Sciences Institute, The University of BritishColumbia, Vancouver, Canada14 For full abstracts see http://www.dentistry.ubc.ca/ResearchDay/201 3/Abstracts.pdf

Exosite Inhibitors of Cathepsin K as Collagenase Blockers to Treat OsteoporosisHsu A* 1 , Du X 1,2 , Panwar P 1 , Brömme D 1,21Department of Oral Biological & Medical Sciences, Faculty of Dentistry, The University of British Columbia,Vancouver, Canada (UBC); 2 Department of Biochemistry & Molecular Biology, Faculty of Medicine, UBCOrthodontic Treatment Needs of Aboriginal Adolescents in Haida Gwaii, CanadaKarim A*, Aleksejūnienė J, Yen EHKDepartment of Oral Health Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, CanadaTransplantation of Neonatal Porcine Islets Encapsulated in 5% Alginate BeadsKiang RL* 1,2 , Mojibian M 3 , Lo BK 2 , Charman E 2 , Hoesli CA 2 , Hu X 3 , Johnson JD 3 , Kieffer TJ 3 , Piret JM 21Faculty of Dentistry, The University of British Columbia, Vancouver, Canada (UBC); 2 Michael SmithLaboratories and Department of Chemical & Biological Engineering, UBC; 3 Department of Cellular &Physiological Sciences and Department of Surgery, UBCRegulation of Macrophage Phenotype by Galectin-3Kianoush F*, Nematollahi M, Waterfield JD, Brunette DMDepartment of Oral Biological & Medical Sciences, Faculty of Dentistry, The University of British Columbia,Vancouver, CanadaPrimer Design to Investigate Surface Topographic Effects on Gene ExpressionKim MR*, Wong ATT, Brunette DMDepartment of Oral Biological & Medical Sciences, Faculty of Dentistry, The University of British Columbia,Vancouver, CanadaMicrosensor Technology to Monitor Compliance with Removable Oral AppliancesKirshenblatt SJ*, Chen H, Lowe A, Pliska B, Almeida FDepartment of Oral Health Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, CanadaShort-Term Treatment of Nocodazole-Rescued Adhesion Defect in Tgfβ3 -/- MiceKitase Y*, Shuler CDepartment of Oral Biological & Medical Sciences, Faculty of Dentistry, The University of British Columbia,Vancouver, CanadaExpression of Progressive Ankylosis Protein in αvβ6 Integrin-Deficient AmeloblastsLeung K*, Mohazab L, Koivisto L, Jiang G, Häkkinen L, Larjava HDepartment of Oral Biological & Medical Sciences, Faculty of Dentistry, The University of British Columbia,Vancouver, CanadaScreening Log in a Pan-Canadian Multi-Centre Study: the COOLS TrialLiu YK* 1 , Duan S 1 , Kami A 1 , Lam S 1 , Poh CF 1,21BC Cancer Research Centre, Vancouver, Canada; 2 Department of Oral Biological & Medical Sciences,Faculty of Dentistry, The University of British Columbia, Vancouver, CanadaOral Squamous Cell Carcinoma in Non-SmokersLubpairee T* 1,2 , Poh CF 1,2 , Rosin MP 1 , Zhang L 1,21BC Oral Cancer Prevention Program, British Columbia Cancer Agency, Vancouver, Canada; 2 Departmentof Oral Biological & Medical Sciences, Faculty of Dentistry, The University of British Columbia,Vancouver, CanadaFor full abstracts see http://www.dentistry.ubc.ca/ResearchDay/201 3/Abstracts.pdf15

18RESEARCH SUPPORTERSThank you to the following organizationsfor supporting our research.

RESEARCH ClusterS· CLINICAL RESEARCH, TECHNOLOGY TRANSFER &DENTAL MATERIALS SCIENCES RESEARCH CLUSTER· COMMUNITY & EDUCATIONAL RESEARCH CLUSTER· iMATRIX RESEARCH CLUSTERClinical Research, Technology Transfer &Dental Materials Sciences Research ClusterThis cluster encompasses groups engaged in research on cancer diagnosis and prevention, dental biofilms, dental hygiene, dentalinstruments and materials, dental sleep medicine, forensic dentistry, and interactive dental anatomy. Our areas of expertise includebiomaterials, dental morphology, obstructive sleep apnea, oral cancer, and root canal irrigation. We study matters such as bacterialeradication, cellular interactions, cephalometrics, community outreach programs, computational fluid dynamics, diagnostic tools,DNA analysis, fracture mechanisms, molecular markers, novel disinfection strategies, oral care products, surface characterization,and treatment strategies.MARKUS P. HAAPASALO, Coordinator, Clinical Research, Technology Transfer & Dental Materials Sciences Research Cluster,markush@dentistry.ubc.caFERNANDA ALMEIDASleep apneafalmeida@dentistry.ubc.caRICARDO CARVALHOLaboratory development and clinical applicationsof biomaterialsrickmc@dentistry.ubc.caBABAK CHEHROUDICell/implant interaction, dental morphologybchehrou@dentistry.ubc.caHUI CHENSleep apneahuichen@dentistry.ubc.caJEFFREY COILSafety and clinical performance of newendodontic instrumentsjcoil@dentistry.ubc.caMARKUS HAAPASALOEndodontic disinfection: novel types of irrigationsolutions, strategies for eradication of dental biofilm,hydrodynamic analysis of root canal irrigationmarkush@dentistry.ubc.caDENISE LARONDEOral cancer screening and risk prediction, including theuse of clinical adjunctive devices, within the communitydlaronde@dentistry.ubc.caALAN LOWEOrthodontics, obstructive sleep apnea, cephalometricsalowe@dentistry.ubc.caADRIANA MANSOAdhesion of biomaterials to dental hard tissues,clinical applications of dental biomaterialsamanso@dentistry.ubc.caCAROLINE NGUYENBiomaterials, oral cancer treatments, oral cancerrehabilitation outcomescaroline.nguyen@ubc.caBENJAMIN PLISKAOrthodontics and obstructive sleep apnea in childrenand adolescentspliska@dentistry.ubc.caCATHERINE POHOral cancer translational research: developingand applying molecular tests and imaging toolsfor screening, early detection, risk assessment,management; translating these findings in medicallyunderserved communitiescpoh@dentistry.ubc.caN. DORIN RUSEBiomaterials, surface characterization, fracturemechanics, fatigue, finite element modelling/analysis,structure—properties relationshipdorin@dentistry.ubc.caYA SHENPredisposing factors in instrument failure, predictionsof NiTi instrument life cycle, oral biofilmsyashen@dentistry.ubc.caDAVID SWEET O.C.Recovery and analysis of trace amounts of forensicDNA evidence from biomaterials and human tissues inhistorical homicide investigationsdsweet@dentistry.ubc.caLEWEI ZHANGCancer risk prediction: molecular markers, histologicalphenotypes as measured by computer-driven imagesystem, clinical visual toolslzhang@dentistry.ubc.ca19

Community & Educational Research ClusterThe research in this cluster relates to three of the four Canadian Institutes of Health Research themes: health services research;social, cultural, environmental, and population health; and clinical research—and to a range of educational studies. These domainsare loosely interconnected and employ various quantitative and qualitative research methods and knowledge transfer. Our membersconduct studies on diverse topics such as healthcare promotion, oral implants, dental caries, systematic literature reviews, andcommunity service learning.MICHAEL I. MACENTEE, Coordinator, Community & Educational Research Cluster, macentee@dentistry.ubc.caJOLANTA ALEKSEJŪNIENĖCaries risk management in the elderly, ePortfolio learning,student-oriented learning in simulation coursesjolanta@dentistry.ubc.caW. LEANDRA BESTEducation-related scholarly activities: enhancing studentlearning experiences through curriculum innovation,assessment, case writing, and faculty developmentlbest@dentistry.ubc.caMARIO BRONDANIDental public health, community service learning andreflective journalling, dental geriatrics and psychometrics,health values and beliefs, HIV/AIDS and agingbrondani@dentistry.ubc.caS. ROSS BRYANTProsthodontics, geriatrics, patient-based assessments,oral implants, jawbone densitometryr.bryant@dentistry.ubc.caKAREN CAMPBELLPediatric dentoalveolar trauma, behaviour guidance,alternative caries management approachescampbkar@dentistry.ubc.caBONNIE J. CRAIGWeb-based online course development and evaluation,quality assurance in health care, dental hygiene care inresidential care settings, dental hygiene educationbjcraig@dentistry.ubc.caLEEANN DONNELLY*Oral malodour, geriatrics, oral health programs forspecial care populationsldonnelly@dentistry.ubc.caLAMIA EL-ADWAREffect of medical grade monitors on radiographic interpretationand clinical management of oral pathologylamia@dentistry.ubc.caINGRID EMANUELSAcquisition of reflective vision skills in students: Doesmirror skills pre-training improve learning, performance,and stress levels during clinical simulation exercises?emanuels@dentistry.ubc.caANDREA ESTEVESBone quality and oral implants, geriatricsaesteves@dentistry.ubc.caMARK FOGELMANEnhancing teaching and learning in dental educationmfog@dentistry.ubc.caKAREN GARDNERHigher education: digital technology as it pertains tohigher education, eLearning including ePortfolios, socialnetworking, peer reviewkgardner@dentistry.ubc.caROSAMUND HARRISONCommunity-based oral health promotion, oral healthdisparities, early childhood tooth decay, randomizedcontrolled trials, program evaluationrosha@dentistry.ubc.caDIANA LINHealth promotion, pregnant and immigrant oral health,program evaluationdianalin@dentistry.ubc.caDAVID MACDONALDSystematic review in diagnostic radiologydmacdon@dentistry.ubc.caMICHAEL MACENTEEProsthodontics, geriatrics, health services, publichealth, prostheses on oral implantsmacentee@dentistry.ubc.caKAVITA MATHU-MUJUFactors affecting children’s access to oral healthcarekmmuju@dentistry.ubc.caJAMES RICHARDSONInvestigating the benefit of “clickers”: pilot projectusing a collaborative wiki platform for topics ofinterest to third year dental classesjrichardson@dentistry.ubc.caBATOUL SHARIATIEconomic evaluations in Dentistrybatoul@dentistry.ubc.caHSINGCHI VON BERGMANNLarge-scale comparative studies (e.g. TIMSS), PBL,quantitative research methods, content analysis, programevaluation, science education (K-16), dental educationhsingchi.von.bergmann@ubc.caJOANNE WALTONOral implant prosthodontics, dental educationjnwalton@dentistry.ubc.caELI WHITNEYCritical thinking skills development, curriculum reviewand developmenteli.whitney@dentistry.ubc.caTRACY WONGEngagement in scholarly approaches to teaching andlearning in clinical dental educationtjwong@dentistry.ubc.caCHRISTOPHER WYATTProsthodontics, geriatrics, dental disease prevention,oral health promotioncwyatt@dentistry.ubc.caCHRISTOPHER ZEDOral health disparities with a specific interest in underservedand under-accessed communities in rural andurban settings and less-developed countriesczed@dentistry.ubc.ca20 *We welcome our new faculty to UBC.

Advancing oral health throughoutstanding education, research,and community service.iMATRIX RESEARCH CLUSTERiMatrix is an interactive research cluster combining the research interests of 12 highly active laboratories in oral and biomedicalsciences. We conduct basic science research in areas such as cancer, cell behaviour, craniofacial development, integrins, molecularbiology, periodontal disease, proteases, proteomics, and wound healing. Highly motivated undergraduate and graduate students,postdoctoral fellows and other trainees, as well as interested collaborators, are welcome to contact our member laboratories.DIETER BRÖMME, Coordinator, iMatrix Research Cluster, dbromme@dentistry.ubc.caDIETER BRÖMMELysosomal proteases and their role in healthand diseasedbromme@dentistry.ubc.caDONALD BRUNETTERegulation of cell behaviour on implant surfaces bysubstratum topographybrunette@dentistry.ubc.caVIRGINIA M. DIEWERTPrenatal craniofacial development in humans and mice:3D morphometric analyses identify abnormalities thatcontribute to facial malformations such as cleft lipand/or palatevdiewert@dentistry.ubc.caNANCY FORDMicro-computed tomography, small animal imaging,cone beam CTnlford@dentistry.ubc.caLARI HÄKKINENCell to extracellular matrix interactions in wound healinglhakkine@dentistry.ubc.caHUGH KIM*Biochemical signalling mechanisms that regulateplatelet functionhughkim@dentistry.ubc.caHANNU LARJAVACell adhesion, integrins and signalling in wound healingand periodontal diseaselarjava@dentistry.ubc.caCHRISTOPHER OVERALLProteomic investigation of inflamed periodontaland synovial tissues and cancer to elucidateproteolytic mechanisms of cell signalling and inregulating inflammationchris.overall@ubc.caEDWARD PUTNINSPeriodontal disease pathogenesis and mesenchymalstem cell regeneration of craniofacial tissuesputnins@dentistry.ubc.caJOY RICHMANEvolution and development of the face and teeth usingbird and reptilian modelsrichman@dentistry.ubc.caCLIVE ROBERTSSynthesis and degradation of proteoglycans in the cellbiology of wound healingclive.roberts@ubc.caCHARLES SHULERStudies focused on characterizing the molecularmechanisms regulating secondary palatal fusion withspecific emphasis on the TGFβ signalling pathwaycshuler@dentistry.ubc.ca*We welcome our new faculty to UBC.21

For more information on graduateprograms visit www.dentistry.ubc.ca/grador contact: Vicki Koulourisvkoulouris@dentistry.ubc.ca T 604 822 4486GRADUATE RESEARCHOPPORTUNITIESPhD or MSc in Craniofacial ScienceThe UBC Faculty of Dentistry offers advanced study leading to a PhD or MSc in Craniofacial Science. The PhD program requires thesuccessful completion of a research-specific curriculum, a comprehensive exam, and defense of a research-based thesis. A minimum of fouryears of full-time study is typically required. The MSc program requires successful completion of a research-specific didactic curriculumin conjunction with a research-based thesis. This program typically requires two years of full-time study; however, an extended part-timeoption for an MSc degree is available. Research options in one of the following three broad areas of study are available:· Population health research explores the complex interactions (social, cultural, environmental) that affect the oral health of individuals,communities, and populations.· Oral health-related clinical research includes both interventional and observational studies focusing on the following: disease prevention,diagnosis, risk, treatment, prognosis, and health care.· Basic science research in the areas of biomaterials, cell biology, developmental biology, microbiology, and molecular biology.These graduate programs are available as stand-alone degrees or may be completed as a combined diploma in a clinical specialty with aPhD or MSc degree (see criteria below). Clinical specialty training options are available in the following areas.EndodonticsPhD or MSc combined with a Diploma in Endodontics· PhD degree (minimum 6 years) or MSc degree (minimum 3 years)· Diploma in EndodonticsGraduates will be eligible to take the examinations for specialtycertification in endodontics offered by the Royal College ofDentists of Canada and the American Board of Endodontics.Research Focus· eradication of microorganisms from the root canal system· development of unique in vitro and ex vivo models for biofilmswhich simulate oral in vivo biofilms· industry collaborations on new devices to improveantimicrobial solutions· safety and effectiveness of instrument systems to deliverdisinfecting agents into the root canal· impact of file design on the eradication of root canal microbesClinical Training· treatment management (including surgery) of diseases andtrauma of the tooth root and pulpCriteria· Applicants must hold a DMD or its equivalent· Application deadline: August 1OrthodonticsPhD or MSc combined with a Diploma in Orthodontics· PhD degree (minimum 6 years) or MSc degree (minimum 3 years)· Diploma in OrthodonticsGraduates will be eligible to take the examinations for specialtycertification in orthodontics offered by the Royal College ofDentists of Canada and the American Board of Orthodontics.Research Focus· craniofacial morphology and function in different populations· efficiency and efficacy of treatment modalities· societal and economic strategies that govern access to care· craniofacial molecular and cellular control mechanisms· impact of biomaterials on delivering orthodontic mechanicsClinical Training· diagnosis, prevention and treatment management of abnormalcongenital or developmental relationships of the dentofacialanatomy from infancy to adulthood in diverse populationsCriteria· Applicants must hold a DMD or its equivalent· Postgraduate clinical and/or academic experience preferred· Application deadline: September 122For more information on graduate programs visit www.dentistry.ubc.ca/grad

Pediatric DentistryPhD or MSc combined with a Diploma in Pediatric Dentistry· PhD degree (minimum 6 years) or MSc degree (minimum 3 years)· Diploma in Pediatric DentistryGraduates will be eligible to take the examination for specialtycertification in pediatric dentistry offered by the Royal Collegeof Dentists of Canada and the diplomate examination of theAmerican Board of Pediatric Dentistry.Research Focus· biomedical research (craniofacial development)· clinical research (facial symmetry of cleft lip and palate)· population health and health services research (oral healthpromotion and access to care for disadvantaged children)Clinical Training· diagnostic, preventive, therapeutic and consultative expertisefor children and adolescents including those with specialhealthcare needs at BC Children’s Hospital Dental Department,Oral Health Centre at UBC Vancouver, and community settingsthroughout the provinceCriteria· Applicants must hold a DMD or its equivalent· Application deadline: October 1PeriodonticsPhD or MSc combined with a Diploma in Periodontics· PhD degree (minimum 6 years) or MSc degree (minimum 3 years)· Diploma in PeriodonticsThis program is recognized by the American Dental Associationand the Academy of Periodontology. Graduates will be eligibleto take the examination for fellowship in the Royal College ofDentists of Canada and the board examination of the AmericanAcademy of Periodontology.Research Focus· molecular pathology of periodontal disease· periodontal and skin wound healing· clinical aspects of tissue healing around implants· stem cell-mediated regeneration of lost tissuesClinical Training· management of tooth-supporting structures using non-surgicaland surgical procedures· tooth replacement with implants when neededCriteria· Applicants must hold a DMD or its equivalent· Application deadline: September 1ProsthodonticsPhD or MSc combined with a Diploma in Prosthodontics· PhD degree (minimum 6 years) or MSc degree (minimum 3 years)· Diploma in ProsthodonticsGraduates will be eligible to take the examinations for specialtycertification in prosthodontics offered by the Royal College ofDentists of Canada and the American Board of Prosthodontics.Research Focus· geriatric dentistry· oral implants and related prostheses· caries management· psychosocial aspects of aging· community healthcare needsClinical Training· diagnosis, restoration and maintenance of oral function, comfort,appearance and health of patients by the restoration of naturalteeth and/or the replacement of missing teeth and contiguous oraland maxillofacial tissues with artificial substitutes· aesthetics/cosmetic dentistry· crowns, bridges, veneers, inlays· complete and removable partial dentures· dental implants· TMD-jaw joint problems· traumatic injuries to the structures of the mouthCriteria· Applicants must hold a DMD or its equivalent· Application deadline: October 1For more information on graduate programs visit www.dentistry.ubc.ca/grad23

For more information on postgraduateprograms visit www.dentistry.ubc.ca/postgrador contact: Dorothy Stanfielddstanf@dentistry.ubc.ca T 604 822 0345PostgraduateOpportunitiesGeneral Practice Residency Program· Advanced postgraduate training in dental specialties ina hospital setting· Approximately 11 salaried, residency positions per year(one- or two-year)Applicants choose to apply to the Pediatric Residency, GeriatricDentistry Residency, or the General Practice Residency.All programs are approved by the Commission on DentalAccreditation of Canada.A variety of local, provincial and international learningopportunities are available to expand the comprehensive trainingeach resident receives. Community clinics provide oralhealthcare to individuals on income assistance, job training andother pre-employment programs. Care to the people of HaidaGwaii supports a community dental health strategy. Internationalexperience broadens the scope of learning to understand regionaldisease processes, treatment modalities and cultural competencies.Local-Based Residencies· BC Cancer Agency, BC Children’s Hospital, VancouverHospital & Health Sciences Centre, St. Paul’s Hospital,Portland Community Clinic, First United Oral Health Program,Vancouver Native Health Society (and other community clinics)Provincial-Based Residencies· Haida Gwaii (Skidegate and Massett dental clinics), KelownaGospel Mission, Prince George Native Friendship Centre,Victoria (Cool Aid Community Health Centre)International-Based Residencies· Vietnam (University of Ho Chi Minh, National Hospital ofOdonto-Stomatology and Ho Chi Minh City Cancer Centre)· Cambodia (Angkor Hospital for Children, Siem Reap)· United Kingdom (Solihull, Queen Elizabeth and BirminghamChildren’s Hospitals)Application deadline: October 15Oral Medicine and Oral Pathology Residency Program· Hospital-based postgraduate specialist residency· Three pathways: Oral Medicine (OM, three years), OralPathology (OP, three years), or Combined (OMOP, four years)Completion of any of the three pathways leads to a certificateand eligibility for the Royal College of Dentists of Canadafellowship examinations.Local hospital-based training sites· UBC-affiliated teaching hospitals: BC Cancer Agency,Vancouver Hospital & Health Sciences Centre, St. Paul’s HospitalClinical practice component (training diagnosis, assessmentand management)· oral mucosal disease· orofacial disorders associated with aging, systemic diseaseand medical therapies· non-surgical salivary gland disorders· rotations in anesthesia, internal medicine, rheumatology,neurosciences, dermatology, diagnostic pathology, oncology,otolaryngology, surgical pathology (including autopsy),head and neck pathology, and dermatopathology· OM pathway: additional training in dental management ofmedically complex patients and diagnosis and treatmentof orofacial pain and neurosensory disorders· OP pathway: additional training in surgical and anatomicalhistopathology and laboratory procedures, techniquesand diagnosisDidactic component· postgraduate-level seminars, case presentations andliterature reviews· teaching rounds· ongoing basic and/or clinical research studiesApplication deadline: November 124For more information on postgraduate programs visit www.dentistry.ubc.ca/postgrad

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CONGRATULATIONS UBC DENTISTRYThe British Columbia Dental Association (BCDA) congratulatesUBC Dentistry on its Research Day which highlightsthe faculty’s research accomplishments.Supporting oral radiology in British Columbia, the BCDA’s Mandatory X-RayInspection Program provides X-ray inspections to our members across theprovince. Developed in conjunction with WorkSafeBC & the BC Centre for DiseaseControl, the program ensures our members’ compliance with the requirements ofHealth Canada’s Safety Code 30. Inspections of cone beam computed tomography(CBCT) units are also offered at a cost of $560 plus HST.Questions?Visit bcdental.org for more information or contactthe BCDA at 604 736 7202 or bcda@bcdental.org.27

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GRADUATE andPOSTGRADUATE STUDIESGRADUATE PROGRAMSCraniofacial ScienceCLINICAL SPECIALTY GRADUATE PROGRAMSEndodonticsOrthodonticsPediatric DentistryPeriodonticsProsthodonticsPOSTGRADUATE PROGRAMSGeneral Practice Residency ProgramOral Medicine and Oral Pathology Residency ProgramUBC DENTISTRY 2199 Wesbrook Mall Vancouver, BC Canada V6T 1Z3 · dentistry.ubc.ca31

UBC DENTISTRY350 – 2194 Health Sciences Mall Vancouver, BC Canada V6T 1Z3 dentistry.ubc.ca© The University of British Columbia, 2013 · Design by Letterbox Design