Case Presentation - Department of Surgery at SUNY Downstate ...

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Prognostic FactorsBucher, P et al. Swiss Med Wkly, 2004.
Page 1 and 2: Case PresentationDaron Geldwert, MD
Page 3 and 4: What is GIST?•
Page 5 and 6: Where do these tumor cellsoriginate
Page 7: C-KIT: A Defining Marker• KIT, a
Page 12: Clinical Presentation• Occur in m
Page 15 and 16: Gastric GIST
Page 17 and 18: Rectal GIST
Page 19 and 20: Low Risk versus High Risk
Page 21 and 22: GISTLMSGISTSchwannoma
Page 23: Predictors of Behavior• Size• M
Page 27 and 28: Treatment Options• Surgery• Rad
Page 29 and 30: Radiation/Chemotherapy• Rarely us
Page 31 and 32: Molecularly Targeted Therapy• Sin
Page 33 and 34: Duffaud et al. Oncology 2003
Page 35 and 36: Proof of Concept Study• 50 year o
Page 39: Phase II Trial: Study Design• Ass
Page 42 and 43: Phase II: Con’d• 86% of tumor s
Page 44: Southwest Oncology Group(S0033)- Do
Page 47 and 48: Adjuvant: Phase II ACSOG Z9000• H
Page 49 and 50: Neoadjuvant Therapy• Currently in
Page 51 and 52: Influence on Mutations onRecurrence
Page 53 and 54: Liver Metastasis• 131 patients at
Page 55 and 56: Treatment AlgorithmWu, P et al. Sur
Page 57 and 58: Questions• What are the FDA appro

Case Presentation - Department of Surgery at SUNY Downstate ...

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