Case Presentation - Department of Surgery at SUNY Downstate ...
Case Presentation - Department of Surgery at SUNY Downstate ...
Case Presentation - Department of Surgery at SUNY Downstate ...
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Influence on Mut<strong>at</strong>ions onRecurrence• Approxim<strong>at</strong>ely 90% <strong>of</strong> allGISTs have a c-Kit cmut<strong>at</strong>ion.• All Kit mutant is<strong>of</strong>orms wereassoci<strong>at</strong>ed with a clinicalresponse:– Exon 11: 84% PR– Exon 9: 48% PR• Time to tre<strong>at</strong>ment failure– Exon 11: 687 days– Exon 9: 200 daysHeinrich, MC et al. J Clin Oncol, , 2003.
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