Case Presentation - Department of Surgery at SUNY Downstate ...

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Gleevec
Duffaud et al. Oncology 2003
Page 1 and 2: Case PresentationDaron Geldwert, MD
Page 3 and 4: What is GIST?•
Page 5 and 6: Where do these tumor cellsoriginate
Page 7: C-KIT: A Defining Marker• KIT, a
Page 12: Clinical Presentation• Occur in m
Page 15 and 16: Gastric GIST
Page 17 and 18: Rectal GIST
Page 19 and 20: Low Risk versus High Risk
Page 21 and 22: GISTLMSGISTSchwannoma
Page 23 and 24: Predictors of Behavior• Size• M
Page 26 and 27: Disease Specific Survival AfterComp
Page 28 and 29: Surgery• Only treatment option th
Page 30 and 31: HUMAN PATHOLOGY, 2002.
Page 34 and 35: • http://www.glivec.com/content/g
Page 36: • MRI:Results- 2wks: 41% reductio
Page 41 and 42: Demetri, , G. et al. NEJM, 2002.
Page 43 and 44: Unanswered Questions?• What is th
Page 46 and 47: Duration of Therapy• French Trial
Page 48 and 49: Adjuvant: Phase III ACSOG(Z9001)
Page 50 and 51: Time to Recurrence• Median time t
Page 52 and 53: Peritoneal Metastasis• Cytoreduct
Page 54 and 55: Liver MetsEisenberg, B. et al. Ann
Page 56 and 57: Summary• GIST tumors are more com
Page 58: Questions• Which test is most sen

Case Presentation - Department of Surgery at SUNY Downstate ...

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