Mehdi Gasmi, PhD
Mehdi Gasmi, PhD
Mehdi Gasmi, PhD
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Comparison rAAV transfection vs. rAAV-BacCriteriaTransfectionBaculovirussystemScale-up No YesPurity Profile of DP Good GoodValidation Potential Poor HighMfg costs(Low demand)Mfg costs(High demand)$ $$$*$$$ $*Regulatory (Quality) OK for PhI/II (serum) Approved (EU)ConclusionVery cumbersomeprocess but useful toget to the clinic fast.Difficult to go pastearly phases ofdevelopmentBetter option forhigh-doseindications. Longerlead-time fromtransgene to product(MVB)