DQ8-villin-IL-15tg

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Healthy tissueIntraepithelialcytotoxic T cell (IE-CTL)Epithelial cellStressed or inflamed tissueCD94/NKG2AcytolysisInhibitionTCRCD94/NKG2C HLA-EIFN-γStressLaminapropriaNKG2DNKG2DAAMICA/BIL-15AALeukotrienes?APCNeutrophilTissue maintenanceGlutenMicrobiotaSelf-antigenGlutenMicrobiotaSelf-antigenEosinophilTissue damageMesentericlymph nodeNKG2DMeresse et al., Immunity 2004TCRNaïve CD8 + T cellMemory CTLHue et al., Immunity 2004Meresse et al., J Exp Med 2006Tang et al., J Exp Med 2009
INNATE IMMUNE ACTIVATION“CD4 anti-gluten T cell responses are requiredbut not sufficient to induce intestinal damage”Adaptive immune response(anti-TG2 antibodies)Innate epithelial response(IL-15, epithelial stress markers)Kaukinen et al. Scand J Gastroenterol, 2005Marietta et al. JCI, 2004de Kauwe et al., J Immunol, 2009IEL activation↓Inhibitory NKG2A↑Activatory NKR (CD94+NKG2A-, NKG2D+)Jabri et al., Gastroenterology 2001Meresse et al., Immunity 2004Hue et al., Immunity 2004Meresse et al., J.Exp.Med. 2006VILLOUS ATROPHYInhibitory NK receptorsActivatory NK receptorsActivatory NK receptorsSetty M. et al., in preparation
Page 1 and 2: SYNERGISTIC ROLE OF IL-15IN THE EPI
Page 3 and 4: Intestinal HomeostasisDefault respo
Page 5 and 6: Is there a link between dysregulate
Page 7 and 8: IL-15 induces an inflammatory IFN-
Page 9 and 10: Perspectives: Blocking IL-15 signal
Page 11 and 12: DQ8-D d -IL-15tg mice fed gluten ph
Page 13: Effector intraepithelial CTL killst
Page 17 and 18: SHAMDQ8 DQ8-D d -IL-15tg DQ8-villin
Page 19 and 20: DQ8-D d -villin-IL-15tg mice fed gl
Page 21 and 22: In absence of DQ8D d -villin-IL-15t
Page 23 and 24: AcknowledgmentsValerie AbadieWillia

DQ8-villin-IL-15tg

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