DQ8-villin-IL-15tg

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IngestedglutenEnvironmentalfactorsgliadinVRVPVPQLQPQNPSQQQPQEQVPLVQQQQFLGQQQPFPPQQPYPQPQPFPSQQPYLQLQPFPQPQLPYSQPQPFRPQQPYGluten is not digested(proline-rich)protease-resistantlong gliadinpeptidesShan et al., Science, 2002(glutamine-rich)Tissue Transglutaminase (TG2)LQLQPFPQPQLPYPQPQLPYPQPQLPYPQPQPFVader et al., J exp Med, 2002Molberg et al., Nat Med, 1998Van de Wal et al., J immunol, 1998TG2QQYPSGQGSFQPSQQNPQPQPELPYPQPPFPQPELPYPimmunogenic gliadin peptidesEGSFQPSQETCRHLA-DQ2CD4CD4TCRHLA-<strong>DQ8</strong>Vader et al., J exp Med, 2002Molberg et al., Nat Med, 1998Van de Wal et al., J immunol, 1998anti-gluten T cell responseNilsen et al., Gut, 1995Molberg et al., Scand.J.Immunol., 1997Nilsen et al., Gastroenterology, 1998
Intestinal HomeostasisDefault response in the gut to oral antigen: REGULATORY IMMUNE RESPONSEGut lumenFood antigenGut floraGlutenEpitheliumEffectorT cellsLaminapropriaORALTOLERANCEIFN-γ<strong>IL</strong>-21CELIACDISEASETGF-βTreg Treg inducible Treg cellsRA?T H 1Mesentericlymph nodeNaïveCD4 T cell
Page 1: SYNERGISTIC ROLE OF IL-15IN THE EPI
Page 5 and 6: Is there a link between dysregulate
Page 7 and 8: IL-15 induces an inflammatory IFN-
Page 9 and 10: Perspectives: Blocking IL-15 signal
Page 11 and 12: DQ8-D d -IL-15tg mice fed gluten ph
Page 13 and 14: Effector intraepithelial CTL killst
Page 15 and 16: INNATE IMMUNE ACTIVATION“CD4 anti
Page 17 and 18: SHAMDQ8 DQ8-D d -IL-15tg DQ8-villin
Page 19 and 20: DQ8-D d -villin-IL-15tg mice fed gl
Page 21 and 22: In absence of DQ8D d -villin-IL-15t
Page 23 and 24: AcknowledgmentsValerie AbadieWillia

DQ8-villin-IL-15tg

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