Inspection Checklist for ABSL-3 Laboratories - Select Agent Program

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Revised November 2007ReferenceABMBL: A1StatementThe animal facility director establishes and enforces policies, procedures, andprotocols for institutional policies and emergency situations. Each institute mustassure that worker safety and health concerns are addressed as part of the animalprotocol review. Prior to beginning a study animal protocols must also be reviewedand approved by the IACUC5 and the Institutional Biosafety Committee.ResponseYes No N/ACommentsBMBL: A2A safety manual specific to the animal facility is prepared or adopted inconsultation with the animal facility director and appropriate safetyprofessionals.BMBL: A2The safety manual must be available and accessible.BMBL: A2Personnel are advised of potential and special hazards, and are required to readand follow instructions on practices and procedures. Consideration should begiven to specific biohazards unique to the animal species and protocol in use.BMBL: A3Supervisor must ensure that animal care, laboratory and support personnel receiveappropriate training regarding their duties, animal husbandryprocedure, potential hazards, manipulations of infectious agents, necessaryprecautions to prevent hazard or exposures, and hazard/exposure evaluationprocedures (physical hazards, splashes, aerosolization, etc.).BMBL: A3BMBL: A3BMBL: A4BMBL: A4Personnel must receive annual updates or additional training when procedures orpolicies change.Records are maintained for all hazard evaluations, employee training sessions andstaff attendance.Appropriate medical surveillance program is in place, as determined by riskassessment.The need for an animal allergy prevention program should be considered. Facilitysupervisors should ensure that medical staff is informed of potential occupationalhazards within the animal facility, to include those associated with research, animalhusbandry duties, animal care and manipulations.BMBL: A4Personal health status may impact an individual’s susceptibility to infection, abilityto receive immunizations or prophylactic interventions. Therefore, all personneland particularly women of child-bearing age should be provided informationregarding immune competence and conditions that may predispose them toinfection. Individuals having these conditions should be encouraged to self-identifyto the institution’s healthcare provider for appropriate counseling and guidance.BMBL: A4BMBL: A5Personnel using respirators must be enrolled in an appropriately constitutedrespiratory protection program.A sign incorporating the universal biohazard symbol must be posted at theentrance to areas where infectious materials and/or animals are housed or aremanipulated.APHIS/CDC Select Agent Program ABSL-3 Inspection Checklist Page 2 of 11
Revised November 2007ReferenceBMBL: A5StatementThe sign must include the animal biosafety level, general occupational healthrequirements, personal protective equipment requirements, the supervisor’s name(or other responsible personnel), telephone number, and required procedures forentering and exiting the animal areas.ResponseYes No N/ACommentsBMBL: A5BMBL: A5BMBL: A5BMBL: A6Identification of specific infectious agents is recommended when more than oneagent is being used within an animal room.Security-sensitive agent information and occupational health requirements shouldbe posted in accordance with the institutional policy.Advance consideration should be given to emergency and disaster recovery plans,as a contingency for man-made or natural disasters.Access to the animal room is limited to the fewest number of individuals possible.Only those persons required for program or support purposes are authorized toenter the animal facility and the areas where infectious materials and/or animalsare housed or are manipulated.BMBL: A6All persons including facility personnel, service workers, and visitors are advised ofthe potential hazards (natural or research pathogens, allergens, etc) and areinstructed on the appropriate safeguards.BMBL: A7BMBL: A7BMBL: A7Protective laboratory coats, gowns, or uniforms are required to preventcontamination of personal clothing.Gloves are worn to prevent skin contact with contaminated, infectious/ andhazardous materials and when handling animals.Double-glove practices should be used when dictated by risk assessment.BMBL: A7Gloves and personal protective equipment should be removed in a manner thatminimizes transfer of infectious materials outside of the areas where infectiousmaterials and/or animals are housed or are manipulated.BMBL: A7Persons must wash their hands after removing gloves, and before leaving theareas where infectious materials and/or animals are housed or are manipulated.BMBL: A7BMBL: A8BMBL: A9BMBL: A10Eye and face and respiratory protection should be used in rooms containinginfected animals, as dictated by the risk assessment.Eating, drinking, smoking, handling contact lenses, applying cosmetics, and storingfood for human use should only be done in designated areas and are not permittedin animal or procedure rooms.All procedures are carefully performed to minimize the creation of aerosols orsplatters of infectious materials and waste.Mouth pipetting is prohibited. Mechanical pipetting devices must be used.BMBL: A11BMBL: A11Policies for the safe handling of sharps, such as needles, scalpels, pipettes, andbroken glassware must be developed and implemented.When applicable, laboratory supervisors should adopt improved engineering andwork practice controls that reduce the risk of sharps injuries. Precautions,including those listed below, must always be taken with sharp items. Theseinclude:APHIS/CDC Select Agent Program ABSL-3 Inspection Checklist Page 3 of 11
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Inspection Checklist for ABSL-3 Laboratories - Select Agent Program

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